Incidental Mutation 'R6287:Zfp937'
| ID |
508262 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp937
|
| Ensembl Gene |
ENSMUSG00000060336 |
| Gene Name |
zinc finger protein 937 |
| Synonyms |
Gm4979 |
| MMRRC Submission |
044457-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.079)
|
| Stock # |
R6287 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
150059993-150082645 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 150080261 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Leucine
at position 97
(H97L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000073454
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000073782]
|
| AlphaFold |
A2ANU7 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000073782
AA Change: H97L
PolyPhen 2
Score 0.891 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000073454
Gene: ENSMUSG00000060336
AA Change: H97L
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
66 |
8.19e-20 |
SMART |
|
ZnF_C2H2
|
103 |
125 |
1.28e-3 |
SMART |
|
ZnF_C2H2
|
131 |
153 |
2.53e-2 |
SMART |
|
ZnF_C2H2
|
159 |
181 |
9.58e-3 |
SMART |
|
ZnF_C2H2
|
187 |
209 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
215 |
237 |
2.2e-2 |
SMART |
|
ZnF_C2H2
|
243 |
265 |
2.2e-2 |
SMART |
|
ZnF_C2H2
|
271 |
293 |
2.2e-2 |
SMART |
|
ZnF_C2H2
|
299 |
321 |
1.82e-3 |
SMART |
|
ZnF_C2H2
|
327 |
349 |
3.69e-4 |
SMART |
|
ZnF_C2H2
|
355 |
377 |
4.47e-3 |
SMART |
|
ZnF_C2H2
|
383 |
405 |
3.89e-3 |
SMART |
|
ZnF_C2H2
|
411 |
433 |
4.79e-3 |
SMART |
|
ZnF_C2H2
|
439 |
461 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
467 |
490 |
7.26e-3 |
SMART |
|
| Meta Mutation Damage Score |
0.0810 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.6%
- 20x: 96.3%
|
| Validation Efficiency |
94% (34/36) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 35 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adcy7 |
A |
G |
8: 89,037,736 (GRCm39) |
N268S |
possibly damaging |
Het |
| Ahnak |
T |
A |
19: 8,992,367 (GRCm39) |
H4550Q |
probably benign |
Het |
| C330018D20Rik |
A |
C |
18: 57,095,407 (GRCm39) |
|
probably null |
Het |
| Camta2 |
G |
C |
11: 70,572,295 (GRCm39) |
Q310E |
probably damaging |
Het |
| Caskin1 |
A |
T |
17: 24,715,683 (GRCm39) |
K149M |
probably damaging |
Het |
| Chml |
T |
C |
1: 175,514,569 (GRCm39) |
K108E |
probably benign |
Het |
| Ddx60 |
T |
C |
8: 62,403,612 (GRCm39) |
L345P |
probably damaging |
Het |
| Defb6 |
T |
A |
8: 19,278,085 (GRCm39) |
C52* |
probably null |
Het |
| Flii |
A |
T |
11: 60,612,423 (GRCm39) |
I288N |
probably damaging |
Het |
| Fmnl2 |
T |
C |
2: 52,904,860 (GRCm39) |
Y55H |
probably damaging |
Het |
| Galk2 |
A |
T |
2: 125,712,268 (GRCm39) |
|
probably benign |
Het |
| Ift140 |
T |
A |
17: 25,269,408 (GRCm39) |
C688S |
probably benign |
Het |
| Lmln |
T |
C |
16: 32,894,555 (GRCm39) |
|
probably null |
Het |
| Muc16 |
T |
C |
9: 18,570,330 (GRCm39) |
T730A |
unknown |
Het |
| Nup88 |
T |
C |
11: 70,856,581 (GRCm39) |
E184G |
probably benign |
Het |
| Omt2b |
T |
C |
9: 78,235,543 (GRCm39) |
F27L |
possibly damaging |
Het |
| Or10g3 |
A |
T |
14: 52,609,748 (GRCm39) |
V254E |
probably damaging |
Het |
| Or2a7 |
A |
G |
6: 43,151,369 (GRCm39) |
I150V |
probably benign |
Het |
| Or2y13 |
A |
G |
11: 49,415,072 (GRCm39) |
N174S |
probably damaging |
Het |
| Or4a15 |
G |
A |
2: 89,193,363 (GRCm39) |
R137* |
probably null |
Het |
| Or6c69b |
T |
C |
10: 129,627,254 (GRCm39) |
E68G |
probably damaging |
Het |
| Peg10 |
T |
TCCC |
6: 4,756,451 (GRCm39) |
|
probably benign |
Het |
