Incidental Mutation 'R6272:Vmn2r97'
| ID |
507423 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r97
|
| Ensembl Gene |
ENSMUSG00000091491 |
| Gene Name |
vomeronasal 2, receptor 97 |
| Synonyms |
EG627367 |
| MMRRC Submission |
044442-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.070)
|
| Stock # |
R6272 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
19134584-19168333 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 19167861 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 705
(I705T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129313
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168710]
[ENSMUST00000232219]
|
| AlphaFold |
K7N6Z2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000168710
AA Change: I705T
PolyPhen 2
Score 0.701 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000129313
Gene: ENSMUSG00000091491
AA Change: I705T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
442 |
2.9e-36 |
PFAM |
|
Pfam:NCD3G
|
513 |
566 |
4.9e-21 |
PFAM |
|
Pfam:7tm_3
|
599 |
834 |
1.7e-52 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000232219
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.2%
- 20x: 95.3%
|
| Validation Efficiency |
98% (55/56) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 59 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgra3 |
A |
T |
5: 50,166,791 (GRCm39) |
M187K |
possibly damaging |
Het |
| Adgrg3 |
A |
G |
8: 95,762,889 (GRCm39) |
I189V |
noncoding transcript |
Het |
| Ampd1 |
A |
G |
3: 102,992,699 (GRCm39) |
K147R |
possibly damaging |
Het |
| Apbb2 |
T |
C |
5: 66,468,415 (GRCm39) |
T561A |
probably damaging |
Het |
| Arfgef3 |
A |
T |
10: 18,522,711 (GRCm39) |
D438E |
probably benign |
Het |
| Atxn1 |
T |
A |
13: 45,721,238 (GRCm39) |
Q219L |
possibly damaging |
Het |
| AW551984 |
A |
T |
9: 39,509,333 (GRCm39) |
D269E |
probably benign |
Het |
| Cryab |
A |
G |
9: 50,665,825 (GRCm39) |
K72R |
possibly damaging |
Het |
| Dbn1 |
G |
A |
13: 55,622,917 (GRCm39) |
A522V |
probably benign |
Het |
| Dip2a |
A |
T |
10: 76,122,241 (GRCm39) |
*158R |
probably null |
Het |
| Edrf1 |
C |
T |
7: 133,239,537 (GRCm39) |
|
probably benign |
Het |
| Ern2 |
A |
T |
7: 121,775,869 (GRCm39) |
D408E |
probably benign |
Het |
| F830016B08Rik |
T |
C |
18: 60,433,150 (GRCm39) |
S78P |
probably damaging |
Het |
| Fah |
C |
A |
7: 84,244,753 (GRCm39) |
G137C |
probably damaging |
Het |
| Foxd3 |
A |
G |
4: 99,544,977 (GRCm39) |
D39G |
probably damaging |
Het |
| Gprin3 |
G |
A |
6: 59,330,316 (GRCm39) |
Q664* |
probably null |
Het |
| H2-Ob |
T |
C |
17: 34,461,618 (GRCm39) |
I119T |
probably benign |
Het |
| H3c6 |
A |
T |
13: 23,746,400 (GRCm39) |
V47E |
probably damaging |
Het |
| Hmgcll1 |
G |
A |
9: 76,037,627 (GRCm39) |
G174R |
probably damaging |
Het |
| Kbtbd11 |
T |
A |
8: 15,079,118 (GRCm39) |
C572* |
probably null |
Het |
| Kynu |
A |
T |
2: 43,525,001 (GRCm39) |
N315Y |
probably benign |
Het |
| Map1lc3b |
G |
A |
8: 122,323,429 (GRCm39) |
E100K |
probably benign |
Het |
| Matn2 |
T |
A |
15: 34,355,753 (GRCm39) |
Q33L |
possibly damaging |
Het |
| Mettl8 |
T |
C |
2: 70,806,419 (GRCm39) |
|
probably null |
Het |
