Incidental Mutation 'R6260:Vmn2r79'
| ID |
506621 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r79
|
| Ensembl Gene |
ENSMUSG00000090362 |
| Gene Name |
vomeronasal 2, receptor 79 |
| Synonyms |
EG621430 |
| MMRRC Submission |
044377-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.092)
|
| Stock # |
R6260 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
86645673-86687176 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 86686365 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 582
(M582K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132478
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164462]
|
| AlphaFold |
E9Q067 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164462
AA Change: M582K
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000132478
Gene: ENSMUSG00000090362
AA Change: M582K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
75 |
464 |
1.9e-31 |
PFAM |
|
Pfam:NCD3G
|
506 |
559 |
3.1e-21 |
PFAM |
|
Pfam:7tm_3
|
592 |
827 |
2.8e-53 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.4%
- 20x: 95.6%
|
| Validation Efficiency |
99% (77/78) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 79 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca7 |
T |
A |
10: 79,844,821 (GRCm39) |
N1514K |
probably damaging |
Het |
| Abcb4 |
G |
T |
5: 8,984,219 (GRCm39) |
G650* |
probably null |
Het |
| Acsbg1 |
T |
A |
9: 54,535,751 (GRCm39) |
|
probably null |
Het |
| Alms1 |
A |
T |
6: 85,605,717 (GRCm39) |
K2456* |
probably null |
Het |
| Alppl2 |
A |
T |
1: 87,016,184 (GRCm39) |
M225K |
probably damaging |
Het |
| Ank2 |
C |
T |
3: 126,737,206 (GRCm39) |
V2806I |
probably benign |
Het |
| Atxn10 |
A |
T |
15: 85,346,612 (GRCm39) |
I457F |
probably benign |
Het |
| Cad |
G |
T |
5: 31,224,144 (GRCm39) |
M800I |
probably null |
Het |
| Carmil3 |
T |
A |
14: 55,737,889 (GRCm39) |
L815Q |
probably damaging |
Het |
| Ccz1 |
A |
G |
5: 143,940,859 (GRCm39) |
|
probably null |
Het |
| Cdc73 |
G |
A |
1: 143,567,211 (GRCm39) |
T104I |
probably benign |
Het |
| Cfap52 |
A |
T |
11: 67,829,780 (GRCm39) |
C330S |
possibly damaging |
Het |
| Clec16a |
C |
T |
16: 10,512,712 (GRCm39) |
|
probably benign |
Het |
| Cntn3 |
A |
G |
6: 102,254,178 (GRCm39) |
|
probably null |
Het |
| Crocc2 |
A |
G |
1: 93,141,360 (GRCm39) |
K1171R |
possibly damaging |
Het |
| Ctsa |
T |
C |
2: 164,676,281 (GRCm39) |
V86A |
probably damaging |
Het |
| Dab1 |
C |
T |
4: 104,588,948 (GRCm39) |
A524V |
probably benign |
Het |
| Ddhd2 |
A |
G |
8: 26,242,144 (GRCm39) |
F244L |
probably benign |
Het |
| Ddn |
A |
G |
15: 98,703,735 (GRCm39) |
V519A |
possibly damaging |
Het |
| Dip2b |
G |
T |
15: 100,060,583 (GRCm39) |
V253L |
probably benign |
Het |
| Dnah17 |
C |
A |
11: 118,017,148 (GRCm39) |
W197C |
probably damaging |
Het |
| Dnah17 |
A |
T |
11: 118,017,150 (GRCm39) |
W197R |
probably damaging |
Het |
| Dnah17 |
C |
T |
11: 118,017,149 (GRCm39) |
W197* |
probably null |
Het |
| Ercc6 |
T |
A |
14: 32,279,813 (GRCm39) |
D609E |
probably benign |
Het |
| Erg |
C |
A |
16: 95,181,100 (GRCm39) |
R147L |
probably damaging |
Het |
| Fbxo41 |
A |
T |
6: 85,455,537 (GRCm39) |
L549H |
probably damaging |
Het |
| Foxd4 |
A |
G |
19: 24,876,968 (GRCm39) |
S411P |
probably benign |
Het |
| Gaa |
C |
A |
11: 119,171,997 (GRCm39) |
A700D |
probably benign |
Het |
| Galntl6 |
T |
A |
8: 58,337,515 (GRCm39) |
D135V |
probably damaging |
Het |
| Gm1043 |
G |
C |
5: 37,331,816 (GRCm39) |
G832A |
probably benign |
Het |
| Gm21103 |
C |
T |
14: 17,484,841 (GRCm39) |
E68K |
probably damaging |
Het |
| Gpam |
A |
G |
19: 55,071,838 (GRCm39) |
