Incidental Mutation 'R6298:Pik3c2g'
| ID |
508895 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pik3c2g
|
| Ensembl Gene |
ENSMUSG00000030228 |
| Gene Name |
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma |
| Synonyms |
|
| MMRRC Submission |
044408-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.087)
|
| Stock # |
R6298 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
139587221-139969284 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 139626563 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Tyrosine
at position 249
(C249Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000140368
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032353]
[ENSMUST00000185968]
[ENSMUST00000187618]
[ENSMUST00000188066]
[ENSMUST00000190962]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000032353
AA Change: C249Y
PolyPhen 2
Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000032353
Gene: ENSMUSG00000030228
AA Change: C249Y
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1e8xa3
|
223 |
344 |
4e-33 |
SMART |
|
Blast:PI3K_rbd
|
272 |
345 |
7e-44 |
BLAST |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000185968
AA Change: C249Y
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000140368
Gene: ENSMUSG00000030228
AA Change: C249Y
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1e8xa3
|
223 |
371 |
2e-42 |
SMART |
|
Blast:PI3K_rbd
|
272 |
371 |
2e-64 |
BLAST |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000186585
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000187618
AA Change: C249Y
PolyPhen 2
Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000141025
Gene: ENSMUSG00000030228
AA Change: C249Y
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1e8xa3
|
223 |
344 |
4e-33 |
SMART |
|
Blast:PI3K_rbd
|
272 |
345 |
7e-44 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000188066
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000190962
AA Change: C249Y
PolyPhen 2
Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000141141
Gene: ENSMUSG00000030228
AA Change: C249Y
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1e8xa3
|
223 |
344 |
4e-33 |
SMART |
|
Blast:PI3K_rbd
|
272 |
345 |
7e-44 |
BLAST |
|
| Meta Mutation Damage Score |
0.7841 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.5%
|
| Validation Efficiency |
98% (79/81) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
PHENOTYPE: Mice homozygous for a knock-out allelel exhibit reduced liver glucogen accumulation, hyperlipidemia, adiposity and insulin resistance with age or after consumption of a high-fat diet. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 81 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700024P04Rik |
T |
A |
13: 98,984,466 (GRCm38) |
R17S |
probably benign |
Het |
| Abtb2 |
A |
T |
2: 103,709,488 (GRCm38) |
M733L |
probably benign |
Het |
| Acss3 |
G |
A |
10: 107,084,856 (GRCm38) |
P131L |
probably damaging |
Het |
| Adgrv1 |
T |
A |
13: 81,391,767 (GRCm38) |
I5678F |