| Pigf |
G |
A |
17: 87,304,967 (GRCm39) |
A192V |
probably damaging |
Het |
| Pikfyve |
T |
C |
1: 65,292,691 (GRCm39) |
|
probably null |
Het |
| Ppat |
A |
T |
5: 77,066,061 (GRCm39) |
Y352* |
probably null |
Het |
| Rapgef6 |
T |
G |
11: 54,517,164 (GRCm39) |
|
probably null |
Het |
| Rrp15 |
A |
T |
1: 186,481,373 (GRCm39) |
S45T |
probably benign |
Het |
| Sap18 |
A |
G |
14: 58,035,771 (GRCm39) |
E30G |
probably damaging |
Het |
| Snx6 |
G |
T |
12: 54,793,813 (GRCm39) |
A284E |
possibly damaging |
Het |
| Tm4sf4 |
T |
A |
3: 57,333,112 (GRCm39) |
I26N |
probably damaging |
Het |
| Traf5 |
A |
G |
1: 191,731,833 (GRCm39) |
L336P |
probably damaging |
Het |
| Ttl |
G |
A |
2: 128,931,041 (GRCm39) |
A335T |
probably damaging |
Het |
| Vmn2r87 |
C |
T |
10: 130,314,291 (GRCm39) |
|
probably null |
Het |
| Zfp74 |
G |
A |
7: 29,635,201 (GRCm39) |
T169I |
probably benign |
Het |
| Zzef1 |
G |
T |
11: 72,813,938 (GRCm39) |
E2842D |
probably damaging |
Het |
|
| Other mutations in Zfp937 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R0350:Zfp937
|
UTSW |
2 |
150,081,222 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0449:Zfp937
|
UTSW |
2 |
150,081,466 (GRCm39) |
missense |
probably benign |
0.13 |
|
R1403:Zfp937
|
UTSW |
2 |
150,080,868 (GRCm39) |
nonsense |
probably null |
|
|
R1403:Zfp937
|
UTSW |
2 |
150,080,868 (GRCm39) |
nonsense |
probably null |
|
|
R1465:Zfp937
|
UTSW |
2 |
150,080,967 (GRCm39) |
nonsense |
probably null |
|
|
R1465:Zfp937
|
UTSW |
2 |
150,080,967 (GRCm39) |
nonsense |
probably null |
|
|
R4510:Zfp937
|
UTSW |
2 |
150,080,431 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4511:Zfp937
|
UTSW |
2 |
150,080,431 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4689:Zfp937
|
UTSW |
2 |
150,078,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5290:Zfp937
|
UTSW |
2 |
150,080,229 (GRCm39) |
nonsense |
probably null |
|
|
R6701:Zfp937
|
UTSW |
2 |
150,081,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6746:Zfp937
|
UTSW |
2 |
150,081,343 (GRCm39) |
nonsense |
probably null |
|
|
R6838:Zfp937
|
UTSW |
2 |
150,081,266 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7162:Zfp937
|
UTSW |
2 |
150,081,439 (GRCm39) |
missense |
probably benign |
0.35 |
|
R7213:Zfp937
|
UTSW |
2 |
150,081,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7441:Zfp937
|
UTSW |
2 |
150,080,630 (GRCm39) |
frame shift |
probably null |
|
|
R7481:Zfp937
|
UTSW |
2 |
150,081,266 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7694:Zfp937
|
UTSW |
2 |
150,081,268 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7856:Zfp937
|
UTSW |
2 |
150,081,467 (GRCm39) |
missense |
probably benign |
0.23 |
|
R7902:Zfp937
|
UTSW |
2 |
150,080,681 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7956:Zfp937
|
UTSW |
2 |
150,081,076 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8058:Zfp937
|
UTSW |
2 |
150,081,421 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8468:Zfp937
|
UTSW |
2 |
150,080,634 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9514:Zfp937
|
UTSW |
2 |
150,080,890 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9617:Zfp937
|
UTSW |
2 |
150,080,452 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0017:Zfp937
|
UTSW |
2 |
150,060,081 (GRCm39) |
splice site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ATCAATGCTCTTACATGACATGCA -3'
(R):5'- GCTTTGCCACATTCATTACAGAC -3'
Sequencing Primer
(F):5'- TAACAGCCCATCATGAAGGTG -3'
(R):5'- TACAGGAGACTAGTTTGACATGC -3'
|
| Posted On |
2018-03-15 |
Incidental Mutation