V301A |
probably benign |
Het |
| H2-M10.1 |
T |
A |
17: 36,634,994 (GRCm39) |
I304F |
unknown |
Het |
| Itgb4 |
C |
T |
11: 115,874,983 (GRCm39) |
R447W |
probably benign |
Het |
| Jak3 |
C |
A |
8: 72,131,954 (GRCm39) |
Q177K |
probably benign |
Het |
| Kcnu1 |
G |
A |
8: 26,341,919 (GRCm39) |
R88H |
probably damaging |
Het |
| Kng1 |
A |
T |
16: 22,877,371 (GRCm39) |
I60F |
possibly damaging |
Het |
| Krt77 |
A |
T |
15: 101,772,807 (GRCm39) |
Y257* |
probably null |
Het |
| Lcor |
A |
T |
19: 41,570,809 (GRCm39) |
S1C |
probably null |
Het |
| Lcor |
G |
T |
19: 41,570,810 (GRCm39) |
S1I |
possibly damaging |
Het |
| Lgr6 |
C |
T |
1: 134,921,748 (GRCm39) |
A199T |
probably damaging |
Het |
| Map4k5 |
C |
A |
12: 69,878,336 (GRCm39) |
R355L |
probably benign |
Het |
| Mefv |
C |
T |
16: 3,530,898 (GRCm39) |
R498H |
probably benign |
Het |
| Mical3 |
A |
T |
6: 120,985,991 (GRCm39) |
L150Q |
probably damaging |
Het |
| Mtcl1 |
T |
A |
17: 66,650,536 (GRCm39) |
Q1340L |
probably damaging |
Het |
| Nfic |
A |
T |
10: 81,256,351 (GRCm39) |
C126* |
probably null |
Het |
| Nisch |
T |
A |
14: 30,899,085 (GRCm39) |
|
probably benign |
Het |
| Nt5dc3 |
A |
G |
10: 86,647,395 (GRCm39) |
Y130C |
probably damaging |
Het |
| Or2ag1b |
A |
T |
7: 106,288,079 (GRCm39) |
N286K |
probably damaging |
Het |
| Or4f15 |
C |
T |
2: 111,814,396 (GRCm39) |
V8I |
probably benign |
Het |
| Or6c65 |
C |
A |
10: 129,603,389 (GRCm39) |
T8K |
probably benign |
Het |
| Pcdhb12 |
T |
C |
18: 37,569,892 (GRCm39) |
V346A |
probably benign |
Het |
| Pla2g4a |
A |
G |
1: 149,733,238 (GRCm39) |
S504P |
probably benign |
Het |
| Plin2 |
G |
T |
4: 86,575,526 (GRCm39) |
A341D |
probably damaging |
Het |
| Plxnb2 |
A |
T |
15: 89,049,494 (GRCm39) |
I575N |
probably benign |
Het |
| Pnma8b |
T |
G |
7: 16,680,158 (GRCm39) |
W381G |
probably benign |
Het |
| Psma8 |
A |
G |
18: 14,854,324 (GRCm39) |
D68G |
probably damaging |
Het |
| Rcor3 |
G |
A |
1: 191,808,559 (GRCm39) |
H207Y |
probably benign |
Het |
| Rwdd2b |
C |
A |
16: 87,231,356 (GRCm39) |
G266V |
probably damaging |
Het |
| Ryr3 |
A |
G |
2: 112,490,449 (GRCm39) |
F3795S |
probably damaging |
Het |
| Slc28a2b |
A |
T |
2: 122,353,963 (GRCm39) |
I530F |
probably damaging |
Het |
| Sord |
T |
A |
2: 122,089,613 (GRCm39) |
|
probably null |
Het |
| Spdl1 |
T |
A |
11: 34,710,713 (GRCm39) |
N345I |
probably damaging |
Het |
| St8sia2 |
T |
A |
7: 73,626,441 (GRCm39) |
R42S |
possibly damaging |
Het |
| Syt9 |
G |
T |
7: 107,035,717 (GRCm39) |
V245F |
possibly damaging |
Het |
| Tbpl2 |
T |
A |
2: 23,984,898 (GRCm39) |
N82I |
possibly damaging |
Het |
| Tcerg1 |
T |
A |
18: 42,686,530 (GRCm39) |
Y696N |
probably damaging |
Het |
| Thsd7b |
A |
G |
1: 129,595,655 (GRCm39) |
T492A |
probably benign |
Het |
| Timm13 |
A |
C |
10: 80,736,135 (GRCm39) |
|
probably benign |
Het |
| Trdmt1 |
T |
A |
2: 13,524,870 (GRCm39) |
Q195L |
probably benign |
Het |
| Ttc27 |
T |
A |
17: 75,165,086 (GRCm39) |
V764D |
probably damaging |
Het |
| Ttc39d |
C |
A |
17: 80,524,076 (GRCm39) |
S245* |
probably null |
Het |
| Ttc41 |
A |
G |
10: 86,567,023 (GRCm39) |
E563G |
probably benign |
Het |
| Ttc41 |
A |
T |
10: 86,569,571 (GRCm39) |
T650S |
probably benign |
Het |
| U2surp |
A |
C |
9: 95,358,210 (GRCm39) |
L723R |
probably damaging |
Het |
| Ubqln3 |
G |
A |
7: 103,791,524 (GRCm39) |
Q189* |
probably null |
Het |
| Vezf1 |
A |
G |
11: 87,972,326 (GRCm39) |
N229S |
probably damaging |
Het |
| Zfp518a |
A |
G |
19: 40,902,567 (GRCm39) |
D832G |
probably benign |
Het |
| Zfyve28 |
T |
C |
5: 34,356,216 (GRCm39) |
N762D |
probably damaging |
Het |
|
