Incidental Mutation 'IGL01062:Cdc14a'
ID 50680
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cdc14a
Ensembl Gene ENSMUSG00000033502
Gene Name CDC14 cell division cycle 14A
Synonyms A830059A17Rik, CDC14a1, CDC14A2, Cdc14
Accession Numbers
Essential gene? Probably non essential (E-score: 0.229) question?
Stock # IGL01062
Quality Score
Status
Chromosome 3
Chromosomal Location 116066202-116222390 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 116068361 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000102100 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090464] [ENSMUST00000106491]
AlphaFold Q6GQT0
Predicted Effect probably benign
Transcript: ENSMUST00000090464
SMART Domains Protein: ENSMUSP00000087950
Gene: ENSMUSG00000033502

DomainStartEndE-ValueType
Pfam:DSPn 13 153 1.6e-66 PFAM
Pfam:Y_phosphatase 210 324 1.1e-7 PFAM
Pfam:DSPc 214 328 1.8e-14 PFAM
low complexity region 539 558 N/A INTRINSIC
low complexity region 573 595 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000106491
SMART Domains Protein: ENSMUSP00000102100
Gene: ENSMUSG00000033502

DomainStartEndE-ValueType
Pfam:DSPn 12 121 9.5e-44 PFAM
Pfam:Y_phosphatase 160 274 6.4e-8 PFAM
Pfam:DSPc 160 280 2.8e-14 PFAM
low complexity region 490 509 N/A INTRINSIC
low complexity region 524 546 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aen G A 7: 78,557,050 (GRCm39) M299I probably damaging Het
Amer3 A G 1: 34,625,820 (GRCm39) K20E probably damaging Het
Arhgap31 A G 16: 38,421,818 (GRCm39) L1416P probably damaging Het
Avpr1a G A 10: 122,285,434 (GRCm39) C242Y probably damaging Het
Bclaf3 T C X: 158,336,415 (GRCm39) Y281H probably benign Het
Cfap206 C T 4: 34,721,562 (GRCm39) S162N probably damaging Het
Cntn4 T C 6: 106,595,239 (GRCm39) probably benign Het
Cyp3a44 T A 5: 145,731,149 (GRCm39) D217V possibly damaging Het
Eprs1 A G 1: 185,111,812 (GRCm39) E274G probably benign Het
Ercc6l2 G T 13: 63,995,268 (GRCm39) Q354H probably null Het
Glb1l A T 1: 75,177,882 (GRCm39) I392N probably damaging Het
Gm3173 T C 14: 15,728,472 (GRCm39) probably null Het
Hadh C T 3: 131,034,640 (GRCm39) V219M probably damaging Het
Hspb9 A G 11: 100,604,761 (GRCm39) H29R possibly damaging Het
Iqgap3 G T 3: 88,017,429 (GRCm39) V240L probably benign Het
Jmjd1c T C 10: 67,062,494 (GRCm39) S1616P probably damaging Het
Knl1 A G 2: 118,907,461 (GRCm39) I1662V probably benign Het
Maco1 A T 4: 134,560,608 (GRCm39) V125E probably damaging Het
Mapre3 A G 5: 31,022,240 (GRCm39) I236V probably benign Het
Med17 T C 9: 15,190,917 (GRCm39) E58G probably benign Het
Myh6 T C 14: 55,189,749 (GRCm39) E1099G probably damaging Het
Myt1 T A 2: 181,439,522 (GRCm39) V348D probably damaging Het
Nat10 A T 2: 103,573,393 (GRCm39) I368N probably damaging Het
Nol6 T C 4: 41,118,205 (GRCm39) I811V probably benign Het
Oas1d C A 5: 121,057,127 (GRCm39) Y244* probably null Het
Or6e1 A T 14: 54,520,181 (GRCm39) M57K probably damaging Het
Osbpl1a A G 18: 13,038,132 (GRCm39) V273A probably benign Het
Pigw T C 11: 84,768,769 (GRCm39) R187G probably benign Het
Plekhg5 G A 4: 152,192,953 (GRCm39) D603N probably damaging Het
Ptprk T C 10: 28,456,414 (GRCm39) V1058A probably damaging Het
Robo4 G A 9: 37,317,296 (GRCm39) S537N probably benign Het
Rptn T A 3: 93,304,489 (GRCm39) F607L probably benign Het
