Mutagenetix > Incidental Mutation

Incidental Mutation 'R6256:Vmn2r120'

506145

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r120

Ensembl Gene

ENSMUSG00000090655

Gene Name

vomeronasal 2, receptor 120

Synonyms

EG224916

MMRRC Submission

044373-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.079) question?

Stock #

R6256 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

57815783-57852314 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 57831700 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Stop codon at position 363 (L363*)

Ref Sequence

ENSEMBL: ENSMUSP00000129296 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165781]

AlphaFold

A0A3Q4EG79

Predicted Effect

probably null
Transcript: ENSMUST00000165781
AA Change: L363*

SMART Domains

Protein: ENSMUSP00000129296
Gene: ENSMUSG00000090655
AA Change: L363*

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	80	474	5.9e-42	PFAM
Pfam:NCD3G	517	570	7.5e-22	PFAM
Pfam:7tm_3	598	836	1.3e-54	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 97.9%
20x: 93.5%

Validation Efficiency

99% (74/75)

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700030K09Rik	A	T	8: 73,205,272 (GRCm39)	Q361L	probably damaging	Het
Abca7	A	G	10: 79,838,456 (GRCm39)	T577A	probably damaging	Het
Acad12	A	T	5: 121,752,149 (GRCm39)	V54E	probably benign	Het
Ago4	A	G	4: 126,414,019 (GRCm39)	Y91H	probably damaging	Het
Akr1b10	T	C	6: 34,364,623 (GRCm39)	V28A	probably damaging	Het
Ccdc33	T	A	9: 58,009,201 (GRCm39)		probably null	Het
Ccdc7a	T	C	8: 129,662,074 (GRCm39)		probably null	Het
Ces1f	A	T	8: 93,992,422 (GRCm39)	V343E	probably damaging	Het
Cftr	T	C	6: 18,274,660 (GRCm39)	L896P	probably damaging	Het
Csmd3	G	A	15: 47,533,125 (GRCm39)	P2375S	probably damaging	Het
Dnajb14	C	T	3: 137,614,124 (GRCm39)	A345V	probably damaging	Het
Dnajb14	G	C	3: 137,614,123 (GRCm39)	A345P	probably damaging	Het
Dnase1	G	A	16: 3,855,485 (GRCm39)	R24K	probably benign	Het
Dnmbp	C	T	19: 43,840,720 (GRCm39)	V560M	probably damaging	Het
Dop1b	T	A	16: 93,604,102 (GRCm39)	I1981N	possibly damaging	Het
Eif3a	A	C	19: 60,759,464 (GRCm39)	S770A	possibly damaging	Het
Fbxl7	A	T	15: 26,553,088 (GRCm39)	C60S	probably benign	Het
Fras1	A	T	5: 96,881,702 (GRCm39)	D2478V	possibly damaging	Het
Hrnr	A	G	3: 93,229,918 (GRCm39)	D52G	probably damaging	Het
Jmjd1c	T	A	10: 67,056,187 (GRCm39)	L823M	probably damaging	Het
Kdm1a	G	T	4: 136,295,911 (GRCm39)	C172*	probably null	Het
Kdm6b	C	T	11: 69,297,555 (GRCm39)	E295K	probably damaging	Het
Mepe	A	T	5: 104,484,940 (GRCm39)	M27L	probably benign	Het
Mogat2	A	T	7: 98,869,102 (GRCm39)	H305Q	probably damaging	Het
Mst1r	T	A	9: 107,794,465 (GRCm39)	Y1215N	probably damaging	Het
Muc5ac	A	T	7: 141,343,532 (GRCm39)	H48L	possibly damaging	Het
Myo7b	T	C	18: 32,116,748 (GRCm39)	D953G	probably damaging	Het
Ocel1	T	C	8: 71,824,472 (GRCm39)		probably benign	Het
Pcdhb6	A	G	18: 37,468,978 (GRCm39)	D633G	probably damaging	Het
Ppm1l	A	G	3: 69,405,230 (GRCm39)	I176V	probably benign	Het
Sall3	C	T	18: 81,013,076 (GRCm39)	R1120H	possibly damaging	Het
Sbf1	G	A	15: 89,185,070 (GRCm39)	P1018S	probably benign	Het
Setbp1	T	C	18: 78,900,472 (GRCm39)	Y1065C	probably damaging	Het
Slc25a2	T	C	18: 37,770,776 (GRCm39)		probably null	Het
Slc4a2	C	A	5: 24,640,888 (GRCm39)	T729K	probably damaging	Het
Sptlc2	T	C	12: 87,402,305 (GRCm39)	E207G	probably damaging	Het
Sult6b1	A	T	17: 79,214,343 (GRCm39)	F27I	probably benign	Het
Syf2	A	T	4: 134,661,889 (GRCm39)	K84N	probably damaging	Het
Tmem209	A	T	6: 30,497,166 (GRCm39)	N183K	probably benign	Het
Tmem232	G	T	17: 65,785,397 (GRCm39)	Q188K	possibly damaging	Het
Tomm70a	A	T	16: 56,973,055 (GRCm39)	T598S	probably benign	Het
Ttll13	A	G	7: 79,908,052 (GRCm39)	T556A	probably benign	Het
Xpo6	G	T	7: 125,707,791 (GRCm39)	Q872K	probably damaging	Het
Xrra1	A	C	7: 99,563,671 (GRCm39)	S553R	probably damaging	Het
Zfy1	A	T	Y: 738,765 (GRCm39)	V147E	unknown	Homo
Zfy2	T	C	Y: 2,116,267 (GRCm39)	I258V	probably benign	Homo

