Incidental Mutation 'R6285:Fbxw15'
ID 508183
Institutional Source Beutler Lab
Gene Symbol Fbxw15
Ensembl Gene ENSMUSG00000074060
Gene Name F-box and WD-40 domain protein 15
Synonyms Fbxo12J
MMRRC Submission 044455-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R6285 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 109381670-109397330 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 109386234 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 249 (M249L)
Ref Sequence ENSEMBL: ENSMUSP00000142894 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056745] [ENSMUST00000198112] [ENSMUST00000198397]
AlphaFold L7N1X6
Predicted Effect probably benign
Transcript: ENSMUST00000056745
AA Change: M302L

PolyPhen 2 Score 0.088 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000058175
Gene: ENSMUSG00000074060
AA Change: M302L

DomainStartEndE-ValueType
FBOX 8 45 3.25e-4 SMART
SCOP:d1flga_ 73 413 3e-7 SMART
Blast:WD40 137 176 5e-6 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196601
Predicted Effect probably benign
Transcript: ENSMUST00000198112
AA Change: M249L

PolyPhen 2 Score 0.088 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000142894
Gene: ENSMUSG00000074060
AA Change: M249L

DomainStartEndE-ValueType
FBOX 8 45 2.1e-6 SMART
SCOP:d1tbga_ 73 196 3e-5 SMART
Blast:WD40 84 123 1e-5 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000198397
SMART Domains Protein: ENSMUSP00000143385
Gene: ENSMUSG00000074060

