Incidental Mutation 'R6255:Zfp990'
ID 506048
Institutional Source Beutler Lab
Gene Symbol Zfp990
Ensembl Gene ENSMUSG00000078503
Gene Name zinc finger protein 990
Synonyms Gm13225
MMRRC Submission 044372-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # R6255 (G1)
Quality Score 182.009
Status Validated
Chromosome 4
Chromosomal Location 145510759-145539188 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 145537789 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 452 (N452K)
Ref Sequence ENSEMBL: ENSMUSP00000101368 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105741] [ENSMUST00000105742] [ENSMUST00000136309]
AlphaFold B1AVN5
Predicted Effect probably benign
Transcript: ENSMUST00000105741
AA Change: N452K

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000101367
Gene: ENSMUSG00000078503
AA Change: N452K

DomainStartEndE-ValueType
KRAB 13 76 1.34e-15 SMART
ZnF_C2H2 240 262 2.24e-3 SMART
ZnF_C2H2 268 290 3.58e-2 SMART
ZnF_C2H2 296 318 8.34e-3 SMART
ZnF_C2H2 324 346 1.22e-4 SMART
ZnF_C2H2 352 374 1.4e-4 SMART
ZnF_C2H2 380 402 9.73e-4 SMART
ZnF_C2H2 408 430 1.6e-4 SMART
ZnF_C2H2 436 458 1.92e-2 SMART
ZnF_C2H2 464 486 1.4e-4 SMART
ZnF_C2H2 492 514 9.73e-4 SMART
ZnF_C2H2 520 542 1.84e-4 SMART
ZnF_C2H2 548 570 4.47e-3 SMART
ZnF_C2H2 576 598 4.47e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000105742
AA Change: N452K

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000101368
Gene: ENSMUSG00000078503
AA Change: N452K

