Incidental Mutation 'R6254:Cadps2'
| ID |
505971 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cadps2
|
| Ensembl Gene |
ENSMUSG00000017978 |
| Gene Name |
Ca2+-dependent activator protein for secretion 2 |
| Synonyms |
Caps2, cpd2, A230044C21Rik |
| MMRRC Submission |
044371-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R6254 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
23262773-23839421 bp(-) (GRCm38) |
| Type of Mutation |
critical splice acceptor site |
| DNA Base Change (assembly) |
T to A
at 23329163 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125972
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000018122]
[ENSMUST00000018122]
[ENSMUST00000069074]
[ENSMUST00000069074]
[ENSMUST00000115358]
[ENSMUST00000115358]
[ENSMUST00000115361]
[ENSMUST00000115361]
[ENSMUST00000125350]
[ENSMUST00000125350]
[ENSMUST00000142913]
[ENSMUST00000142913]
[ENSMUST00000163871]
[ENSMUST00000163871]
[ENSMUST00000166458]
[ENSMUST00000166458]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably null
Transcript: ENSMUST00000018122
|
| SMART Domains |
Protein: ENSMUSP00000018122
Gene: ENSMUSG00000017978
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
902 |
1.14e-52 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000018122
|
| SMART Domains |
Protein: ENSMUSP00000018122
Gene: ENSMUSG00000017978
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
902 |
1.14e-52 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000069074
|
| SMART Domains |
Protein: ENSMUSP00000064876
Gene: ENSMUSG00000017978
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
895 |
5.54e-51 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000069074
|
| SMART Domains |
Protein: ENSMUSP00000064876
Gene: ENSMUSG00000017978
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
895 |
5.54e-51 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000115358
|
| SMART Domains |
Protein: ENSMUSP00000111015
Gene: ENSMUSG00000017978
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
902 |
1.14e-52 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000115358
|
| SMART Domains |
Protein: ENSMUSP00000111015
Gene: ENSMUSG00000017978
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
902 |
1.14e-52 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000115361
|
| SMART Domains |
Protein: ENSMUSP00000111018
Gene: ENSMUSG00000017978
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
892 |
1.9e-49 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000115361
|
| SMART Domains |
Protein: ENSMUSP00000111018
Gene: ENSMUSG00000017978
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
892 |
1.9e-49 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000125350
|
| SMART Domains |
Protein: ENSMUSP00000115866
Gene: ENSMUSG00000017978
| Domain | Start | End | E-Value | Type |
|---|
|
C2
|
14 |
112 |
1.51e-1 |
SMART |
|
PH
|
137 |
241 |
2.94e-11 |
SMART |
|
DUF1041
|
446 |
537 |
1.9e-49 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000125350
|
| SMART Domains |
Protein: ENSMUSP00000115866
Gene: ENSMUSG00000017978
| Domain | Start | End | E-Value | Type |
|---|
|
C2
|
14 |
112 |
1.51e-1 |
SMART |
|
PH
|
137 |
241 |
2.94e-11 |
SMART |
|
DUF1041
|
446 |
537 |
1.9e-49 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000142913
|
| SMART Domains |
Protein: ENSMUSP00000138167
Gene: ENSMUSG00000017978
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
22 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
85 |
97 |
N/A |
INTRINSIC |
|
coiled coil region
|
236 |
