Incidental Mutation 'IGL01139:Or9g4'
ID 50609
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or9g4
Ensembl Gene ENSMUSG00000075211
Gene Name olfactory receptor family 9 subfamily G member 4
Synonyms MOR213-4, Olfr1006, GA_x6K02T2Q125-47154544-47153606
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01139
Quality Score
Status
Chromosome 2
Chromosomal Location 85504555-85509085 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 85504841 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Serine at position 218 (Y218S)
Ref Sequence ENSEMBL: ENSMUSP00000149868 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099917] [ENSMUST00000216084]
AlphaFold A2ALD2
Predicted Effect probably damaging
Transcript: ENSMUST00000099917
AA Change: Y218S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097501
Gene: ENSMUSG00000075211
AA Change: Y218S

DomainStartEndE-ValueType
Pfam:7tm_4 39 315 1.3e-51 PFAM
Pfam:7tm_1 49 298 3.6e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000099919
AA Change: Y218S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097503
Gene: ENSMUSG00000075211
AA Change: Y218S

DomainStartEndE-ValueType
Pfam:7tm_1 41 290 3.7e-30 PFAM
Pfam:7tm_4 139 283 3.3e-51 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216084
AA Change: Y218S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216207
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4fm5 A T 4: 144,504,259 (GRCm39) Y297* probably null Het
Actr3 A T 1: 125,333,622 (GRCm39) I215N probably damaging Het
Ambn C T 5: 88,612,376 (GRCm39) probably benign Het
Arhgef1 T A 7: 24,625,376 (GRCm39) probably benign Het
Arid1a A C 4: 133,421,308 (GRCm39) S832R unknown Het
Clca4a A T 3: 144,672,030 (GRCm39) I304N probably damaging Het
Dmxl2 G A 9: 54,366,248 (GRCm39) P274S probably damaging Het
Eif4enif1 T A 11: 3,171,143 (GRCm39) D211E probably damaging Het
Eri2 A G 7: 119,385,960 (GRCm39) probably null Het
Fhod3 C T 18: 25,199,401 (GRCm39) P691S probably benign Het
Flnb A G 14: 7,945,989 (GRCm38) S2465G probably damaging Het
Ftsj1 G A X: 8,112,831 (GRCm39) R171C probably damaging Het
Glb1l3 G A 9: 26,729,523 (GRCm39) T648I probably benign Het
Gm4222 T A 2: 89,978,889 (GRCm39) probably benign Het
Gm5475 G A 15: 100,322,096 (GRCm39) probably benign Het
Jaml C A 9: 45,012,317 (GRCm39) T268N possibly damaging Het
Kank3 G A 17: 34,036,375 (GRCm39) G81E probably damaging Het
Lrba A G 3: 86,549,969 (GRCm39) T217A possibly damaging Het
Ltn1 A G 16: 87,212,897 (GRCm39) S555P probably benign Het
Map3k15 T A X: 158,855,875 (GRCm39) M350K probably damaging Het
Mipol1 C A 12: 57,352,821 (GRCm39) Y53* probably null Het
Mn1 A G 5: 111,569,315 (GRCm39) D1095G probably damaging Het
Myh14 T C 7: 44,255,716 (GRCm39) probably benign Het
Nrn1 A G 13: 36,914,190 (GRCm39) C31R probably damaging Het
Nup210 A T 6: 91,007,079 (GRCm39) L579H possibly damaging Het
Nxf2 T C X: 133,851,145 (GRCm39) I578V probably benign Het
Obscn G A 11: 58,969,178 (GRCm39) A172V probably damaging Het
Or10h1b T A 17: 33,395,756 (GRCm39) Y123N probably damaging Het
Phtf1 A G 3: 103,912,918 (GRCm39) D748G probably damaging Het
Psd3 A T 8: 68,361,187 (GRCm39) Y863N probably damaging Het
Psmc6 C T 14: 45,581,167 (GRCm39) T321I probably benign Het
Rassf6 T C 5: 90,756,825 (GRCm39) *31W probably null Het
Rictor A C 15: 6,807,749 (GRCm39) K791Q probably damaging Het
Slc12a9 C T 5: 137,321,104 (GRCm39) M470I probably damaging Het
Tex28 A T X: 73,194,830 (GRCm39) M367K possibly damaging Het
Thnsl2 A T 6: 71,115,718 (GRCm39) V163D probably damaging Het
Tmco3 G A 8: 13,369,887 (GRCm39) R633Q possibly damaging Het
Trf A T 9: 103,100,803 (GRCm39) V224D probably damaging Het
Ttc8 C T 12: 98,930,804 (GRCm39) Q273* probably null Het
Usp9x A G X: 12,970,815 (GRCm39) probably benign Het
Vmn2r117 A G 17: 23,696,778 (GRCm39) W210R probably damaging Het
Vmn2r5 A G 3: 64,398,826 (GRCm39) S718P probably benign Het
Vps13a T C 19: 16,617,989 (GRCm39) D2932G probably damaging Het
Whamm T C 7: 81,245,662 (GRCm39) L706P probably damaging Het
Yeats2 G A 16: 20,033,143 (GRCm39) V45I probably damaging Het
Yipf3 G A 17: 46,561,383 (GRCm39) probably null Het
Zeb1 T C 18: 5,705,061 (GRCm39) V26A possibly damaging Het
Other mutations in Or9g4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01520:Or9g4 APN 2 85,504,701 (GRCm39) missense probably benign 0.00
IGL01939:Or9g4 APN 2 85,505,285 (GRCm39) missense probably damaging 1.00
IGL02060:Or9g4 APN 2 85,505,178 (GRCm39) missense probably benign 0.34
IGL02171:Or9g4 APN 2 85,505,285 (GRCm39) missense probably damaging 1.00
IGL03058:Or9g4 APN 2 85,505,025 (GRCm39) missense probably benign 0.00
IGL03210:Or9g4 APN 2 85,504,697 (GRCm39) missense probably damaging 1.00
BB002:Or9g4 UTSW 2 85,504,907 (GRCm39) missense
BB012:Or9g4 UTSW 2 85,504,907 (GRCm39) missense
R0294:Or9g4 UTSW 2 85,505,060 (GRCm39) missense probably damaging 0.99
R1304:Or9g4 UTSW 2 85,504,682 (GRCm39) missense probably damaging 1.00
R1476:Or9g4 UTSW 2 85,505,262 (GRCm39) missense possibly damaging 0.92
R4757:Or9g4 UTSW 2 85,504,664 (GRCm39) missense probably damaging 1.00
R4793:Or9g4 UTSW 2 85,504,842 (GRCm39) missense probably damaging 1.00
R5804:Or9g4 UTSW 2 85,504,682 (GRCm39) missense probably damaging 1.00
R6146:Or9g4 UTSW 2 85,504,938 (GRCm39) nonsense probably null
R6511:Or9g4 UTSW 2 85,505,184 (GRCm39) missense possibly damaging 0.61
R6896:Or9g4 UTSW 2 85,505,277 (GRCm39) missense probably damaging 0.97
R7075:Or9g4 UTSW 2 85,505,168 (GRCm39) missense
R7344:Or9g4 UTSW 2 85,505,275 (GRCm39) nonsense probably null
R7350:Or9g4 UTSW 2 85,505,189 (GRCm39) missense
R7925:Or9g4 UTSW 2 85,504,907 (GRCm39) missense
R8704:Or9g4 UTSW 2 85,504,562 (GRCm39) missense
Posted On 2013-06-21