Incidental Mutation 'R6245:Or5w15'
ID 505503
Institutional Source Beutler Lab
Gene Symbol Or5w15
Ensembl Gene ENSMUSG00000075149
Gene Name olfactory receptor family 5 subfamily W member 15
Synonyms MOR177-8, Olfr1138, GA_x6K02T2Q125-49242149-49241214
MMRRC Submission 044403-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.103) question?
Stock # R6245 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 87567731-87568666 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to C at 87568240 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Glutamic Acid at position 143 (Q143E)
Ref Sequence ENSEMBL: ENSMUSP00000148941 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099848] [ENSMUST00000214573]
AlphaFold Q8VFQ9
Predicted Effect possibly damaging
Transcript: ENSMUST00000099848
AA Change: Q143E

PolyPhen 2 Score 0.540 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000097435
Gene: ENSMUSG00000075149
AA Change: Q143E

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.3e-45 PFAM
Pfam:7tm_1 41 290 1.5e-18 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214573
AA Change: Q143E

PolyPhen 2 Score 0.540 (Sensitivity: 0.88; Specificity: 0.90)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 A G 11: 110,026,249 (GRCm39) I937T probably damaging Het
Adgrl3 T A 5: 81,836,403 (GRCm39) N720K probably benign Het
Akr1c21 T G 13: 4,625,231 (GRCm39) V54G possibly damaging Het
Alpi G T 1: 87,028,556 (GRCm39) D111E probably damaging Het
Armc3 C T 2: 19,253,516 (GRCm39) T219M probably damaging Het
Bms1 T A 6: 118,373,797 (GRCm39) E780V probably damaging Het
Ccdc159 T C 9: 21,846,864 (GRCm39) S244P probably damaging Het
Cdon T C 9: 35,388,235 (GRCm39) W737R probably damaging Het
Chdh T A 14: 29,757,262 (GRCm39) V395D probably damaging Het
Col22a1 C A 15: 71,845,665 (GRCm39) D366Y probably damaging Het
Cplane1 T C 15: 8,207,902 (GRCm39) Y218H probably benign Het
Crnkl1 T A 2: 145,770,051 (GRCm39) N264I probably benign Het
Ctnnd2 T C 15: 30,905,894 (GRCm39) L847P probably damaging Het
Cyp4a31 A C 4: 115,428,545 (GRCm39) T382P possibly damaging Het
Dcaf8 A T 1: 171,993,434 (GRCm39) M1L probably benign Het
Ddx31 T A 2: 28,734,994 (GRCm39) F52I probably benign Het
Dynlt5 A G 4: 102,845,864 (GRCm39) N32S probably benign Het
Efcab3 A T 11: 104,675,834 (GRCm39) Y1542F probably benign Het
Eps15 G A 4: 109,240,063 (GRCm39) S852N possibly damaging Het
Fchsd1 A T 18: 38,095,828 (GRCm39) L552Q probably damaging Het
Fetub C T 16: 22,751,081 (GRCm39) R143C probably damaging Het
Frem2 T C 3: 53,563,245 (GRCm39) M421V probably benign Het
Gm1110 T G 9: 26,832,043 (GRCm39) H36P probably benign Het
Hadha C T 5: 30,325,042 (GRCm39) probably null Het
Hspa4 C T 11: 53,153,766 (GRCm39) E702K probably benign Het
Intu C A 3: 40,629,756 (GRCm39) T362K probably damaging Het
Jaml C T 9: 45,009,217 (GRCm39) T248I probably damaging Het
Kcnj1 A T 9: 32,308,163 (GRCm39) S176C probably damaging Het
Kcnj9 A G 1: 172,153,704 (GRCm39) L140P probably damaging Het
Kif7 T C 7: 79,351,891 (GRCm39) K957R probably damaging Het
Klc4 T A 17: 46,947,605 (GRCm39) I366F probably damaging Het
Lamb2 A G 9: 108,365,398 (GRCm39) probably null Het
Madd T C 2: 91,008,449 (GRCm39) D151G probably benign Het
Man2a1 C A 17: 65,017,821 (GRCm39) A689E probably damaging Het
Mapk8ip1 C A 2: 92,219,589 (GRCm39) G81C probably damaging Het
Msmp T C 4: 43,583,909 (GRCm39) Y48C probably damaging Het
Muc6 T C 7: 141,235,086 (GRCm39) N567S probably damaging Het
Nrap A G 19: 56,342,653 (GRCm39) Y748H probably damaging Het
Nrap C T 19: 56,368,307 (GRCm39) A192T possibly damaging Het
Or2p2 T A 13: 21,256,860 (GRCm39) T204S possibly damaging Het
Or2y14 T A 11: 49,404,992 (GRCm39) F176I possibly damaging Het
