Incidental Mutation 'IGL01115:Zranb2'
ID50756
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zranb2
Ensembl Gene ENSMUSG00000028180
Gene Namezinc finger, RAN-binding domain containing 2
SynonymsZis, Zfp265, Znf265
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #IGL01115
Quality Score
Status
Chromosome3
Chromosomal Location157534160-157548410 bp(+) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) T to C at 157546691 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000143533 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029831] [ENSMUST00000106057] [ENSMUST00000106058] [ENSMUST00000184802] [ENSMUST00000198915]
Predicted Effect unknown
Transcript: ENSMUST00000029831
AA Change: S279P
SMART Domains Protein: ENSMUSP00000029831
Gene: ENSMUSG00000028180
AA Change: S279P

DomainStartEndE-ValueType
ZnF_RBZ 11 35 1.02e-2 SMART
ZnF_RBZ 36 54 2.09e-1 SMART
low complexity region 70 82 N/A INTRINSIC
low complexity region 108 145 N/A INTRINSIC
low complexity region 156 293 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000083497
Predicted Effect probably benign
Transcript: ENSMUST00000106057
SMART Domains Protein: ENSMUSP00000101672
Gene: ENSMUSG00000028180

DomainStartEndE-ValueType
ZnF_RBZ 11 37 1.24e-6 SMART
ZnF_RBZ 77 101 3.11e-7 SMART
low complexity region 117 129 N/A INTRINSIC
low complexity region 155 192 N/A INTRINSIC
low complexity region 203 312 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000106058
AA Change: S316P
SMART Domains Protein: ENSMUSP00000101673
Gene: ENSMUSG00000028180
AA Change: S316P

DomainStartEndE-ValueType
ZnF_RBZ 11 37 1.24e-6 SMART
ZnF_RBZ 77 101 3.11e-7 SMART
low complexity region 117 129 N/A INTRINSIC
low complexity region 155 192 N/A INTRINSIC
low complexity region 203 340 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000106063
AA Change: S193P
SMART Domains Protein: ENSMUSP00000101678
Gene: ENSMUSG00000028180
AA Change: S193P

DomainStartEndE-ValueType
ZnF_RBZ 11 37 8.79e-7 SMART
ZnF_RBZ 67 91 3.11e-7 SMART
low complexity region 107 119 N/A INTRINSIC
low complexity region 145 182 N/A INTRINSIC
low complexity region 193 330 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152882
Predicted Effect probably benign
Transcript: ENSMUST00000184802
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196900
Predicted Effect probably benign
Transcript: ENSMUST00000198915
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4430402I18Rik T C 19: 28,944,442 probably null Het
Abcc10 T C 17: 46,310,426 T934A probably benign Het
Ankzf1 T C 1: 75,192,615 L55P probably damaging Het
Aoc1 T C 6: 48,906,197 S336P probably damaging Het
Bmper T C 9: 23,399,689 probably benign Het
Capza2 A G 6: 17,654,123 N58S probably damaging Het
Cdca2 A G 14: 67,714,697 V75A probably damaging Het
Chmp7 A G 14: 69,721,323 S181P probably damaging Het
Colq A G 14: 31,545,128 probably benign Het
Dennd5b A G 6: 149,009,748 probably benign Het
Has3 A G 8: 106,878,688 T509A probably benign Het
Hsh2d T C 8: 72,200,619 S282P probably damaging Het
Impg2 C T 16: 56,259,440 P536S possibly damaging Het
Naip1 T A 13: 100,443,720 probably null Het
Napb T C 2: 148,707,169 Y111C probably damaging Het
Olfr1132 T C 2: 87,635,384 D121G probably damaging Het
Osmr A G 15: 6,847,201 probably benign Het
Pcdh10 A G 3: 45,392,775 T1002A probably damaging Het
Plcg2 T C 8: 117,557,329 W122R probably damaging Het
Prpf19 C T 19: 10,900,203 T204M probably damaging Het
Ptbp1 T A 10: 79,859,962 probably benign Het
Ptpre T A 7: 135,670,764 D402E probably damaging Het
Siglec1 T C 2: 131,074,502 N1176S probably benign Het
Son A G 16: 91,659,458 T1698A probably benign Het
Speer2 C T 16: 69,861,651 W42* probably null Het
Taf5 T C 19: 47,075,082 V357A probably benign Het
Tctn1 A G 5: 122,264,207 S55P probably benign Het
Tmem115 T A 9: 107,534,582 L35Q probably damaging Het
Tmem30c T A 16: 57,276,117 probably benign Het
Tmprss7 T C 16: 45,660,789 D678G probably damaging Het
Ugt1a7c A T 1: 88,095,245 Q42L probably damaging Het
Unc13b T A 4: 43,258,492 V4099E probably damaging Het
Usp36 G A 11: 118,285,960 L11F probably damaging Het
Zfp955a T A 17: 33,242,580 K193* probably null Het
Other mutations in Zranb2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01528:Zranb2 APN 3 157544965 unclassified probably benign
IGL03008:Zranb2 APN 3 157546665 splice site probably null
R0528:Zranb2 UTSW 3 157534459 missense probably benign 0.26
R0659:Zranb2 UTSW 3 157541763 missense probably benign 0.23
R1170:Zranb2 UTSW 3 157541865 utr 3 prime probably benign
R1673:Zranb2 UTSW 3 157537640 missense probably damaging 1.00
R1885:Zranb2 UTSW 3 157543156 critical splice acceptor site probably null
R4127:Zranb2 UTSW 3 157537590 nonsense probably null
R4610:Zranb2 UTSW 3 157541884 splice site probably benign
R4981:Zranb2 UTSW 3 157546741 unclassified probably benign
R5053:Zranb2 UTSW 3 157541159 missense probably damaging 0.96
R5742:Zranb2 UTSW 3 157540703 nonsense probably null
R5873:Zranb2 UTSW 3 157536383 nonsense probably null
R6086:Zranb2 UTSW 3 157543246 critical splice donor site probably null
R7015:Zranb2 UTSW 3 157536733 critical splice acceptor site probably null
R7547:Zranb2 UTSW 3 157541169 missense possibly damaging 0.93
Posted On2013-06-21