Incidental Mutation 'R6271:Serinc3'
ID 507315
Institutional Source Beutler Lab
Gene Symbol Serinc3
Ensembl Gene ENSMUSG00000017707
Gene Name serine incorporator 3
Synonyms DIFF33, TMS-1, Tde1, AIGP1
MMRRC Submission 044379-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6271 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 163466577-163487767 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to C at 163472896 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Valine at position 245 (L245V)
Ref Sequence ENSEMBL: ENSMUSP00000017851 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000017851]
AlphaFold Q9QZI9
Predicted Effect probably benign
Transcript: ENSMUST00000017851
AA Change: L245V

PolyPhen 2 Score 0.150 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000017851
Gene: ENSMUSG00000017707
AA Change: L245V

DomainStartEndE-ValueType
Pfam:Serinc 16 470 9e-168 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahdc1 G T 4: 132,792,035 (GRCm39) C1092F possibly damaging Het
Aplf T C 6: 87,623,230 (GRCm39) E304G possibly damaging Het
Atp12a A G 14: 56,615,879 (GRCm39) D547G probably benign Het
B3gat2 T C 1: 23,854,342 (GRCm39) L212P probably damaging Het
Babam2 G T 5: 32,158,706 (GRCm39) A219S probably damaging Het
Ccdc18 A C 5: 108,322,753 (GRCm39) S618R possibly damaging Het
Ces2c G A 8: 105,578,748 (GRCm39) G342D probably damaging Het
Cfap57 A C 4: 118,452,956 (GRCm39) D582E probably benign Het
Cisd2 T C 3: 135,114,627 (GRCm39) N115D possibly damaging Het
Cyp17a1 A G 19: 46,661,159 (GRCm39) F42L probably benign Het
Fam234a T C 17: 26,437,211 (GRCm39) D156G probably benign Het
Fer1l6 T A 15: 58,513,767 (GRCm39) I1554K probably benign Het
Fv1 A G 4: 147,954,474 (GRCm39) T347A possibly damaging Het
Gm5134 T A 10: 75,831,643 (GRCm39) C361S probably benign Het
Grin3a T C 4: 49,792,516 (GRCm39) I406V probably benign Het
Hyls1 G A 9: 35,472,480 (GRCm39) S312F probably benign Het
Ifna13 A C 4: 88,562,082 (GRCm39) L181V possibly damaging Het
Irx4 A G 13: 73,414,713 (GRCm39) probably null Het
Kcna3 T A 3: 106,944,922 (GRCm39) M395K probably damaging Het
Kcnma1 A T 14: 23,559,957 (GRCm39) V347D probably damaging Het
Kng2 A T 16: 22,822,698 (GRCm39) V218E probably benign Het
Krt36 G A 11: 99,995,298 (GRCm39) Q167* probably null Het
Lama2 T C 10: 26,899,325 (GRCm39) D2457G possibly damaging Het
Ldah G A 12: 8,318,599 (GRCm39) probably null Het
Lhfpl3 G T 5: 22,951,242 (GRCm39) A18S probably benign Het
Lrrk1 A G 7: 65,956,851 (GRCm39) probably null Het
Ltv1 T C 10: 13,055,445 (GRCm39) Y352C probably damaging Het
Lyst G T 13: 13,833,339 (GRCm39) M1720I probably benign Het
Mkx A T 18: 6,937,059 (GRCm39) probably null Het
Myo18a A G 11: 77,711,635 (GRCm39) H626R probably damaging Het
Nop9 A C 14: 55,991,198 (GRCm39) Q618H probably damaging Het
Or12k5 T C 2: 36,895,554 (GRCm39) Q24R probably damaging Het
Or4c12b T C 2: 89,646,906 (GRCm39) S73P probably damaging Het
Or7g32 A G 9: 19,389,337 (GRCm39) S67P probably damaging Het
Or8c9 T C 9: 38,241,578 (GRCm39) S232P probably benign Het
