Incidental Mutation 'IGL01074:Lingo4'
ID50704
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lingo4
Ensembl Gene ENSMUSG00000044505
Gene Nameleucine rich repeat and Ig domain containing 4
SynonymsLrrn6d, LERN4, A530050P17Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.061) question?
Stock #IGL01074
Quality Score
Status
Chromosome3
Chromosomal Location94398517-94404501 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 94403288 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 511 (V511A)
Ref Sequence ENSEMBL: ENSMUSP00000058050 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050975]
Predicted Effect probably benign
Transcript: ENSMUST00000050975
AA Change: V511A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000058050
Gene: ENSMUSG00000044505
AA Change: V511A

DomainStartEndE-ValueType
LRRNT 55 89 1.23e-4 SMART
LRR 88 107 2.76e2 SMART
LRR_TYP 108 131 1.02e-6 SMART
LRR_TYP 132 155 7.26e-3 SMART
LRR 156 179 1.33e1 SMART
LRR_TYP 180 203 5.42e-2 SMART
LRR 204 227 4.45e1 SMART
LRR 228 251 3.27e1 SMART
LRR 300 323 4.83e0 SMART
LRR 324 347 3.07e-1 SMART
LRR 348 371 3.36e1 SMART
LRRCT 383 436 5.24e-5 SMART
IGc2 451 516 3.53e-13 SMART
transmembrane domain 560 582 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198829
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 A G 10: 80,013,892 D1934G possibly damaging Het
Adcy2 A T 13: 68,796,654 I203N possibly damaging Het
Asxl3 T C 18: 22,522,845 V1304A probably damaging Het
Cmah A G 13: 24,464,255 D491G possibly damaging Het
Cobll1 A G 2: 65,107,848 S364P probably damaging Het
Cspg4 T C 9: 56,898,865 L2320P probably damaging Het
Defa5 T A 8: 21,297,576 F46L possibly damaging Het
Erich6b T A 14: 75,658,768 N31K probably benign Het
Fcrl6 C T 1: 172,599,113 V89M possibly damaging Het
Gm5458 G T 14: 19,599,692 L155I probably damaging Het
Hlx T C 1: 184,727,813 D376G probably damaging Het
Hmcn1 A G 1: 150,627,033 S3948P possibly damaging Het
Igf2bp2 G A 16: 22,063,704 R416W probably damaging Het
Lama4 T C 10: 39,098,488 probably null Het
Mllt3 C A 4: 87,791,881 V29L probably benign Het
Mmp16 T C 4: 18,110,584 probably benign Het
Moxd1 A G 10: 24,279,384 R228G probably benign Het
Myrfl T C 10: 116,779,585 N802S possibly damaging Het
Nmu C A 5: 76,343,927 V121F probably damaging Het
Npepps T C 11: 97,217,811 T760A probably damaging Het
Ogfod1 G T 8: 94,063,006 W445L probably damaging Het
Olfr1221 T C 2: 89,111,679 T278A probably benign Het
Oplah G A 15: 76,305,748 P222S probably damaging Het
Slc4a4 T A 5: 89,179,774 L699H probably damaging Het
Sod3 C T 5: 52,368,198 Q80* probably null Het
Syne2 C T 12: 76,031,587 Q4732* probably null Het
Syne2 T C 12: 75,987,011 I3678T probably benign Het
Tedc1 C T 12: 113,163,188 R357* probably null Het
Tmem220 T C 11: 67,032,173 probably benign Het
Uhrf1bp1 A G 17: 27,879,291 I136V possibly damaging Het
Ush1c A G 7: 46,225,250 probably benign Het
Wbp2nl T C 15: 82,314,290 S343P possibly damaging Het
Other mutations in Lingo4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02662:Lingo4 APN 3 94401817 unclassified probably benign
IGL02687:Lingo4 APN 3 94402097 missense probably damaging 1.00
IGL02711:Lingo4 APN 3 94403393 missense probably benign
IGL03001:Lingo4 APN 3 94402396 missense probably damaging 1.00
IGL03260:Lingo4 APN 3 94401943 missense probably benign
PIT4449001:Lingo4 UTSW 3 94401932 missense probably benign
R0088:Lingo4 UTSW 3 94402033 missense probably benign 0.39
R0616:Lingo4 UTSW 3 94403081 missense probably benign 0.00
R1455:Lingo4 UTSW 3 94399392 unclassified probably benign
R1733:Lingo4 UTSW 3 94403178 missense probably benign 0.00
R2001:Lingo4 UTSW 3 94403075 missense probably damaging 1.00
R2085:Lingo4 UTSW 3 94402245 missense probably damaging 1.00
R3793:Lingo4 UTSW 3 94402378 missense probably benign
R3805:Lingo4 UTSW 3 94402100 missense probably damaging 1.00
R3806:Lingo4 UTSW 3 94402100 missense probably damaging 1.00
R4438:Lingo4 UTSW 3 94402897 missense possibly damaging 0.79
R4660:Lingo4 UTSW 3 94403365 missense probably benign 0.00
R4724:Lingo4 UTSW 3 94402876 nonsense probably null
R4981:Lingo4 UTSW 3 94399454 missense probably benign 0.18
R4994:Lingo4 UTSW 3 94402541 missense probably benign
R4994:Lingo4 UTSW 3 94403001 missense probably benign 0.02
R5600:Lingo4 UTSW 3 94401913 missense probably benign
R6188:Lingo4 UTSW 3 94402850 missense probably damaging 1.00
R6267:Lingo4 UTSW 3 94403390 missense probably benign 0.02
R6303:Lingo4 UTSW 3 94403206 missense probably damaging 1.00
R6304:Lingo4 UTSW 3 94403206 missense probably damaging 1.00
R6789:Lingo4 UTSW 3 94399355 unclassified probably benign
R7313:Lingo4 UTSW 3 94403144 missense possibly damaging 0.95
R7329:Lingo4 UTSW 3 94402855 missense probably benign
R7631:Lingo4 UTSW 3 94399460 missense possibly damaging 0.93
R7908:Lingo4 UTSW 3 94402234 missense probably benign 0.19
R7989:Lingo4 UTSW 3 94402234 missense probably benign 0.19
X0054:Lingo4 UTSW 3 94403376 missense possibly damaging 0.54
Z1177:Lingo4 UTSW 3 94402994 missense probably damaging 1.00
Posted On2013-06-21