Incidental Mutation 'R6268:Vmn2r14'
| ID |
507147 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r14
|
| Ensembl Gene |
ENSMUSG00000091059 |
| Gene Name |
vomeronasal 2, receptor 14 |
| Synonyms |
EG231591 |
| MMRRC Submission |
044439-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.526)
|
| Stock # |
R6268 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
109362822-109372488 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 109369283 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Alanine
at position 97
(S97A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128015
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170341]
|
| AlphaFold |
E9Q759 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000170341
AA Change: S97A
PolyPhen 2
Score 0.870 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000128015
Gene: ENSMUSG00000091059
AA Change: S97A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
76 |
466 |
8.3e-31 |
PFAM |
|
Pfam:NCD3G
|
507 |
561 |
1.1e-17 |
PFAM |
|
Pfam:7tm_3
|
594 |
829 |
1.2e-55 |
PFAM |
|
| Meta Mutation Damage Score |
0.1795 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.3%
- 20x: 95.5%
|
| Validation Efficiency |
99% (68/69) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 70 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4921504E06Rik |
A |
G |
2: 19,545,219 (GRCm39) |
I78T |
probably benign |
Het |
| Afg3l1 |
A |
T |
8: 124,219,665 (GRCm39) |
I398F |
probably damaging |
Het |
| Ahctf1 |
T |
C |
1: 179,591,048 (GRCm39) |
H1244R |
probably benign |
Het |
| Ank1 |
A |
T |
8: 23,599,687 (GRCm39) |
K797N |
probably damaging |
Het |
| Anxa6 |
G |
T |
11: 54,877,903 (GRCm39) |
|
probably null |
Het |
| Aoc1l1 |
T |
A |
6: 48,954,616 (GRCm39) |
Y585N |
probably benign |
Het |
| Ap1b1 |
T |
A |
11: 4,969,493 (GRCm39) |
V310E |
probably damaging |
Het |
| C2cd2l |
T |
C |
9: 44,228,963 (GRCm39) |
I123V |
probably damaging |
Het |
| Cars2 |
TCCCC |
TCCC |
8: 11,579,599 (GRCm39) |
|
probably null |
Het |
| Cfap54 |
T |
A |
10: 92,874,771 (GRCm39) |
I542F |
probably damaging |
Het |
| Cfap57 |
G |
T |
4: 118,426,648 (GRCm39) |
Y1100* |
probably null |
Het |
| Coq9 |
A |
G |
8: 95,576,862 (GRCm39) |
E158G |
probably benign |
Het |
| Cox15 |
A |
T |
19: 43,728,365 (GRCm39) |
W303R |
possibly damaging |
Het |
| Cpa5 |
A |
G |
6: 30,615,172 (GRCm39) |
Y103C |
probably damaging |
Het |
| Crygn |
A |
T |
5: 24,961,189 (GRCm39) |
V39E |
probably damaging |
Het |
| Csf1 |
G |
T |
3: 107,654,473 (GRCm39) |
S132R |
possibly damaging |
Het |
| Dapk1 |
G |
A |
13: 60,909,580 (GRCm39) |
V1398M |
possibly damaging |
Het |
| Degs2 |
C |
A |
12: 108,658,839 (GRCm39) |
V47L |
probably damaging |
Het |
| Dock5 |
C |
A |
14: 68,027,724 (GRCm39) |
E1057* |
probably null |
Het |
| Dsg1b |
C |
A |
18: 20,521,220 (GRCm39) |
Q26K |
probably benign |
Het |
| Elp1 |
T |
C |
4: 56,762,305 (GRCm39) |
Y1098C |
probably damaging |
Het |
| Fam181a |
T |
C |
12: 103,282,803 (GRCm39) |
V236A |
possibly damaging |
Het |
| Fam78b |
C |
A |
1: 166,906,122 (GRCm39) |
P94T |
probably damaging |
Het |
| Fbxw25 |
T |
G |
9: 109,483,718 (GRCm39) |
T165P |
probably damaging |
Het |
| Flg |
C |
A |
3: 93,195,482 (GRCm39) |
|
probably benign |
Het |
| Frrs1 |
G |
T |
3: 116,696,748 (GRCm39) |
V573F |
probably damaging |
Het |
| Gm7298 |
A |
G |
6: 121,756,032 (GRCm39) |
T964A |
possibly damaging |
Het |
| Hoxd9 |
G |
T |
2: 74,528,433 (GRCm39) |
V12L |
probably damaging |
Het |
| Kcnt1 |
A |
G |
2: 25,793,609 (GRCm39) |
|
probably null |
Het |
| Klhl3 |
G |
T |
13: 58,161,656 (GRCm39) |
R480S |
