Incidental Mutation 'R6261:Or8g36'
ID 506707
Institutional Source Beutler Lab
Gene Symbol Or8g36
Ensembl Gene ENSMUSG00000095322
Gene Name olfactory receptor family 8 subfamily G member 36
Synonyms Olfr957, MOR171-12, GA_x6K02T2PVTD-33208209-33207274
MMRRC Submission 044404-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.083) question?
Stock # R6261 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 39422079-39423014 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 39422105 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Phenylalanine at position 304 (V304F)
Ref Sequence ENSEMBL: ENSMUSP00000149559 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051653] [ENSMUST00000216177]
AlphaFold Q9EQB7
Predicted Effect probably benign
Transcript: ENSMUST00000051653
AA Change: V304F

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000054536
Gene: ENSMUSG00000095322
AA Change: V304F

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.8e-50 PFAM
Pfam:7tm_1 41 290 3.8e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216177
AA Change: V304F

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.7%
  • 20x: 96.7%
Validation Efficiency 100% (65/65)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot8 T C 2: 164,636,979 (GRCm39) D257G probably damaging Het
Adamtsl1 T C 4: 86,255,115 (GRCm39) V736A probably benign Het
Anln A G 9: 22,275,342 (GRCm39) L521S probably damaging Het
Arfgap2 T G 2: 91,100,627 (GRCm39) S311A probably benign Het
Brdt A T 5: 107,496,369 (GRCm39) E160D probably benign Het
Ccdc187 A G 2: 26,166,215 (GRCm39) I738T probably damaging Het
Cd59a G C 2: 103,934,550 (GRCm39) G6A probably damaging Het
Cd5l C T 3: 87,275,915 (GRCm39) P295L probably benign Het
Cdhr17 T C 5: 17,017,183 (GRCm39) noncoding transcript Het
Cnot1 A G 8: 96,468,549 (GRCm39) S1432P probably benign Het
Cnot8 T A 11: 58,004,877 (GRCm39) I192N probably damaging Het
Col4a1 G T 8: 11,257,409 (GRCm39) probably null Het
Cuta A G 17: 27,158,301 (GRCm39) L11P possibly damaging Het
Cyp2c39 G A 19: 39,556,463 (GRCm39) R433H probably damaging Het
Cyp4a12b T A 4: 115,271,740 (GRCm39) Y150* probably null Het
Dcaf15 G A 8: 84,825,734 (GRCm39) A291V probably benign Het
Dcstamp A T 15: 39,618,131 (GRCm39) H180L possibly damaging Het
Egfr A G 11: 16,839,964 (GRCm39) I659M probably benign Het
Fzd8 A G 18: 9,214,598 (GRCm39) E560G possibly damaging Het
Gm5111 A T 6: 48,566,526 (GRCm39) probably benign Het
Gm7945 T C 14: 41,104,780 (GRCm39) T214A unknown Het
Gpi1 T C 7: 33,920,170 (GRCm39) T168A possibly damaging Het
Gys2 T C 6: 142,405,134 (GRCm39) I218V probably benign Het
Gzmf T A 14: 56,443,949 (GRCm39) I74L probably benign Het
Hacl1 G A 14: 31,357,728 (GRCm39) A70V probably damaging Het
Herc2 T A 7: 55,846,820 (GRCm39) L3590* probably null Het
Idh2 GGTCCCAG GG 7: 79,748,077 (GRCm39) probably benign Het
Igfals G T 17: 25,100,339 (GRCm39) V477F possibly damaging Het
Igkv8-28 A T 6: 70,120,874 (GRCm39) V23E probably benign Het
Isg20l2 T A 3: 87,839,395 (GRCm39) V202E probably damaging Het
Jakmip2 A G 18: 43,708,599 (GRCm39) I288T probably benign Het
Kansl3 A G 1: 36,404,686 (GRCm39) V88A probably benign Het
Kcna3 A G 3: 106,945,266 (GRCm39) T510A possibly damaging Het
Map2k5 G T 9: 63,245,380 (GRCm39) L140I probably benign Het
Map3k19 A G 1: 127,750,336 (GRCm39) I1005T possibly damaging Het
Mmp25 G A 17: 23,849,768 (GRCm39) A541V possibly damaging Het
Ms4a14 T A 19: 11,281,384 (GRCm39) E391D probably benign Het