256 |
N/A |
INTRINSIC |
|
C2
|
340 |
438 |
1.51e-1 |
SMART |
|
PH
|
463 |
567 |
2.94e-11 |
SMART |
|
DUF1041
|
772 |
873 |
1.14e-52 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000142913
|
| SMART Domains |
Protein: ENSMUSP00000138167
Gene: ENSMUSG00000017978
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
22 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
85 |
97 |
N/A |
INTRINSIC |
|
coiled coil region
|
236 |
256 |
N/A |
INTRINSIC |
|
C2
|
340 |
438 |
1.51e-1 |
SMART |
|
PH
|
463 |
567 |
2.94e-11 |
SMART |
|
DUF1041
|
772 |
873 |
1.14e-52 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000156986
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000163871
|
| SMART Domains |
Protein: ENSMUSP00000128905
Gene: ENSMUSG00000017978
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
902 |
7.2e-50 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000163871
|
| SMART Domains |
Protein: ENSMUSP00000128905
Gene: ENSMUSG00000017978
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
902 |
7.2e-50 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000166458
|
| SMART Domains |
Protein: ENSMUSP00000125972
Gene: ENSMUSG00000017978
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
85 |
97 |
N/A |
INTRINSIC |
|
coiled coil region
|
236 |
256 |
N/A |
INTRINSIC |
|
C2
|
340 |
438 |
1.51e-1 |
SMART |
|
PH
|
463 |
567 |
2.94e-11 |
SMART |
|
DUF1041
|
772 |
873 |
1.05e-51 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000166458
|
| SMART Domains |
Protein: ENSMUSP00000125972
Gene: ENSMUSG00000017978
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
85 |
97 |
N/A |
INTRINSIC |
|
coiled coil region
|
236 |
256 |
N/A |
INTRINSIC |
|
C2
|
340 |
438 |
1.51e-1 |
SMART |
|
PH
|
463 |
567 |
2.94e-11 |
SMART |
|
DUF1041
|
772 |
873 |
1.05e-51 |
SMART |
|
| Meta Mutation Damage Score |
0.9495 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.2%
- 20x: 94.4%
|
| Validation Efficiency |
100% (82/82) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
PHENOTYPE: Mice homozygous for a null allele exhibit defects in cerebellum, Purkinje cell and interneuron morphology, paired-pulse facilitation, and behaviors including emotional behavior, vestibuoocular reflex, circadium and sleep patterns, social investigation and nurturing behavior. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 82 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4932443I19Rik |
A |
G |
8: 13,706,043 (GRCm38) |
D26G |
possibly damaging |
Het |
| Adam6b |
A |
T |
12: 113,489,570 (GRCm38) |
L2F |
probably damaging |
Het |
| Ank2 |
T |
A |
3: 126,941,804 (GRCm38) |
|
probably benign |
Het |
| Anpep |
T |
G |
7: 79,839,233 (GRCm38) |
D369A |
probably damaging |
Het |
| App |
T |
C |
16: 84,978,177 (GRCm38) |
E599G |
probably damaging |
Het |
| Asphd1 |
C |
T |
7: 126,948,868 (GRCm38) |
V88I |
probably benign |
Het |
| Atad5 |
A |
T |
11: 80,127,389 (GRCm38) |
I1389F |
probably damaging |
Het |
| Blm |
T |
C |
7: 80,480,342 (GRCm38) |
N950S |
probably benign |
Het |
| Bsn |
A |
T |
9: 108,111,866 (GRCm38) |
M2229K |
probably damaging |
Het |
| Cacna2d2 |
A |
G |
9: 107,509,216 (GRCm38) |
M181V |
probably benign |
Het |
| Cdh1 |
T |
A |
8: 106,663,798 (GRCm38) |
V590D |
probably damaging |
Het |
| Cdk5rap2 |
G |
A |
4: 70,364,032 (GRCm38) |
T160M |
probably damaging |
Het |
| Chrna5 |
A |
G |
9: 55,006,456 (GRCm38) |
M325V |
probably benign |
Het |
| Clca3a2 |
A |
G |
3: 144,802,134 (GRCm38) |
I116T |
probably benign |
Het |
| Cyp2c23 |
T |
C |
19: 44,005,463 (GRCm38) |
