Incidental Mutation 'R6285:Vmn2r103'
| ID |
508206 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r103
|
| Ensembl Gene |
ENSMUSG00000091771 |
| Gene Name |
vomeronasal 2, receptor 103 |
| Synonyms |
EG627636 |
| MMRRC Submission |
044455-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.059)
|
| Stock # |
R6285 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
19773363-19812536 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 19812144 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 727
(T727A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126756
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000172203]
|
| AlphaFold |
E9PWW0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000172203
AA Change: T727A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: T727A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
449 |
1.3e-37 |
PFAM |
|
Pfam:NCD3G
|
509 |
562 |
3.5e-22 |
PFAM |
|
Pfam:7tm_3
|
595 |
830 |
1.1e-51 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.8%
- 10x: 98.8%
- 20x: 96.9%
|
| Validation Efficiency |
100% (68/68) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 69 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A730017C20Rik |
A |
G |
18: 59,072,224 (GRCm38) |
K28R |
probably benign |
Het |
| Acad9 |
A |
T |
3: 36,082,175 (GRCm38) |
M370L |
probably benign |
Het |
| Aimp1 |
A |
G |
3: 132,667,504 (GRCm38) |
M225T |
possibly damaging |
Het |
| Atp8a1 |
T |
C |
5: 67,667,607 (GRCm38) |
I809V |
possibly damaging |
Het |
| Bbs10 |
A |
G |
10: 111,299,761 (GRCm38) |
Y245C |
probably damaging |
Het |
| Cabin1 |
A |
T |
10: 75,684,323 (GRCm38) |
F1572Y |
probably damaging |
Het |
| Cd79a |
A |
G |
7: 24,899,347 (GRCm38) |
N107S |
possibly damaging |
Het |
| Cdc7 |
G |
A |
5: 106,983,059 (GRCm38) |
A428T |
probably benign |
Het |
| Cep290 |
A |
G |
10: 100,523,329 (GRCm38) |
T974A |
probably benign |
Het |
| Cep350 |
A |
T |
1: 155,953,374 (GRCm38) |
N261K |
possibly damaging |
Het |
| Cfap46 |
T |
A |
7: 139,661,085 (GRCm38) |
D8V |
probably damaging |
Het |
| Col6a4 |
T |
C |
9: 106,074,986 (GRCm38) |
D571G |
probably damaging |
Het |
| Cpe |
A |
C |
8: 64,617,611 (GRCm38) |
V200G |
probably benign |
Het |
| Ctnnd1 |
C |
T |
2: 84,613,887 (GRCm38) |
|
probably null |
Het |
| D5Ertd579e |
A |
C |
5: 36,615,577 (GRCm38) |
C491W |
probably damaging |
Het |
| Dek |
A |
G |
13: 47,099,380 (GRCm38) |
I183T |
probably damaging |
Het |
| Dennd1a |
A |
T |
2: 37,852,441 (GRCm38) |
H437Q |
possibly damaging |
Het |
| Dido1 |
C |
T |
2: 180,661,147 (GRCm38) |
A1655T |
probably benign |
Het |
| Eva1b |
A |
G |
4: 126,149,485 (GRCm38) |
D106G |
probably damaging |
Het |
| Evc2 |
G |
T |
5: 37,424,579 (GRCm38) |
S1189I |
possibly damaging |
Het |
| Faap100 |
A |
T |
11: 120,376,732 (GRCm38) |
L405Q |
probably damaging |
Het |
| Fbxw15 |
T |
A |
9: 109,557,166 (GRCm38) |
M249L |
probably benign |
Het |
| Gbp10 |
A |
T |
5: 105,218,460 (GRCm38) |
L526Q |
probably damaging |
Het |
| Gm13084 |
A |
G |
4: 143,816,039 (GRCm38) |
C4R |
probably damaging |
Het |
| Gm14025 |
T |
G |
2: 129,037,799 (GRCm38) |
T736P |
possibly damaging |
Het |
| Gm19402 |
A |
C |
10: 77,690,520 (GRCm38) |
|
probably benign |
Het |
| Gm2244 |
A |
G |
14: 19,540,797 (GRCm38) |
Y141H |