Other mutations in Vmn2r120

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01335:Vmn2r120	APN	17	57,832,732 (GRCm39)	missense	possibly damaging	0.86
IGL01346:Vmn2r120	APN	17	57,852,232 (GRCm39)	missense	probably benign	0.11
IGL01996:Vmn2r120	APN	17	57,832,222 (GRCm39)	missense	possibly damaging	0.92
IGL02503:Vmn2r120	APN	17	57,816,385 (GRCm39)	missense	probably benign	0.40
IGL02582:Vmn2r120	APN	17	57,831,724 (GRCm39)	missense	probably damaging	0.99
IGL02747:Vmn2r120	APN	17	57,831,719 (GRCm39)	missense	probably benign	0.19
IGL02896:Vmn2r120	APN	17	57,816,008 (GRCm39)	missense	probably damaging	1.00
IGL03139:Vmn2r120	APN	17	57,831,742 (GRCm39)	missense	probably benign	0.39
IGL03342:Vmn2r120	APN	17	57,816,372 (GRCm39)	missense	probably benign	0.03
A4554:Vmn2r120	UTSW	17	57,832,715 (GRCm39)	missense	probably benign	0.01
R0207:Vmn2r120	UTSW	17	57,832,052 (GRCm39)	missense	probably benign	0.17
R0472:Vmn2r120	UTSW	17	57,831,518 (GRCm39)	missense	probably benign	0.03
R0517:Vmn2r120	UTSW	17	57,815,949 (GRCm39)	missense	probably damaging	1.00
R1109:Vmn2r120	UTSW	17	57,832,829 (GRCm39)	missense	probably benign	0.09
R1316:Vmn2r120	UTSW	17	57,832,939 (GRCm39)	missense	probably benign	0.28
R1543:Vmn2r120	UTSW	17	57,829,374 (GRCm39)	missense	probably benign	0.09
R1795:Vmn2r120	UTSW	17	57,832,038 (GRCm39)	missense	probably benign	0.35
R1850:Vmn2r120	UTSW	17	57,832,826 (GRCm39)	missense	probably benign	0.19
R1920:Vmn2r120	UTSW	17	57,831,839 (GRCm39)	missense	probably benign	0.01
R1921:Vmn2r120	UTSW	17	57,831,839 (GRCm39)	missense	probably benign	0.01
R1922:Vmn2r120	UTSW	17	57,831,839 (GRCm39)	missense	probably benign	0.01
R2063:Vmn2r120	UTSW	17	57,831,553 (GRCm39)	missense	possibly damaging	0.88
R2064:Vmn2r120	UTSW	17	57,831,553 (GRCm39)	missense	possibly damaging	0.88
R2065:Vmn2r120	UTSW	17	57,831,553 (GRCm39)	missense	possibly damaging	0.88
R2067:Vmn2r120	UTSW	17	57,831,553 (GRCm39)	missense	possibly damaging	0.88
R2286:Vmn2r120	UTSW	17	57,815,958 (GRCm39)	missense	probably damaging	1.00
R2291:Vmn2r120	UTSW	17	57,816,479 (GRCm39)	missense	probably damaging	1.00
R3416:Vmn2r120	UTSW	17	57,816,241 (GRCm39)	missense	possibly damaging	0.89
R3874:Vmn2r120	UTSW	17	57,831,954 (GRCm39)	missense	probably benign	0.40
R4023:Vmn2r120	UTSW	17	57,843,718 (GRCm39)	missense	possibly damaging	0.92
R4024:Vmn2r120	UTSW	17	57,843,718 (GRCm39)	missense	possibly damaging	0.92
R4348:Vmn2r120	UTSW	17	57,829,466 (GRCm39)	missense	possibly damaging	0.47
R4409:Vmn2r120	UTSW	17	57,816,477 (GRCm39)	missense	probably damaging	1.00
R4610:Vmn2r120	UTSW	17	57,816,120 (GRCm39)	missense	probably damaging	1.00
R4771:Vmn2r120	UTSW	17	57,831,887 (GRCm39)	missense	probably damaging	1.00
R4786:Vmn2r120	UTSW	17	57,829,048 (GRCm39)	missense	probably benign	0.14