Sall1 A G 8: 89,759,972 (GRCm39) V44A probably damaging Het
Sh3bp4 C A 1: 89,071,682 (GRCm39) Q177K probably benign Het
Skic3 T A 13: 76,303,581 (GRCm39) L1225* probably null Het
Spmip6 T A 4: 41,511,433 (GRCm39) E93D probably damaging Het
Srrt C A 5: 137,294,569 (GRCm39) G779V probably damaging Het
Tamalin A G 15: 101,126,777 (GRCm39) probably benign Het
Tex21 T C 12: 76,245,718 (GRCm39) D526G probably benign Het
Vmn1r10 A G 6: 57,090,821 (GRCm39) S138G possibly damaging Het
Yars2 C T 16: 16,124,406 (GRCm39) R338* probably null Het
Zfp454 T C 11: 50,765,033 (GRCm39) E22G probably benign Het
Zzef1 T A 11: 72,765,795 (GRCm39) C1441S probably benign Het
Other mutations in Cdc14a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00801:Cdc14a APN 3 116,088,493 (GRCm39) nonsense probably null
IGL01584:Cdc14a APN 3 116,186,474 (GRCm39) nonsense probably null
IGL03084:Cdc14a APN 3 116,142,101 (GRCm39) critical splice donor site probably null
IGL03237:Cdc14a APN 3 116,198,275 (GRCm39) intron probably benign
IGL03296:Cdc14a APN 3 116,090,807 (GRCm39) missense probably benign 0.02
PIT4131001:Cdc14a UTSW 3 116,122,310 (GRCm39) missense possibly damaging 0.66
R0707:Cdc14a UTSW 3 116,087,362 (GRCm39) splice site probably benign
R0782:Cdc14a UTSW 3 116,115,785 (GRCm39) missense probably damaging 1.00
R0835:Cdc14a UTSW 3 116,122,171 (GRCm39) missense probably benign 0.12
R1363:Cdc14a UTSW 3 116,087,509 (GRCm39) small deletion probably benign
R1507:Cdc14a UTSW 3 116,087,646 (GRCm39) missense possibly damaging 0.47
R1545:Cdc14a UTSW 3 116,087,373 (GRCm39) critical splice donor site probably null
R1795:Cdc14a UTSW 3 116,092,122 (GRCm39) missense possibly damaging 0.81
R1797:Cdc14a UTSW 3 116,115,843 (GRCm39) missense probably damaging 1.00
R1830:Cdc14a UTSW 3 116,216,296 (GRCm39) nonsense probably null
R4229:Cdc14a UTSW 3 116,087,413 (GRCm39) missense probably damaging 0.99
R4655:Cdc14a UTSW 3 116,122,136 (GRCm39) missense probably damaging 1.00
R4769:Cdc14a UTSW 3 116,088,399 (GRCm39) critical splice donor site probably null
R4870:Cdc14a UTSW 3 116,217,109 (GRCm39) missense probably benign 0.30
R4980:Cdc14a UTSW 3 116,186,506 (GRCm39) nonsense probably null
R6228:Cdc14a UTSW 3 116,144,862 (GRCm39) missense probably damaging 1.00
R6248:Cdc14a UTSW 3 116,101,843 (GRCm39) missense probably benign 0.01
R6402:Cdc14a UTSW 3 116,142,108 (GRCm39) missense probably damaging 1.00
R6749:Cdc14a UTSW 3 116,090,807 (GRCm39) missense possibly damaging 0.68
R6852:Cdc14a UTSW 3 116,122,325 (GRCm39) missense possibly damaging 0.94
R6996:Cdc14a UTSW 3 116,122,355 (GRCm39) missense probably damaging 1.00
R7185:Cdc14a UTSW 3 116,087,676 (GRCm39) missense probably benign
R7783:Cdc14a UTSW 3 116,198,236 (GRCm39) missense probably damaging 1.00
R7896:Cdc14a UTSW 3 116,088,482 (GRCm39) missense probably benign 0.00
R7991:Cdc14a UTSW 3 116,101,887 (GRCm39) missense probably benign 0.01
R8049:Cdc14a UTSW 3 116,087,577 (GRCm39) missense probably benign 0.33
R9163:Cdc14a UTSW 3 116,122,213 (GRCm39) missense possibly damaging 0.95
R9434:Cdc14a UTSW 3 116,217,092 (GRCm39) missense probably benign
R9526:Cdc14a UTSW 3 116,087,509 (GRCm39) small deletion probably benign
R9662:Cdc14a UTSW 3 116,088,484 (GRCm39) missense probably damaging 0.99
R9781:Cdc14a UTSW 3 116,122,274 (GRCm39) missense probably benign 0.01
Posted On 2013-06-21