Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01066:Agrn'

50841

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Agrn

Ensembl Gene

ENSMUSG00000041936

Gene Name

agrin

Synonyms

NMF380, Agrin, nmf380

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.464) question?

Stock #

IGL01066

Quality Score

Status

Chromosome

Chromosomal Location

156165290-156197488 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 156177343 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 497 (S497P)

Ref Sequence

ENSEMBL: ENSMUSP00000137931 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071248] [ENSMUST00000105574] [ENSMUST00000105575] [ENSMUST00000180572]

AlphaFold

A2ASQ1

Predicted Effect

probably benign
Transcript: ENSMUST00000071248
AA Change: S390P

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000071229
Gene: ENSMUSG00000041936
AA Change: S390P

Domain	Start	End	E-Value	Type
transmembrane domain	25	47	N/A	INTRINSIC
FOLN	66	91	8.25e-6	SMART
KAZAL	91	137	1.22e-17	SMART
FOLN	142	166	7.58e-5	SMART
EGF_like	142	181	7.38e1	SMART
KAZAL	166	212	1.51e-13	SMART
KAZAL	241	284	1.8e-6	SMART
KAZAL	310	356	1.55e-10	SMART
FOLN	362	384	8.25e-6	SMART
KAZAL	384	429	1.14e-17	SMART
KAZAL	449	494	6.43e-17	SMART
FOLN	496	519	2.94e-2	SMART
KAZAL	507	559	8.96e-16	SMART
low complexity region	565	572	N/A	INTRINSIC
KAZAL	599	645	1.12e-16	SMART
EGF_Lam	688	739	3.29e-15	SMART
EGF_Lam	742	786	6.7e-7	SMART
FOLN	795	817	1.94e-2	SMART
KAZAL	817	864	3.9e-16	SMART
low complexity region	889	906	N/A	INTRINSIC
low complexity region	949	978	N/A	INTRINSIC
SEA	1014	1139	5.57e-35	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000105574
AA Change: S390P

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000101199
Gene: ENSMUSG00000041936
AA Change: S390P

Domain	Start	End	E-Value	Type
transmembrane domain	25	47	N/A	INTRINSIC
FOLN	66	91	8.25e-6	SMART
KAZAL	91	137	1.22e-17	SMART
FOLN	142	166	7.58e-5	SMART
EGF_like	142	181	7.38e1	SMART
KAZAL	166	212	1.51e-13	SMART
KAZAL	241	284	1.8e-6	SMART
KAZAL	310	356	1.55e-10	SMART
FOLN	362	384	8.25e-6	SMART
KAZAL	384	429	1.14e-17	SMART
KAZAL	449	494	6.43e-17	SMART
FOLN	496	519	2.94e-2	SMART
KAZAL	507	559	8.96e-16	SMART
low complexity region	565	572	N/A	INTRINSIC
KAZAL	599	645	1.12e-16	SMART
EGF_Lam	688	739	3.29e-15	SMART
EGF_Lam	742	786	6.7e-7	SMART
FOLN	795	817	1.94e-2	SMART
KAZAL	817	864	3.9e-16	SMART
low complexity region	889	906	N/A	INTRINSIC
low complexity region	949	978	N/A	INTRINSIC
SEA	1014	1136	2.26e-35	SMART
low complexity region	1142	1169	N/A	INTRINSIC
low complexity region	1183	1198	N/A	INTRINSIC
EGF	1214	1249	1.49e-4	SMART
LamG	1274	1410	4e-45	SMART
EGF	1434	1468	2.23e-3	SMART
EGF	1473	1507	7.13e-2	SMART
LamG	1542	1678	6.51e-36	SMART
EGF	1699	1735	4.35e-6	SMART
LamG	1771	1907	5.01e-37	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000105575
AA Change: S390P

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000101200
Gene: ENSMUSG00000041936
AA Change: S390P