R4927:Vmn2r120	UTSW	17	57,816,125 (GRCm39)	missense	probably damaging	1.00
R5285:Vmn2r120	UTSW	17	57,843,703 (GRCm39)	missense	probably damaging	1.00
R5566:Vmn2r120	UTSW	17	57,852,290 (GRCm39)	missense	possibly damaging	0.95
R5578:Vmn2r120	UTSW	17	57,829,514 (GRCm39)	missense	probably benign	0.01
R5643:Vmn2r120	UTSW	17	57,831,977 (GRCm39)	missense	probably benign	0.01
R5644:Vmn2r120	UTSW	17	57,831,977 (GRCm39)	missense	probably benign	0.01
R5781:Vmn2r120	UTSW	17	57,831,938 (GRCm39)	missense	probably benign	0.00
R6084:Vmn2r120	UTSW	17	57,832,721 (GRCm39)	missense	probably benign	0.15
R6120:Vmn2r120	UTSW	17	57,832,973 (GRCm39)	missense	probably benign	0.02
R6160:Vmn2r120	UTSW	17	57,816,418 (GRCm39)	missense	probably benign	0.03
R6248:Vmn2r120	UTSW	17	57,852,287 (GRCm39)	missense	probably benign	0.03
R6730:Vmn2r120	UTSW	17	57,832,012 (GRCm39)	missense	probably benign	0.03
R6821:Vmn2r120	UTSW	17	57,843,659 (GRCm39)	missense	probably benign	0.00
R6868:Vmn2r120	UTSW	17	57,852,218 (GRCm39)	missense	probably benign	0.00
R6880:Vmn2r120	UTSW	17	57,816,187 (GRCm39)	missense	probably damaging	1.00
R6986:Vmn2r120	UTSW	17	57,816,340 (GRCm39)	missense	probably damaging	1.00
R7276:Vmn2r120	UTSW	17	57,831,881 (GRCm39)	missense	probably benign	0.11
R7373:Vmn2r120	UTSW	17	57,816,406 (GRCm39)	missense	probably benign	0.35
R7653:Vmn2r120	UTSW	17	57,816,258 (GRCm39)	missense	possibly damaging	0.93
R7667:Vmn2r120	UTSW	17	57,843,657 (GRCm39)	missense	probably benign	0.04
R7775:Vmn2r120	UTSW	17	57,832,942 (GRCm39)	missense	probably damaging	1.00
R7778:Vmn2r120	UTSW	17	57,832,942 (GRCm39)	missense	probably damaging	1.00
R7797:Vmn2r120	UTSW	17	57,815,874 (GRCm39)	missense	probably damaging	1.00
R7824:Vmn2r120	UTSW	17	57,832,942 (GRCm39)	missense	probably damaging	1.00
R7902:Vmn2r120	UTSW	17	57,816,244 (GRCm39)	missense	possibly damaging	0.87
R7922:Vmn2r120	UTSW	17	57,831,683 (GRCm39)	missense	probably damaging	0.99
R8508:Vmn2r120	UTSW	17	57,832,843 (GRCm39)	missense	probably benign	0.03
R8847:Vmn2r120	UTSW	17	57,816,217 (GRCm39)	missense	probably benign	0.01
R8882:Vmn2r120	UTSW	17	57,852,229 (GRCm39)	missense	probably benign	0.01
R9134:Vmn2r120	UTSW	17	57,832,093 (GRCm39)	missense	probably damaging	1.00
R9161:Vmn2r120	UTSW	17	57,831,864 (GRCm39)	missense
R9336:Vmn2r120	UTSW	17	57,832,201 (GRCm39)	missense	possibly damaging	0.91
RF005:Vmn2r120	UTSW	17	57,828,991 (GRCm39)	missense	possibly damaging	0.65
Z1177:Vmn2r120	UTSW	17	57,816,245 (GRCm39)	missense	probably benign	0.00
Z1188:Vmn2r120	UTSW	17	57,829,436 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ATCTGCATGTTCTTGGAGCATTTC -3'
(R):5'- AGCATCAGGACAAGTAGACCCG -3'

Sequencing Primer
(F):5'- TCATGGAGGCTGTGGGCAAC -3'
(R):5'- GTCACAACCTCACAGTGGGATATTG -3'

Posted On

2018-02-28