Incidental Mutation 'R6251:Daglb'
ID 506220
Institutional Source Beutler Lab
Gene Symbol Daglb
Ensembl Gene ENSMUSG00000039206
Gene Name diacylglycerol lipase, beta
Synonyms E330036I19Rik
MMRRC Submission 044368-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.114) question?
Stock # R6251 (G1)
Quality Score 215.009
Status Not validated
Chromosome 5
Chromosomal Location 143450239-143490197 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 143475689 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 383 (L383Q)
Ref Sequence ENSEMBL: ENSMUSP00000043088 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045593]
AlphaFold Q91WC9
Predicted Effect probably damaging
Transcript: ENSMUST00000045593
AA Change: L383Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000043088
Gene: ENSMUSG00000039206
AA Change: L383Q

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
transmembrane domain 55 77 N/A INTRINSIC
transmembrane domain 97 119 N/A INTRINSIC
transmembrane domain 131 153 N/A INTRINSIC
Pfam:Lipase_3 370 505 1.1e-18 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155383
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.3%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for null mutations have a reduction in endocannabinoids in the brain and a decrease in adult neuronal proliferation in the hippocampus. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3100002H09Rik A G 4: 124,504,445 (GRCm39) S36P probably damaging Het
Agmo A G 12: 37,302,538 (GRCm39) D125G probably damaging Het
Arhgap26 A T 18: 39,490,880 (GRCm39) S328C probably null Het
Arl6 T C 16: 59,439,169 (GRCm39) D175G probably damaging Het
Asb3 G A 11: 31,005,559 (GRCm39) A192T probably damaging Het
Atp10b A T 11: 43,126,573 (GRCm39) M1110L possibly damaging Het
Cacna1i T C 15: 80,220,883 (GRCm39) I175T probably damaging Het
Car15 A T 16: 17,655,227 (GRCm39) I71N probably benign Het
Casq1 T A 1: 172,044,407 (GRCm39) Y140F probably benign Het
Ccdc93 C T 1: 121,362,269 (GRCm39) T17M possibly damaging Het
Cfap46 CCTTCTTCT CCTTCT 7: 139,218,816 (GRCm39) probably benign Het
Ciart G A 3: 95,788,323 (GRCm39) probably benign Het
Cul5 A T 9: 53,558,094 (GRCm39) V170D probably benign Het
Cyb5r3 T C 15: 83,038,917 (GRCm39) D224G probably benign Het
Daam1 G A 12: 72,035,723 (GRCm39) G964R probably damaging Het
Dazap2 T G 15: 100,514,864 (GRCm39) H28Q possibly damaging Het
Dnttip2 A T 3: 122,068,905 (GRCm39) D40V probably benign Het
Dynlt2b T A 16: 32,245,727 (GRCm39) D125E possibly damaging Het
Epn1 G T 7: 5,098,925 (GRCm39) D406Y probably damaging Het
Epn1 G T 7: 5,098,935 (GRCm39) R409L probably damaging Het
Evc T C 5: 37,457,843 (GRCm39) T966A probably benign Het
Extl3 T C 14: 65,314,375 (GRCm39) D269G probably damaging Het
Gfra3 TGCGC TGC 18: 34,828,864 (GRCm39) probably null Het
Gpr87 A T 3: 59,086,528 (GRCm39) F326I probably damaging Het
Hivep3 C A 4: 119,952,137 (GRCm39) P151H probably damaging Het
Kcnj14 T A 7: 45,467,440 (GRCm39) E302V probably damaging Het
Kdm5d T C Y: 921,693 (GRCm39) Y534H probably damaging Homo
Map3k5 T A 10: 20,014,006 (GRCm39) probably null Het
Mdn1 A G 4: 32,748,590 (GRCm39) T4212A probably benign Het