Domain	Start	End	E-Value	Type
transmembrane domain	25	47	N/A	INTRINSIC
FOLN	66	91	8.25e-6	SMART
KAZAL	91	137	1.22e-17	SMART
FOLN	142	166	7.58e-5	SMART
EGF_like	142	181	7.38e1	SMART
KAZAL	166	212	1.51e-13	SMART
KAZAL	241	284	1.8e-6	SMART
KAZAL	310	356	1.55e-10	SMART
FOLN	362	384	8.25e-6	SMART
KAZAL	384	429	1.14e-17	SMART
KAZAL	449	494	6.43e-17	SMART
FOLN	496	519	2.94e-2	SMART
KAZAL	507	559	8.96e-16	SMART
low complexity region	565	572	N/A	INTRINSIC
KAZAL	599	645	1.12e-16	SMART
EGF_Lam	688	739	3.29e-15	SMART
EGF_Lam	742	786	6.7e-7	SMART
FOLN	795	817	1.94e-2	SMART
KAZAL	817	864	3.9e-16	SMART
low complexity region	889	906	N/A	INTRINSIC
low complexity region	949	978	N/A	INTRINSIC
SEA	1014	1136	2.26e-35	SMART
low complexity region	1142	1169	N/A	INTRINSIC
low complexity region	1183	1198	N/A	INTRINSIC
EGF	1214	1249	1.49e-4	SMART
LamG	1274	1410	4e-45	SMART
EGF	1434	1468	2.23e-3	SMART
EGF	1473	1507	7.13e-2	SMART
LamG	1542	1682	9.2e-36	SMART
EGF	1703	1739	4.35e-6	SMART
LamG	1794	1930	5.01e-37	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000144749

Predicted Effect

probably benign
Transcript: ENSMUST00000180572
AA Change: S497P

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000137931
Gene: ENSMUSG00000041936
AA Change: S497P

Domain	Start	End	E-Value	Type
signal peptide	1	31	N/A	INTRINSIC
Pfam:NtA	32	159	5.1e-91	PFAM
FOLN	173	198	8.25e-6	SMART
KAZAL	198	244	1.22e-17	SMART
FOLN	249	273	7.58e-5	SMART
EGF_like	249	288	7.38e1	SMART
KAZAL	273	319	1.51e-13	SMART
KAZAL	348	391	1.8e-6	SMART
KAZAL	417	463	1.55e-10	SMART
FOLN	469	491	8.25e-6	SMART
KAZAL	491	536	1.14e-17	SMART
KAZAL	556	601	6.43e-17	SMART
FOLN	603	626	2.94e-2	SMART
KAZAL	614	666	8.96e-16	SMART
low complexity region	672	679	N/A	INTRINSIC
KAZAL	706	752	1.12e-16	SMART
EGF_Lam	795	846	3.29e-15	SMART
EGF_Lam	849	893	6.7e-7	SMART
FOLN	902	924	1.94e-2	SMART
KAZAL	924	971	3.9e-16	SMART
low complexity region	996	1013	N/A	INTRINSIC
low complexity region	1056	1085	N/A	INTRINSIC
SEA	1121	1243	2.26e-35	SMART
low complexity region	1249	1276	N/A	INTRINSIC
low complexity region	1290	1305	N/A	INTRINSIC
EGF	1321	1356	1.49e-4	SMART
LamG	1381	1517	4e-45	SMART
EGF	1541	1575	2.23e-3	SMART
EGF	1580	1614	7.13e-2	SMART
LamG	1649	1785	6.51e-36	SMART
EGF	1806	1842	4.35e-6	SMART
LamG	1878	2014	5.01e-37	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000181062

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
PHENOTYPE: Nullizygous mice display embryonic failure of NMJ formation, inability to breathe or move and perinatal lethality. Homozygotes for an ENU-induced allele show poor hindlimb motor control, myopathy, muscle atrophy, spasms and fiber-type switching, NMJ disaggregation, camptodactyly and premature death. [provided by MGI curators]

Allele List at MGI

All alleles(12) : Targeted, knock-out(4) Targeted, other(1) Gene trapped(7)

