Incidental Mutation 'R6276:Zscan2'
ID507642
Institutional Source Beutler Lab
Gene Symbol Zscan2
Ensembl Gene ENSMUSG00000038797
Gene Namezinc finger and SCAN domain containing 2
SynonymsZfp-29, Zfp29
MMRRC Submission
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R6276 (G1)
Quality Score225.009
Status Not validated
Chromosome7
Chromosomal Location80860920-80876537 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 80875809 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Serine at position 426 (N426S)
Ref Sequence ENSEMBL: ENSMUSP00000121143 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044115] [ENSMUST00000132163] [ENSMUST00000147125] [ENSMUST00000155128]
Predicted Effect probably benign
Transcript: ENSMUST00000044115
AA Change: N426S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000042321
Gene: ENSMUSG00000038797
AA Change: N426S

DomainStartEndE-ValueType
SCAN 64 160 3.18e-21 SMART
low complexity region 164 177 N/A INTRINSIC
ZnF_C2H2 222 244 3.49e-5 SMART
ZnF_C2H2 250 272 5.21e-4 SMART
ZnF_C2H2 278 300 1.72e-4 SMART
ZnF_C2H2 306 328 3.69e-4 SMART
ZnF_C2H2 334 356 9.88e-5 SMART
ZnF_C2H2 362 384 4.87e-4 SMART
ZnF_C2H2 390 412 2.43e-4 SMART
ZnF_C2H2 418 440 1.69e-3 SMART
ZnF_C2H2 446 468 2.4e-3 SMART
ZnF_C2H2 474 496 1.69e-3 SMART
ZnF_C2H2 502 524 3.21e-4 SMART
ZnF_C2H2 530 552 1.92e-2 SMART
ZnF_C2H2 558 580 4.24e-4 SMART
ZnF_C2H2 586 608 4.61e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000132163
SMART Domains Protein: ENSMUSP00000118774
Gene: ENSMUSG00000038797

DomainStartEndE-ValueType
SCAN 64 144 5.98e-17 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000147125
AA Change: N426S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000121143
Gene: ENSMUSG00000038797
AA Change: N426S

DomainStartEndE-ValueType
SCAN 64 160 3.18e-21 SMART
low complexity region 164 177 N/A INTRINSIC
ZnF_C2H2 222 244 3.49e-5 SMART
ZnF_C2H2 250 272 5.21e-4 SMART
ZnF_C2H2 278 300 1.72e-4 SMART
ZnF_C2H2 306 328 3.69e-4 SMART
ZnF_C2H2 334 356 9.88e-5 SMART
ZnF_C2H2 362 384 4.87e-4 SMART
ZnF_C2H2 390 412 2.43e-4 SMART
ZnF_C2H2 418 440 1.69e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000155128
SMART Domains Protein: ENSMUSP00000117886
Gene: ENSMUSG00000038797