DomainStartEndE-ValueType
KRAB 13 76 1.34e-15 SMART
ZnF_C2H2 240 262 2.24e-3 SMART
ZnF_C2H2 268 290 3.58e-2 SMART
ZnF_C2H2 296 318 8.34e-3 SMART
ZnF_C2H2 324 346 1.22e-4 SMART
ZnF_C2H2 352 374 1.4e-4 SMART
ZnF_C2H2 380 402 9.73e-4 SMART
ZnF_C2H2 408 430 1.6e-4 SMART
ZnF_C2H2 436 458 1.92e-2 SMART
ZnF_C2H2 464 486 1.4e-4 SMART
ZnF_C2H2 492 514 9.73e-4 SMART
ZnF_C2H2 520 542 1.84e-4 SMART
ZnF_C2H2 548 570 4.47e-3 SMART
ZnF_C2H2 576 598 4.47e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000136309
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.8%
Validation Efficiency 100% (58/58)
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4833420G17Rik T A 13: 119,466,123 (GRCm38) V7E possibly damaging Het
Aars2 G A 17: 45,514,609 (GRCm38) G333S probably damaging Het
Aen T A 7: 78,905,844 (GRCm38) I85N probably damaging Het
Ahnak C A 19: 9,008,025 (GRCm38) H2224Q possibly damaging Het
Aldh18a1 C T 19: 40,580,043 (GRCm38) R41H possibly damaging Het
Bpifb9b T A 2: 154,309,364 (GRCm38) W2R probably damaging Het
Caprin2 A G 6: 148,877,892 (GRCm38) I139T probably benign Het
Cdhr3 T A 12: 33,053,475 (GRCm38) N381I probably damaging Het
Cecr2 A G 6: 120,758,050 (GRCm38) Y721C probably damaging Het
Cherp G T 8: 72,470,881 (GRCm38) A125D probably damaging Het
Cped1 G A 6: 22,138,715 (GRCm38) probably null Het
Ctdp1 T A 18: 80,459,297 (GRCm38) probably null Het
Cyp2c55 T C 19: 39,018,667 (GRCm38) I169T probably benign Het
Cyp4a31 T C 4: 115,574,920 (GRCm38) L418P possibly damaging Het
Efcab7 T C 4: 99,829,390 (GRCm38) probably benign Het
Efcab8 T C 2: 153,810,268 (GRCm38) W466R possibly damaging Het
Ehd3 C A 17: 73,805,413 (GRCm38) N57K probably benign Het
Ern2 C A 7: 122,173,272 (GRCm38) K654N probably damaging Het
Fbxo18 A T 2: 11,748,446 (GRCm38) F879L probably benign Het
Gde1 T C 7: 118,691,781 (GRCm38) D92G probably null Het
Gm4788 A T 1: 139,753,011 (GRCm38) C256* probably null Het
Heatr5b A G 17: 78,803,434 (GRCm38) V995A probably damaging Het
Ifrd2 A G 9: 107,592,091 (GRCm38) E346G probably damaging Het
Ism1 AACGGACCCGTTCTTGTGGCTATGCA AA 2: 139,746,042 (GRCm38) probably benign Het
Itgb4 T C 11: 115,998,137 (GRCm38) V1102A possibly damaging Het
Itgb6 A T 2: 60,605,276 (GRCm38) I710N probably damaging Het
Kif1a T C 1: 93,019,983 (GRCm38) K1578E probably damaging Het
Kif9 T C 9: 110,517,834 (GRCm38) probably null Het
Kitl T C 10: 100,089,233 (GRCm38) *57Q probably null Het
Lrat C A 3: 82,903,505 (GRCm38) V70F probably damaging Het
Lrrc9 T A 12: 72,487,023 (GRCm38) M1022K probably benign Het
Muc16 T C 9: 18,655,599 (GRCm38) T1875A unknown Het
Mup4 T A 4: 59,957,890 (GRCm38) N171I probably damaging Het
Npas4 G A 19: 4,986,375 (GRCm38) T587I probably damaging Het
Oas3 A G 5: 120,771,230 (GRCm38) V217A probably benign Het
Olfr786 A G 10: 129,437,688 (GRCm38) N292S possibly damaging Het
Osbp C A 19: 11,977,953 (GRCm38) A323D possibly damaging Het
Panx2 G A 15: 89,067,618 (GRCm38) R96H probably damaging Het
Pcdhb18 G A 18: 37,490,484 (GRCm38) R289Q probably benign Het
Piezo2 T C 18: 63,121,270 (GRCm38) R385G possibly damaging Het
Pkn2 T C 3: 142,811,599 (GRCm38) T476A probably damaging Het
Plekha4 T C 7: 45,553,802 (GRCm38) probably benign Het
Ppfibp2 T C 7: 107,681,762 (GRCm38) S94P probably damaging Het
Pramel7 T A 2: 87,489,663 (GRCm38) I429L probably benign Het
Rif1 A G 2: 52,085,053 (GRCm38) K325E probably damaging Het
Ror2 T C 13: 53,110,542 (GRCm38) Y826C probably damaging Het
Rsph10b G A 5: 143,959,746 (GRCm38) G19R probably damaging Het
Slc20a1 A G 2: 129,208,004 (GRCm38) N361D probably damaging Het
Slc26a9 A G 1: 131,763,909 (GRCm38) D630G probably benign Het
Smtnl2 G A 11: 72,401,399 (GRCm38) A274V probably damaging Het
Trank1 T C 9: 111,352,246 (GRCm38) probably null Het