K488R |
probably benign |
Het |
| Edil3 |
T |
A |
13: 89,319,729 (GRCm38) |
I451N |
probably damaging |
Het |
| Exph5 |
T |
G |
9: 53,372,710 (GRCm38) |
S364A |
possibly damaging |
Het |
| Fam84b |
A |
G |
15: 60,823,801 (GRCm38) |
I32T |
probably damaging |
Het |
| Fam98c |
A |
G |
7: 29,154,517 (GRCm38) |
S209P |
probably damaging |
Het |
| Fat3 |
G |
A |
9: 15,996,145 (GRCm38) |
L2854F |
probably benign |
Het |
| Fbxo38 |
T |
C |
18: 62,505,500 (GRCm38) |
|
probably null |
Het |
| Fermt2 |
T |
C |
14: 45,476,059 (GRCm38) |
D205G |
probably damaging |
Het |
| Fmnl1 |
G |
A |
11: 103,196,315 (GRCm38) |
|
probably benign |
Het |
| Fn3k |
A |
G |
11: 121,435,068 (GRCm38) |
E27G |
probably damaging |
Het |
| Foxj2 |
A |
G |
6: 122,838,139 (GRCm38) |
H378R |
probably damaging |
Het |
| Fubp1 |
A |
G |
3: 152,232,408 (GRCm38) |
K140E |
possibly damaging |
Het |
| Gm4788 |
A |
G |
1: 139,754,390 (GRCm38) |
I156T |
probably damaging |
Het |
| Gm7694 |
A |
T |
1: 170,302,534 (GRCm38) |
C98* |
probably null |
Het |
| Golgb1 |
T |
C |
16: 36,913,978 (GRCm38) |
S1196P |
probably damaging |
Het |
| Gpm6a |
G |
A |
8: 55,047,396 (GRCm38) |
|
probably null |
Het |
| Hltf |
T |
A |
3: 20,063,829 (GRCm38) |
N80K |
possibly damaging |
Het |
| Il1rap |
G |
A |
16: 26,695,270 (GRCm38) |
R251H |
probably benign |
Het |
| Ipo7 |
T |
A |
7: 110,049,060 (GRCm38) |
D688E |
probably benign |
Het |
| Itgal |
T |
A |
7: 127,325,203 (GRCm38) |
N897K |
probably damaging |
Het |
| Itsn2 |
A |
G |
12: 4,624,982 (GRCm38) |
|
probably null |
Het |
| Kcnk13 |
A |
G |
12: 99,965,372 (GRCm38) |
|
probably benign |
Het |
| Kdm7a |
A |
G |
6: 39,170,269 (GRCm38) |
L248P |
probably damaging |
Het |
| Kmt2c |
T |
C |
5: 25,349,874 (GRCm38) |
E1254G |
possibly damaging |
Het |
| Ldah |
G |
A |
12: 8,275,912 (GRCm38) |
|
probably benign |
Het |
| Lingo1 |
T |
A |
9: 56,620,087 (GRCm38) |
D406V |
possibly damaging |
Het |
| Lrriq1 |
A |
T |
10: 103,215,451 (GRCm38) |
V480E |
probably benign |
Het |
| Mtcl1 |
C |
T |
17: 66,358,134 (GRCm38) |
R1142H |
probably benign |
Het |
| Mtmr3 |
G |
A |
11: 4,497,381 (GRCm38) |
Q360* |
probably null |
Het |
| Muc6 |
T |
C |
7: 141,651,115 (GRCm38) |
N252S |
probably benign |
Het |
| Naa20 |
T |
C |
2: 145,903,320 (GRCm38) |
L4P |
probably damaging |
Het |
| Neb |
T |
A |
2: 52,222,961 (GRCm38) |
I4274L |
probably benign |
Het |
| Noa1 |
A |
T |
5: 77,309,669 (GRCm38) |
F130I |
probably benign |
Het |
| Nrg4 |
G |
T |
9: 55,236,512 (GRCm38) |
H87N |
possibly damaging |
Het |
| Olfr1024 |
T |
A |
2: 85,904,505 (GRCm38) |
Y183F |
probably damaging |
Het |
| Olfr632 |
T |
A |
7: 103,937,534 (GRCm38) |
H51Q |
probably benign |
Het |
| P3h3 |
C |
T |
6: 124,845,601 (GRCm38) |
E536K |
probably damaging |
Het |
| Pcdhb11 |
T |
C |
18: 37,421,718 (GRCm38) |
S34P |
probably damaging |
Het |
| Pik3r1 |
T |
C |
13: 101,689,406 (GRCm38) |
T71A |
possibly damaging |
Het |
| Plaur |
T |
A |
7: 24,466,800 (GRCm38) |
C99S |
possibly damaging |
Het |
| Plekha5 |
G |
A |
6: 140,586,436 (GRCm38) |
G501E |
probably damaging |
Het |
| Plxnd1 |
C |
T |
6: 115,977,960 (GRCm38) |
V614M |
probably benign |
Het |
| Ppp2r3a |
T |
C |
9: 101,148,587 (GRCm38) |
D307G |
possibly damaging |
Het |
| Prl3d3 |
C |
T |
13: 27,157,470 (GRCm38) |
S28F |
possibly damaging |
Het |
| Prpf40a |
T |
C |
2: 53,157,915 (GRCm38) |
M197V |
probably benign |
Het |
| Ptk7 |
C |
A |
17: 46,572,642 (GRCm38) |
Q832H |
probably damaging |
Het |
| Qser1 |
T |
C |
2: 104,790,090 (GRCm38) |
S126G |
probably benign |