Otog C A 7: 45,901,464 (GRCm39) Q388K probably damaging Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Oxct2b T G 4: 123,011,508 (GRCm39) V476G probably damaging Het
Parp10 T C 15: 76,126,202 (GRCm39) T329A probably benign Het
Pcdhga5 T C 18: 37,829,735 (GRCm39) S728P probably benign Het
Piezo1 G T 8: 123,221,671 (GRCm39) H574Q probably damaging Het
Pnpla1 G A 17: 29,100,342 (GRCm39) G403E probably benign Het
Preb C A 5: 31,115,395 (GRCm39) V255F probably damaging Het
Prmt9 A G 8: 78,304,092 (GRCm39) N725S probably damaging Het
Ric1 A T 19: 29,544,765 (GRCm39) probably null Het
Semp2l1 T A 1: 32,584,572 (GRCm39) D446V probably damaging Het
Sgce T C 6: 4,730,015 (GRCm39) K70E possibly damaging Het
Simc1 T G 13: 54,687,537 (GRCm39) V102G probably damaging Het
Slc66a3 T C 12: 17,047,704 (GRCm39) D76G probably damaging Het
Smyd2 A G 1: 189,616,049 (GRCm39) Y362H probably damaging Het
Sptbn1 G T 11: 30,050,660 (GRCm39) H2310N probably benign Het
Syne1 T C 10: 5,184,652 (GRCm39) Y4077C probably damaging Het
Syne2 C A 12: 75,937,155 (GRCm39) A251E probably damaging Het
Taok1 A T 11: 77,464,609 (GRCm39) L159Q probably damaging Het
Tasor2 C T 13: 3,631,891 (GRCm39) R870H possibly damaging Het
Timeless T C 10: 128,086,593 (GRCm39) L1043P probably damaging Het
Tmprss3 T C 17: 31,405,536 (GRCm39) E352G probably damaging Het
Trav6-4 A T 14: 53,692,039 (GRCm39) T46S probably benign Het
Ubiad1 A T 4: 148,521,083 (GRCm39) Y180* probably null Het
Usp47 A G 7: 111,686,263 (GRCm39) E627G probably damaging Het
Vmn2r124 A G 17: 18,283,145 (GRCm39) T280A probably benign Het
Other mutations in Serinc3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00569:Serinc3 APN 2 163,469,921 (GRCm39) missense probably damaging 1.00
IGL01152:Serinc3 APN 2 163,478,831 (GRCm39) missense probably damaging 0.99
IGL02879:Serinc3 APN 2 163,474,172 (GRCm39) splice site probably benign
IGL02945:Serinc3 APN 2 163,472,836 (GRCm39) splice site probably benign
R0783:Serinc3 UTSW 2 163,478,923 (GRCm39) missense possibly damaging 0.95
R1181:Serinc3 UTSW 2 163,467,446 (GRCm39) missense probably damaging 1.00
R1848:Serinc3 UTSW 2 163,487,409 (GRCm39) unclassified probably benign
R4254:Serinc3 UTSW 2 163,478,888 (GRCm39) missense probably benign
R6225:Serinc3 UTSW 2 163,469,799 (GRCm39) missense probably damaging 1.00
R6860:Serinc3 UTSW 2 163,476,366 (GRCm39) missense probably benign
R6986:Serinc3 UTSW 2 163,469,891 (GRCm39) missense probably benign 0.00
R7060:Serinc3 UTSW 2 163,478,879 (GRCm39) missense probably benign 0.01
R7618:Serinc3 UTSW 2 163,472,889 (GRCm39) missense possibly damaging 0.88
R9223:Serinc3 UTSW 2 163,478,812 (GRCm39) missense probably benign 0.26
R9274:Serinc3 UTSW 2 163,468,371 (GRCm39) missense probably damaging 1.00
R9766:Serinc3 UTSW 2 163,471,095 (GRCm39) missense probably damaging 1.00
T0970:Serinc3 UTSW 2 163,469,835 (GRCm39) small deletion probably benign
Predicted Primers PCR Primer
(F):5'- ATAGCACATACCGACTTCTGC -3'
(R):5'- CTGTGATTGACATGGTGGACAC -3'

Sequencing Primer
(F):5'- GCACATACCGACTTCTGCTTAATAAG -3'
(R):5'- ACATGGTGGACACTGTTCATGC -3'
Posted On 2018-03-15