Mtrf1l A G 10: 5,765,550 (GRCm39) probably null Het
Myom1 A G 17: 71,433,132 (GRCm39) N1591S probably damaging Het
Nos1 G A 5: 118,074,635 (GRCm39) V1060M probably benign Het
Nsun5 C T 5: 135,400,385 (GRCm39) T142M probably damaging Het
Odc1 A G 12: 17,600,655 (GRCm39) E430G probably benign Het
P2ry12 T C 3: 59,125,328 (GRCm39) I116V probably null Het
Patl1 T A 19: 11,897,695 (GRCm39) V94E probably damaging Het
Plin3 A T 17: 56,588,488 (GRCm39) Y255* probably null Het
Pou6f1 T C 15: 100,477,827 (GRCm39) T439A probably damaging Het
Prdm13 T C 4: 21,678,366 (GRCm39) K708R probably damaging Het
Prr14l A G 5: 32,986,748 (GRCm39) S916P possibly damaging Het
Rab34 T A 11: 78,082,028 (GRCm39) probably null Het
Rps7 A G 12: 28,685,593 (GRCm39) S21P possibly damaging Het
Scn9a A T 2: 66,314,240 (GRCm39) L1815Q probably damaging Het
Sesn3 A G 9: 14,232,459 (GRCm39) Y244C probably benign Het
Slc15a2 A G 16: 36,581,973 (GRCm39) F284L probably benign Het
Slc25a44 C T 3: 88,328,218 (GRCm39) G72D probably damaging Het
Slco6d1 A G 1: 98,427,588 (GRCm39) T640A probably benign Het
Sspo A T 6: 48,439,125 (GRCm39) E1591V possibly damaging Het
Tbata C A 10: 61,011,644 (GRCm39) T60K possibly damaging Het
Tbc1d2 T A 4: 46,637,692 (GRCm39) T185S possibly damaging Het
Tlcd4 T A 3: 121,028,708 (GRCm39) I60F possibly damaging Het
Tmem87a A G 2: 120,234,502 (GRCm39) S14P possibly damaging Het
Tnnt2 C A 1: 135,778,292 (GRCm39) probably null Het
Trex1 A G 9: 108,887,709 (GRCm39) V94A probably benign Het
Ubtfl1 A C 9: 18,320,592 (GRCm39) D40A possibly damaging Het
Zc3hav1 A T 6: 38,309,935 (GRCm39) Y296N probably benign Het
Zfp521 T A 18: 13,977,684 (GRCm39) N910Y probably damaging Het
Zfp53 A G 17: 21,728,975 (GRCm39) E336G possibly damaging Het
Other mutations in Or8g36
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01520:Or8g36 APN 9 39,422,342 (GRCm39) missense possibly damaging 0.64
R0603:Or8g36 UTSW 9 39,422,810 (GRCm39) missense possibly damaging 0.76
R1642:Or8g36 UTSW 9 39,422,650 (GRCm39) missense possibly damaging 0.78
R2044:Or8g36 UTSW 9 39,422,674 (GRCm39) missense probably damaging 0.99
R2182:Or8g36 UTSW 9 39,422,722 (GRCm39) missense probably damaging 1.00
R2290:Or8g36 UTSW 9 39,422,974 (GRCm39) missense possibly damaging 0.87
R4246:Or8g36 UTSW 9 39,422,899 (GRCm39) missense probably benign 0.31
R4248:Or8g36 UTSW 9 39,422,899 (GRCm39) missense probably benign 0.31
R5273:Or8g36 UTSW 9 39,422,795 (GRCm39) missense possibly damaging 0.95
R5495:Or8g36 UTSW 9 39,422,441 (GRCm39) missense probably benign 0.39
R5718:Or8g36 UTSW 9 39,422,338 (GRCm39) missense probably damaging 1.00
R5827:Or8g36 UTSW 9 39,422,354 (GRCm39) missense probably damaging 1.00
R6917:Or8g36 UTSW 9 39,422,495 (GRCm39) missense probably damaging 1.00
R7965:Or8g36 UTSW 9 39,422,810 (GRCm39) missense probably benign 0.00
R8357:Or8g36 UTSW 9 39,422,442 (GRCm39) missense probably benign 0.38
R8457:Or8g36 UTSW 9 39,422,442 (GRCm39) missense probably benign 0.38
R8896:Or8g36 UTSW 9 39,422,770 (GRCm39) missense probably damaging 1.00
R8938:Or8g36 UTSW 9 39,422,910 (GRCm39) nonsense probably null
R9249:Or8g36 UTSW 9 39,422,149 (GRCm39) missense probably damaging 1.00
R9629:Or8g36 UTSW 9 39,422,497 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GAGTGGCAGTGGACTTCATC -3'
(R):5'- ACTGAAGGCAGGTCCAAAGC -3'

Sequencing Primer
(F):5'- GACTTCATCCTCGGAGTCCAGTG -3'
(R):5'- AGGCAGGTCCAAAGCCTTCAG -3'
Posted On 2018-03-15