Het |
| Rab3ip |
A |
T |
10: 116,915,867 (GRCm38) |
C332S |
probably damaging |
Het |
| Raly |
C |
A |
2: 154,857,366 (GRCm38) |
T30K |
probably damaging |
Het |
| Rbp2 |
G |
T |
9: 98,490,647 (GRCm38) |
S13I |
probably benign |
Het |
| Rps6ka1 |
C |
T |
4: 133,867,224 (GRCm38) |
M159I |
possibly damaging |
Het |
| Rufy3 |
C |
T |
5: 88,584,309 (GRCm38) |
T57I |
probably benign |
Het |
| Samd4 |
A |
G |
14: 47,016,631 (GRCm38) |
D184G |
probably damaging |
Het |
| Slc35f3 |
T |
C |
8: 126,321,094 (GRCm38) |
C58R |
possibly damaging |
Het |
| Smarca4 |
T |
C |
9: 21,699,877 (GRCm38) |
I1467T |
probably damaging |
Het |
| Spag17 |
T |
G |
3: 100,065,585 (GRCm38) |
I1371S |
probably benign |
Het |
| Sptan1 |
T |
C |
2: 30,007,549 (GRCm38) |
L1228P |
possibly damaging |
Het |
| Stk31 |
C |
T |
6: 49,421,697 (GRCm38) |
A344V |
probably benign |
Het |
| Supt16 |
A |
G |
14: 52,170,834 (GRCm38) |
W885R |
probably damaging |
Het |
| Tdrd9 |
T |
A |
12: 112,025,900 (GRCm38) |
|
probably null |
Het |
| Tmod1 |
A |
G |
4: 46,078,469 (GRCm38) |
|
probably null |
Het |
| Tnfsf13 |
A |
C |
11: 69,684,483 (GRCm38) |
|
probably null |
Het |
| Trim75 |
C |
A |
8: 64,983,442 (GRCm38) |
E119* |
probably null |
Het |
| Wdr6 |
T |
C |
9: 108,574,911 (GRCm38) |
Y591C |
probably damaging |
Het |
| Wdr86 |
C |
T |
5: 24,718,283 (GRCm38) |
R137H |
probably benign |
Het |
| Ythdf1 |
T |
A |
2: 180,911,150 (GRCm38) |
Y424F |
probably damaging |
Het |
| Zfp984 |
G |
T |
4: 147,756,186 (GRCm38) |
S69R |
possibly damaging |
Het |
| Zyg11a |
A |
G |
4: 108,181,794 (GRCm38) |
F743L |
probably damaging |
Het |
|
| Other mutations in Cadps2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01014:Cadps2
|
APN |
6 |
23,496,874 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
IGL01105:Cadps2
|
APN |
6 |
23,321,700 (GRCm38) |
splice site |
probably benign |
|
|
IGL01317:Cadps2
|
APN |
6 |
23,314,173 (GRCm38) |
missense |
possibly damaging |
0.76 |
|
IGL01409:Cadps2
|
APN |
6 |
23,587,441 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01477:Cadps2
|
APN |
6 |
23,263,673 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01620:Cadps2
|
APN |
6 |
23,587,462 (GRCm38) |
missense |
probably benign |
0.19 |
|
IGL01674:Cadps2
|
APN |
6 |
23,355,852 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01675:Cadps2
|
APN |
6 |
23,382,905 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01895:Cadps2
|
APN |
6 |
23,427,275 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL02095:Cadps2
|
APN |
6 |
23,427,310 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL02200:Cadps2
|
APN |
6 |
23,385,528 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02380:Cadps2
|
APN |
6 |
23,287,732 (GRCm38) |
missense |
probably benign |
0.11 |
|
IGL02680:Cadps2
|
APN |
6 |
23,838,896 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02814:Cadps2
|
APN |
6 |
23,321,707 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02940:Cadps2
|
APN |
6 |
23,496,809 (GRCm38) |
missense |
probably benign |
0.08 |
|
IGL03061:Cadps2
|
APN |
6 |
23,287,660 (GRCm38) |
splice site |
probably null |
|
|
IGL03233:Cadps2
|
APN |
6 |
23,263,601 (GRCm38) |
missense |
probably benign |
0.10 |
|
R0193:Cadps2
|
UTSW |
6 |
23,599,440 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0389:Cadps2
|
UTSW |
6 |
23,321,782 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R0571:Cadps2
|
UTSW |
6 |
23,583,412 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0595:Cadps2
|
UTSW |
6 |
