Incidental Mutation 'IGL01080:Zyg11b'
ID50864
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zyg11b
Ensembl Gene ENSMUSG00000034636
Gene Namezyg-ll family member B, cell cycle regulator
Synonyms1110046I03Rik, LOC242610, 2810482G21Rik, D4Mgi23
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.612) question?
Stock #IGL01080
Quality Score
Status
Chromosome4
Chromosomal Location108229724-108301096 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 108237416 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Glutamine at position 657 (L657Q)
Ref Sequence ENSEMBL: ENSMUSP00000043844 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043616]
Predicted Effect probably damaging
Transcript: ENSMUST00000043616
AA Change: L657Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000043844
Gene: ENSMUSG00000034636
AA Change: L657Q

DomainStartEndE-ValueType
SCOP:d1jdha_ 370 722 3e-16 SMART
Blast:ARM 480 526 1e-17 BLAST
Blast:ARM 528 570 3e-19 BLAST
Blast:ARM 638 679 3e-10 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130508
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb4 A T 5: 8,934,258 R663W probably damaging Het
Cacng5 A T 11: 107,877,928 F179L probably damaging Het
Cacng5 C T 11: 107,881,705 V106I probably benign Het
Cd96 T C 16: 46,049,693 E471G possibly damaging Het
Cpt1c T C 7: 44,960,909 D621G probably damaging Het
Csmd3 T C 15: 47,881,403 I1503V probably benign Het
Dmgdh T C 13: 93,703,778 probably benign Het
Flg A T 3: 93,279,599 K119N probably benign Het
Gale T C 4: 135,966,078 Y104H probably damaging Het
Gm8005 T C 14: 42,437,014 D119G unknown Het
Gstk1 A T 6: 42,246,626 D50V possibly damaging Het
Kmt2a T C 9: 44,809,092 D3866G unknown Het
Mastl A G 2: 23,146,148 S119P probably damaging Het
Olfr169 A T 16: 19,566,208 V225E probably damaging Het
Phf11c G A 14: 59,393,199 T19I probably benign Het
Ppp1r16b A G 2: 158,757,172 T355A probably damaging Het
Prmt7 T G 8: 106,237,214 probably benign Het
Rad50 T C 11: 53,706,068 T44A probably damaging Het
Rangap1 C T 15: 81,705,752 probably benign Het
Slc27a3 A T 3: 90,385,460 V634E probably benign Het
Tbxas1 T A 6: 39,021,181 L228I probably damaging Het
Tnfaip3 T C 10: 19,011,655 K41E probably benign Het
Tti1 C T 2: 157,982,459 V1025I probably damaging Het
Tyrobp T C 7: 30,417,416 probably null Het
Wfdc16 A T 2: 164,638,486 W30R probably damaging Het
Other mutations in Zyg11b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01143:Zyg11b APN 4 108244994 missense possibly damaging 0.69
IGL01627:Zyg11b APN 4 108250788 missense probably benign 0.19
IGL02517:Zyg11b APN 4 108266318 missense probably damaging 0.96
IGL03166:Zyg11b APN 4 108265889 missense probably benign 0.32
arch UTSW 4 108237380 nonsense probably null
R0326:Zyg11b UTSW 4 108272253 missense possibly damaging 0.77
R0345:Zyg11b UTSW 4 108266407 missense probably damaging 1.00
R0396:Zyg11b UTSW 4 108255308 missense probably damaging 1.00
R0571:Zyg11b UTSW 4 108260042 missense probably damaging 1.00
R0718:Zyg11b UTSW 4 108242076 missense possibly damaging 0.94
R1426:Zyg11b UTSW 4 108250812 missense probably damaging 1.00
R1495:Zyg11b UTSW 4 108266213 missense probably damaging 1.00
R1829:Zyg11b UTSW 4 108266093 missense possibly damaging 0.65
R1907:Zyg11b UTSW 4 108255226 missense probably damaging 1.00
R1916:Zyg11b UTSW 4 108272283 missense probably damaging 0.99
R1980:Zyg11b UTSW 4 108265930 missense probably damaging 0.99
R2070:Zyg11b UTSW 4 108250819 missense possibly damaging 0.73
R2495:Zyg11b UTSW 4 108244724 critical splice donor site probably null
R4717:Zyg11b UTSW 4 108241872 missense probably damaging 0.99
R5889:Zyg11b UTSW 4 108237380 nonsense probably null
R5957:Zyg11b UTSW 4 108245013 missense probably damaging 1.00
R6606:Zyg11b UTSW 4 108236089 missense probably benign 0.00
R7151:Zyg11b UTSW 4 108244922 missense possibly damaging 0.49
R7316:Zyg11b UTSW 4 108250502 missense possibly damaging 0.81
R7488:Zyg11b UTSW 4 108266458 missense possibly damaging 0.65
X0022:Zyg11b UTSW 4 108236101 missense probably benign
X0067:Zyg11b UTSW 4 108255346 missense probably benign
Z1177:Zyg11b UTSW 4 108255364 missense probably damaging 1.00
Posted On2013-06-21