probably damaging |
Het |
| Gm4181 |
A |
T |
14: 51,633,209 (GRCm38) |
N98K |
probably damaging |
Het |
| Gm765 |
T |
C |
6: 98,238,173 (GRCm38) |
D163G |
probably damaging |
Het |
| Golga4 |
C |
T |
9: 118,558,627 (GRCm38) |
R616* |
probably null |
Het |
| Gpank1 |
T |
A |
17: 35,124,290 (GRCm38) |
S226T |
probably damaging |
Het |
| Hipk3 |
T |
C |
2: 104,471,425 (GRCm38) |
M141V |
probably damaging |
Het |
| Hoxc11 |
T |
C |
15: 102,954,743 (GRCm38) |
V73A |
probably benign |
Het |
| Igf1r |
T |
G |
7: 68,004,137 (GRCm38) |
I141S |
possibly damaging |
Het |
| Jak2 |
T |
A |
19: 29,295,659 (GRCm38) |
F628I |
probably benign |
Het |
| Kcp |
C |
A |
6: 29,502,365 (GRCm38) |
V227L |
probably benign |
Het |
| Knl1 |
T |
G |
2: 119,071,941 (GRCm38) |
C1374W |
probably damaging |
Het |
| Larp6 |
A |
T |
9: 60,737,760 (GRCm38) |
R394S |
probably benign |
Het |
| Lilra5 |
G |
A |
7: 4,242,115 (GRCm38) |
G253R |
probably damaging |
Het |
| Map3k4 |
A |
G |
17: 12,264,058 (GRCm38) |
S591P |
probably damaging |
Het |
| Mrpl16 |
T |
A |
19: 11,772,968 (GRCm38) |
I72K |
probably damaging |
Het |
| Nol11 |
C |
G |
11: 107,181,034 (GRCm38) |
R244S |
probably benign |
Het |
| Nr2f1 |
T |
C |
13: 78,195,663 (GRCm38) |
T161A |
probably benign |
Het |
| Nrd1 |
G |
T |
4: 109,038,006 (GRCm38) |
V476F |
probably damaging |
Het |
| Olfr1406 |
G |
T |
1: 173,183,910 (GRCm38) |
H175N |
probably damaging |
Het |
| Olfr419 |
A |
T |
1: 174,250,829 (GRCm38) |
S33T |
possibly damaging |
Het |
| Olfr451-ps1 |
A |
T |
6: 42,800,909 (GRCm38) |
H56L |
probably benign |
Het |
| Olfr535 |
T |
A |
7: 140,492,713 (GRCm38) |
L25Q |
possibly damaging |
Het |
| P2rx1 |
A |
G |
11: 73,008,148 (GRCm38) |
I62V |
probably benign |
Het |
| Pcdhgc5 |
A |
T |
18: 37,820,621 (GRCm38) |
Y316F |
probably benign |
Het |
| Pecam1 |
T |
C |
11: 106,685,239 (GRCm38) |
D490G |
probably benign |
Het |
| Pfkfb2 |
A |
T |
1: 130,707,562 (GRCm38) |
Y87* |
probably null |
Het |
| Poldip2 |
A |
G |
11: 78,517,632 (GRCm38) |
|
probably null |
Het |
| Ppp2r5b |
T |
A |
19: 6,230,536 (GRCm38) |
Q304L |
probably benign |
Het |
| Psg26 |
A |
G |
7: 18,482,828 (GRCm38) |
F29L |
probably benign |
Het |
| Ptk6 |
A |
T |
2: 181,197,093 (GRCm38) |
L289Q |
probably null |
Het |
| Ptprt |
A |
T |
2: 161,901,497 (GRCm38) |
I508N |
possibly damaging |
Het |
| Rasgrp4 |
T |
C |
7: 29,148,383 (GRCm38) |
F406S |
probably damaging |
Het |
| Rspo3 |
A |
G |
10: 29,499,930 (GRCm38) |
|
probably null |
Het |
| Sept8 |
G |
T |
11: 53,534,767 (GRCm38) |
|
probably null |
Het |
| Sirt2 |
A |
C |
7: 28,788,046 (GRCm38) |
T345P |
probably benign |
Het |
| Slc6a20b |
T |
C |
9: 123,609,096 (GRCm38) |
E205G |
possibly damaging |
Het |
| Sqstm1 |
G |
A |
11: 50,202,591 (GRCm38) |
Q327* |
probably null |
Het |
| Susd3 |
T |
A |
13: 49,237,521 (GRCm38) |
S98C |
probably damaging |
Het |
| Tada2b |
G |
A |
5: 36,476,842 (GRCm38) |
R56W |
probably damaging |
Het |
| Tbc1d2 |
A |
T |
4: 46,615,045 (GRCm38) |
V546E |
possibly damaging |
Het |
| Tbx6 |
A |
G |
7: 126,781,568 (GRCm38) |
Q21R |
possibly damaging |
Het |
| Usp24 |
T |
G |
4: 106,374,100 (GRCm38) |
|
probably null |
Het |
| Wdr48 |
C |
T |
9: 119,920,610 (GRCm38) |
T531M |
probably damaging |
Het |
|