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110038F14Rik	G	A	15: 76,950,275 (GRCm38)	V124I	probably damaging	Het
2300003K06Rik	T	A	11: 99,837,628 (GRCm38)	R130*	probably null	Het
9030624J02Rik	T	A	7: 118,773,011 (GRCm38)		probably null	Het
Abca12	T	A	1: 71,353,730 (GRCm38)	R117W	possibly damaging	Het
Alpk1	A	T	3: 127,680,225 (GRCm38)	S710T	probably benign	Het
Anapc4	T	A	5: 52,857,209 (GRCm38)	N471K	probably benign	Het
Ano3	A	T	2: 110,661,445 (GRCm38)	M879K	probably null	Het
Apoe	A	G	7: 19,696,600 (GRCm38)	L239P	probably damaging	Het
Ash1l	T	C	3: 88,984,635 (GRCm38)	Y1274H	probably damaging	Het
B3glct	C	T	5: 149,709,425 (GRCm38)	T80I	possibly damaging	Het
Casc1	C	T	6: 145,176,222 (GRCm38)	G624S	probably damaging	Het
Ccdc146	T	C	5: 21,319,542 (GRCm38)	T271A	probably benign	Het
Chd8	T	A	14: 52,217,766 (GRCm38)	N1088I	probably damaging	Het
Csnk1g2	T	C	10: 80,634,647 (GRCm38)		probably benign	Het
Daxx	T	A	17: 33,913,893 (GRCm38)	V627D	probably benign	Het
Dpy19l3	A	G	7: 35,692,767 (GRCm38)		probably benign	Het
Enc1	A	G	13: 97,245,314 (GRCm38)	I111V	probably benign	Het
Ep400	A	G	5: 110,668,199 (GRCm38)		probably benign	Het
Fig4	T	C	10: 41,285,417 (GRCm38)		probably benign	Het
Fkbp7	A	T	2: 76,672,908 (GRCm38)	L36*	probably null	Het
Fxn	A	T	19: 24,267,298 (GRCm38)		probably benign	Het
Gm10152	C	T	7: 144,763,256 (GRCm38)	P16L	unknown	Het
Hivep2	T	C	10: 14,149,024 (GRCm38)	V2194A	possibly damaging	Het
Hook3	T	G	8: 26,048,298 (GRCm38)	E525A	probably damaging	Het
Icam1	A	G	9: 21,016,105 (GRCm38)		probably null	Het
Ifngr1	C	T	10: 19,609,198 (GRCm38)	T315I	probably damaging	Het
Igsf10	A	G	3: 59,327,782 (GRCm38)		probably null	Het
Krt87	A	G	15: 101,438,385 (GRCm38)		probably null	Het
Lama1	T	A	17: 67,743,326 (GRCm38)	C311S	probably damaging	Het
Lig3	T	A	11: 82,797,315 (GRCm38)	M714K	possibly damaging	Het
Lrmp	T	C	6: 145,160,955 (GRCm38)	S222P	probably damaging	Het
Lypd5	C	T	7: 24,353,485 (GRCm38)	T189I	probably benign	Het
Mapk8ip3	C	T	17: 24,901,718 (GRCm38)	G807D	probably benign	Het
Met	T	C	6: 17,535,105 (GRCm38)		probably null	Het
Nlrp4g	C	A	9: 124,349,526 (GRCm38)		noncoding transcript	Het
Nlrp6	T	A	7: 140,921,796 (GRCm38)	V62D	possibly damaging	Het
Nme7	A	G	1: 164,345,430 (GRCm38)		probably null	Het
Olfr1034	A	G	2: 86,047,258 (GRCm38)	R259G	probably damaging	Het
Olfr1392	T	C	11: 49,293,630 (GRCm38)	I103T	possibly damaging	Het
Olfr507	T	C	7: 108,621,857 (GRCm38)	F15S	probably damaging	Het
Pcnx	G	A	12: 81,992,021 (GRCm38)	R2020Q	possibly damaging	Het
Pdzd2	T	A	15: 12,402,632 (GRCm38)		probably benign	Het
Pi4ka	A	G	16: 17,348,773 (GRCm38)		probably benign	Het
Pkdrej	T	G	15: 85,816,159 (GRCm38)	I1859L	probably benign	Het
Plcg1	A	T	2: 160,754,398 (GRCm38)	H638L	probably damaging	Het
Polr1b	C	T	2: 129,119,152 (GRCm38)	S677L	probably damaging	Het
Ppef2	A	G	5: 92,234,237 (GRCm38)	L533P	probably damaging	Het
Sh3rf1	T	A	8: 61,329,336 (GRCm38)	W171R	probably damaging	Het
Son	T	C	16: 91,660,136 (GRCm38)		probably benign	Het
Sycp1	A	G	3: 102,920,634 (GRCm38)	S266P	probably damaging	Het
Tedc1	A	G	12: 113,163,150 (GRCm38)	E344G	probably damaging	Het
Tkfc	T	C	19: 10,594,528 (GRCm38)	I381M	probably benign	Het
Tmprss6	T	C	15: 78,442,434 (GRCm38)	D1G	probably null	Het
Ttn	T	C	2: 76,752,426 (GRCm38)	T22708A	probably damaging	Het
Ubtf	T	C	11: 102,308,884 (GRCm38)		probably benign	Het
Vwc2l	T	C	1: 70,728,911 (GRCm38)	F45L	probably damaging	Het
Xpo7	T	C	14: 70,701,755 (GRCm38)	T154A	probably benign	Het
Yars2	C	T	16: 16,306,542 (GRCm38)	R338*	probably null	Het