probably damaging |
Het |
| Klhl36 |
A |
G |
8: 120,597,406 (GRCm39) |
D369G |
probably damaging |
Het |
| Lama3 |
T |
A |
18: 12,657,794 (GRCm39) |
N303K |
probably damaging |
Het |
| Lhcgr |
T |
C |
17: 89,050,132 (GRCm39) |
T465A |
probably damaging |
Het |
| Llgl1 |
T |
C |
11: 60,602,989 (GRCm39) |
V888A |
probably benign |
Het |
| Lrp1b |
T |
A |
2: 40,711,729 (GRCm39) |
T3164S |
probably benign |
Het |
| Mmp3 |
T |
G |
9: 7,447,622 (GRCm39) |
D202E |
possibly damaging |
Het |
| Mocs1 |
C |
A |
17: 49,742,183 (GRCm39) |
T104K |
probably damaging |
Het |
| Mrpl42 |
A |
T |
10: 95,332,569 (GRCm39) |
|
probably null |
Het |
| Mtch2 |
T |
C |
2: 90,693,992 (GRCm39) |
C279R |
probably benign |
Het |
| Muc4 |
A |
T |
16: 32,589,141 (GRCm39) |
D2836V |
probably damaging |
Het |
| Myh7 |
T |
C |
14: 55,226,741 (GRCm39) |
E370G |
probably benign |
Het |
| Naa11 |
A |
G |
5: 97,540,069 (GRCm39) |
Y30H |
probably damaging |
Het |
| Ntng1 |
T |
C |
3: 109,842,351 (GRCm39) |
T141A |
probably damaging |
Het |
| Or5h26 |
A |
C |
16: 58,987,656 (GRCm39) |
|
probably null |
Het |
| Or8c11 |
T |
C |
9: 38,289,384 (GRCm39) |
I69T |
probably benign |
Het |
| Or9i14 |
A |
T |
19: 13,792,671 (GRCm39) |
Y94* |
probably null |
Het |
| Pcdha12 |
G |
A |
18: 37,155,477 (GRCm39) |
C732Y |
possibly damaging |
Het |
| Plekhm2 |
G |
A |
4: 141,359,652 (GRCm39) |
Q392* |
probably null |
Het |
| Prr22 |
G |
A |
17: 57,078,587 (GRCm39) |
V247M |
probably damaging |
Het |
| Rapgef6 |
T |
A |
11: 54,540,073 (GRCm39) |
L716Q |
probably damaging |
Het |
| Rasgrp4 |
G |
A |
7: 28,842,493 (GRCm39) |
V246I |
probably damaging |
Het |
| Rhbdd2 |
C |
T |
5: 135,672,114 (GRCm39) |
T323I |
probably benign |
Het |
| Rsf1 |
CG |
CGACGGCGGTG |
7: 97,229,115 (GRCm39) |
|
probably benign |
Homo |
| Scgb2b20 |
A |
T |
7: 33,063,973 (GRCm39) |
I99K |
possibly damaging |
Het |
| Scyl3 |
C |
T |
1: 163,773,786 (GRCm39) |
R324* |
probably null |
Het |
| Slc23a1 |
T |
C |
18: 35,752,624 (GRCm39) |
Y551C |
probably damaging |
Het |
| Slc5a5 |
A |
T |
8: 71,341,264 (GRCm39) |
S358R |
probably damaging |
Het |
| Sorcs3 |
T |
A |
19: 48,778,605 (GRCm39) |
N1007K |
probably damaging |
Het |
| Stxbp4 |
T |
A |
11: 90,431,027 (GRCm39) |
K428* |
probably null |
Het |
| Tmem63c |
T |
A |
12: 87,128,727 (GRCm39) |
I584N |
probably damaging |
Het |
| Traf3ip3 |
C |
T |
1: 192,880,344 (GRCm39) |
|
probably benign |
Het |
| Trgv2 |
G |
A |
13: 19,521,001 (GRCm39) |
T31I |
probably benign |
Het |
| Ttll3 |
C |
T |
6: 113,369,524 (GRCm39) |
R23C |
probably benign |
Het |
| Ugt2a3 |
A |
C |
5: 87,477,472 (GRCm39) |
L309R |
probably damaging |
Het |
| Urb1 |
A |
G |
16: 90,550,807 (GRCm39) |
M2015T |
probably benign |
Het |
| Vps13c |
C |
A |
9: 67,858,731 (GRCm39) |
T2727K |
probably benign |
Het |
| Xrn1 |
T |
A |
9: 95,846,067 (GRCm39) |
I40K |
probably damaging |
Het |
| Zc3h11a |
A |
G |
1: 133,552,295 (GRCm39) |
V604A |
probably benign |
Het |
| Zfp410 |
G |
A |
12: 84,378,612 (GRCm39) |
R259H |
probably benign |
Het |
| Zfp748 |
A |
G |
13: 67,690,705 (GRCm39) |
V185A |
possibly damaging |
Het |
|
| Other mutations in Vmn2r14 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01472:Vmn2r14
|
APN |
5 |
109,364,180 (GRCm39) |
nonsense |
probably null |
|
|
IGL01504:Vmn2r14
|
APN |
5 |
109,369,285 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01828:Vmn2r14
|
APN |
5 |
109,372,443 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02093:Vmn2r14
|
APN |
5 |
109,368,275 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02103:Vmn2r14
|
APN |
5 |
109,372,349 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02123:Vmn2r14