| Other mutations in Vmn2r103 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00333:Vmn2r103
|
APN |
17 |
19,793,102 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL00939:Vmn2r103
|
APN |
17 |
19,794,965 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01120:Vmn2r103
|
APN |
17 |
19,792,997 (GRCm38) |
missense |
probably benign |
0.06 |
|
IGL01403:Vmn2r103
|
APN |
17 |
19,792,967 (GRCm38) |
missense |
probably benign |
|
|
IGL01404:Vmn2r103
|
APN |
17 |
19,812,434 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01713:Vmn2r103
|
APN |
17 |
19,794,068 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01802:Vmn2r103
|
APN |
17 |
19,799,208 (GRCm38) |
missense |
probably benign |
|
|
IGL02251:Vmn2r103
|
APN |
17 |
19,793,969 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
IGL02466:Vmn2r103
|
APN |
17 |
19,773,369 (GRCm38) |
missense |
probably benign |
|
|
IGL02555:Vmn2r103
|
APN |
17 |
19,811,611 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02668:Vmn2r103
|
APN |
17 |
19,794,127 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL02715:Vmn2r103
|
APN |
17 |
19,793,956 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL02735:Vmn2r103
|
APN |
17 |
19,812,248 (GRCm38) |
missense |
probably benign |
0.27 |
|
IGL03101:Vmn2r103
|
APN |
17 |
19,773,520 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0003:Vmn2r103
|
UTSW |
17 |
19,811,979 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0052:Vmn2r103
|
UTSW |
17 |
19,811,641 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0375:Vmn2r103
|
UTSW |
17 |
19,793,464 (GRCm38) |
missense |
probably benign |
0.12 |
|
R0375:Vmn2r103
|
UTSW |
17 |
19,792,859 (GRCm38) |
missense |
probably benign |
0.06 |
|
R0755:Vmn2r103
|
UTSW |
17 |
19,773,568 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0837:Vmn2r103
|
UTSW |
17 |
19,793,927 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1345:Vmn2r103
|
UTSW |
17 |
19,794,247 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1396:Vmn2r103
|
UTSW |
17 |
19,792,968 (GRCm38) |
missense |
probably benign |
|
|
R1488:Vmn2r103
|
UTSW |
17 |
19,793,660 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1533:Vmn2r103
|
UTSW |
17 |
19,773,400 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1590:Vmn2r103
|
UTSW |
17 |
19,794,234 (GRCm38) |
missense |
probably benign |
|
|
R1928:Vmn2r103
|
UTSW |
17 |
19,811,767 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R1942:Vmn2r103
|
UTSW |
17 |
19,812,300 (GRCm38) |
missense |
probably benign |
0.02 |
|
R2071:Vmn2r103
|
UTSW |
17 |
19,793,794 (GRCm38) |
missense |
probably benign |
|
|
R2219:Vmn2r103
|
UTSW |
17 |
19,793,647 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2442:Vmn2r103
|
UTSW |
17 |
19,773,531 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2889:Vmn2r103
|
UTSW |
17 |
19,793,600 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3762:Vmn2r103
|
UTSW |
17 |
19,812,149 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4014:Vmn2r103
|
UTSW |
17 |
19,793,604 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R4331:Vmn2r103
|
UTSW |
17 |
19,794,233 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4630:Vmn2r103
|
UTSW |
17 |
19,793,696 (GRCm38) |
missense |
probably benign |
0.04 |
|
R4631:Vmn2r103
|
UTSW |
17 |
19,793,696 (GRCm38) |