Other mutations in Agrn

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00479:Agrn	APN	4	156,170,572 (GRCm38)	splice site	probably benign
IGL00811:Agrn	APN	4	156,168,774 (GRCm38)	missense	possibly damaging	0.70
IGL01412:Agrn	APN	4	156,171,034 (GRCm38)	splice site	probably benign
IGL01414:Agrn	APN	4	156,195,239 (GRCm38)	splice site	probably null
IGL02075:Agrn	APN	4	156,170,210 (GRCm38)	missense	probably benign	0.40
IGL02609:Agrn	APN	4	156,175,223 (GRCm38)	splice site	probably benign
IGL02669:Agrn	APN	4	156,174,561 (GRCm38)	splice site	probably benign
IGL02671:Agrn	APN	4	156,174,561 (GRCm38)	splice site	probably benign
IGL02672:Agrn	APN	4	156,174,561 (GRCm38)	splice site	probably benign
IGL02674:Agrn	APN	4	156,174,561 (GRCm38)	splice site	probably benign
IGL02724:Agrn	APN	4	156,172,807 (GRCm38)	nonsense	probably null
IGL02804:Agrn	APN	4	156,174,055 (GRCm38)	missense	probably benign	0.00
IGL02986:Agrn	APN	4	156,178,854 (GRCm38)	missense	possibly damaging	0.84
IGL03160:Agrn	APN	4	156,170,363 (GRCm38)	missense	probably damaging	0.98
BB004:Agrn	UTSW	4	156,172,809 (GRCm38)	missense	probably damaging	0.99
BB014:Agrn	UTSW	4	156,172,809 (GRCm38)	missense	probably damaging	0.99
F6893:Agrn	UTSW	4	156,174,179 (GRCm38)	missense	probably benign
R0092:Agrn	UTSW	4	156,178,953 (GRCm38)	missense	probably damaging	1.00
R0100:Agrn	UTSW	4	156,174,958 (GRCm38)	missense	probably damaging	1.00
R0100:Agrn	UTSW	4	156,174,958 (GRCm38)	missense	probably damaging	1.00
R0482:Agrn	UTSW	4	156,173,555 (GRCm38)	missense	probably damaging	0.98
R0531:Agrn	UTSW	4	156,179,434 (GRCm38)	missense	probably benign	0.38
R0536:Agrn	UTSW	4	156,179,553 (GRCm38)	missense	probably benign	0.01
R0690:Agrn	UTSW	4	156,174,453 (GRCm38)	missense	probably damaging	1.00
R0750:Agrn	UTSW	4	156,166,937 (GRCm38)	nonsense	probably null
R1079:Agrn	UTSW	4	156,177,225 (GRCm38)	missense	probably damaging	1.00
R1199:Agrn	UTSW	4	156,172,299 (GRCm38)	missense	probably benign	0.00
R1222:Agrn	UTSW	4	156,177,385 (GRCm38)	missense	probably damaging	0.99
R1534:Agrn	UTSW	4	156,176,684 (GRCm38)	missense	probably damaging	1.00
R1587:Agrn	UTSW	4	156,179,440 (GRCm38)	missense	probably damaging	0.99
R1625:Agrn	UTSW	4	156,172,860 (GRCm38)	missense	probably damaging	1.00
R1698:Agrn	UTSW	4	156,166,558 (GRCm38)	missense	probably benign	0.03
R1717:Agrn	UTSW	4	156,166,519 (GRCm38)	frame shift	probably null
R1718:Agrn	UTSW	4	156,166,519 (GRCm38)	frame shift	probably null
R1721:Agrn	UTSW	4	156,175,173 (GRCm38)	nonsense	probably null
R1765:Agrn	UTSW	4	156,176,827 (GRCm38)	nonsense	probably null
