Incidental Mutation 'R6296:Adgra3'
ID 508756
Institutional Source Beutler Lab
Gene Symbol Adgra3
Ensembl Gene ENSMUSG00000029090
Gene Name adhesion G protein-coupled receptor A3
Synonyms Tem5-like, 3830613O22Rik, Gpr125
MMRRC Submission 044407-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6296 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 50117293-50216338 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 50118189 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Serine at position 1120 (P1120S)
Ref Sequence ENSEMBL: ENSMUSP00000030971 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030971]
AlphaFold Q7TT36
Predicted Effect probably benign
Transcript: ENSMUST00000030971
AA Change: P1120S

PolyPhen 2 Score 0.211 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000030971
Gene: ENSMUSG00000029090
AA Change: P1120S

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
low complexity region 36 48 N/A INTRINSIC
LRR 68 92 1.71e1 SMART
LRR_TYP 93 116 2.27e-4 SMART
LRR_TYP 117 140 4.11e-2 SMART
LRR_TYP 141 164 3.89e-3 SMART
LRRCT 176 225 5.24e-5 SMART
IG 238 331 8.26e-5 SMART
GPS 686 738 4.81e-3 SMART
Pfam:7tm_2 746 1031 1.6e-16 PFAM
low complexity region 1251 1262 N/A INTRINSIC
Meta Mutation Damage Score 0.0708 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the G protein-coupled receptor superfamily. This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. This gene is mapped to a candidate region of chromosome 4 which may be associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2012]
PHENOTYPE: Homozygous mutant mice are fertile and grossly normal. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 82 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933427D14Rik T C 11: 72,086,580 (GRCm39) K277R probably damaging Het
Aatf T C 11: 84,363,926 (GRCm39) Y267C probably benign Het
Adcy5 A G 16: 35,124,080 (GRCm39) Y1253C probably damaging Het
Adm A G 7: 110,227,561 (GRCm39) T26A probably benign Het
Ahnak T G 19: 8,980,669 (GRCm39) V651G probably damaging Het
Akr7a5 G A 4: 139,045,532 (GRCm39) V358I probably benign Het
Ankar T G 1: 72,682,417 (GRCm39) T1383P probably damaging Het
Bpifb6 G C 2: 153,748,812 (GRCm39) K269N possibly damaging Het
Cacna1c T C 6: 118,575,684 (GRCm39) E1927G possibly damaging Het
Cacna1c T A 6: 118,629,675 (GRCm39) T1249S probably benign Het
Cacna1h G A 17: 25,602,053 (GRCm39) R1596C probably damaging Het
Cbll1 A G 12: 31,537,507 (GRCm39) V415A probably benign Het
Cd300lf C T 11: 115,015,195 (GRCm39) V132I probably benign Het
Cfap54 T C 10: 92,902,708 (GRCm39) Y148C probably damaging Het
Coa5 A G 1: 37,467,428 (GRCm39) S60P probably damaging Het
Col6a2 T C 10: 76,446,883 (GRCm39) N342D probably damaging Het
Cyp2c29 T G 19: 39,318,705 (GRCm39) I434S possibly damaging Het
Ddx11 G A 17: 66,457,724 (GRCm39) probably null Het
Dgke C T 11: 88,931,575 (GRCm39) V560I probably benign Het
Dusp16 C A 6: 134,697,456 (GRCm39) probably null Het
Enpp4 G T 17: 44,413,371 (GRCm39) N54K probably benign Het
Epn1 G A 7: 5,093,122 (GRCm39) A145T probably damaging Het
Erc2 A T 14: 27,802,112 (GRCm39) K764M probably damaging Het
Ercc6 G T 14: 32,248,360 (GRCm39) E304* probably null Het
Fam117a T A 11: 95,254,971 (GRCm39) C115S possibly damaging Het
Galntl5 T C 5: 25,391,163 (GRCm39) S21P probably benign Het