Pcdhb8 T G 18: 37,490,222 (GRCm39) D633E possibly damaging Het
Pcdhb9 G A 18: 37,536,207 (GRCm39) V734M probably damaging Het
Plscr1 T C 9: 92,141,374 (GRCm39) Y21H unknown Het
Ptk2b G T 14: 66,400,515 (GRCm39) P767T probably damaging Het
Ptprz1 T C 6: 23,051,989 (GRCm39) Y1424H probably damaging Het
Sec31a T A 5: 100,534,043 (GRCm39) Q118L probably benign Het
Selenop A G 15: 3,304,216 (GRCm39) S21G probably damaging Het
Shank1 G A 7: 44,001,677 (GRCm39) S1132N unknown Het
Slf1 A G 13: 77,232,502 (GRCm39) L534P probably damaging Het
Sparcl1 T A 5: 104,233,013 (GRCm39) H596L probably damaging Het
Spocd1 C T 4: 129,850,901 (GRCm39) probably null Het
Tbc1d24 A T 17: 24,404,967 (GRCm39) I59N probably damaging Het
Tjp3 G A 10: 81,113,110 (GRCm39) T580I probably benign Het
Tmem154 C T 3: 84,591,603 (GRCm39) T51M possibly damaging Het
Tmem8b G A 4: 43,690,246 (GRCm39) V894I probably benign Het
Trbv20 A T 6: 41,165,840 (GRCm39) L88F possibly damaging Het
Tssk2 A C 16: 17,716,812 (GRCm39) I72L possibly damaging Het
Tub T A 7: 108,626,265 (GRCm39) I267N probably damaging Het
Vmn2r104 A T 17: 20,261,829 (GRCm39) F434I possibly damaging Het
Vmn2r42 T C 7: 8,195,733 (GRCm39) N471S probably damaging Het
Vmn2r94 C G 17: 18,478,385 (GRCm39) G121R probably damaging Het
Wdr72 T C 9: 74,055,505 (GRCm39) S245P probably damaging Het
Zbtb42 A G 12: 112,645,969 (GRCm39) Y48C probably damaging Het
Zdbf2 T C 1: 63,343,592 (GRCm39) V657A possibly damaging Het
Zfp768 A T 7: 126,943,263 (GRCm39) C288* probably null Het
Zfp988 T A 4: 147,416,470 (GRCm39) C301* probably null Het
Other mutations in Or5w15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02304:Or5w15 APN 2 87,568,330 (GRCm39) missense probably benign 0.01
IGL02490:Or5w15 APN 2 87,568,299 (GRCm39) missense probably damaging 1.00
IGL02730:Or5w15 APN 2 87,567,985 (GRCm39) missense probably damaging 1.00
IGL03106:Or5w15 APN 2 87,568,462 (GRCm39) missense probably benign 0.02
IGL03113:Or5w15 APN 2 87,568,506 (GRCm39) missense probably benign 0.01
R0450:Or5w15 UTSW 2 87,567,825 (GRCm39) missense probably damaging 0.98
R0469:Or5w15 UTSW 2 87,567,825 (GRCm39) missense probably damaging 0.98
R0510:Or5w15 UTSW 2 87,567,825 (GRCm39) missense probably damaging 0.98
R3696:Or5w15 UTSW 2 87,568,360 (GRCm39) missense probably benign
R3698:Or5w15 UTSW 2 87,568,360 (GRCm39) missense probably benign
R5149:Or5w15 UTSW 2 87,567,749 (GRCm39) missense probably benign
R5156:Or5w15 UTSW 2 87,568,119 (GRCm39) missense possibly damaging 0.95
R6701:Or5w15 UTSW 2 87,567,753 (GRCm39) missense probably benign
R7170:Or5w15 UTSW 2 87,568,056 (GRCm39) missense probably damaging 0.99
R7185:Or5w15 UTSW 2 87,568,489 (GRCm39) missense probably damaging 1.00
R7260:Or5w15 UTSW 2 87,568,852 (GRCm39) splice site probably null
R8065:Or5w15 UTSW 2 87,568,147 (GRCm39) missense probably damaging 1.00
R8067:Or5w15 UTSW 2 87,568,147 (GRCm39) missense probably damaging 1.00
R8671:Or5w15 UTSW 2 87,567,990 (GRCm39) missense probably damaging 0.96
R8953:Or5w15 UTSW 2 87,568,371 (GRCm39) missense probably benign 0.01
R9254:Or5w15 UTSW 2 87,568,372 (GRCm39) missense probably benign
R9356:Or5w15 UTSW 2 87,568,089 (GRCm39) missense probably benign 0.01
R9481:Or5w15 UTSW 2 87,568,576 (GRCm39) missense probably benign 0.44
R9544:Or5w15 UTSW 2 87,568,644 (GRCm39) missense probably benign
R9588:Or5w15 UTSW 2 87,568,644 (GRCm39) missense probably benign
R9646:Or5w15 UTSW 2 87,568,512 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- GGTGCTCAGTTCAATGAAACC -3'
(R):5'- TGGTCCTAAGATGCTTGTAGACC -3'

Sequencing Primer
(F):5'- GTGCTCAGTTCAATGAAACCAAAAAC -3'
(R):5'- GTCCTAAGATGCTTGTAGACCTACTG -3'
Posted On 2018-02-28