Ms4a6d A T 19: 11,564,504 (GRCm39) S122R probably damaging Het
Mtarc1 G A 1: 184,527,648 (GRCm39) R271W probably damaging Het
Nectin3 A T 16: 46,215,513 (GRCm39) H76Q probably damaging Het
Notch1 C A 2: 26,364,182 (GRCm39) E846D possibly damaging Het
Or1e23 A G 11: 73,407,534 (GRCm39) S164P probably benign Het
Or4a67 T C 2: 88,598,632 (GRCm39) E9G probably damaging Het
Or8b36 GTTT GTTTGCTTTTT 9: 37,937,842 (GRCm39) probably null Het
Or8b36 TT TTGCTGTGT 9: 37,937,844 (GRCm39) probably null Het
Or8b36 G GGGATTGC 9: 37,937,833 (GRCm39) probably null Het
Or8b36 TGTTT TGTTTGCAGTTT 9: 37,937,841 (GRCm39) probably null Het
Or8g18 T A 9: 39,149,514 (GRCm39) I72F possibly damaging Het
Pfkl C T 10: 77,825,399 (GRCm39) probably null Het
Pigz T C 16: 31,764,424 (GRCm39) V494A possibly damaging Het
Pik3r4 T C 9: 105,531,247 (GRCm39) V516A probably benign Het
Polr2b G A 5: 77,496,141 (GRCm39) R1104K probably benign Het
Rap1a A T 3: 105,639,311 (GRCm39) L116* probably null Het
Rnf114 T C 2: 167,356,649 (GRCm39) *230R probably null Het
Rtl1 G T 12: 109,560,083 (GRCm39) N585K probably benign Het
Serpinb5 G T 1: 106,802,795 (GRCm39) R110I possibly damaging Het
Spink6 T C 18: 44,207,498 (GRCm39) probably null Het
Spopfm1 G T 3: 94,173,208 (GRCm39) S72I probably damaging Het
Stk39 A T 2: 68,137,383 (GRCm39) probably null Het
Tcstv2a T C 13: 120,724,907 (GRCm39) probably benign Het
Tcte1 A T 17: 45,846,085 (GRCm39) T230S probably benign Het
Tecpr1 C A 5: 144,135,394 (GRCm39) V1020L probably damaging Het
Tmc7 T C 7: 118,160,261 (GRCm39) Y192C possibly damaging Het
Trim63 A T 4: 134,050,537 (GRCm39) T274S probably benign Het
Wdr43 G A 17: 71,957,048 (GRCm39) probably null Het
Zfr T C 15: 12,160,677 (GRCm39) I750T probably benign Het
Other mutations in Daglb
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03046:Daglb UTSW 5 143,486,948 (GRCm39) missense probably damaging 1.00
PIT4802001:Daglb UTSW 5 143,488,803 (GRCm39) missense probably benign 0.04
R0145:Daglb UTSW 5 143,460,363 (GRCm39) splice site probably benign
R0348:Daglb UTSW 5 143,472,951 (GRCm39) missense probably benign 0.01
R0504:Daglb UTSW 5 143,479,952 (GRCm39) missense probably benign
R1695:Daglb UTSW 5 143,480,361 (GRCm39) missense probably benign 0.02
R4043:Daglb UTSW 5 143,472,906 (GRCm39) missense possibly damaging 0.92
R4358:Daglb UTSW 5 143,458,889 (GRCm39) intron probably benign
R4666:Daglb UTSW 5 143,489,104 (GRCm39) missense probably damaging 0.99
R5609:Daglb UTSW 5 143,464,274 (GRCm39) missense probably benign 0.00
R6062:Daglb UTSW 5 143,480,358 (GRCm39) missense probably benign 0.07
R6153:Daglb UTSW 5 143,489,096 (GRCm39) missense probably benign 0.00
R6475:Daglb UTSW 5 143,467,406 (GRCm39) missense probably benign
R7690:Daglb UTSW 5 143,479,938 (GRCm39) missense possibly damaging 0.95
R8053:Daglb UTSW 5 143,489,024 (GRCm39) missense probably benign 0.00
R8114:Daglb UTSW 5 143,464,218 (GRCm39) missense probably benign 0.01
Z1177:Daglb UTSW 5 143,458,873 (GRCm39) missense probably null 0.99
Predicted Primers PCR Primer
(F):5'- ATGACAGTTCTCTCAGCAGC -3'
(R):5'- AGCTGGACTGTGCATGTCTG -3'

Sequencing Primer
(F):5'- TCTTAGGTGACCCCCATGACAG -3'
(R):5'- GATTGACAGTCCATCCTCCCTGG -3'
Posted On 2018-03-15