probably benign |
Het |
| Aff1 |
C |
T |
5: 103,754,720 (GRCm38) |
L6F |
possibly damaging |
Het |
| AI314180 |
T |
G |
4: 58,877,157 (GRCm38) |
T93P |
probably damaging |
Het |
| Ank3 |
G |
T |
10: 69,850,176 (GRCm38) |
R273L |
probably damaging |
Het |
| Anks1b |
G |
A |
10: 90,680,837 (GRCm38) |
G898D |
probably damaging |
Het |
| Anxa11 |
C |
T |
14: 25,872,734 (GRCm38) |
P131S |
unknown |
Het |
| Ap4e1 |
T |
A |
2: 127,047,115 (GRCm38) |
M500K |
probably benign |
Het |
| Bag3 |
T |
C |
7: 128,540,198 (GRCm38) |
S138P |
probably damaging |
Het |
| Capn9 |
T |
C |
8: 124,617,454 (GRCm38) |
V670A |
probably benign |
Het |
| Ccne2 |
T |
A |
4: 11,199,306 (GRCm38) |
W236R |
probably damaging |
Het |
| Cdh23 |
A |
T |
10: 60,426,672 (GRCm38) |
Y702* |
probably null |
Het |
| Chd1l |
G |
A |
3: 97,587,167 (GRCm38) |
A399V |
probably damaging |
Het |
| Cit |
A |
T |
5: 115,948,065 (GRCm38) |
E896V |
probably damaging |
Het |
| Cntln |
T |
A |
4: 85,096,761 (GRCm38) |
N1096K |
probably damaging |
Het |
| Cntnap5c |
T |
C |
17: 58,104,752 (GRCm38) |
C544R |
probably damaging |
Het |
| Csf1 |
A |
T |
3: 107,748,359 (GRCm38) |
L452Q |
possibly damaging |
Het |
| Cts8 |
T |
A |
13: 61,249,223 (GRCm38) |
K294N |
possibly damaging |
Het |
| D430042O09Rik |
T |
C |
7: 125,870,697 (GRCm38) |
V1446A |
probably benign |
Het |
| Dcakd |
T |
G |
11: 102,999,792 (GRCm38) |
E56D |
possibly damaging |
Het |
| Dnah17 |
T |
C |
11: 118,108,161 (GRCm38) |
I929V |
probably benign |
Het |
| Dnah2 |
G |
T |
11: 69,491,641 (GRCm38) |
H1214Q |
probably benign |
Het |
| Dock9 |
T |
C |
14: 121,634,594 (GRCm38) |
D536G |
probably damaging |
Het |
| Drc3 |
A |
G |
11: 60,393,770 (GRCm38) |
N467S |
possibly damaging |
Het |
| Dysf |
A |
G |
6: 84,107,136 (GRCm38) |
|
probably null |
Het |
| Evpl |
A |
T |
11: 116,230,922 (GRCm38) |
L378Q |
probably damaging |
Het |
| Fer1l4 |
A |
T |
2: 156,024,740 (GRCm38) |
H1520Q |
probably damaging |
Het |
| Fhod1 |
A |
T |
8: 105,337,148 (GRCm38) |
|
probably benign |
Het |
| Gabra1 |
T |
A |
11: 42,182,378 (GRCm38) |
|
probably benign |
Het |
| Gm10549 |
C |
A |
18: 33,464,305 (GRCm38) |
|
probably benign |
Het |
| Gm14137 |
A |
G |
2: 119,175,091 (GRCm38) |
T44A |
possibly damaging |
Het |
| Gm9833 |
T |
C |
3: 10,089,179 (GRCm38) |
I336T |
probably damaging |
Het |
| Herc2 |
T |
C |
7: 56,191,265 (GRCm38) |
M3444T |
probably benign |
Het |
| Igsf5 |
T |
C |
16: 96,396,448 (GRCm38) |
S208P |
possibly damaging |
Het |
| Ino80b |
A |
G |
6: 83,125,085 (GRCm38) |
L12P |
possibly damaging |
Het |
| Insrr |
A |
G |
3: 87,812,965 (GRCm38) |
D970G |
probably damaging |
Het |
| Iqcf4 |
G |
A |
9: 106,568,675 (GRCm38) |
A91V |
probably benign |
Het |
| Itga10 |
A |
G |
3: 96,656,762 (GRCm38) |
T911A |
probably benign |
Het |
| Klhl30 |
A |
T |
1: 91,357,364 (GRCm38) |
D314V |
probably benign |
Het |
| Lpcat1 |
T |
C |
13: 73,510,955 (GRCm38) |
V330A |
possibly damaging |
Het |
| Nhlrc3 |
A |
T |
3: 53,452,523 (GRCm38) |
D306E |
possibly damaging |