Gm6358 T C 16: 88,937,970 (GRCm39) S70P unknown Het
Grip1 C T 10: 119,911,369 (GRCm39) Q696* probably null Het
Haus5 C T 7: 30,358,401 (GRCm39) W298* probably null Het
Hsfy2 T A 1: 56,676,351 (GRCm39) H62L probably benign Het
Ighm T C 12: 113,385,187 (GRCm39) I258V unknown Het
Igkv13-71-1 G T 6: 69,212,783 (GRCm39) noncoding transcript Het
Inava C T 1: 136,148,809 (GRCm39) probably null Het
Irx1 A C 13: 72,107,787 (GRCm39) S298R probably damaging Het
Jarid2 T A 13: 45,056,539 (GRCm39) Y443N possibly damaging Het
Kcnc1 G A 7: 46,084,740 (GRCm39) A555T probably benign Het
Krtap4-6 T A 11: 99,556,245 (GRCm39) R161* probably null Het
Lipo3 T C 19: 33,757,737 (GRCm39) D244G probably benign Het
Lmo2 T G 2: 103,800,946 (GRCm39) V39G possibly damaging Het
Lrch2 C T X: 146,263,553 (GRCm39) A369T probably damaging Homo
Macf1 A T 4: 123,326,668 (GRCm39) I4943N probably damaging Het
Mkx A T 18: 7,000,591 (GRCm39) probably null Het
Nek1 C T 8: 61,525,343 (GRCm39) Q594* probably null Het
Nipbl T C 15: 8,330,379 (GRCm39) M2349V possibly damaging Het
Nup155 T A 15: 8,182,639 (GRCm39) C1201S probably damaging Het
Or2y8 C A 11: 52,035,423 (GRCm39) R311S probably benign Het
Or4a76 G A 2: 89,460,975 (GRCm39) T89I probably damaging Het
Or5ac25 T C 16: 59,181,769 (GRCm39) K271E probably benign Het
Osbpl1a A G 18: 12,952,560 (GRCm39) probably null Het
Pbx1 T C 1: 168,011,184 (GRCm39) D372G possibly damaging Het
Pikfyve T A 1: 65,302,112 (GRCm39) S1668T probably damaging Het
Pitpnc1 T C 11: 107,117,092 (GRCm39) H193R probably damaging Het
Plag1 G T 4: 3,904,499 (GRCm39) H231N probably damaging Het
Prmt8 A G 6: 127,688,767 (GRCm39) I201T probably damaging Het
Ptpn23 A T 9: 110,222,894 (GRCm39) N54K probably damaging Het
Rab11fip4 T C 11: 79,581,655 (GRCm39) probably null Het
Rassf9 T A 10: 102,381,614 (GRCm39) I332N probably damaging Het
Rgs9 T C 11: 109,159,813 (GRCm39) N173S probably benign Het
Rhbdl1 A G 17: 26,053,943 (GRCm39) L309P probably damaging Het
Rnf214 A G 9: 45,779,119 (GRCm39) S389P probably benign Het
Rxfp1 A C 3: 79,575,155 (GRCm39) L181R probably damaging Het
Sfxn1 C T 13: 54,247,899 (GRCm39) T208I probably benign Het
Sgo2b C T 8: 64,380,827 (GRCm39) M668I probably benign Het
Sh3bp4 C A 1: 89,073,211 (GRCm39) S686R probably damaging Het
Spata31d1d G A 13: 59,876,278 (GRCm39) T419I possibly damaging Het
Spata31d1e T C 13: 59,890,497 (GRCm39) D441G probably benign Het
Spink5 T C 18: 44,147,824 (GRCm39) S857P probably damaging Het
Stard13 A T 5: 150,986,138 (GRCm39) S339R probably damaging Het
Stk35 T A 2: 129,652,808 (GRCm39) Y436* probably null Het
Supt6 C T 11: 78,116,885 (GRCm39) R589Q possibly damaging Het
Tinag T A 9: 76,904,217 (GRCm39) E402V possibly damaging Het
Tmem183a T C 1: 134,289,349 (GRCm39) D27G probably damaging Het
Tnfrsf13c T C 15: 82,108,103 (GRCm39) T56A probably damaging Het
Tnrc18 A C 5: 142,719,331 (GRCm39) L1985R unknown Het
Ttn G A 2: 76,579,673 (GRCm39) T23740M probably damaging Het
Ufl1 G T 4: 25,270,572 (GRCm39) Q215K probably benign Het
Unkl T C 17: 25,450,839 (GRCm39) *232R probably null Het
Wnk4 A T 11: 101,164,824 (GRCm39) N718Y probably damaging Het
Xkr4 T C 1: 3,286,793 (GRCm39) T466A probably benign Het
Zfp451 T A 1: 33,808,898 (GRCm39) K988* probably null Het
Zfp503 G C 14: 22,035,868 (GRCm39) Y349* probably null Het