DomainStartEndE-ValueType
FBOX 8 45 3.25e-4 SMART
SCOP:d1tbga_ 116 240 1e-3 SMART
Blast:WD40 137 176 6e-6 BLAST
Meta Mutation Damage Score 0.4634 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 98.8%
  • 20x: 96.9%
Validation Efficiency 100% (68/68)
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acad9 A T 3: 36,136,324 (GRCm39) M370L probably benign Het
Aimp1 A G 3: 132,373,265 (GRCm39) M225T possibly damaging Het
Atp8a1 T C 5: 67,824,950 (GRCm39) I809V possibly damaging Het
Bbs10 A G 10: 111,135,622 (GRCm39) Y245C probably damaging Het
Cabin1 A T 10: 75,520,157 (GRCm39) F1572Y probably damaging Het
Cd79a A G 7: 24,598,772 (GRCm39) N107S possibly damaging Het
Cdc7 G A 5: 107,130,925 (GRCm39) A428T probably benign Het
Cep290 A G 10: 100,359,191 (GRCm39) T974A probably benign Het
Cep350 A T 1: 155,829,120 (GRCm39) N261K possibly damaging Het
Cfap46 T A 7: 139,241,001 (GRCm39) D8V probably damaging Het
Col6a4 T C 9: 105,952,185 (GRCm39) D571G probably damaging Het
Cpe A C 8: 65,070,645 (GRCm39) V200G probably benign Het
Ctnnd1 C T 2: 84,444,231 (GRCm39) probably null Het
D5Ertd579e A C 5: 36,772,921 (GRCm39) C491W probably damaging Het
Dek A G 13: 47,252,856 (GRCm39) I183T probably damaging Het
Dennd1a A T 2: 37,742,453 (GRCm39) H437Q possibly damaging Het
Dido1 C T 2: 180,302,940 (GRCm39) A1655T probably benign Het
Eva1b A G 4: 126,043,278 (GRCm39) D106G probably damaging Het
Evc2 G T 5: 37,581,923 (GRCm39) S1189I possibly damaging Het
Faap100 A T 11: 120,267,558 (GRCm39) L405Q probably damaging Het
Gbp10 A T 5: 105,366,326 (GRCm39) L526Q probably damaging Het
Gm19402 A C 10: 77,526,354 (GRCm39) probably benign Het
Gm2244 A G 14: 19,590,865 (GRCm39) Y141H probably damaging Het
Gm4181 A T 14: 51,870,666 (GRCm39) N98K probably damaging Het
Golga4 C T 9: 118,387,695 (GRCm39) R616* probably null Het
Gpank1 T A 17: 35,343,266 (GRCm39) S226T probably damaging Het
Hipk3 T C 2: 104,301,770 (GRCm39) M141V probably damaging Het
Hoxc11 T C 15: 102,863,178 (GRCm39) V73A probably benign Het
Igf1r T G 7: 67,653,885 (GRCm39) I141S possibly damaging Het
Jak2 T A 19: 29,273,059 (GRCm39) F628I probably benign Het
Kcp C A 6: 29,502,364 (GRCm39) V227L probably benign Het
Knl1 T G 2: 118,902,422 (GRCm39) C1374W probably damaging Het
Larp6 A T 9: 60,645,043 (GRCm39) R394S probably benign Het
Lilra5 G A 7: 4,245,114 (GRCm39) G253R probably damaging Het
Map3k4 A G 17: 12,482,945 (GRCm39) S591P probably damaging Het
Mdfic2 T C 6: 98,215,134 (GRCm39) D163G probably damaging Het
Minar2 A G 18: 59,205,296 (GRCm39) K28R probably benign Het
Mrpl16 T A 19: 11,750,332 (GRCm39) I72K probably damaging Het
Nol11 C G 11: 107,071,860 (GRCm39) R244S probably benign Het
Nr2f1 T C 13: 78,343,782 (GRCm39) T161A probably benign Het
Nrdc G T 4: 108,895,203 (GRCm39) V476F probably damaging Het
Or10j7 G T 1: 173,011,477 (GRCm39) H175N probably damaging Het
Or10z1 A T 1: 174,078,395 (GRCm39) S33T possibly damaging Het
Or13a22 T A 7: 140,072,626 (GRCm39) L25Q possibly damaging Het
Or13m2-ps1 A T 6: 42,777,843 (GRCm39) H56L probably benign Het
P2rx1 A G 11: 72,898,974 (GRCm39) I62V probably benign Het
Pcdhgc5 A T 18: 37,953,674 (GRCm39) Y316F probably benign Het
Pecam1 T C 11: 106,576,065 (GRCm39) D490G probably benign Het
Pfkfb2 A T 1: 130,635,299 (GRCm39) Y87* probably null Het
Poldip2 A G 11: 78,408,458 (GRCm39) probably null Het
Ppp2r5b T A 19: 6,280,566 (GRCm39) Q304L probably benign Het
Pramel26 A G 4: 143,542,609 (GRCm39) C4R probably damaging Het
Psg26 A G 7: 18,216,753 (GRCm39) F29L probably benign Het
Ptk6 A T 2: 180,838,886 (GRCm39) L289Q probably null Het
Ptprt A T 2: 161,743,417 (GRCm39) I508N possibly damaging Het
Rasgrp4 T C 7: 28,847,808 (GRCm39) F406S probably damaging Het
Rspo3 A G 10: 29,375,926 (GRCm39) probably null Het
Septin8 G T 11: 53,425,594 (GRCm39) probably null Het
Sirt2 A C 7: 28,487,471 (GRCm39) T345P probably benign Het
Slc6a20b T C 9: 123,438,161 (GRCm39) E205G possibly damaging Het
