Incidental Mutation 'R6274:Prodh'
ID 507548
Institutional Source Beutler Lab
Gene Symbol Prodh
Ensembl Gene ENSMUSG00000003526
Gene Name proline dehydrogenase
Synonyms Pro-1, Ym24d07, Pro1
MMRRC Submission 044444-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6274 (G1)
Quality Score 225.009
Status Validated
Chromosome 16
Chromosomal Location 17889590-17907148 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 17898922 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 178 (K178E)
Ref Sequence ENSEMBL: ENSMUSP00000003620 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000003620] [ENSMUST00000132241] [ENSMUST00000136776] [ENSMUST00000139861] [ENSMUST00000232554]
AlphaFold Q9WU79
Predicted Effect possibly damaging
Transcript: ENSMUST00000003620
AA Change: K178E

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000003620
Gene: ENSMUSG00000003526
AA Change: K178E

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
low complexity region 23 35 N/A INTRINSIC
low complexity region 41 52 N/A INTRINSIC
Pfam:Pro_dh 119 578 7.7e-87 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123969
Predicted Effect probably benign
Transcript: ENSMUST00000126087
SMART Domains Protein: ENSMUSP00000121736
Gene: ENSMUSG00000003526

DomainStartEndE-ValueType
Pfam:Pro_dh 25 244 2.9e-76 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000132241
Predicted Effect possibly damaging
Transcript: ENSMUST00000136776
AA Change: K76E

PolyPhen 2 Score 0.555 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000117597
Gene: ENSMUSG00000003526
AA Change: K76E

DomainStartEndE-ValueType
low complexity region 118 129 N/A INTRINSIC
Pfam:Pro_dh 159 479 1.8e-108 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000139861
SMART Domains Protein: ENSMUSP00000123223
Gene: ENSMUSG00000003526

