Mutagenetix > Incidental Mutation

Incidental Mutation 'R6268:Vmn2r14'

507147

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r14

Ensembl Gene

ENSMUSG00000091059

Gene Name

vomeronasal 2, receptor 14

Synonyms

EG231591

MMRRC Submission

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.447) question?

Stock #

R6268 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

109215502-109224622 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 109221417 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Alanine at position 97 (S97A)

Ref Sequence

ENSEMBL: ENSMUSP00000128015 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170341]

AlphaFold

E9Q759

Predicted Effect

possibly damaging
Transcript: ENSMUST00000170341
AA Change: S97A

PolyPhen 2 Score 0.870 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000128015
Gene: ENSMUSG00000091059
AA Change: S97A

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
Pfam:ANF_receptor	76	466	8.3e-31	PFAM
Pfam:NCD3G	507	561	1.1e-17	PFAM
Pfam:7tm_3	594	829	1.2e-55	PFAM

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.3%
20x: 95.5%

Validation Efficiency

99% (68/69)

Allele List at MGI

Other mutations in this stock

Total: 70 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921504E06Rik	A	G	2: 19,540,408	I78T	probably benign	Het
Afg3l1	A	T	8: 123,492,926	I398F	probably damaging	Het
Ahctf1	T	C	1: 179,763,483	H1244R	probably benign	Het
Ank1	A	T	8: 23,109,671	K797N	probably damaging	Het
Anxa6	G	T	11: 54,987,077		probably null	Het
Ap1b1	T	A	11: 5,019,493	V310E	probably damaging	Het
C2cd2l	T	C	9: 44,317,666	I123V	probably damaging	Het
Cars2	TCCCC	TCCC	8: 11,529,599		probably null	Het
Cfap54	T	A	10: 93,038,909	I542F	probably damaging	Het
Cfap57	G	T	4: 118,569,451	Y1100*	probably null	Het
Coq9	A	G	8: 94,850,234	E158G	probably benign	Het
Cox15	A	T	19: 43,739,926	W303R	possibly damaging	Het
Cpa5	A	G	6: 30,615,173	Y103C	probably damaging	Het
Crygn	A	T	5: 24,756,191	V39E	probably damaging	Het
Csf1	G	T	3: 107,747,157	S132R	possibly damaging	Het
Dapk1	G	A	13: 60,761,766	V1398M	possibly damaging	Het
Degs2	C	A	12: 108,692,580	V47L	probably damaging	Het
Dock5	C	A	14: 67,790,275	E1057*	probably null	Het
Doxl2	T	A	6: 48,977,682	Y585N	probably benign	Het
Dsg1b	C	A	18: 20,388,163	Q26K	probably benign	Het
Fam181a	T	C	12: 103,316,544	V236A	possibly damaging	Het
Fam78b	C	A	1: 167,078,553	P94T	probably damaging	Het
Fbxw25	T	G	9: 109,654,650	T165P	probably damaging	Het
Flg	C	A	3: 93,288,175		probably benign	Het
Frrs1	G	T	3: 116,903,099	V573F	probably damaging	Het
Gm7298	A	G	6: 121,779,073	T964A	possibly damaging	Het
Hoxd9	G	T	2: 74,698,089	V12L	probably damaging	Het
Ikbkap	T	C	4: 56,762,305	Y1098C	probably damaging	Het
Kcnt1	A	G	2: 25,903,597		probably null	Het
Klhl3	G	T	13: 58,013,842	R480S	probably damaging	Het
Klhl36	A	G	8: 119,870,667	D369G	probably damaging	Het
Lama3	T	A	18: 12,524,737	N303K	probably damaging	Het
Lhcgr	T	C	17: 88,742,704	T465A	probably damaging	Het
Llgl1	T	C	11: 60,712,163	V888A	probably benign	Het
Lrp1b	T	A	2: 40,821,717	T3164S	probably benign	Het
Mmp3	T	G	9: 7,447,622	D202E	possibly damaging	Het
Mocs1	C	A	17: 49,435,155	T104K	probably damaging	Het
Mrpl42	A	T	10: 95,496,707		probably null	Het
Mtch2	T	C	2: 90,863,648	C279R	probably benign	Het
Muc4	A	T	16: 32,768,767	D2836V	probably damaging	Het
Myh7	T	C	14: 54,989,284	E370G	probably benign	Het
Naa11	A	G	5: 97,392,210	Y30H	probably damaging	Het
Ntng1	T	C	3: 109,935,035	T141A	probably damaging	Het
Olfr1499	A	T	19: 13,815,307	Y94*	probably null	Het
Olfr196	A	C	16: 59,167,293		probably null	Het
Olfr251	T	C	9: 38,378,088	I69T	probably benign	Het
Pcdha12	G	A	18: 37,022,424	C732Y	possibly damaging	Het
Plekhm2	G	A	4: 141,632,341	Q392*	probably null	Het
Prr22	G	A	17: 56,771,587	V247M	probably damaging	Het
Rapgef6	T	A	11: 54,649,247	L716Q	probably damaging	Het
Rasgrp4	G	A	7: 29,143,068	V246I	probably damaging	Het
Rhbdd2	C	T	5: 135,643,260	T323I	probably benign	Het
Rsf1	CG	CGACGGCGGTG	7: 97,579,908		probably benign	Homo
Scgb2b20	A	T	7: 33,364,548	I99K	possibly damaging	Het
Scyl3	C	T	1: 163,946,217	R324*	probably null	Het
Slc23a1	T	C	18: 35,619,571	Y551C	probably damaging	Het
Slc5a5	A	T	8: 70,888,620	S358R	probably damaging	Het
Sorcs3	T	A	19: 48,790,166	N1007K	probably damaging	Het
Stxbp4	T	A	11: 90,540,201	K428*	probably null	Het
Tmem63c	T	A	12: 87,081,953	I584N	probably damaging	Het
Traf3ip3	C	T	1: 193,198,036		probably benign	Het
Trgv2	G	A	13: 19,336,831	T31I	probably benign	Het
Ttll3	C	T	6: 113,392,563	R23C	probably benign	Het
Ugt2a3	A	C	5: 87,329,613	L309R	probably damaging	Het
Urb1	A	G	16: 90,753,919	M2015T	probably benign	Het
Vps13c	C	A	9: 67,951,449	T2727K	probably benign	Het
Xrn1	T	A	9: 95,964,014	I40K	probably damaging	Het
Zc3h11a	A	G	1: 133,624,557	V604A	probably benign	Het
Zfp410	G	A	12: 84,331,838	R259H	probably benign	Het
Zfp748	A	G	13: 67,542,586	V185A	possibly damaging	Het

