|Institutional Source||Beutler Lab|
|Gene Name||somatostatin receptor 3|
|Synonyms||sst3, Smstr-3, Smstr3|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R6247 (G1)|
|Chromosomal Location||78537008-78544685 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to A at 78539588 bp|
|Amino Acid Change||Isoleucine to Phenylalanine at position 320 (I320F)|
|Ref Sequence||ENSEMBL: ENSMUSP00000058040 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000053239] [ENSMUST00000230400]|
|Predicted Effect||probably damaging
AA Change: I320F
PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
AA Change: I320F
|Predicted Effect||probably benign
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This protein is functionally coupled to adenylyl cyclase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Sstr3||
(F):5'- TGGCTGTTGTCCACTAGTGC -3'
(R):5'- CTCATTGTGGTAAAGGTGCG -3'
(F):5'- TGTGCGATCTGACTGAGCCTC -3'
(R):5'- TAAAGGTGCGGTCGACCAC -3'