R1840:Agrn	UTSW	4	156,167,415 (GRCm38)	missense	probably damaging	1.00
R1865:Agrn	UTSW	4	156,166,519 (GRCm38)	frame shift	probably null
R2105:Agrn	UTSW	4	156,177,299 (GRCm38)	nonsense	probably null
R2265:Agrn	UTSW	4	156,179,218 (GRCm38)	missense	probably damaging	0.99
R2266:Agrn	UTSW	4	156,179,218 (GRCm38)	missense	probably damaging	0.99
R2269:Agrn	UTSW	4	156,179,218 (GRCm38)	missense	probably damaging	0.99
R2382:Agrn	UTSW	4	156,176,516 (GRCm38)	missense	probably damaging	0.97
R2497:Agrn	UTSW	4	156,173,811 (GRCm38)	missense	probably benign	0.28
R2509:Agrn	UTSW	4	156,166,424 (GRCm38)	splice site	probably null
R2510:Agrn	UTSW	4	156,166,424 (GRCm38)	splice site	probably null
R2511:Agrn	UTSW	4	156,166,424 (GRCm38)	splice site	probably null
R2994:Agrn	UTSW	4	156,167,328 (GRCm38)	missense	possibly damaging	0.79
R3824:Agrn	UTSW	4	156,169,302 (GRCm38)	missense	probably damaging	1.00
R4736:Agrn	UTSW	4	156,172,401 (GRCm38)	missense	probably benign	0.38
R4755:Agrn	UTSW	4	156,173,522 (GRCm38)	intron	probably benign
R4853:Agrn	UTSW	4	156,185,550 (GRCm38)	critical splice donor site	probably null
R4878:Agrn	UTSW	4	156,170,845 (GRCm38)	missense	probably damaging	1.00
R5117:Agrn	UTSW	4	156,185,553 (GRCm38)	missense	probably benign	0.30
R5228:Agrn	UTSW	4	156,166,946 (GRCm38)	missense	probably damaging	1.00
R5236:Agrn	UTSW	4	156,178,858 (GRCm38)	missense	possibly damaging	0.93
R5269:Agrn	UTSW	4	156,168,990 (GRCm38)	missense	probably benign	0.10
R5282:Agrn	UTSW	4	156,173,035 (GRCm38)	missense	probably damaging	1.00
R5449:Agrn	UTSW	4	156,167,280 (GRCm38)	critical splice donor site	probably null
R5560:Agrn	UTSW	4	156,178,497 (GRCm38)	missense	probably damaging	0.99
R5668:Agrn	UTSW	4	156,167,313 (GRCm38)	missense	probably damaging	0.97
R5725:Agrn	UTSW	4	156,173,875 (GRCm38)	missense	probably benign	0.25
R5967:Agrn	UTSW	4	156,175,103 (GRCm38)	missense	probably damaging	1.00
R6226:Agrn	UTSW	4	156,173,609 (GRCm38)	missense	probably damaging	0.96
R6338:Agrn	UTSW	4	156,170,585 (GRCm38)	missense	probably benign	0.17
R6351:Agrn	UTSW	4	156,179,434 (GRCm38)	missense	probably benign	0.00
R6437:Agrn	UTSW	4	156,176,778 (GRCm38)	missense	probably damaging	0.96
R6490:Agrn	UTSW	4	156,167,362 (GRCm38)	nonsense	probably null
R6909:Agrn	UTSW	4	156,177,007 (GRCm38)	missense	possibly damaging	0.90
R7110:Agrn	UTSW	4	156,178,875 (GRCm38)	missense	possibly damaging	0.88
R7123:Agrn	UTSW	4	156,172,840 (GRCm38)	missense	probably benign
R7163:Agrn	UTSW	4	156,178,509 (GRCm38)	missense	probably damaging	1.00