missense |
probably benign |
0.04 |
|
R4632:Vmn2r103
|
UTSW |
17 |
19,793,696 (GRCm38) |
missense |
probably benign |
0.04 |
|
R4660:Vmn2r103
|
UTSW |
17 |
19,811,815 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4801:Vmn2r103
|
UTSW |
17 |
19,795,076 (GRCm38) |
missense |
probably benign |
0.06 |
|
R4802:Vmn2r103
|
UTSW |
17 |
19,795,076 (GRCm38) |
missense |
probably benign |
0.06 |
|
R4931:Vmn2r103
|
UTSW |
17 |
19,811,769 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4995:Vmn2r103
|
UTSW |
17 |
19,773,511 (GRCm38) |
missense |
probably benign |
0.14 |
|
R5309:Vmn2r103
|
UTSW |
17 |
19,793,034 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5312:Vmn2r103
|
UTSW |
17 |
19,793,034 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5329:Vmn2r103
|
UTSW |
17 |
19,812,171 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5611:Vmn2r103
|
UTSW |
17 |
19,793,642 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5684:Vmn2r103
|
UTSW |
17 |
19,792,989 (GRCm38) |
missense |
probably benign |
0.02 |
|
R5715:Vmn2r103
|
UTSW |
17 |
19,794,939 (GRCm38) |
missense |
probably benign |
0.17 |
|
R5907:Vmn2r103
|
UTSW |
17 |
19,812,453 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R6029:Vmn2r103
|
UTSW |
17 |
19,794,216 (GRCm38) |
nonsense |
probably null |
|
|
R6114:Vmn2r103
|
UTSW |
17 |
19,812,325 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6292:Vmn2r103
|
UTSW |
17 |
19,793,604 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R6334:Vmn2r103
|
UTSW |
17 |
19,794,082 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R6501:Vmn2r103
|
UTSW |
17 |
19,811,904 (GRCm38) |
missense |
probably benign |
0.29 |
|
R6710:Vmn2r103
|
UTSW |
17 |
19,811,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6774:Vmn2r103
|
UTSW |
17 |
19,773,511 (GRCm38) |
missense |
probably benign |
0.14 |
|
R6981:Vmn2r103
|
UTSW |
17 |
19,793,477 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7768:Vmn2r103
|
UTSW |
17 |
19,812,052 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7816:Vmn2r103
|
UTSW |
17 |
19,794,214 (GRCm38) |
missense |
probably benign |
0.06 |
|
R7885:Vmn2r103
|
UTSW |
17 |
19,793,123 (GRCm38) |
missense |
probably benign |
0.25 |
|
R8002:Vmn2r103
|
UTSW |
17 |
19,799,249 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8031:Vmn2r103
|
UTSW |
17 |
19,793,497 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8140:Vmn2r103
|
UTSW |
17 |
19,811,796 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8186:Vmn2r103
|
UTSW |
17 |
19,811,943 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8559:Vmn2r103
|
UTSW |
17 |
19,812,384 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9413:Vmn2r103
|
UTSW |
17 |
19,811,896 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
R9591:Vmn2r103
|
UTSW |
17 |
19,811,659 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
R9652:Vmn2r103
|
UTSW |
17 |
19,793,765 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9680:Vmn2r103
|
UTSW |
17 |
19,799,263 (GRCm38) |
nonsense |
probably null |
|
|
R9743:Vmn2r103
|
UTSW |
17 |
19,812,213 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r103
|
UTSW |
17 |
19,795,047 (GRCm38) |
missense |
probably benign |
0.08 |
|
| Predicted Primers |
|
| Posted On |
2018-03-15 |
Incidental Mutation