DomainStartEndE-ValueType
SCAN 64 160 3.18e-21 SMART
low complexity region 164 177 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.3%
  • 20x: 95.5%
Validation Efficiency 100% (71/71)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains several copies of zinc finger motif, which is commonly found in transcriptional regulatory proteins. Studies in mice show that this gene is expressed during embryonic development, and specifically in the testis in adult mice, suggesting that it may play a role in regulating genes in germ cells. Alternative splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930504O13Rik T A 11: 58,446,366 I94L possibly damaging Het
4931406P16Rik A T 7: 34,242,377 Y627* probably null Het
Actr3 A T 1: 125,395,137 D364E probably benign Het
Adra2c C T 5: 35,280,079 T65I probably damaging Het
Agap2 T A 10: 127,089,360 probably null Het
Ager T C 17: 34,598,754 V126A possibly damaging Het
Arhgap39 T C 15: 76,737,536 I288M probably benign Het
Arhgap45 A T 10: 80,026,234 S541C probably benign Het
Asb4 A G 6: 5,431,043 Y426C probably damaging Het
Azi2 C T 9: 118,049,338 T82I probably damaging Het
Baz2b T A 2: 59,948,223 R764S probably damaging Het
Ccdc146 A C 5: 21,301,340 I701S probably damaging Het
Cd55b T A 1: 130,418,166 I172F probably damaging Het
Cdk11b A G 4: 155,634,190 E199G probably benign Het
Cntnap4 A T 8: 112,752,289 T216S possibly damaging Het
D5Ertd579e A T 5: 36,604,514 N1336K possibly damaging Het
Dlg5 T C 14: 24,164,568 N649S probably damaging Het
Dmxl1 A G 18: 49,846,586 E96G probably benign Het
Dscaml1 C T 9: 45,668,160 T335I possibly damaging Het
Epb41l2 G T 10: 25,502,124 G695C probably damaging Het
Erbb4 C T 1: 68,560,576 R114H probably damaging Het
F2rl1 G T 13: 95,513,938 Y145* probably null Het
Fam58b T C 11: 78,751,230 K145E probably damaging Het
Fsip2 A T 2: 82,980,441 Y2368F possibly damaging Het
Galnt7 C T 8: 57,536,578 probably null Het
Gm6811 T A 17: 21,093,983 noncoding transcript Het
Gm6811 T G 17: 21,094,690 noncoding transcript Het
H2-M1 G A 17: 36,671,710 T86M possibly damaging Het
Hk2 T C 6: 82,743,366 D170G probably benign Het
Hmcn1 C T 1: 150,738,681 A1325T possibly damaging Het
Insrr T A 3: 87,800,519 Y89* probably null Het
Itga1 T C 13: 114,980,852 E871G probably benign Het
Kat6a T C 8: 22,939,405 L1592P possibly damaging Het
Kndc1 C A 7: 139,921,063 A756E probably benign Het
Krt12 A T 11: 99,421,902 C105* probably null Het
Lama1 G A 17: 67,784,088 probably null Het
Lama3 A G 18: 12,506,949 N67S probably benign Het
Lrrk1 A G 7: 66,306,839 probably null Het
Map2 T C 1: 66,399,419 V34A probably damaging Het
Mroh6 A G 15: 75,885,700 L487P probably damaging Het
Myo18b A T 5: 112,811,642 S1430T probably benign Het
Notch3 G A 17: 32,154,749 T495I probably benign Het
Olfr391-ps A T 11: 73,799,403 M118K probably damaging Het
Palld C T 8: 61,513,423 A980T probably damaging Het
Paxip1 A T 5: 27,761,668 I620N probably damaging Het
Pcdha6 A G 18: 36,969,767 probably null Het
Pcdhb11 G A 18: 37,421,760 V48M probably benign Het
Pcdhga6 A G 18: 37,707,644 E139G probably benign Het
Pck1 T C 2: 173,157,319 V426A probably damaging Het
Pck2 T A 14: 55,542,624 I110N probably damaging Het
Peg10 GAT GATCAT 6: 4,756,449 probably benign Het
Phactr3 G A 2: 178,279,019 E222K probably damaging Het
Ppip5k1 A T 2: 121,323,203 probably benign Het
Prodh2 A G 7: 30,506,651 H278R probably benign Het
Rspry1 T A 8: 94,623,258 H91Q probably damaging Het
Slc13a2 CGTTATCTGT CGT 11: 78,403,480 probably benign Het
Smn1 A G 13: 100,127,995 N78S possibly damaging Het
Spta1 T A 1: 174,218,512 I1614N probably damaging Het
Syt17 T C 7: 118,434,290 D165G probably damaging Het
Tbck A G 3: 132,743,005 Y593C probably damaging Het
Tcaf2 G C 6: 42,629,753 F422L probably benign Het
Tex15 T A 8: 33,577,189 F2216I possibly damaging Het
Trpc4 A G 3: 54,318,020 E846G probably benign Het
Ttc41 T C 10: 86,744,449 I753T probably benign Het
Vdac1 C T 11: 52,376,482 T70M possibly damaging Het
Vmn1r124 A C 7: 21,260,179 F147V probably benign Het
Vmn1r220 T C 13: 23,184,295 D77G probably damaging Het
Vmn2r28 T C 7: 5,490,731 H72R probably benign Het
Vmn2r78 A T 7: 86,921,110 I279L probably benign Het
Vmn2r95 G T 17: 18,451,470 A490S possibly damaging Het
Wdfy4 C T 14: 33,109,525 A915T possibly damaging Het
Zmiz2 G T 11: 6,395,604 probably null Het
Other mutations in Zscan2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00536:Zscan2 APN 7 80875416 missense probably damaging 1.00
IGL01793:Zscan2 APN 7 80874944 missense probably null 0.79
R1570:Zscan2 UTSW 7 80863393 missense probably damaging 1.00
R1618:Zscan2 UTSW 7 80875786 nonsense probably null
R1622:Zscan2 UTSW 7 80875386 missense probably benign 0.01
R1842:Zscan2 UTSW 7 80875553 missense probably damaging 1.00
R3122:Zscan2 UTSW 7 80863344 missense probably benign 0.41
R3415:Zscan2 UTSW 7 80875402 missense probably damaging 1.00
R4674:Zscan2 UTSW 7 80875402 missense probably damaging 1.00
R5988:Zscan2 UTSW 7 80876199 missense possibly damaging 0.47
R6379:Zscan2 UTSW 7 80863337 missense probably benign 0.00
R7897:Zscan2 UTSW 7 80875700 missense probably damaging 1.00
R7980:Zscan2 UTSW 7 80875700 missense probably damaging 1.00
Predicted Primers
Posted On2018-03-15