|
APN |
5 |
109,367,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02145:Vmn2r14
|
APN |
5 |
109,368,454 (GRCm39) |
nonsense |
probably null |
|
|
IGL02676:Vmn2r14
|
APN |
5 |
109,367,882 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02720:Vmn2r14
|
APN |
5 |
109,369,305 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02877:Vmn2r14
|
APN |
5 |
109,368,054 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02974:Vmn2r14
|
APN |
5 |
109,369,292 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL03151:Vmn2r14
|
APN |
5 |
109,364,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03297:Vmn2r14
|
APN |
5 |
109,363,973 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03386:Vmn2r14
|
APN |
5 |
109,368,350 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL03394:Vmn2r14
|
APN |
5 |
109,367,702 (GRCm39) |
missense |
probably null |
0.83 |
|
ANU74:Vmn2r14
|
UTSW |
5 |
109,366,910 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0316:Vmn2r14
|
UTSW |
5 |
109,366,762 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0755:Vmn2r14
|
UTSW |
5 |
109,364,226 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1219:Vmn2r14
|
UTSW |
5 |
109,372,440 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1321:Vmn2r14
|
UTSW |
5 |
109,364,117 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1465:Vmn2r14
|
UTSW |
5 |
109,368,195 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R1465:Vmn2r14
|
UTSW |
5 |
109,368,195 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R1509:Vmn2r14
|
UTSW |
5 |
109,363,862 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1551:Vmn2r14
|
UTSW |
5 |
109,369,283 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1628:Vmn2r14
|
UTSW |
5 |
109,367,838 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1668:Vmn2r14
|
UTSW |
5 |
109,366,913 (GRCm39) |
nonsense |
probably null |
|
|
R2013:Vmn2r14
|
UTSW |
5 |
109,369,109 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2201:Vmn2r14
|
UTSW |
5 |
109,366,698 (GRCm39) |
splice site |
probably null |
|
|
R2417:Vmn2r14
|
UTSW |
5 |
109,372,329 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3029:Vmn2r14
|
UTSW |
5 |
109,363,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3120:Vmn2r14
|
UTSW |
5 |
109,372,431 (GRCm39) |
missense |
probably null |
0.00 |
|
R3729:Vmn2r14
|
UTSW |
5 |
109,364,095 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3762:Vmn2r14
|
UTSW |
5 |
109,368,033 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3943:Vmn2r14
|
UTSW |
5 |
109,363,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3944:Vmn2r14
|
UTSW |
5 |
109,363,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4222:Vmn2r14
|
UTSW |
5 |
109,364,149 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4224:Vmn2r14
|
UTSW |
5 |
109,364,149 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4239:Vmn2r14
|
UTSW |
5 |
109,364,277 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4240:Vmn2r14
|
UTSW |
5 |
109,364,277 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4782:Vmn2r14
|
UTSW |
5 |
109,369,370 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4832:Vmn2r14
|
UTSW |
5 |
109,363,976 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4884:Vmn2r14
|
UTSW |
5 |
109,369,384 (GRCm39) |
splice site |
probably null |
|
|
R4896:Vmn2r14
|
UTSW |
5 |
109,368,246 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5004:Vmn2r14
|
UTSW |
5 |
109,368,246 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5117:Vmn2r14
|
UTSW |
5 |
109,363,961 (GRCm39) |
missense |
probably benign |
