Incidental Mutation 'R6270:Zswim4'
ID 507275
Institutional Source Beutler Lab
Gene Symbol Zswim4
Ensembl Gene ENSMUSG00000035671
Gene Name zinc finger SWIM-type containing 4
Synonyms E130119J17Rik
MMRRC Submission 044441-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.202) question?
Stock # R6270 (G1)
Quality Score 225.009
Status Validated
Chromosome 8
Chromosomal Location 84937571-84963671 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 84957580 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 163 (V163M)
Ref Sequence ENSEMBL: ENSMUSP00000040078 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039480]
AlphaFold Q8C7B8
Predicted Effect probably damaging
Transcript: ENSMUST00000039480
AA Change: V163M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000040078
Gene: ENSMUSG00000035671
AA Change: V163M

DomainStartEndE-ValueType
low complexity region 531 545 N/A INTRINSIC
low complexity region 576 588 N/A INTRINSIC
low complexity region 607 628 N/A INTRINSIC
low complexity region 672 683 N/A INTRINSIC
low complexity region 907 917 N/A INTRINSIC
Meta Mutation Damage Score 0.3496 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.7%
  • 20x: 96.6%
Validation Efficiency 98% (51/52)
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsl6 A G 11: 54,242,933 (GRCm39) E648G probably benign Het
Ak7 A G 12: 105,734,960 (GRCm39) H642R probably benign Het
Akap11 T C 14: 78,756,239 (GRCm39) E53G probably damaging Het
Ark2n T C 18: 77,762,117 (GRCm39) D65G probably damaging Het
Ddr2 T G 1: 169,816,109 (GRCm39) T533P probably benign Het
Dhx40 A G 11: 86,690,431 (GRCm39) S197P possibly damaging Het
Dolpp1 C A 2: 30,282,281 (GRCm39) probably benign Het
Eng A G 2: 32,563,655 (GRCm39) D347G probably benign Het
Esrra C T 19: 6,891,488 (GRCm39) probably null Het
Fap T C 2: 62,378,132 (GRCm39) I159V probably damaging Het
Fn1 C T 1: 71,676,434 (GRCm39) C599Y probably damaging Het
Fnbp4 T C 2: 90,587,807 (GRCm39) V395A probably damaging Het
Foxn3 T C 12: 99,354,676 (GRCm39) R163G probably damaging Het
Gphn T G 12: 78,569,724 (GRCm39) L306R probably benign Het
Gse1 T C 8: 121,295,902 (GRCm39) probably benign Het
Habp2 A G 19: 56,295,295 (GRCm39) D62G possibly damaging Het
Hdac7 AGGG AGGGG 15: 97,706,376 (GRCm39) probably null Het
Hyls1 G A 9: 35,472,480 (GRCm39) S312F probably benign Het
Kit A G 5: 75,770,169 (GRCm39) T194A probably benign Het
Krt16 C A 11: 100,138,029 (GRCm39) A316S possibly damaging Het
Krt7 A G 15: 101,317,439 (GRCm39) D244G probably damaging Het
Lhfpl3 T A 5: 23,478,349 (GRCm39) Y77* probably null Het
Lrrc18 A T 14: 32,731,078 (GRCm39) M206L probably benign Het
Magel2 C A 7: 62,030,406 (GRCm39) C1103* probably null Het
Mcf2l T C 8: 13,068,701 (GRCm39) V1058A probably damaging Het
Nbas G A 12: 13,374,294 (GRCm39) A541T probably damaging Het
Nrap C T 19: 56,308,630 (GRCm39) M1485I probably benign Het
Nudt18 T C 14: 70,816,830 (GRCm39) Y145H probably benign Het
Or51b6b T C 7: 103,309,620 (GRCm39) Y279C possibly damaging Het
Or51f1d T C 7: 102,700,538 (GRCm39) L11P probably benign Het
Or5k8 A T 16: 58,644,782 (GRCm39) C97S probably damaging Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Pcdhb12 A T 18: 37,569,838 (GRCm39) Q328L possibly damaging Het
Pde6c T C 19: 38,146,884 (GRCm39) W431R probably damaging Het
Pga5 T C 19: 10,652,225 (GRCm39) E139G probably benign Het
Pkdrej G T 15: 85,705,306 (GRCm39) S210* probably null Het
Pnpla1 G A 17: 29,100,342 (GRCm39) G403E probably benign Het
Sema3d A T 5: 12,498,074 (GRCm39) M27L probably benign Het
Serinc5 T C 13: 92,825,170 (GRCm39) S200P probably damaging Het
Sf3b3 T C 8: 111,568,452 (GRCm39) D174G probably damaging Het
Sult1b1 A T 5: 87,665,413 (GRCm39) probably null Het
Tasor2 C T 13: 3,631,891 (GRCm39) R870H possibly damaging Het
Tcaf3 T C 6: 42,570,725 (GRCm39) I342M probably benign Het
Tenm3 G A 8: 48,820,429 (GRCm39) T136M probably damaging Het
Tet3 T C 6: 83,352,773 (GRCm39) T1008A possibly damaging Het
