Incidental Mutation 'R6270:Sult1b1'
ID 507266
Institutional Source Beutler Lab
Gene Symbol Sult1b1
Ensembl Gene ENSMUSG00000029269
Gene Name sulfotransferase family 1B, member 1
Synonyms Dopa/tyrosine sulfotransferase
MMRRC Submission 044441-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6270 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 87661198-87686054 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 87665413 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000112844 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031199] [ENSMUST00000117455] [ENSMUST00000120150]
AlphaFold Q9QWG7
Predicted Effect probably null
Transcript: ENSMUST00000031199
SMART Domains Protein: ENSMUSP00000031199
Gene: ENSMUSG00000029269

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 38 289 7.5e-93 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000117455
SMART Domains Protein: ENSMUSP00000112679
Gene: ENSMUSG00000029269

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 38 289 7.5e-93 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000120150
SMART Domains Protein: ENSMUSP00000112844
Gene: ENSMUSG00000029269

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 38 289 7.5e-93 PFAM
Meta Mutation Damage Score 0.9756 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.7%
  • 20x: 96.6%
Validation Efficiency 98% (51/52)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. However, the total genomic length of this gene is greater than that of other SULT1 genes. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsl6 A G 11: 54,242,933 (GRCm39) E648G probably benign Het
Ak7 A G 12: 105,734,960 (GRCm39) H642R probably benign Het
Akap11 T C 14: 78,756,239 (GRCm39) E53G probably damaging Het
Ark2n T C 18: 77,762,117 (GRCm39) D65G probably damaging Het
Ddr2 T G 1: 169,816,109 (GRCm39) T533P probably benign Het
Dhx40 A G 11: 86,690,431 (GRCm39) S197P possibly damaging Het
Dolpp1 C A 2: 30,282,281 (GRCm39) probably benign Het
Eng A G 2: 32,563,655 (GRCm39) D347G probably benign Het
Esrra C T 19: 6,891,488 (GRCm39) probably null Het
Fap T C 2: 62,378,132 (GRCm39) I159V probably damaging Het
Fn1 C T 1: 71,676,434 (GRCm39) C599Y probably damaging Het
Fnbp4 T C 2: 90,587,807 (GRCm39) V395A probably damaging Het
Foxn3 T C 12: 99,354,676 (GRCm39) R163G probably damaging Het
Gphn T G 12: 78,569,724 (GRCm39) L306R probably benign Het
Gse1 T C 8: 121,295,902 (GRCm39) probably benign Het
Habp2 A G 19: 56,295,295 (GRCm39) D62G possibly damaging Het
Hdac7 AGGG AGGGG 15: 97,706,376 (GRCm39) probably null Het
Hyls1 G A 9: 35,472,480 (GRCm39) S312F probably benign Het
Kit A G 5: 75,770,169 (GRCm39) T194A probably benign Het
Krt16 C A 11: 100,138,029 (GRCm39) A316S possibly damaging Het
Krt7 A G 15: 101,317,439 (GRCm39) D244G probably damaging Het
Lhfpl3 T A 5: 23,478,349 (GRCm39) Y77* probably null Het
Lrrc18 A T 14: 32,731,078 (GRCm39) M206L probably benign Het
Magel2 C A 7: 62,030,406 (GRCm39) C1103* probably null Het
Mcf2l T C 8: 13,068,701 (GRCm39) V1058A probably damaging Het
Nbas G A 12: 13,374,294 (GRCm39) A541T probably damaging Het
Nrap C T 19: 56,308,630 (GRCm39) M1485I probably benign Het
Nudt18 T C 14: 70,816,830 (GRCm39) Y145H probably benign Het