Het |
| Notum |
T |
A |
11: 120,657,940 (GRCm38) |
I187F |
probably damaging |
Het |
| Nphp3 |
T |
C |
9: 104,015,441 (GRCm38) |
L288P |
probably damaging |
Het |
| Ntrk2 |
G |
T |
13: 58,871,756 (GRCm38) |
E394* |
probably null |
Het |
| Olfr420 |
T |
A |
1: 174,152,182 (GRCm38) |
V222D |
probably benign |
Het |
| Pbld2 |
A |
G |
10: 63,039,152 (GRCm38) |
K63E |
probably benign |
Het |
| Phc2 |
T |
C |
4: 128,748,189 (GRCm38) |
M768T |
possibly damaging |
Het |
| Plod1 |
G |
A |
4: 147,916,315 (GRCm38) |
|
probably benign |
Het |
| Plscr2 |
A |
T |
9: 92,290,719 (GRCm38) |
T9S |
probably benign |
Het |
| Pnrc1 |
T |
A |
4: 33,246,315 (GRCm38) |
M215L |
probably benign |
Het |
| Prcp |
G |
T |
7: 92,928,633 (GRCm38) |
C370F |
probably damaging |
Het |
| Pter |
A |
G |
2: 12,978,394 (GRCm38) |
N70S |
probably damaging |
Het |
| Ptprt |
G |
T |
2: 161,553,859 (GRCm38) |
H1131Q |
probably damaging |
Het |
| Rasal2 |
T |
C |
1: 157,411,862 (GRCm38) |
D8G |
possibly damaging |
Het |
| Rcn2 |
A |
C |
9: 56,052,925 (GRCm38) |
K159Q |
probably benign |
Het |
| Rex2 |
T |
A |
4: 147,057,515 (GRCm38) |
C153* |
probably null |
Het |
| Rps6ka2 |
T |
C |
17: 7,170,367 (GRCm38) |
F8S |
possibly damaging |
Het |
| Samd9l |
A |
G |
6: 3,375,383 (GRCm38) |
L626S |
probably damaging |
Het |
| Sptb |
A |
G |
12: 76,620,654 (GRCm38) |
|
probably null |
Het |
| Srgap3 |
A |
T |
6: 112,816,610 (GRCm38) |
V135D |
probably damaging |
Het |
| Srsf7 |
T |
C |
17: 80,207,253 (GRCm38) |
|
probably benign |
Het |
| Tacc2 |
A |
G |
7: 130,626,525 (GRCm38) |
T1647A |
probably benign |
Het |
| Thap12 |
G |
T |
7: 98,703,405 (GRCm38) |
A6S |
probably damaging |
Het |
| Tmem33 |
T |
A |
5: 67,268,551 (GRCm38) |
L146* |
probably null |
Het |
| Trip13 |
C |
A |
13: 73,936,259 (GRCm38) |
E36* |
probably null |
Het |
| Vkorc1l1 |
T |
A |
5: 129,942,238 (GRCm38) |
C23S |
probably damaging |
Het |
| Vmn1r20 |
G |
A |
6: 57,432,127 (GRCm38) |
R146H |
probably benign |
Het |
| Vmn1r222 |
T |
A |
13: 23,232,795 (GRCm38) |
I83F |
probably benign |
Het |
| Vmn2r107 |
A |
T |
17: 20,355,782 (GRCm38) |
I125F |
probably benign |
Het |
| Vmn2r116 |
A |
G |
17: 23,386,762 (GRCm38) |
D216G |
probably damaging |
Het |
| Vwa3a |
C |
T |
7: 120,795,651 (GRCm38) |
T898I |
probably benign |
Het |
| Wdfy3 |
T |
C |
5: 101,968,946 (GRCm38) |
D76G |
probably damaging |
Het |
| Wdhd1 |
T |
C |
14: 47,273,122 (GRCm38) |
D148G |
possibly damaging |
Het |
| Xylt1 |
T |
C |
7: 117,656,737 (GRCm38) |
I844T |
probably damaging |
Het |
| Zfp106 |
A |
T |
2: 120,522,704 (GRCm38) |
V1535D |
probably damaging |
Het |
| Zfp385b |
A |
T |
2: 77,413,979 (GRCm38) |
L315Q |
possibly damaging |
Het |
| Zfp458 |
T |
A |
13: 67,256,806 (GRCm38) |
H523L |
probably damaging |
Het |
| Zfp712 |
T |
C |
13: 67,041,329 (GRCm38) |
H378R |
probably damaging |
Het |
| Zic1 |
T |
C |
9: 91,364,503 (GRCm38) |
Y172C |
probably damaging |
Het |
|
| Other mutations in Pik3c2g |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00159:Pik3c2g