Zfp990 T A 4: 145,264,673 (GRCm39) F557Y possibly damaging Het
Other mutations in Adgra3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00777:Adgra3 APN 5 50,183,100 (GRCm39) missense probably damaging 1.00
IGL00848:Adgra3 APN 5 50,159,291 (GRCm39) missense probably damaging 1.00
IGL01455:Adgra3 APN 5 50,144,899 (GRCm39) nonsense probably null
IGL01665:Adgra3 APN 5 50,164,272 (GRCm39) missense possibly damaging 0.64
IGL02151:Adgra3 APN 5 50,136,484 (GRCm39) missense probably benign
IGL02239:Adgra3 APN 5 50,118,054 (GRCm39) missense probably damaging 1.00
IGL02351:Adgra3 APN 5 50,215,900 (GRCm39) missense probably benign 0.19
IGL02358:Adgra3 APN 5 50,215,900 (GRCm39) missense probably benign 0.19
IGL02938:Adgra3 APN 5 50,118,659 (GRCm39) missense probably benign 0.01
IGL03028:Adgra3 APN 5 50,174,194 (GRCm39) missense probably benign 0.30
aperture UTSW 5 50,156,487 (GRCm39) nonsense probably null
saltatory UTSW 5 50,117,901 (GRCm39) missense probably benign 0.09
ANU74:Adgra3 UTSW 5 50,118,380 (GRCm39) missense probably benign 0.16
R0041:Adgra3 UTSW 5 50,117,901 (GRCm39) missense probably benign 0.09
R0041:Adgra3 UTSW 5 50,117,901 (GRCm39) missense probably benign 0.09
R0121:Adgra3 UTSW 5 50,183,128 (GRCm39) splice site probably benign
R0125:Adgra3 UTSW 5 50,159,194 (GRCm39) splice site probably benign
R0137:Adgra3 UTSW 5 50,121,182 (GRCm39) splice site probably benign
R0415:Adgra3 UTSW 5 50,119,099 (GRCm39) splice site probably benign
R0479:Adgra3 UTSW 5 50,147,607 (GRCm39) missense probably benign 0.00
R0505:Adgra3 UTSW 5 50,166,676 (GRCm39) critical splice donor site probably null
R0831:Adgra3 UTSW 5 50,128,144 (GRCm39) missense probably damaging 1.00
R0883:Adgra3 UTSW 5 50,118,065 (GRCm39) missense probably damaging 1.00
R0920:Adgra3 UTSW 5 50,118,503 (GRCm39) missense probably benign 0.19
R1139:Adgra3 UTSW 5 50,119,097 (GRCm39) splice site probably null
R1211:Adgra3 UTSW 5 50,164,218 (GRCm39) missense possibly damaging 0.88
R1370:Adgra3 UTSW 5 50,118,129 (GRCm39) missense possibly damaging 0.56
R1530:Adgra3 UTSW 5 50,118,479 (GRCm39) missense probably benign 0.00
R1703:Adgra3 UTSW 5 50,164,117 (GRCm39) missense probably benign 0.00
R1782:Adgra3 UTSW 5 50,129,404 (GRCm39) missense probably benign 0.02
R1843:Adgra3 UTSW 5 50,118,834 (GRCm39) missense probably damaging 1.00
R2157:Adgra3 UTSW 5 50,159,283 (GRCm39) missense possibly damaging 0.87
R2281:Adgra3 UTSW 5 50,159,222 (GRCm39) missense probably benign 0.04
R2385:Adgra3 UTSW 5 50,136,908 (GRCm39) missense possibly damaging 0.95
R2426:Adgra3 UTSW 5 50,166,791 (GRCm39) missense possibly damaging 0.61
R3084:Adgra3 UTSW 5 50,170,733 (GRCm39) critical splice donor site probably null
R3086:Adgra3 UTSW 5 50,170,733 (GRCm39) critical splice donor site probably null
R3409:Adgra3 UTSW 5 50,159,272 (GRCm39) missense probably damaging 1.00
R3410:Adgra3 UTSW 5 50,159,272 (GRCm39) missense probably damaging 1.00
R3411:Adgra3 UTSW 5 50,159,272 (GRCm39) missense probably damaging 1.00
R4301:Adgra3 UTSW 5 50,118,420 (GRCm39) missense possibly damaging 0.94
R4360:Adgra3 UTSW 5 50,147,552 (GRCm39) missense possibly damaging 0.92
R4475:Adgra3 UTSW 5 50,159,240 (GRCm39) missense probably damaging 1.00
R4569:Adgra3 UTSW 5 50,117,905 (GRCm39) missense probably damaging 1.00
R4607:Adgra3 UTSW 5 50,128,081 (GRCm39) missense probably damaging 0.98