23,321,704 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0620:Cadps2
|
UTSW |
6 |
23,583,396 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0723:Cadps2
|
UTSW |
6 |
23,287,698 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0831:Cadps2
|
UTSW |
6 |
23,321,740 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R0836:Cadps2
|
UTSW |
6 |
23,328,776 (GRCm38) |
splice site |
probably benign |
|
|
R0942:Cadps2
|
UTSW |
6 |
23,263,562 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1099:Cadps2
|
UTSW |
6 |
23,599,479 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1120:Cadps2
|
UTSW |
6 |
23,838,794 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1216:Cadps2
|
UTSW |
6 |
23,583,473 (GRCm38) |
splice site |
probably benign |
|
|
R1575:Cadps2
|
UTSW |
6 |
23,429,218 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1780:Cadps2
|
UTSW |
6 |
23,320,932 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1924:Cadps2
|
UTSW |
6 |
23,688,858 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1944:Cadps2
|
UTSW |
6 |
23,599,480 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1956:Cadps2
|
UTSW |
6 |
23,287,686 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1986:Cadps2
|
UTSW |
6 |
23,323,380 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2045:Cadps2
|
UTSW |
6 |
23,839,122 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
R2146:Cadps2
|
UTSW |
6 |
23,838,999 (GRCm38) |
intron |
probably benign |
|
|
R2147:Cadps2
|
UTSW |
6 |
23,838,999 (GRCm38) |
intron |
probably benign |
|
|
R2148:Cadps2
|
UTSW |
6 |
23,838,999 (GRCm38) |
intron |
probably benign |
|
|
R2150:Cadps2
|
UTSW |
6 |
23,838,999 (GRCm38) |
intron |
probably benign |
|
|
R2219:Cadps2
|
UTSW |
6 |
23,410,832 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2264:Cadps2
|
UTSW |
6 |
23,323,340 (GRCm38) |
missense |
probably benign |
0.15 |
|
R2338:Cadps2
|
UTSW |
6 |
23,838,978 (GRCm38) |
splice site |
probably benign |
|
|
R3861:Cadps2
|
UTSW |
6 |
23,355,861 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3898:Cadps2
|
UTSW |
6 |
23,528,126 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3982:Cadps2
|
UTSW |
6 |
23,263,531 (GRCm38) |
utr 3 prime |
probably benign |
|
|
R4213:Cadps2
|
UTSW |
6 |
23,599,463 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4384:Cadps2
|
UTSW |
6 |
23,412,988 (GRCm38) |
missense |
probably benign |
0.18 |
|
R4432:Cadps2
|
UTSW |
6 |
23,626,738 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4609:Cadps2
|
UTSW |
6 |
23,587,579 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4806:Cadps2
|
UTSW |
6 |
23,688,860 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R4977:Cadps2
|
UTSW |
6 |
23,599,479 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5174:Cadps2
|
UTSW |
6 |
23,287,743 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5267:Cadps2
|
UTSW |
6 |
23,626,668 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
R5389:Cadps2
|
UTSW |
6 |
23,329,104 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5737:Cadps2
|
UTSW |
6 |
23,328,805 (GRCm38) |
missense |
probably benign |
0.28 |
|
R6074:Cadps2
|
UTSW |
6 |
23,626,671 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6323:Cadps2
|
UTSW |
6 |
23,263,578 (GRCm38) |
missense |
probably benign |
0.04 |
|
R6463:Cadps2
|
UTSW |
6 |
23,323,334 (GRCm38) |
nonsense |
probably null |
|
|
R6907:Cadps2
|
UTSW |
6 |
23,599,506 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6940:Cadps2
|
UTSW |
6 |
23,302,492 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6964:Cadps2
|
