|Institutional Source||Beutler Lab|
|Gene Name||syndecan 4|
|Synonyms||ryudocan, syndecan-4, Synd4|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R6250 (G1)|
|Chromosomal Location||164424247-164443887 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to T at 164431218 bp|
|Amino Acid Change||Aspartic acid to Glutamic Acid at position 57 (D57E)|
|Ref Sequence||ENSEMBL: ENSMUSP00000017153 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000017153]|
|Predicted Effect||probably damaging
AA Change: D57E
PolyPhen 2 Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
AA Change: D57E
|Predicted Effect||noncoding transcript
|Meta Mutation Damage Score||0.0978|
|Coding Region Coverage||
|Validation Efficiency||98% (60/61)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous or heterozygous for a knock-out allele show delayed wound healing and impaired angiogenesis. Homozygotes for a different knock-out allele exhibit degenerated fetal vessels in the placental labyrinth, abnormal cell adhesion, and high susceptibility to induced renal and hepatic injury. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Sdc4||
(F):5'- TTGTTTACAACTCACCCCAGAGAC -3'
(R):5'- CACTTTGGGGCACTCTTGTC -3'
(F):5'- GGGAAAATGTTACTTTTGTTTCCC -3'
(R):5'- GGCACTCTTGTCTCCGAG -3'