|
APN |
6 |
139,896,125 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01355:Pik3c2g
|
APN |
6 |
139,852,857 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL01579:Pik3c2g
|
APN |
6 |
139,754,741 (GRCm38) |
nonsense |
probably null |
|
|
IGL01580:Pik3c2g
|
APN |
6 |
139,622,516 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01587:Pik3c2g
|
APN |
6 |
139,754,741 (GRCm38) |
nonsense |
probably null |
|
|
IGL01813:Pik3c2g
|
APN |
6 |
139,622,409 (GRCm38) |
missense |
possibly damaging |
0.55 |
|
IGL02218:Pik3c2g
|
APN |
6 |
139,860,355 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02479:Pik3c2g
|
APN |
6 |
139,918,004 (GRCm38) |
missense |
probably benign |
0.40 |
|
IGL02480:Pik3c2g
|
APN |
6 |
139,852,800 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02721:Pik3c2g
|
APN |
6 |
139,736,973 (GRCm38) |
missense |
probably benign |
0.15 |
|
IGL02967:Pik3c2g
|
APN |
6 |
139,967,828 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL03221:Pik3c2g
|
APN |
6 |
139,772,407 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
FR4304:Pik3c2g
|
UTSW |
6 |
139,635,656 (GRCm38) |
frame shift |
probably null |
|
|
FR4340:Pik3c2g
|
UTSW |
6 |
139,635,656 (GRCm38) |
frame shift |
probably null |
|
|
FR4976:Pik3c2g
|
UTSW |
6 |
139,635,654 (GRCm38) |
frame shift |
probably null |
|
|
IGL02837:Pik3c2g
|
UTSW |
6 |
139,626,564 (GRCm38) |
nonsense |
probably null |
|
|
PIT4531001:Pik3c2g
|
UTSW |
6 |
139,859,370 (GRCm38) |
missense |
|
|
|
R0002:Pik3c2g
|
UTSW |
6 |
139,768,745 (GRCm38) |
missense |
probably benign |
0.08 |
|
R0081:Pik3c2g
|
UTSW |
6 |
139,957,793 (GRCm38) |
missense |
probably benign |
0.05 |
|
R0098:Pik3c2g
|
UTSW |
6 |
139,662,443 (GRCm38) |
missense |
unknown |
|
|
R0719:Pik3c2g
|
UTSW |
6 |
139,629,725 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0740:Pik3c2g
|
UTSW |
6 |
139,633,793 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0837:Pik3c2g
|
UTSW |
6 |
139,957,699 (GRCm38) |
splice site |
probably benign |
|
|
R0840:Pik3c2g
|
UTSW |
6 |
139,896,072 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1306:Pik3c2g
|
UTSW |
6 |
139,772,428 (GRCm38) |
missense |
probably benign |
|
|
R1501:Pik3c2g
|
UTSW |
6 |
139,844,070 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1591:Pik3c2g
|
UTSW |
6 |
139,748,178 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1666:Pik3c2g
|
UTSW |
6 |
139,635,636 (GRCm38) |
intron |
probably benign |
|
|
R1907:Pik3c2g
|
UTSW |
6 |
139,844,042 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1970:Pik3c2g
|
UTSW |
6 |
139,900,386 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1982:Pik3c2g
|
UTSW |
6 |
139,622,548 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2171:Pik3c2g
|
UTSW |
6 |
139,855,286 (GRCm38) |
nonsense |
probably null |
|
|
R2188:Pik3c2g
|
UTSW |
6 |
139,852,874 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3777:Pik3c2g
|
UTSW |
6 |
139,622,387 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3778:Pik3c2g