UTSW |
6 |
23,583,459 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7079:Cadps2
|
UTSW |
6 |
23,323,409 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7139:Cadps2
|
UTSW |
6 |
23,410,889 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7156:Cadps2
|
UTSW |
6 |
23,688,956 (GRCm38) |
missense |
probably benign |
0.02 |
|
R7184:Cadps2
|
UTSW |
6 |
23,583,429 (GRCm38) |
missense |
probably benign |
0.18 |
|
R7325:Cadps2
|
UTSW |
6 |
23,409,935 (GRCm38) |
missense |
unknown |
|
|
R7526:Cadps2
|
UTSW |
6 |
23,496,851 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7546:Cadps2
|
UTSW |
6 |
23,626,608 (GRCm38) |
missense |
probably benign |
0.15 |
|
R7772:Cadps2
|
UTSW |
6 |
23,390,446 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7870:Cadps2
|
UTSW |
6 |
23,263,642 (GRCm38) |
missense |
probably benign |
0.14 |
|
R8040:Cadps2
|
UTSW |
6 |
23,412,943 (GRCm38) |
splice site |
probably benign |
|
|
R8048:Cadps2
|
UTSW |
6 |
23,838,863 (GRCm38) |
missense |
probably benign |
0.14 |
|
R8082:Cadps2
|
UTSW |
6 |
23,323,314 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8100:Cadps2
|
UTSW |
6 |
23,838,809 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8115:Cadps2
|
UTSW |
6 |
23,328,898 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8497:Cadps2
|
UTSW |
6 |
23,355,919 (GRCm38) |
missense |
probably benign |
0.27 |
|
R8768:Cadps2
|
UTSW |
6 |
23,382,939 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8783:Cadps2
|
UTSW |
6 |
23,302,304 (GRCm38) |
missense |
possibly damaging |
0.57 |
|
R8804:Cadps2
|
UTSW |
6 |
23,496,806 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8832:Cadps2
|
UTSW |
6 |
23,587,537 (GRCm38) |
missense |
possibly damaging |
0.52 |
|
R8848:Cadps2
|
UTSW |
6 |
23,344,257 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8854:Cadps2
|
UTSW |
6 |
23,385,508 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8896:Cadps2
|
UTSW |
6 |
23,410,877 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8910:Cadps2
|
UTSW |
6 |
23,344,224 (GRCm38) |
missense |
probably benign |
0.11 |
|
R8921:Cadps2
|
UTSW |
6 |
23,302,301 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9228:Cadps2
|
UTSW |
6 |
23,688,928 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9297:Cadps2
|
UTSW |
6 |
23,496,888 (GRCm38) |
missense |
probably benign |
|
|
R9318:Cadps2
|
UTSW |
6 |
23,496,888 (GRCm38) |
missense |
probably benign |
|
|
R9348:Cadps2
|
UTSW |
6 |
23,344,263 (GRCm38) |
missense |
probably benign |
0.20 |
|
R9447:Cadps2
|
UTSW |
6 |
23,323,298 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R9484:Cadps2
|
UTSW |
6 |
23,626,647 (GRCm38) |
missense |
probably benign |
0.02 |
|
R9492:Cadps2
|
UTSW |
6 |
23,427,239 (GRCm38) |
missense |
probably benign |
|
|
R9630:Cadps2
|
UTSW |
6 |
23,587,572 (GRCm38) |
missense |
probably benign |
0.08 |
|
R9729:Cadps2
|
UTSW |
6 |
23,382,983 (GRCm38) |
missense |
probably benign |
0.28 |
|
Z1176:Cadps2
|
UTSW |
6 |
23,321,801 (GRCm38) |
missense |
probably benign |
0.24 |
|
Z1177:Cadps2
|
UTSW |
6 |
23,838,818 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1177:Cadps2
|
UTSW |
6 |
23,626,695 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1177:Cadps2
|
UTSW |
6 |
23,385,478 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
| Predicted Primers |
PCR Primer
(F):5'- CATAAGGTCAGGACTGCGAC -3'
(R):5'- GAATGTACAAGCATACCACCTG -3'
Sequencing Primer
(F):5'- TCAGGACTGCGACAGATGCTC -3'
(R):5'- GTTTTGACAGGCATATATGAAAGGC -3'
|
| Posted On |
2018-02-28 |
Incidental Mutation