Sqstm1 G A 11: 50,093,418 (GRCm39) Q327* probably null Het
Susd3 T A 13: 49,390,997 (GRCm39) S98C probably damaging Het
Tada2b G A 5: 36,634,186 (GRCm39) R56W probably damaging Het
Tbc1d2 A T 4: 46,615,045 (GRCm39) V546E possibly damaging Het
Tbx6 A G 7: 126,380,740 (GRCm39) Q21R possibly damaging Het
Usp24 T G 4: 106,231,297 (GRCm39) probably null Het
Vinac1 T G 2: 128,879,719 (GRCm39) T736P possibly damaging Het
Vmn2r103 A G 17: 20,032,406 (GRCm39) T727A probably benign Het
Wdr48 C T 9: 119,749,676 (GRCm39) T531M probably damaging Het
Other mutations in Fbxw15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02094:Fbxw15 APN 9 109,387,308 (GRCm39) missense possibly damaging 0.87
IGL02239:Fbxw15 APN 9 109,388,905 (GRCm39) missense probably benign 0.01
IGL02343:Fbxw15 APN 9 109,381,723 (GRCm39) utr 3 prime probably benign
IGL02748:Fbxw15 APN 9 109,387,278 (GRCm39) missense possibly damaging 0.66
IGL03206:Fbxw15 APN 9 109,394,430 (GRCm39) missense possibly damaging 0.90
IGL03370:Fbxw15 APN 9 109,384,219 (GRCm39) missense probably benign 0.00
lagging UTSW 9 109,384,741 (GRCm39) splice site probably null
R0321:Fbxw15 UTSW 9 109,394,453 (GRCm39) missense probably benign 0.03
R0742:Fbxw15 UTSW 9 109,384,624 (GRCm39) splice site probably null
R1141:Fbxw15 UTSW 9 109,387,314 (GRCm39) missense probably damaging 0.99
R1143:Fbxw15 UTSW 9 109,387,314 (GRCm39) missense probably damaging 0.99
R1276:Fbxw15 UTSW 9 109,387,314 (GRCm39) missense probably damaging 0.99
R1282:Fbxw15 UTSW 9 109,387,314 (GRCm39) missense probably damaging 0.99
R1283:Fbxw15 UTSW 9 109,387,314 (GRCm39) missense probably damaging 0.99
R1321:Fbxw15 UTSW 9 109,387,314 (GRCm39) missense probably damaging 0.99
R1324:Fbxw15 UTSW 9 109,387,314 (GRCm39) missense probably damaging 0.99
R1341:Fbxw15 UTSW 9 109,387,314 (GRCm39) missense probably damaging 0.99
R1716:Fbxw15 UTSW 9 109,386,204 (GRCm39) missense probably benign 0.00
R1750:Fbxw15 UTSW 9 109,387,314 (GRCm39) missense probably damaging 0.99
R1757:Fbxw15 UTSW 9 109,386,347 (GRCm39) missense probably damaging 0.99
R1765:Fbxw15 UTSW 9 109,387,314 (GRCm39) missense probably damaging 0.99
R1799:Fbxw15 UTSW 9 109,387,314 (GRCm39) missense probably damaging 0.99
R1826:Fbxw15 UTSW 9 109,388,782 (GRCm39) splice site probably null
R1897:Fbxw15 UTSW 9 109,387,271 (GRCm39) nonsense probably null
R2237:Fbxw15 UTSW 9 109,384,303 (GRCm39) missense probably damaging 0.99
R2346:Fbxw15 UTSW 9 109,394,500 (GRCm39) missense probably damaging 1.00
R4391:Fbxw15 UTSW 9 109,397,300 (GRCm39) start gained probably benign
R4392:Fbxw15 UTSW 9 109,397,300 (GRCm39) start gained probably benign
R4812:Fbxw15 UTSW 9 109,388,990 (GRCm39) missense probably benign 0.01
R5198:Fbxw15 UTSW 9 109,387,242 (GRCm39) missense probably benign 0.00
R5278:Fbxw15 UTSW 9 109,384,752 (GRCm39) missense probably benign 0.03
R5541:Fbxw15 UTSW 9 109,394,498 (GRCm39) missense probably benign 0.23
R5899:Fbxw15 UTSW 9 109,384,741 (GRCm39) splice site probably null
R5975:Fbxw15 UTSW 9 109,384,320 (GRCm39) missense probably damaging 1.00
R6065:Fbxw15 UTSW 9 109,397,246 (GRCm39) missense probably damaging 1.00
R7357:Fbxw15 UTSW 9 109,387,308 (GRCm39) missense probably benign 0.28
R7781:Fbxw15 UTSW 9 109,386,330 (GRCm39) missense possibly damaging 0.71
R8145:Fbxw15 UTSW 9 109,384,658 (GRCm39) missense probably benign 0.01
R8182:Fbxw15 UTSW 9 109,384,778 (GRCm39) missense probably benign 0.00
R8272:Fbxw15 UTSW 9 109,388,828 (GRCm39) missense probably benign 0.18
R8713:Fbxw15 UTSW 9 109,384,667 (GRCm39) missense possibly damaging 0.93
R9069:Fbxw15 UTSW 9 109,394,468 (GRCm39) nonsense probably null
R9496:Fbxw15 UTSW 9 109,397,291 (GRCm39) missense probably benign 0.01
X0026:Fbxw15 UTSW 9 109,387,255 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- ACAGATCTGTGTGGGTGTATATATGCA -3'
(R):5'- ATGCAGCCATTCTGGGGTTT -3'

Sequencing Primer
(F):5'- ATATATGCATGTGCTCCTGATTTG -3'
(R):5'- CATGTACCAGGCTGCAGAGATTTAC -3'
Posted On 2018-03-15