R7180:Agrn	UTSW	4	156,171,839 (GRCm38)	missense	probably benign	0.00
R7251:Agrn	UTSW	4	156,174,606 (GRCm38)	missense	probably damaging	1.00
R7289:Agrn	UTSW	4	156,178,932 (GRCm38)	missense	probably damaging	1.00
R7335:Agrn	UTSW	4	156,176,532 (GRCm38)	missense	probably damaging	1.00
R7336:Agrn	UTSW	4	156,174,914 (GRCm38)	nonsense	probably null
R7406:Agrn	UTSW	4	156,172,301 (GRCm38)	missense	possibly damaging	0.93
R7460:Agrn	UTSW	4	156,174,424 (GRCm38)	missense	probably damaging	0.98
R7531:Agrn	UTSW	4	156,169,804 (GRCm38)	missense	probably damaging	1.00
R7585:Agrn	UTSW	4	156,170,674 (GRCm38)	missense	probably benign	0.08
R7646:Agrn	UTSW	4	156,195,354 (GRCm38)	missense	probably damaging	0.99
R7652:Agrn	UTSW	4	156,169,218 (GRCm38)	critical splice donor site	probably null
R7714:Agrn	UTSW	4	156,195,397 (GRCm38)	missense	probably damaging	1.00
R7751:Agrn	UTSW	4	156,176,429 (GRCm38)	missense	probably damaging	1.00
R7852:Agrn	UTSW	4	156,169,057 (GRCm38)	missense	probably benign	0.01
R7927:Agrn	UTSW	4	156,172,809 (GRCm38)	missense	probably damaging	0.99
R8039:Agrn	UTSW	4	156,169,011 (GRCm38)	missense	probably benign	0.12
R8056:Agrn	UTSW	4	156,170,411 (GRCm38)	missense	probably benign
R8061:Agrn	UTSW	4	156,178,954 (GRCm38)	missense	probably damaging	1.00
R8158:Agrn	UTSW	4	156,173,889 (GRCm38)	missense	probably benign
R8159:Agrn	UTSW	4	156,172,368 (GRCm38)	missense	probably benign	0.27
R8325:Agrn	UTSW	4	156,173,662 (GRCm38)	missense	probably benign	0.01
R8338:Agrn	UTSW	4	156,168,561 (GRCm38)	missense	probably benign	0.01
R8739:Agrn	UTSW	4	156,172,588 (GRCm38)	missense	probably benign
R8956:Agrn	UTSW	4	156,166,538 (GRCm38)	missense	probably damaging	0.99
R9094:Agrn	UTSW	4	156,168,807 (GRCm38)	missense	probably benign	0.01
R9112:Agrn	UTSW	4	156,177,057 (GRCm38)	missense	probably damaging	1.00
R9384:Agrn	UTSW	4	156,172,649 (GRCm38)	missense	probably damaging	1.00
R9472:Agrn	UTSW	4	156,170,384 (GRCm38)	missense
R9619:Agrn	UTSW	4	156,174,033 (GRCm38)	missense	probably benign	0.00
R9629:Agrn	UTSW	4	156,172,637 (GRCm38)	nonsense	probably null
R9732:Agrn	UTSW	4	156,173,989 (GRCm38)	missense	probably benign	0.13
R9749:Agrn	UTSW	4	156,173,657 (GRCm38)	missense	probably benign	0.02
R9757:Agrn	UTSW	4	156,176,778 (GRCm38)	missense	probably benign	0.03
R9792:Agrn	UTSW	4	156,176,672 (GRCm38)	missense	probably benign	0.09
R9793:Agrn	UTSW	4	156,176,672 (GRCm38)	missense	probably benign	0.09
Z1177:Agrn	UTSW	4	156,179,576 (GRCm38)	missense	possibly damaging	0.95
Z1177:Agrn	UTSW	4	156,171,544 (GRCm38)	nonsense	probably null

Posted On

2013-06-21