R4667:Adgra3 UTSW 5 50,136,298 (GRCm39) missense possibly damaging 0.94
R4671:Adgra3 UTSW 5 50,136,710 (GRCm39) missense probably damaging 1.00
R4886:Adgra3 UTSW 5 50,156,537 (GRCm39) missense probably benign 0.07
R5197:Adgra3 UTSW 5 50,118,096 (GRCm39) missense probably benign 0.01
R5208:Adgra3 UTSW 5 50,168,857 (GRCm39) missense probably damaging 0.99
R5313:Adgra3 UTSW 5 50,118,651 (GRCm39) missense probably benign 0.24
R5435:Adgra3 UTSW 5 50,147,468 (GRCm39) missense probably damaging 0.99
R5663:Adgra3 UTSW 5 50,156,627 (GRCm39) missense probably benign 0.14
R6038:Adgra3 UTSW 5 50,156,487 (GRCm39) nonsense probably null
R6038:Adgra3 UTSW 5 50,156,487 (GRCm39) nonsense probably null
R6064:Adgra3 UTSW 5 50,117,667 (GRCm39) missense probably damaging 0.97
R6259:Adgra3 UTSW 5 50,156,483 (GRCm39) missense possibly damaging 0.63
R6272:Adgra3 UTSW 5 50,166,791 (GRCm39) missense possibly damaging 0.61
R6293:Adgra3 UTSW 5 50,118,189 (GRCm39) missense probably benign 0.21
R6297:Adgra3 UTSW 5 50,118,189 (GRCm39) missense probably benign 0.21
R6352:Adgra3 UTSW 5 50,147,592 (GRCm39) missense probably benign 0.01
R6352:Adgra3 UTSW 5 50,136,478 (GRCm39) missense probably benign
R6989:Adgra3 UTSW 5 50,164,226 (GRCm39) missense probably damaging 1.00
R7026:Adgra3 UTSW 5 50,118,083 (GRCm39) missense probably benign
R7147:Adgra3 UTSW 5 50,118,587 (GRCm39) missense probably damaging 1.00
R7206:Adgra3 UTSW 5 50,164,238 (GRCm39) missense probably damaging 1.00
R7381:Adgra3 UTSW 5 50,216,116 (GRCm39) start codon destroyed probably null
R7508:Adgra3 UTSW 5 50,174,209 (GRCm39) missense probably benign 0.10
R7538:Adgra3 UTSW 5 50,118,792 (GRCm39) missense probably benign 0.01
R7579:Adgra3 UTSW 5 50,144,977 (GRCm39) missense probably benign
R7951:Adgra3 UTSW 5 50,121,126 (GRCm39) missense probably damaging 1.00
R8269:Adgra3 UTSW 5 50,121,079 (GRCm39) missense probably damaging 0.98
R8458:Adgra3 UTSW 5 50,145,013 (GRCm39) missense probably damaging 0.99
R8486:Adgra3 UTSW 5 50,147,621 (GRCm39) missense probably damaging 0.98
R8912:Adgra3 UTSW 5 50,118,273 (GRCm39) missense possibly damaging 0.61
R8955:Adgra3 UTSW 5 50,118,731 (GRCm39) missense probably benign 0.05
R9108:Adgra3 UTSW 5 50,136,295 (GRCm39) missense probably damaging 1.00
R9112:Adgra3 UTSW 5 50,118,395 (GRCm39) missense probably damaging 1.00
R9191:Adgra3 UTSW 5 50,145,006 (GRCm39) missense possibly damaging 0.88
R9267:Adgra3 UTSW 5 50,155,618 (GRCm39) missense possibly damaging 0.87
R9312:Adgra3 UTSW 5 50,117,900 (GRCm39) missense probably damaging 1.00
R9537:Adgra3 UTSW 5 50,118,207 (GRCm39) missense possibly damaging 0.82
R9614:Adgra3 UTSW 5 50,164,250 (GRCm39) missense probably damaging 1.00
RF005:Adgra3 UTSW 5 50,170,729 (GRCm39) splice site probably null
RF024:Adgra3 UTSW 5 50,170,729 (GRCm39) splice site probably null
RF036:Adgra3 UTSW 5 50,215,983 (GRCm39) small deletion probably benign
X0065:Adgra3 UTSW 5 50,129,304 (GRCm39) missense probably benign
Z1187:Adgra3 UTSW 5 50,136,421 (GRCm39) missense probably damaging 1.00
Z1192:Adgra3 UTSW 5 50,156,623 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TCATAGGCATACTCTCGCAGG -3'
(R):5'- GATCATGATGTGCTGCCCAG -3'

Sequencing Primer
(F):5'- CATACTCTCGCAGGACTGTG -3'
(R):5'- GTACTCCGTGCAAGTCAACGTC -3'
Posted On 2018-04-02