Tgif1 T C 17: 71,151,861 (GRCm39) probably null Het
Trav15-2-dv6-2 A G 14: 53,887,323 (GRCm39) D81G probably benign Het
Trpv5 T A 6: 41,651,293 (GRCm39) H251L possibly damaging Het
Ttc14 C A 3: 33,854,537 (GRCm39) T37K possibly damaging Het
Vmn2r80 A T 10: 79,030,159 (GRCm39) I662L probably benign Het
Vmn2r81 A G 10: 79,129,649 (GRCm39) I847V probably benign Het
Zfp474 A G 18: 52,771,436 (GRCm39) T30A probably benign Het
Other mutations in Zswim4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00493:Zswim4 APN 8 84,938,769 (GRCm39) missense probably damaging 1.00
IGL03048:Zswim4 UTSW 8 84,938,604 (GRCm39) missense possibly damaging 0.95
R0217:Zswim4 UTSW 8 84,939,293 (GRCm39) missense probably damaging 1.00
R0688:Zswim4 UTSW 8 84,955,517 (GRCm39) missense possibly damaging 0.93
R1217:Zswim4 UTSW 8 84,946,601 (GRCm39) missense possibly damaging 0.89
R1853:Zswim4 UTSW 8 84,950,829 (GRCm39) missense probably damaging 1.00
R1878:Zswim4 UTSW 8 84,939,405 (GRCm39) missense possibly damaging 0.55
R2205:Zswim4 UTSW 8 84,952,498 (GRCm39) missense possibly damaging 0.70
R2940:Zswim4 UTSW 8 84,950,377 (GRCm39) missense probably damaging 1.00
R3747:Zswim4 UTSW 8 84,938,676 (GRCm39) missense possibly damaging 0.86
R3748:Zswim4 UTSW 8 84,938,676 (GRCm39) missense possibly damaging 0.86
R3750:Zswim4 UTSW 8 84,938,676 (GRCm39) missense possibly damaging 0.86
R4777:Zswim4 UTSW 8 84,963,586 (GRCm39) missense probably benign
R4831:Zswim4 UTSW 8 84,938,948 (GRCm39) missense probably damaging 1.00
R4959:Zswim4 UTSW 8 84,938,852 (GRCm39) missense probably benign 0.22
R4968:Zswim4 UTSW 8 84,944,001 (GRCm39) missense probably benign 0.37
R4973:Zswim4 UTSW 8 84,938,852 (GRCm39) missense probably benign 0.22
R4977:Zswim4 UTSW 8 84,953,296 (GRCm39) splice site probably null
R4978:Zswim4 UTSW 8 84,953,296 (GRCm39) splice site probably null
R4980:Zswim4 UTSW 8 84,953,296 (GRCm39) splice site probably null
R4981:Zswim4 UTSW 8 84,953,296 (GRCm39) splice site probably null
R4982:Zswim4 UTSW 8 84,953,296 (GRCm39) splice site probably null
R4983:Zswim4 UTSW 8 84,953,296 (GRCm39) splice site probably null
R5248:Zswim4 UTSW 8 84,946,561 (GRCm39) missense probably benign 0.13
R5337:Zswim4 UTSW 8 84,961,708 (GRCm39) missense probably damaging 1.00
R5366:Zswim4 UTSW 8 84,939,419 (GRCm39) missense probably benign 0.39
R5646:Zswim4 UTSW 8 84,957,739 (GRCm39) splice site probably null
R5845:Zswim4 UTSW 8 84,943,871 (GRCm39) splice site probably null
R6193:Zswim4 UTSW 8 84,952,774 (GRCm39) missense probably benign
R6648:Zswim4 UTSW 8 84,957,543 (GRCm39) missense probably benign 0.22
R6920:Zswim4 UTSW 8 84,940,714 (GRCm39) missense probably benign 0.01
R7117:Zswim4 UTSW 8 84,940,681 (GRCm39) missense probably damaging 1.00
R7155:Zswim4 UTSW 8 84,946,556 (GRCm39) missense probably damaging 1.00
R7344:Zswim4 UTSW 8 84,950,327 (GRCm39) nonsense probably null
R7354:Zswim4 UTSW 8 84,955,478 (GRCm39) missense probably damaging 1.00
R8036:Zswim4 UTSW 8 84,949,918 (GRCm39) missense probably benign 0.22
R8408:Zswim4 UTSW 8 84,939,014 (GRCm39) missense possibly damaging 0.82
R8518:Zswim4 UTSW 8 84,938,586 (GRCm39) missense probably damaging 1.00
R8750:Zswim4 UTSW 8 84,939,313 (GRCm39) missense possibly damaging 0.82
R8830:Zswim4 UTSW 8 84,949,945 (GRCm39) missense possibly damaging 0.92
R8838:Zswim4 UTSW 8 84,940,699 (GRCm39) missense probably damaging 1.00
R8840:Zswim4 UTSW 8 84,940,699 (GRCm39) missense probably damaging 1.00
R8842:Zswim4 UTSW 8 84,940,699 (GRCm39) missense probably damaging 1.00
R9185:Zswim4 UTSW 8 84,963,633 (GRCm39) start codon destroyed probably null 0.94
R9355:Zswim4 UTSW 8 84,955,687 (GRCm39) missense probably damaging 1.00
R9432:Zswim4 UTSW 8 84,963,539 (GRCm39) missense probably damaging 1.00
R9635:Zswim4 UTSW 8 84,939,354 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- AGGAGGATCTCGTCAGCAAGAC -3'
(R):5'- CCTGAGTGGGAACATCAGAG -3'

Sequencing Primer
(F):5'- TCAGCAAGACGTTGGGC -3'
(R):5'- GCGATCCCGTCTCCTCAGTG -3'
Posted On 2018-03-15