Other mutations in Vmn2r14

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01472:Vmn2r14	APN	5	109216314	nonsense	probably null
IGL01504:Vmn2r14	APN	5	109221419	missense	probably benign	0.01
IGL01828:Vmn2r14	APN	5	109224577	missense	possibly damaging	0.71
IGL02093:Vmn2r14	APN	5	109220409	missense	possibly damaging	0.94
IGL02103:Vmn2r14	APN	5	109224483	missense	probably damaging	0.96
IGL02123:Vmn2r14	APN	5	109220067	missense	probably damaging	1.00
IGL02145:Vmn2r14	APN	5	109220588	nonsense	probably null
IGL02676:Vmn2r14	APN	5	109220016	missense	probably benign	0.03
IGL02720:Vmn2r14	APN	5	109221439	missense	probably damaging	1.00
IGL02877:Vmn2r14	APN	5	109220188	missense	probably damaging	0.99
IGL02974:Vmn2r14	APN	5	109221426	missense	possibly damaging	0.55
IGL03151:Vmn2r14	APN	5	109216394	missense	probably damaging	1.00
IGL03297:Vmn2r14	APN	5	109216107	missense	probably damaging	1.00
IGL03386:Vmn2r14	APN	5	109220484	missense	possibly damaging	0.90
IGL03394:Vmn2r14	APN	5	109219836	missense	probably null	0.83
ANU74:Vmn2r14	UTSW	5	109219044	missense	probably benign	0.00
R0316:Vmn2r14	UTSW	5	109218896	missense	probably benign	0.07
R0755:Vmn2r14	UTSW	5	109216360	missense	possibly damaging	0.81
R1219:Vmn2r14	UTSW	5	109224574	missense	probably benign	0.17
R1321:Vmn2r14	UTSW	5	109216251	missense	probably benign	0.08
R1465:Vmn2r14	UTSW	5	109220329	missense	possibly damaging	0.47
R1465:Vmn2r14	UTSW	5	109220329	missense	possibly damaging	0.47
R1509:Vmn2r14	UTSW	5	109215996	missense	probably benign	0.00
R1551:Vmn2r14	UTSW	5	109221417	missense	probably damaging	1.00
R1628:Vmn2r14	UTSW	5	109219972	missense	probably benign	0.00
R1668:Vmn2r14	UTSW	5	109219047	nonsense	probably null
R2013:Vmn2r14	UTSW	5	109221243	missense	probably benign	0.00
R2201:Vmn2r14	UTSW	5	109218832	splice site	probably null
R2417:Vmn2r14	UTSW	5	109224463	missense	probably benign	0.00
R3029:Vmn2r14	UTSW	5	109215910	missense	probably damaging	1.00
R3120:Vmn2r14	UTSW	5	109224565	missense	probably null	0.00
R3729:Vmn2r14	UTSW	5	109216229	missense	probably damaging	1.00
R3762:Vmn2r14	UTSW	5	109220167	missense	probably benign	0.02
R3943:Vmn2r14	UTSW	5	109216064	missense	probably damaging	1.00
R3944:Vmn2r14	UTSW	5	109216064	missense	probably damaging	1.00
R4222:Vmn2r14	UTSW	5	109216283	missense	probably benign	0.00
R4224:Vmn2r14	UTSW	5	109216283	missense	probably benign	0.00
R4239:Vmn2r14	UTSW	5	109216411	critical splice acceptor site	probably null
R4240:Vmn2r14	UTSW	5	109216411	critical splice acceptor site	probably null
R4782:Vmn2r14	UTSW	5	109221504	missense	probably benign	0.01
R4832:Vmn2r14	UTSW	5	109216110	missense	probably damaging	1.00
R4884:Vmn2r14	UTSW	5	109221518	splice site	probably null