| Neto1 |
A |
T |
18: 86,512,940 (GRCm39) |
N312Y |
probably damaging |
Het |
| Nhsl1 |
A |
G |
10: 18,400,253 (GRCm39) |
D493G |
probably benign |
Het |
| Nup210l |
A |
G |
3: 90,077,331 (GRCm39) |
E889G |
possibly damaging |
Het |
| Or13l2 |
A |
G |
3: 97,318,207 (GRCm39) |
F97L |
probably benign |
Het |
| Or14c42-ps1 |
A |
G |
7: 86,211,081 (GRCm39) |
Y47C |
unknown |
Het |
| Or2y13 |
C |
A |
11: 49,414,953 (GRCm39) |
S134R |
possibly damaging |
Het |
| Or5ac25 |
A |
C |
16: 59,181,948 (GRCm39) |
M211R |
possibly damaging |
Het |
| Or5w20 |
G |
A |
2: 87,727,001 (GRCm39) |
V153I |
probably benign |
Het |
| Or6k2 |
C |
T |
1: 173,986,741 (GRCm39) |
T134I |
probably benign |
Het |
| Or8g4 |
A |
T |
9: 39,661,816 (GRCm39) |
M45L |
probably benign |
Het |
| Otx1 |
C |
A |
11: 21,947,037 (GRCm39) |
A91S |
probably damaging |
Het |
| Phc2 |
A |
G |
4: 128,603,440 (GRCm39) |
Y190C |
probably damaging |
Het |
| Platr25 |
T |
C |
13: 62,820,811 (GRCm39) |
T347A |
possibly damaging |
Het |
| Plec |
T |
C |
15: 76,059,053 (GRCm39) |
E3655G |
probably damaging |
Het |
| Plekhg3 |
A |
T |
12: 76,623,619 (GRCm39) |
Q954L |
probably benign |
Het |
| Pnpla1 |
G |
A |
17: 29,100,342 (GRCm39) |
G403E |
probably benign |
Het |
| Prdm4 |
G |
A |
10: 85,743,694 (GRCm39) |
T187I |
possibly damaging |
Het |
| Prg4 |
T |
C |
1: 150,330,517 (GRCm39) |
|
probably benign |
Het |
| Prpf18 |
G |
A |
2: 4,638,258 (GRCm39) |
R312W |
probably damaging |
Het |
| Rnf213 |
T |
A |
11: 119,305,374 (GRCm39) |
V535D |
probably damaging |
Het |
| Rtcb |
A |
T |
10: 85,791,638 (GRCm39) |
N39K |
probably damaging |
Het |
| Slc4a3 |
G |
A |
1: 75,531,341 (GRCm39) |
|
probably null |
Het |
| Szt2 |
A |
C |
4: 118,231,487 (GRCm39) |
|
probably benign |
Het |
| Tasor2 |
C |
T |
13: 3,631,891 (GRCm39) |
R870H |
possibly damaging |
Het |
| Tfap2e |
A |
T |
4: 126,615,657 (GRCm39) |
V259D |
probably damaging |
Het |
| Trav19 |
A |
G |
14: 54,083,255 (GRCm39) |
D110G |
probably damaging |
Het |
| Ttc17 |
A |
C |
2: 94,189,100 (GRCm39) |
C749W |
probably damaging |
Het |
| Ttc8 |
A |
G |
12: 98,948,753 (GRCm39) |
K490E |
possibly damaging |
Het |
| Ube4b |
A |
G |
4: 149,471,590 (GRCm39) |
S99P |
probably damaging |
Het |
| Ubqln3 |
C |
T |
7: 103,791,385 (GRCm39) |
R235H |
probably damaging |
Het |
| Vmn2r61 |
A |
T |
7: 41,949,242 (GRCm39) |
D554V |
probably damaging |
Het |
| Vmn2r70 |
A |
T |
7: 85,208,194 (GRCm39) |
V761E |
probably damaging |
Het |
| Wwox |
G |
A |
8: 115,215,692 (GRCm39) |
C155Y |
probably damaging |
Het |
| Zfp451 |
T |
C |
1: 33,842,325 (GRCm39) |
|
probably benign |
Het |
| Zfp582 |
C |
T |
7: 6,356,844 (GRCm39) |
P219L |
probably damaging |
Het |
|
| Other mutations in Vmn2r97 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00897:Vmn2r97
|
APN |
17 |
19,167,921 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL00962:Vmn2r97
|
APN |
17 |
19,149,490 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01704:Vmn2r97
|
APN |
17 |
19,168,073 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01888:Vmn2r97
|
APN |
17 |
19,149,286 (GRCm39) |
nonsense |
probably null |
|
|
IGL02429:Vmn2r97
|
APN |
17 |