Tspan10 T A 11: 120,444,542 (GRCm38) C159* probably null Het
Uba6 G A 5: 86,164,765 (GRCm38) T23I probably benign Het
Vmn2r74 T C 7: 85,952,451 (GRCm38) T660A possibly damaging Het
Vwa5b1 T C 4: 138,578,672 (GRCm38) N905S probably benign Het
Zfp831 T C 2: 174,646,421 (GRCm38) L963P possibly damaging Het
Other mutations in Zfp990
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00841:Zfp990 APN 4 145,537,868 (GRCm38) missense probably damaging 0.99
IGL01774:Zfp990 APN 4 145,536,948 (GRCm38) missense probably benign 0.28
IGL01895:Zfp990 APN 4 145,536,858 (GRCm38) missense probably damaging 0.99
IGL01895:Zfp990 APN 4 145,536,857 (GRCm38) missense probably damaging 0.97
IGL02349:Zfp990 APN 4 145,530,877 (GRCm38) utr 5 prime probably benign
IGL02598:Zfp990 APN 4 145,536,963 (GRCm38) missense possibly damaging 0.67
IGL02940:Zfp990 APN 4 145,534,922 (GRCm38) splice site probably null
IGL03026:Zfp990 APN 4 145,537,110 (GRCm38) missense possibly damaging 0.54
R0007:Zfp990 UTSW 4 145,537,438 (GRCm38) missense probably benign 0.00
R0352:Zfp990 UTSW 4 145,536,604 (GRCm38) missense probably damaging 0.99
R0631:Zfp990 UTSW 4 145,537,302 (GRCm38) missense possibly damaging 0.89
R1490:Zfp990 UTSW 4 145,537,283 (GRCm38) missense probably benign 0.44
R1537:Zfp990 UTSW 4 145,536,996 (GRCm38) missense possibly damaging 0.67
R1832:Zfp990 UTSW 4 145,538,210 (GRCm38) missense possibly damaging 0.51
R1956:Zfp990 UTSW 4 145,534,882 (GRCm38) missense probably damaging 1.00
R1982:Zfp990 UTSW 4 145,536,869 (GRCm38) missense probably damaging 0.99
R2024:Zfp990 UTSW 4 145,537,404 (GRCm38) missense possibly damaging 0.69
R2097:Zfp990 UTSW 4 145,537,322 (GRCm38) missense possibly damaging 0.94
R2235:Zfp990 UTSW 4 145,537,891 (GRCm38) missense probably damaging 0.99
R4194:Zfp990 UTSW 4 145,536,977 (GRCm38) splice site probably null
R4195:Zfp990 UTSW 4 145,536,977 (GRCm38) splice site probably null
R4418:Zfp990 UTSW 4 145,536,728 (GRCm38) missense possibly damaging 0.87
R4617:Zfp990 UTSW 4 145,537,046 (GRCm38) missense possibly damaging 0.59
R4736:Zfp990 UTSW 4 145,536,942 (GRCm38) missense possibly damaging 0.95
R4880:Zfp990 UTSW 4 145,537,920 (GRCm38) missense probably benign
R4941:Zfp990 UTSW 4 145,536,837 (GRCm38) missense probably damaging 1.00
R5014:Zfp990 UTSW 4 145,538,099 (GRCm38) missense possibly damaging 0.93
R5945:Zfp990 UTSW 4 145,538,043 (GRCm38) missense probably damaging 0.98
R6238:Zfp990 UTSW 4 145,537,913 (GRCm38) missense probably damaging 1.00
R6267:Zfp990 UTSW 4 145,538,103 (GRCm38) missense possibly damaging 0.59
R6296:Zfp990 UTSW 4 145,538,103 (GRCm38) missense possibly damaging 0.59
R6412:Zfp990 UTSW 4 145,537,568 (GRCm38) missense probably benign 0.00
R6616:Zfp990 UTSW 4 145,537,145 (GRCm38) missense probably benign 0.01
R6701:Zfp990 UTSW 4 145,538,178 (GRCm38) missense probably benign 0.45
R6720:Zfp990 UTSW 4 145,536,927 (GRCm38) missense possibly damaging 0.67
R7015:Zfp990 UTSW 4 145,536,635 (GRCm38) missense probably damaging 0.99
R7487:Zfp990 UTSW 4 145,537,587 (GRCm38) missense probably damaging 1.00
R7722:Zfp990 UTSW 4 145,536,962 (GRCm38) missense possibly damaging 0.86
R8749:Zfp990 UTSW 4 145,537,586 (GRCm38) missense probably damaging 0.96
R8785:Zfp990 UTSW 4 145,537,676 (GRCm38) missense probably benign 0.00
R9161:Zfp990 UTSW 4 145,534,939 (GRCm38) missense possibly damaging 0.71
R9211:Zfp990 UTSW 4 145,537,601 (GRCm38) missense probably damaging 0.98
Z1176:Zfp990 UTSW 4 145,536,811 (GRCm38) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- AAGCAGTCTGAGAATTCATCAGAGAAT -3'
(R):5'- CCAAGATGGGATTTTCGGGTAA -3'

Sequencing Primer
(F):5'- TTCATCAGAGAATTCATACAGGAGAG -3'
(R):5'- CGGGTAAAGCATTTGTCACATTCAC -3'
Posted On 2018-02-28