R4896:Vmn2r14	UTSW	5	109220380	missense	probably benign	0.19
R5004:Vmn2r14	UTSW	5	109220380	missense	probably benign	0.19
R5117:Vmn2r14	UTSW	5	109216095	missense	probably benign	0.16
R5285:Vmn2r14	UTSW	5	109217576	missense	probably damaging	0.98
R5413:Vmn2r14	UTSW	5	109221288	missense	probably benign	0.29
R5569:Vmn2r14	UTSW	5	109220395	missense	probably benign	0.44
R5701:Vmn2r14	UTSW	5	109219950	missense	probably damaging	1.00
R5726:Vmn2r14	UTSW	5	109217620	missense	possibly damaging	0.95
R5763:Vmn2r14	UTSW	5	109215858	missense	possibly damaging	0.49
R5872:Vmn2r14	UTSW	5	109221356	missense	probably benign
R5985:Vmn2r14	UTSW	5	109220216	missense	possibly damaging	0.89
R6273:Vmn2r14	UTSW	5	109221267	missense	probably benign	0.44
R6409:Vmn2r14	UTSW	5	109216230	missense	probably benign	0.09
R6944:Vmn2r14	UTSW	5	109216059	missense	probably benign	0.22
R6944:Vmn2r14	UTSW	5	109216274	missense	probably benign	0.06
R7608:Vmn2r14	UTSW	5	109221410	missense	probably benign	0.03
R7740:Vmn2r14	UTSW	5	109220458	missense	probably benign	0.41
R7768:Vmn2r14	UTSW	5	109220220	missense	probably benign	0.01
R7804:Vmn2r14	UTSW	5	109220458	missense	probably benign	0.41
R7872:Vmn2r14	UTSW	5	109221353	missense	probably benign	0.02
R7993:Vmn2r14	UTSW	5	109215996	missense	probably benign	0.00
R8006:Vmn2r14	UTSW	5	109220458	missense	probably benign	0.41
R8007:Vmn2r14	UTSW	5	109220458	missense	probably benign	0.41
R8187:Vmn2r14	UTSW	5	109220554	missense	probably benign	0.03
R8369:Vmn2r14	UTSW	5	109221476	missense	probably damaging	1.00
R8463:Vmn2r14	UTSW	5	109221474	missense	probably benign	0.30
R8968:Vmn2r14	UTSW	5	109217667	missense	probably benign	0.01
R9008:Vmn2r14	UTSW	5	109220027	missense	probably benign	0.00
R9030:Vmn2r14	UTSW	5	109220188	missense	probably damaging	0.99
R9039:Vmn2r14	UTSW	5	109220036	nonsense	probably null
R9150:Vmn2r14	UTSW	5	109219917	missense	probably damaging	1.00
R9164:Vmn2r14	UTSW	5	109216221	missense	probably damaging	1.00
R9216:Vmn2r14	UTSW	5	109221246	missense	probably benign	0.01
R9225:Vmn2r14	UTSW	5	109221422	missense	probably damaging	1.00
R9245:Vmn2r14	UTSW	5	109220310	missense	possibly damaging	0.89
R9342:Vmn2r14	UTSW	5	109220562	missense	probably damaging	1.00
R9472:Vmn2r14	UTSW	5	109220096	missense	probably benign	0.00
R9678:Vmn2r14	UTSW	5	109216175	missense	probably damaging	1.00
R9774:Vmn2r14	UTSW	5	109221260	missense	probably benign	0.07
Z1177:Vmn2r14	UTSW	5	109219875	missense	probably benign	0.33

Predicted Primers

PCR Primer
(F):5'- GTGTCCCAGAATTTGTTGAGAG -3'
(R):5'- CTGTAATCTAGTTCAAGGTTGGCATTC -3'

Sequencing Primer
(F):5'- GTCCCAGAATTTGTTGAGAGTTTTAC -3'
(R):5'- GTTCAAGGTTGGCATTCAATAAAAC -3'

Posted On

2018-03-15