Or51b6b T C 7: 103,309,620 (GRCm39) Y279C possibly damaging Het
Or51f1d T C 7: 102,700,538 (GRCm39) L11P probably benign Het
Or5k8 A T 16: 58,644,782 (GRCm39) C97S probably damaging Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Pcdhb12 A T 18: 37,569,838 (GRCm39) Q328L possibly damaging Het
Pde6c T C 19: 38,146,884 (GRCm39) W431R probably damaging Het
Pga5 T C 19: 10,652,225 (GRCm39) E139G probably benign Het
Pkdrej G T 15: 85,705,306 (GRCm39) S210* probably null Het
Pnpla1 G A 17: 29,100,342 (GRCm39) G403E probably benign Het
Sema3d A T 5: 12,498,074 (GRCm39) M27L probably benign Het
Serinc5 T C 13: 92,825,170 (GRCm39) S200P probably damaging Het
Sf3b3 T C 8: 111,568,452 (GRCm39) D174G probably damaging Het
Tasor2 C T 13: 3,631,891 (GRCm39) R870H possibly damaging Het
Tcaf3 T C 6: 42,570,725 (GRCm39) I342M probably benign Het
Tenm3 G A 8: 48,820,429 (GRCm39) T136M probably damaging Het
Tet3 T C 6: 83,352,773 (GRCm39) T1008A possibly damaging Het
Tgif1 T C 17: 71,151,861 (GRCm39) probably null Het
Trav15-2-dv6-2 A G 14: 53,887,323 (GRCm39) D81G probably benign Het
Trpv5 T A 6: 41,651,293 (GRCm39) H251L possibly damaging Het
Ttc14 C A 3: 33,854,537 (GRCm39) T37K possibly damaging Het
Vmn2r80 A T 10: 79,030,159 (GRCm39) I662L probably benign Het
Vmn2r81 A G 10: 79,129,649 (GRCm39) I847V probably benign Het
Zfp474 A G 18: 52,771,436 (GRCm39) T30A probably benign Het
Zswim4 C T 8: 84,957,580 (GRCm39) V163M probably damaging Het
Other mutations in Sult1b1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01296:Sult1b1 APN 5 87,662,815 (GRCm39) missense probably benign 0.28
IGL02214:Sult1b1 APN 5 87,682,949 (GRCm39) utr 5 prime probably benign
R0377:Sult1b1 UTSW 5 87,665,235 (GRCm39) missense probably damaging 1.00
R0835:Sult1b1 UTSW 5 87,665,311 (GRCm39) missense probably benign 0.00
R1850:Sult1b1 UTSW 5 87,668,700 (GRCm39) missense probably damaging 1.00
R2059:Sult1b1 UTSW 5 87,682,892 (GRCm39) missense probably damaging 0.98
R4792:Sult1b1 UTSW 5 87,662,906 (GRCm39) missense probably damaging 1.00
R4904:Sult1b1 UTSW 5 87,682,912 (GRCm39) missense probably benign 0.39
R5127:Sult1b1 UTSW 5 87,669,407 (GRCm39) missense probably damaging 1.00
R5282:Sult1b1 UTSW 5 87,678,510 (GRCm39) missense probably benign 0.01
R5981:Sult1b1 UTSW 5 87,682,816 (GRCm39) missense probably damaging 1.00
R6442:Sult1b1 UTSW 5 87,682,912 (GRCm39) missense probably benign 0.39
R7681:Sult1b1 UTSW 5 87,678,495 (GRCm39) missense probably damaging 1.00
R8236:Sult1b1 UTSW 5 87,669,383 (GRCm39) missense probably damaging 0.97
R8539:Sult1b1 UTSW 5 87,681,838 (GRCm39) missense possibly damaging 0.93
R8923:Sult1b1 UTSW 5 87,662,893 (GRCm39) missense probably damaging 1.00
R8978:Sult1b1 UTSW 5 87,682,900 (GRCm39) missense possibly damaging 0.80
R9141:Sult1b1 UTSW 5 87,665,280 (GRCm39) missense probably damaging 0.97
R9426:Sult1b1 UTSW 5 87,665,280 (GRCm39) missense probably damaging 0.97
R9776:Sult1b1 UTSW 5 87,662,815 (GRCm39) missense probably benign 0.28
Predicted Primers PCR Primer
(F):5'- CCTTCATCATTTCAAAGGAGGTG -3'
(R):5'- TGAAACCAACCTCTCAATAGATGG -3'

Sequencing Primer
(F):5'- GTGATGGACGATCCTGTCCAAG -3'
(R):5'- TGTCTACCTTAAAGTAACAAAC -3'
Posted On 2018-03-15