| Other mutations in Vmn2r79 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01401:Vmn2r79
|
APN |
7 |
86,686,481 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01675:Vmn2r79
|
APN |
7 |
86,645,856 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01760:Vmn2r79
|
APN |
7 |
86,651,366 (GRCm39) |
missense |
probably benign |
|
|
IGL01834:Vmn2r79
|
APN |
7 |
86,686,354 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01843:Vmn2r79
|
APN |
7 |
86,686,485 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01914:Vmn2r79
|
APN |
7 |
86,686,571 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL01980:Vmn2r79
|
APN |
7 |
86,686,290 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02438:Vmn2r79
|
APN |
7 |
86,651,744 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02740:Vmn2r79
|
APN |
7 |
86,653,366 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03052:Vmn2r79
|
UTSW |
7 |
86,652,799 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4445001:Vmn2r79
|
UTSW |
7 |
86,651,408 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R0096:Vmn2r79
|
UTSW |
7 |
86,686,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0096:Vmn2r79
|
UTSW |
7 |
86,686,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0270:Vmn2r79
|
UTSW |
7 |
86,652,594 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0336:Vmn2r79
|
UTSW |
7 |
86,651,287 (GRCm39) |
missense |
probably benign |
0.15 |
|
R0418:Vmn2r79
|
UTSW |
7 |
86,651,611 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1070:Vmn2r79
|
UTSW |
7 |
86,652,681 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1234:Vmn2r79
|
UTSW |
7 |
86,653,307 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1459:Vmn2r79
|
UTSW |
7 |
86,687,002 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1513:Vmn2r79
|
UTSW |
7 |
86,686,652 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1624:Vmn2r79
|
UTSW |
7 |
86,653,247 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1633:Vmn2r79
|
UTSW |
7 |
86,687,042 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1676:Vmn2r79
|
UTSW |
7 |
86,651,839 (GRCm39) |
missense |
probably benign |
|
|
R1781:Vmn2r79
|
UTSW |
7 |
86,651,555 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1794:Vmn2r79
|
UTSW |
7 |
86,650,621 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1823:Vmn2r79
|
UTSW |
7 |
86,687,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2013:Vmn2r79
|
UTSW |
7 |
86,653,289 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2018:Vmn2r79
|
UTSW |
7 |
86,651,634 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2019:Vmn2r79
|
UTSW |
7 |
86,651,634 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2177:Vmn2r79
|
UTSW |
7 |
86,645,839 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2984:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R3719:Vmn2r79
|
UTSW |
7 |
86,651,245 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3798:Vmn2r79
|
UTSW |
7 |
86,651,402 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R3969:Vmn2r79
|
UTSW |
7 |
86,652,801 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4182:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4183:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4245:Vmn2r79
|
UTSW |
7 |
86,651,624 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4301:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4391:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4393:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4394:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4396:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4397:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4592:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4697:Vmn2r79