0.16 |
|
R5285:Vmn2r14
|
UTSW |
5 |
109,365,442 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5413:Vmn2r14
|
UTSW |
5 |
109,369,154 (GRCm39) |
missense |
probably benign |
0.29 |
|
R5569:Vmn2r14
|
UTSW |
5 |
109,368,261 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5701:Vmn2r14
|
UTSW |
5 |
109,367,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5726:Vmn2r14
|
UTSW |
5 |
109,365,486 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5763:Vmn2r14
|
UTSW |
5 |
109,363,724 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R5872:Vmn2r14
|
UTSW |
5 |
109,369,222 (GRCm39) |
missense |
probably benign |
|
|
R5985:Vmn2r14
|
UTSW |
5 |
109,368,082 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6273:Vmn2r14
|
UTSW |
5 |
109,369,133 (GRCm39) |
missense |
probably benign |
0.44 |
|
R6409:Vmn2r14
|
UTSW |
5 |
109,364,096 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6944:Vmn2r14
|
UTSW |
5 |
109,364,140 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6944:Vmn2r14
|
UTSW |
5 |
109,363,925 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7608:Vmn2r14
|
UTSW |
5 |
109,369,276 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7740:Vmn2r14
|
UTSW |
5 |
109,368,324 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7768:Vmn2r14
|
UTSW |
5 |
109,368,086 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7804:Vmn2r14
|
UTSW |
5 |
109,368,324 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7872:Vmn2r14
|
UTSW |
5 |
109,369,219 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7993:Vmn2r14
|
UTSW |
5 |
109,363,862 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8006:Vmn2r14
|
UTSW |
5 |
109,368,324 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8007:Vmn2r14
|
UTSW |
5 |
109,368,324 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8187:Vmn2r14
|
UTSW |
5 |
109,368,420 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8369:Vmn2r14
|
UTSW |
5 |
109,369,342 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8463:Vmn2r14
|
UTSW |
5 |
109,369,340 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8968:Vmn2r14
|
UTSW |
5 |
109,365,533 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9008:Vmn2r14
|
UTSW |
5 |
109,367,893 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9030:Vmn2r14
|
UTSW |
5 |
109,368,054 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9039:Vmn2r14
|
UTSW |
5 |
109,367,902 (GRCm39) |
nonsense |
probably null |
|
|
R9150:Vmn2r14
|
UTSW |
5 |
109,367,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9164:Vmn2r14
|
UTSW |
5 |
109,364,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9216:Vmn2r14
|
UTSW |
5 |
109,369,112 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9225:Vmn2r14
|
UTSW |
5 |
109,369,288 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9245:Vmn2r14
|
UTSW |
5 |
109,368,176 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9342:Vmn2r14
|
UTSW |
5 |
109,368,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9472:Vmn2r14
|
UTSW |
5 |
109,367,962 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9678:Vmn2r14
|
UTSW |
5 |
109,364,041 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9774:Vmn2r14
|
UTSW |
5 |
109,369,126 (GRCm39) |
missense |
probably benign |
0.07 |
|
Z1177:Vmn2r14
|
UTSW |
5 |
109,367,741 (GRCm39) |
missense |
probably benign |
0.33 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTGTCCCAGAATTTGTTGAGAG -3'
(R):5'- CTGTAATCTAGTTCAAGGTTGGCATTC -3'
Sequencing Primer
(F):5'- GTCCCAGAATTTGTTGAGAGTTTTAC -3'
(R):5'- GTTCAAGGTTGGCATTCAATAAAAC -3'
|
| Posted On |
2018-03-15 |
Incidental Mutation