Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01154:Olfr1265'

50660

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfr1265

Ensembl Gene

ENSMUSG00000059910

Gene Name

olfactory receptor 1265

Synonyms

GA_x6K02T2Q125-51469027-51469956, MOR228-2

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.069) question?

Stock #

IGL01154

Quality Score

Status

Chromosome

Chromosomal Location

90035337-90042214 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 90037468 bp

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 183 (L183P)

Ref Sequence

ENSEMBL: ENSMUSP00000149684 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080311] [ENSMUST00000214855]

Predicted Effect

probably damaging
Transcript: ENSMUST00000080311
AA Change: L183P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000079190
Gene: ENSMUSG00000059910
AA Change: L183P

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	303	1.9e-49	PFAM
Pfam:7tm_1	39	285	1.4e-20	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000214855
AA Change: L183P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110038F14Rik	G	A	15: 76,950,275	V124I	probably damaging	Het
2210408I21Rik	T	G	13: 77,281,094	F767V	probably benign	Het
A2m	C	A	6: 121,673,542	S1203*	probably null	Het
Abcc3	T	C	11: 94,359,232		probably benign	Het
Adamts13	T	C	2: 27,006,194	Y1200H	probably benign	Het
Aldh1l2	T	C	10: 83,520,373	D51G	probably damaging	Het
Apc2	A	G	10: 80,313,069	E1319G	possibly damaging	Het
Arap3	A	T	18: 37,996,734	S125T	probably benign	Het
Atp2b1	T	A	10: 98,996,888	V417E	probably damaging	Het
Bpifa1	T	A	2: 154,144,000	D78E	probably benign	Het
Catsperb	C	A	12: 101,625,681	A1090E	possibly damaging	Het
Ceacam9	C	A	7: 16,723,961	T138K	probably damaging	Het
Cenpf	T	A	1: 189,680,333	E244D	probably benign	Het
Cep135	A	T	5: 76,606,796		probably benign	Het
Cfap206	C	T	4: 34,721,562	S162N	probably damaging	Het
Col15a1	A	C	4: 47,208,450	T6P	possibly damaging	Het
Cyp11b1	T	A	15: 74,838,534	Q306L	probably benign	Het
Defa22	T	A	8: 21,163,037		probably null	Het
Dnah5	A	T	15: 28,458,656	T4480S	possibly damaging	Het
Fastkd1	T	C	2: 69,690,060		probably null	Het
Flt1	A	G	5: 147,576,156	Y1124H	possibly damaging	Het
Fsd1l	A	G	4: 53,701,074	M469V	probably benign	Het
Fxr2	T	C	11: 69,641,433		probably benign	Het
Gm10801	A	T	2: 98,663,983	Y135F	probably benign	Het
Grm4	A	T	17: 27,434,737	C699*	probably null	Het
Hcn4	A	G	9: 58,859,079	T677A	unknown	Het
Igkv9-123	G	T	6: 67,954,534		probably benign	Het
Irf4	T	A	13: 30,757,421	H253Q	possibly damaging	Het
Jakmip2	T	C	18: 43,590,679		probably benign	Het
Kmt2c	A	G	5: 25,284,399	V1134A	probably damaging	Het
Limch1	G	T	5: 66,745,958	E17*	probably null	Het
Nap1l1	T	A	10: 111,486,675	N72K	probably damaging	Het
Olfr574	T	C	7: 102,948,839	S115P	probably damaging	Het
Otud6b	A	T	4: 14,811,732	Y304N	probably damaging	Het
Pdcd10	A	C	3: 75,541,233	M8R	probably damaging	Het
Ppip5k1	T	C	2: 121,343,179	T404A	probably damaging	Het
Ppp2r2d	C	T	7: 138,882,211	A197V	probably benign	Het
Psg25	C	T	7: 18,524,699	D351N	probably benign	Het
Sbno1	A	T	5: 124,410,249	I87N	probably damaging	Het
Stfa2l1	C	T	16: 36,159,937		probably benign	Het
Sugp2	T	A	8: 70,242,699	D107E	probably damaging	Het
Syne1	G	T	10: 5,360,848	F576L	probably damaging	Het
Syne3	A	G	12: 104,958,069	F357S	probably benign	Het
Tenm2	A	G	11: 36,041,544	L1741P	probably damaging	Het
Tgs1	A	T	4: 3,585,473	K117*	probably null	Het
Tram1	C	T	1: 13,579,449		probably null	Het
Trank1	T	A	9: 111,386,400	D1799E	probably benign	Het
Ttc14	A	T	3: 33,803,099	Y198F	probably benign	Het
Ube3b	A	G	5: 114,406,252	N570S	probably null	Het
Ube4b	A	G	4: 149,365,470	F412S	probably benign	Het
Vac14	T	C	8: 110,653,607		probably benign	Het
Vmn2r65	T	C	7: 84,943,521	T493A	probably benign	Het
Zfp408	T	C	2: 91,648,006		probably benign	Het
Zfp580	C	T	7: 5,053,268	T209I	possibly damaging	Het

Other mutations in Olfr1265

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01470:Olfr1265	APN	2	90037818	missense	possibly damaging	0.81
IGL01878:Olfr1265	APN	2	90037134	missense	probably damaging	0.97
IGL02716:Olfr1265	APN	2	90037794	missense	probably benign	0.05
IGL03066:Olfr1265	APN	2	90037434	missense	probably damaging	0.99
R1310:Olfr1265	UTSW	2	90037703	missense	probably benign	0.02
R4986:Olfr1265	UTSW	2	90037428	missense	probably damaging	1.00
R5101:Olfr1265	UTSW	2	90037047	missense	probably benign	0.00
R6149:Olfr1265	UTSW	2	90037516	missense	probably benign	0.01
R6400:Olfr1265	UTSW	2	90037395	missense	probably benign	0.00
R7367:Olfr1265	UTSW	2	90037812	missense	probably benign	0.02
R7432:Olfr1265	UTSW	2	90037184	missense	probably damaging	0.99
X0019:Olfr1265	UTSW	2	90037644	missense	probably benign	0.02

Posted On

2013-06-21