|
UTSW |
7 |
86,687,168 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4897:Vmn2r79
|
UTSW |
7 |
86,650,675 (GRCm39) |
missense |
probably benign |
|
|
R5016:Vmn2r79
|
UTSW |
7 |
86,686,548 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5058:Vmn2r79
|
UTSW |
7 |
86,651,423 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5177:Vmn2r79
|
UTSW |
7 |
86,651,177 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6078:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6079:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6138:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6257:Vmn2r79
|
UTSW |
7 |
86,651,778 (GRCm39) |
missense |
probably benign |
0.27 |
|
R6307:Vmn2r79
|
UTSW |
7 |
86,686,976 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6323:Vmn2r79
|
UTSW |
7 |
86,650,522 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6374:Vmn2r79
|
UTSW |
7 |
86,651,498 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6530:Vmn2r79
|
UTSW |
7 |
86,651,252 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6546:Vmn2r79
|
UTSW |
7 |
86,652,741 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6682:Vmn2r79
|
UTSW |
7 |
86,653,370 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6858:Vmn2r79
|
UTSW |
7 |
86,686,580 (GRCm39) |
missense |
probably benign |
|
|
R6965:Vmn2r79
|
UTSW |
7 |
86,651,100 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7130:Vmn2r79
|
UTSW |
7 |
86,651,474 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7156:Vmn2r79
|
UTSW |
7 |
86,686,851 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7604:Vmn2r79
|
UTSW |
7 |
86,652,592 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7691:Vmn2r79
|
UTSW |
7 |
86,687,111 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8055:Vmn2r79
|
UTSW |
7 |
86,686,541 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8070:Vmn2r79
|
UTSW |
7 |
86,651,336 (GRCm39) |
missense |
probably benign |
|
|
R8073:Vmn2r79
|
UTSW |
7 |
86,651,462 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8145:Vmn2r79
|
UTSW |
7 |
86,686,862 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8263:Vmn2r79
|
UTSW |
7 |
86,686,726 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8350:Vmn2r79
|
UTSW |
7 |
86,686,741 (GRCm39) |
nonsense |
probably null |
|
|
R8400:Vmn2r79
|
UTSW |
7 |
86,651,308 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8814:Vmn2r79
|
UTSW |
7 |
86,651,714 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8862:Vmn2r79
|
UTSW |
7 |
86,645,712 (GRCm39) |
missense |
probably benign |
0.23 |
|
R9146:Vmn2r79
|
UTSW |
7 |
86,650,681 (GRCm39) |
nonsense |
probably null |
|
|
R9276:Vmn2r79
|
UTSW |
7 |
86,687,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9361:Vmn2r79
|
UTSW |
7 |
86,652,822 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9676:Vmn2r79
|
UTSW |
7 |
86,686,452 (GRCm39) |
missense |
probably damaging |
1.00 |
|
U15987:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
X0054:Vmn2r79
|
UTSW |
7 |
86,653,270 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1088:Vmn2r79
|
UTSW |
7 |
86,651,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Vmn2r79
|
UTSW |
7 |
86,686,377 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Vmn2r79
|
UTSW |
7 |
86,651,526 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATGCGATGAATGACGAATCTAAGAC -3'
(R):5'- GGATACAGCTAACCATACTGGG -3'
Sequencing Primer
(F):5'- GACGAATCTAAGACATTCTATTGTGG -3'
(R):5'- GATACAGCTAACCATACTGGGATAAC -3'
|
| Posted On |
2018-03-15 |
Incidental Mutation