|
UTSW |
6 |
139,622,387 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3965:Pik3c2g
|
UTSW |
6 |
139,855,292 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R4076:Pik3c2g
|
UTSW |
6 |
139,852,863 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4078:Pik3c2g
|
UTSW |
6 |
139,635,610 (GRCm38) |
intron |
probably benign |
|
|
R4108:Pik3c2g
|
UTSW |
6 |
139,730,370 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4461:Pik3c2g
|
UTSW |
6 |
139,841,681 (GRCm38) |
intron |
probably benign |
|
|
R4474:Pik3c2g
|
UTSW |
6 |
139,633,751 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4509:Pik3c2g
|
UTSW |
6 |
139,720,006 (GRCm38) |
missense |
probably benign |
0.25 |
|
R4646:Pik3c2g
|
UTSW |
6 |
139,720,018 (GRCm38) |
missense |
probably benign |
0.05 |
|
R4732:Pik3c2g
|
UTSW |
6 |
139,935,985 (GRCm38) |
missense |
probably benign |
0.28 |
|
R4733:Pik3c2g
|
UTSW |
6 |
139,935,985 (GRCm38) |
missense |
probably benign |
0.28 |
|
R4854:Pik3c2g
|
UTSW |
6 |
139,768,779 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4928:Pik3c2g
|
UTSW |
6 |
139,967,802 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R4959:Pik3c2g
|
UTSW |
6 |
139,843,931 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R4973:Pik3c2g
|
UTSW |
6 |
139,843,931 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R5032:Pik3c2g
|
UTSW |
6 |
139,896,202 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5071:Pik3c2g
|
UTSW |
6 |
139,720,147 (GRCm38) |
missense |
probably null |
0.00 |
|
R5072:Pik3c2g
|
UTSW |
6 |
139,720,147 (GRCm38) |
missense |
probably null |
0.00 |
|
R5073:Pik3c2g
|
UTSW |
6 |
139,720,147 (GRCm38) |
missense |
probably null |
0.00 |
|
R5074:Pik3c2g
|
UTSW |
6 |
139,720,147 (GRCm38) |
missense |
probably null |
0.00 |
|
R5107:Pik3c2g
|
UTSW |
6 |
139,635,625 (GRCm38) |
intron |
probably benign |
|
|
R5186:Pik3c2g
|
UTSW |
6 |
139,622,018 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5253:Pik3c2g
|
UTSW |
6 |
139,896,257 (GRCm38) |
critical splice donor site |
probably null |
|
|
R5359:Pik3c2g
|
UTSW |
6 |
139,622,123 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5394:Pik3c2g
|
UTSW |
6 |
139,720,082 (GRCm38) |
missense |
probably benign |
|
|
R5417:Pik3c2g
|
UTSW |
6 |
139,736,943 (GRCm38) |
missense |
probably benign |
|
|
R5435:Pik3c2g
|
UTSW |
6 |
139,715,855 (GRCm38) |
splice site |
probably null |
|
|
R5580:Pik3c2g
|
UTSW |
6 |
139,626,533 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5664:Pik3c2g
|
UTSW |
6 |
139,737,007 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5908:Pik3c2g
|
UTSW |
6 |
139,768,710 (GRCm38) |
missense |
|
|
|
R5914:Pik3c2g
|
UTSW |
6 |
139,622,479 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6046:Pik3c2g
|
UTSW |
6 |
139,896,792 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6046:Pik3c2g
|
UTSW |
6 |
139,622,139 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R6382:Pik3c2g
|
UTSW |
6 |
139,719,998 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R6480:Pik3c2g