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
low complexity region 23 35 N/A INTRINSIC
low complexity region 41 52 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000141635
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232384
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232502
Predicted Effect probably benign
Transcript: ENSMUST00000232554
Meta Mutation Damage Score 0.0896 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 94.1%
Validation Efficiency 100% (56/56)
MGI Phenotype PHENOTYPE: Homozygotes for a spontaneous null mutation exhibit a slight reduction in male body weight, hyperprolinemia, increased startle reflex, and regionally altered brain levels of proline, glutamate, gamma-aminobutyric acid, and aspartate. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ank3 G A 10: 69,838,395 (GRCm39) R1566K possibly damaging Het
Ano1 A T 7: 144,172,600 (GRCm39) S528T probably benign Het
Araf G T X: 20,726,339 (GRCm39) R601L probably damaging Homo
Bcl2l10 T C 9: 75,258,354 (GRCm39) I172T possibly damaging Het
Bpifb3 A T 2: 153,771,243 (GRCm39) N385I possibly damaging Het
Bsnd A G 4: 106,343,832 (GRCm39) V158A probably damaging Het
Cacna1s A G 1: 136,016,783 (GRCm39) N481S probably benign Het
Cdk5rap1 A G 2: 154,210,161 (GRCm39) V138A probably damaging Het
Cep290 A G 10: 100,366,069 (GRCm39) E1099G probably damaging Het
Cers1 T A 8: 70,783,727 (GRCm39) L225Q probably damaging Het
Cfb T C 17: 35,081,069 (GRCm39) Q7R probably benign Het
Clk4 A G 11: 51,162,748 (GRCm39) S98G possibly damaging Het
Clock A G 5: 76,385,000 (GRCm39) S406P probably benign Het
Csmd3 T C 15: 47,484,833 (GRCm39) I3178V probably benign Het
Dock10 A G 1: 80,516,540 (GRCm39) S1397P probably damaging Het
Fer1l4 A G 2: 155,871,188 (GRCm39) L1421P probably damaging Het
Fetub C T 16: 22,751,081 (GRCm39) R143C probably damaging Het
Greb1 G T 12: 16,785,152 (GRCm39) T91K probably damaging Het
Grid2ip G A 5: 143,366,184 (GRCm39) S379N probably damaging Het
Gucy1b2 A T 14: 62,653,388 (GRCm39) C336S probably damaging Het
Hdac1 A G 4: 129,412,902 (GRCm39) C261R probably damaging Het
Htt T C 5: 35,009,431 (GRCm39) S1471P possibly damaging Het
Ice1 A G 13: 70,742,958 (GRCm39) V2134A probably damaging Het
Ikzf1 C T 11: 11,718,961 (GRCm39) Q310* probably null Het
Il3ra G A 14: 14,350,180 (GRCm38) V112I probably benign Het
Kif21b A G 1: 136,077,156 (GRCm39) I393V possibly damaging Het
Krt74 T C 15: 101,671,872 (GRCm39) noncoding transcript Het
Krtap29-1 T C 11: 99,869,809 (GRCm39) N24S probably null Het
Mmut T C 17: 41,267,136 (GRCm39) V570A probably benign Het
Myh7 T C 14: 55,216,943 (GRCm39) D1138G probably damaging Het
Nktr T C 9: 121,560,631 (GRCm39) I125T probably damaging Het
Nlrp2 A T 7: 5,320,554 (GRCm39) L861Q probably damaging Het
Notch3 C A 17: 32,366,264 (GRCm39) R990L probably benign Het
Nrap T C 19: 56,350,153 (GRCm39) D655G probably benign Het
Or10ak8 A T 4: 118,774,427 (GRCm39) V79E probably benign Het
Or5b99 G A 19: 12,977,234 (GRCm39) V295I probably damaging Het
Osbpl11 T A 16: 33,047,426 (GRCm39) I463N probably damaging Het
Pcsk6 A T 7: 65,683,592 (GRCm39) R749W probably damaging Het
Plaat5 C T 19: 7,614,831 (GRCm39) T231I probably damaging Het
Plxnb1 T C 9: 108,941,209 (GRCm39) probably null Het
Polr1a T A 6: 71,931,874 (GRCm39) probably null Het
Ppm1g T C 5: 31,363,750 (GRCm39) I153V probably damaging Het
Ppp1r12a T C 10: 108,096,751 (GRCm39) S191P probably benign Het
Rilpl2 A G 5: 124,607,911 (GRCm39) V103A possibly damaging Het
Sap18b C T 8: 96,552,169 (GRCm39) H60Y probably benign Het
Sclt1 A G 3: 41,583,951 (GRCm39) probably null Het
Serpinb1a G T 13: 33,026,849 (GRCm39) H364Q probably damaging Het
Sez6l G A 5: 112,623,231 (GRCm39) Q107* probably null Het
Sipa1l2 C T 8: 126,196,611 (GRCm39) V708I probably damaging Het
Tbc1d2 C T 4: 46,629,912 (GRCm39) G252R probably benign Het
Uaca T A 9: 60,757,573 (GRCm39) probably null Het
Uqcrc1 C A 9: 108,771,224 (GRCm39) H95N probably damaging Het
Usp9y C T Y: 1,316,735 (GRCm39) R1938H probably damaging Homo
Wnk4 C T 11: 101,156,257 (GRCm39) R42W probably damaging Het
Zfp326 T A 5: 106,053,846 (GRCm39) L242Q probably damaging Het
Other mutations in Prodh
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01085:Prodh APN 16 17,894,208 (GRCm39) missense probably damaging 0.99
IGL02063:Prodh APN 16 17,897,049 (GRCm39) critical splice donor site probably null
IGL02525:Prodh APN 16 17,890,332 (GRCm39) nonsense probably null
R0147:Prodh UTSW 16 17,895,677 (GRCm39) missense probably damaging 1.00
R0148:Prodh UTSW 16 17,895,677 (GRCm39) missense probably damaging 1.00
R1643:Prodh UTSW 16 17,898,933 (GRCm39) missense probably benign 0.23
R1913:Prodh UTSW 16 17,898,891 (GRCm39) missense probably damaging 1.00
R4190:Prodh UTSW 16 17,891,504 (GRCm39) missense probably benign 0.27
R4191:Prodh UTSW 16 17,891,504 (GRCm39) missense probably benign 0.27
R4193:Prodh UTSW 16 17,891,504 (GRCm39) missense probably benign 0.27
R4204:Prodh UTSW 16 17,890,182 (GRCm39) missense probably damaging 1.00
R5074:Prodh UTSW 16 17,895,653 (GRCm39) critical splice donor site probably null
R6194:Prodh UTSW 16 17,890,381 (GRCm39) missense probably benign 0.16
R6376:Prodh UTSW 16 17,897,849 (GRCm39) missense probably benign
R6744:Prodh UTSW 16 17,897,064 (GRCm39) missense probably benign 0.43
R8985:Prodh UTSW 16 17,890,362 (GRCm39) missense probably null 0.00
R9335:Prodh UTSW 16 17,894,160 (GRCm39) missense probably damaging 1.00
R9361:Prodh UTSW 16 17,898,834 (GRCm39) missense probably benign 0.44
R9568:Prodh UTSW 16 17,902,619 (GRCm39) intron probably benign
R9789:Prodh UTSW 16 17,898,049 (GRCm39) missense probably damaging 1.00
Z1177:Prodh UTSW 16 17,906,891 (GRCm39) missense probably benign 0.34
Predicted Primers PCR Primer
(F):5'- TCAGGAACAAGCAGATGCCC -3'
(R):5'- CCAGGGGAATATCAGTGCCTATC -3'

Sequencing Primer
(F):5'- TGCCAATGAGCTGCCTAC -3'
(R):5'- TATCAGTGCCTATCAGGAGAGC -3'
Posted On 2018-03-15