19,150,596 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02742:Vmn2r97
|
APN |
17 |
19,149,432 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02934:Vmn2r97
|
APN |
17 |
19,149,947 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02978:Vmn2r97
|
APN |
17 |
19,168,298 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03230:Vmn2r97
|
APN |
17 |
19,149,668 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL03241:Vmn2r97
|
APN |
17 |
19,148,438 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL03050:Vmn2r97
|
UTSW |
17 |
19,167,900 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
PIT4469001:Vmn2r97
|
UTSW |
17 |
19,149,878 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0482:Vmn2r97
|
UTSW |
17 |
19,167,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0514:Vmn2r97
|
UTSW |
17 |
19,134,734 (GRCm39) |
missense |
probably benign |
0.25 |
|
R0944:Vmn2r97
|
UTSW |
17 |
19,167,665 (GRCm39) |
missense |
probably benign |
0.13 |
|
R1061:Vmn2r97
|
UTSW |
17 |
19,148,440 (GRCm39) |
nonsense |
probably null |
|
|
R1546:Vmn2r97
|
UTSW |
17 |
19,168,110 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1725:Vmn2r97
|
UTSW |
17 |
19,149,397 (GRCm39) |
missense |
probably benign |
0.43 |
|
R1860:Vmn2r97
|
UTSW |
17 |
19,167,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1938:Vmn2r97
|
UTSW |
17 |
19,149,593 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1944:Vmn2r97
|
UTSW |
17 |
19,160,500 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2027:Vmn2r97
|
UTSW |
17 |
19,149,944 (GRCm39) |
missense |
unknown |
|
|
R2106:Vmn2r97
|
UTSW |
17 |
19,168,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2151:Vmn2r97
|
UTSW |
17 |
19,167,584 (GRCm39) |
nonsense |
probably null |
|
|
R2153:Vmn2r97
|
UTSW |
17 |
19,167,584 (GRCm39) |
nonsense |
probably null |
|
|
R2154:Vmn2r97
|
UTSW |
17 |
19,167,584 (GRCm39) |
nonsense |
probably null |
|
|
R2516:Vmn2r97
|
UTSW |
17 |
19,167,814 (GRCm39) |
missense |
probably benign |
|
|
R3739:Vmn2r97
|
UTSW |
17 |
19,148,413 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3744:Vmn2r97
|
UTSW |
17 |
19,149,890 (GRCm39) |
missense |
probably benign |
|
|
R3885:Vmn2r97
|
UTSW |
17 |
19,148,596 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3899:Vmn2r97
|
UTSW |
17 |
19,167,873 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4115:Vmn2r97
|
UTSW |
17 |
19,148,332 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4247:Vmn2r97
|
UTSW |
17 |
19,167,542 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4287:Vmn2r97
|
UTSW |
17 |
19,168,337 (GRCm39) |
intron |
probably benign |
|
|
R4439:Vmn2r97
|
UTSW |
17 |
19,150,616 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4523:Vmn2r97
|
UTSW |
17 |
19,149,333 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4783:Vmn2r97
|
UTSW |
17 |
19,149,550 (GRCm39) |
missense |
probably benign |
|
|
R4948:Vmn2r97
|
UTSW |
17 |
19,167,561 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4981:Vmn2r97
|
UTSW |
17 |
19,160,436 (GRCm39) |
nonsense |
probably null |
|
|
R5029:Vmn2r97
|
UTSW |
17 |
19,168,173 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5200:Vmn2r97
|
UTSW |
17 |