|
UTSW |
6 |
139,730,469 (GRCm38) |
missense |
probably benign |
0.27 |
|
R6917:Pik3c2g
|
UTSW |
6 |
139,896,173 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6929:Pik3c2g
|
UTSW |
6 |
139,957,776 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R7022:Pik3c2g
|
UTSW |
6 |
139,622,063 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R7144:Pik3c2g
|
UTSW |
6 |
139,629,870 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7213:Pik3c2g
|
UTSW |
6 |
139,860,264 (GRCm38) |
missense |
|
|
|
R7215:Pik3c2g
|
UTSW |
6 |
139,754,863 (GRCm38) |
missense |
|
|
|
R7332:Pik3c2g
|
UTSW |
6 |
139,896,255 (GRCm38) |
missense |
|
|
|
R7357:Pik3c2g
|
UTSW |
6 |
139,633,793 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7359:Pik3c2g
|
UTSW |
6 |
139,967,894 (GRCm38) |
missense |
unknown |
|
|
R7385:Pik3c2g
|
UTSW |
6 |
139,855,353 (GRCm38) |
missense |
|
|
|
R7455:Pik3c2g
|
UTSW |
6 |
139,967,917 (GRCm38) |
missense |
unknown |
|
|
R7651:Pik3c2g
|
UTSW |
6 |
139,622,072 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R7888:Pik3c2g
|
UTSW |
6 |
139,896,744 (GRCm38) |
missense |
|
|
|
R7923:Pik3c2g
|
UTSW |
6 |
139,633,793 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7964:Pik3c2g
|
UTSW |
6 |
139,882,060 (GRCm38) |
missense |
|
|
|
R8005:Pik3c2g
|
UTSW |
6 |
139,622,069 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8371:Pik3c2g
|
UTSW |
6 |
139,936,056 (GRCm38) |
missense |
unknown |
|
|
R8724:Pik3c2g
|
UTSW |
6 |
139,967,893 (GRCm38) |
missense |
unknown |
|
|
R8733:Pik3c2g
|
UTSW |
6 |
139,768,700 (GRCm38) |
nonsense |
probably null |
|
|
R8809:Pik3c2g
|
UTSW |
6 |
139,768,710 (GRCm38) |
missense |
|
|
|
R8888:Pik3c2g
|
UTSW |
6 |
139,730,366 (GRCm38) |
nonsense |
probably null |
|
|
R8931:Pik3c2g
|
UTSW |
6 |
139,875,367 (GRCm38) |
missense |
probably benign |
0.02 |
|
R9188:Pik3c2g
|
UTSW |
6 |
139,622,403 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R9336:Pik3c2g
|
UTSW |
6 |
139,875,435 (GRCm38) |
missense |
|
|
|
R9383:Pik3c2g
|
UTSW |
6 |
139,882,016 (GRCm38) |
nonsense |
probably null |
|
|
R9524:Pik3c2g
|
UTSW |
6 |
139,629,770 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9531:Pik3c2g
|
UTSW |
6 |
139,896,200 (GRCm38) |
missense |
|
|
|
R9630:Pik3c2g
|
UTSW |
6 |
139,622,239 (GRCm38) |
missense |
possibly damaging |
0.66 |
|
R9697:Pik3c2g
|
UTSW |
6 |
139,967,791 (GRCm38) |
missense |
unknown |
|
|
R9708:Pik3c2g
|
UTSW |
6 |
139,629,867 (GRCm38) |
missense |
probably benign |
|
|
R9717:Pik3c2g
|
UTSW |
6 |
139,896,184 (GRCm38) |
missense |
|
|
|
RF015:Pik3c2g
|
UTSW |
6 |
139,754,771 (GRCm38) |
missense |
|
|
|
RF032:Pik3c2g
|
UTSW |
6 |
139,635,658 (GRCm38) |
frame shift |
probably null |
|
|
X0024:Pik3c2g
|
UTSW |
6 |
139,860,258 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTGACAGGACAGATGCATACATTC -3'
(R):5'- AGCCAGCAAGGTGATCAATG -3'
Sequencing Primer
(F):5'- GACAGATGCATACATTCCTGAAG -3'
(R):5'- CCAGCAAGGTGATCAATGATAGCTTG -3'
|
| Posted On |
2018-04-02 |
Incidental Mutation