19,148,615 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5541:Vmn2r97
|
UTSW |
17 |
19,148,617 (GRCm39) |
nonsense |
probably null |
|
|
R5637:Vmn2r97
|
UTSW |
17 |
19,167,628 (GRCm39) |
nonsense |
probably null |
|
|
R5765:Vmn2r97
|
UTSW |
17 |
19,167,442 (GRCm39) |
nonsense |
probably null |
|
|
R5885:Vmn2r97
|
UTSW |
17 |
19,168,035 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R6553:Vmn2r97
|
UTSW |
17 |
19,150,566 (GRCm39) |
nonsense |
probably null |
|
|
R6818:Vmn2r97
|
UTSW |
17 |
19,168,193 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6880:Vmn2r97
|
UTSW |
17 |
19,134,770 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7012:Vmn2r97
|
UTSW |
17 |
19,167,756 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7023:Vmn2r97
|
UTSW |
17 |
19,134,663 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7044:Vmn2r97
|
UTSW |
17 |
19,134,629 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7191:Vmn2r97
|
UTSW |
17 |
19,150,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7503:Vmn2r97
|
UTSW |
17 |
19,148,470 (GRCm39) |
missense |
probably benign |
|
|
R7862:Vmn2r97
|
UTSW |
17 |
19,167,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7876:Vmn2r97
|
UTSW |
17 |
19,149,326 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7890:Vmn2r97
|
UTSW |
17 |
19,149,802 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7936:Vmn2r97
|
UTSW |
17 |
19,150,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7978:Vmn2r97
|
UTSW |
17 |
19,167,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8405:Vmn2r97
|
UTSW |
17 |
19,134,802 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8755:Vmn2r97
|
UTSW |
17 |
19,168,104 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8790:Vmn2r97
|
UTSW |
17 |
19,160,472 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8850:Vmn2r97
|
UTSW |
17 |
19,149,607 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9060:Vmn2r97
|
UTSW |
17 |
19,134,585 (GRCm39) |
start codon destroyed |
probably null |
0.94 |
|
R9079:Vmn2r97
|
UTSW |
17 |
19,149,640 (GRCm39) |
missense |
probably benign |
|
|
R9252:Vmn2r97
|
UTSW |
17 |
19,167,849 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9278:Vmn2r97
|
UTSW |
17 |
19,134,762 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9342:Vmn2r97
|
UTSW |
17 |
19,149,368 (GRCm39) |
missense |
probably benign |
|
|
R9422:Vmn2r97
|
UTSW |
17 |
19,149,333 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9496:Vmn2r97
|
UTSW |
17 |
19,149,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9571:Vmn2r97
|
UTSW |
17 |
19,149,919 (GRCm39) |
missense |
probably benign |
|
|
R9601:Vmn2r97
|
UTSW |
17 |
19,134,770 (GRCm39) |
missense |
probably benign |
|
|
R9672:Vmn2r97
|
UTSW |
17 |
19,149,442 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9773:Vmn2r97
|
UTSW |
17 |
19,168,221 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9795:Vmn2r97
|
UTSW |
17 |
19,167,561 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGGCAAATAATCGAGCTCTGAG -3'
(R):5'- TAGCATAACTCCCAAGGGCC -3'
Sequencing Primer
(F):5'- GTTCTTTGAACTTCATTGGTAAGCC -3'
(R):5'- GGCCATCAAGCAGAGGTATCC -3'
|
| Posted On |
2018-03-15 |
Incidental Mutation