Mutagenetix > Incidental Mutation

Incidental Mutation 'R6298:Dnah2'

508918

Institutional Source

Beutler Lab

Gene Symbol

Dnah2

Ensembl Gene

ENSMUSG00000005237

Gene Name

dynein, axonemal, heavy chain 2

Synonyms

2900022L05Rik, D330014H01Rik, Dnahc2, Dnhd3

MMRRC Submission

044408-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R6298 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

69311635-69439934 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 69382467 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Glutamine at position 1214 (H1214Q)

Ref Sequence

ENSEMBL: ENSMUSP00000104299 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000035539] [ENSMUST00000108659]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000035539
AA Change: H1214Q

PolyPhen 2 Score 0.046 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000047329
Gene: ENSMUSG00000005237
AA Change: H1214Q

Domain	Start	End	E-Value	Type
low complexity region	4	25	N/A	INTRINSIC
Pfam:DHC_N1	273	429	6.6e-37	PFAM
Pfam:DHC_N1	432	761	1.3e-54	PFAM
Pfam:DHC_N2	1253	1668	3.4e-144	PFAM
AAA	1826	1962	2.95e-1	SMART
Pfam:AAA_5	2108	2251	1.3e-5	PFAM
AAA	2437	2584	3.63e-5	SMART
Pfam:AAA_8	2752	3022	1.1e-75	PFAM
Pfam:MT	3034	3370	8.7e-55	PFAM
Pfam:AAA_9	3386	3616	7.4e-68	PFAM
Pfam:Dynein_heavy	3748	4453	1.2e-220	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000108659
AA Change: H1214Q

PolyPhen 2 Score 0.252 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000104299
Gene: ENSMUSG00000005237
AA Change: H1214Q

Domain	Start	End	E-Value	Type
low complexity region	4	25	N/A	INTRINSIC
Pfam:DHC_N1	274	429	1.1e-47	PFAM
Pfam:DHC_N1	438	760	1.5e-75	PFAM
Pfam:DHC_N2	1255	1666	4.4e-144	PFAM
low complexity region	1711	1720	N/A	INTRINSIC
AAA	1832	1968	2.95e-1	SMART
Blast:AAA	2111	2251	2e-86	BLAST
AAA	2443	2590	3.63e-5	SMART
Pfam:AAA_8	2758	3028	5.5e-77	PFAM
Pfam:MT	3040	3376	7.6e-55	PFAM
Pfam:AAA_9	3396	3621	7.5e-94	PFAM
Pfam:Dynein_heavy	3759	4458	4.9e-264	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.5%
20x: 98.5%

Validation Efficiency

98% (79/81)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH2 is an axonemal inner arm dynein heavy chain (Chapelin et al., 1997 [PubMed 9256245]).[supplied by OMIM, Mar 2008]

Allele List at MGI

Other mutations in this stock

Total: 81 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abtb2	A	T	2: 103,539,833 (GRCm39)	M733L	probably benign	Het
Acss3	G	A	10: 106,920,717 (GRCm39)	P131L	probably damaging	Het
Adgrv1	T	A	13: 81,539,886 (GRCm39)	I5678F	probably benign	Het
Aff1	C	T	5: 103,902,586 (GRCm39)	L6F	possibly damaging	Het
Ank3	G	T	10: 69,686,006 (GRCm39)	R273L	probably damaging	Het
Anks1b	G	A	10: 90,516,699 (GRCm39)	G898D	probably damaging	Het
Anxa11	C	T	14: 25,873,158 (GRCm39)	P131S	unknown	Het
Ap4e1	T	A	2: 126,889,035 (GRCm39)	M500K	probably benign	Het
Bag3	T	C	7: 128,141,922 (GRCm39)	S138P	probably damaging	Het
Capn9	T	C	8: 125,344,193 (GRCm39)	V670A	probably benign	Het
Ccne2	T	A	4: 11,199,306 (GRCm39)	W236R	probably damaging	Het
Cdh23	A	T	10: 60,262,451 (GRCm39)	Y702*	probably null	Het
Chd1l	G	A	3: 97,494,483 (GRCm39)	A399V	probably damaging	Het
Cit	A	T	5: 116,086,124 (GRCm39)	E896V	probably damaging	Het
Cntln	T	A	4: 85,014,998 (GRCm39)	N1096K	probably damaging	Het
Cntnap5c	T	C	17: 58,411,747 (GRCm39)	C544R	probably damaging	Het
Csf1	A	T	3: 107,655,675 (GRCm39)	L452Q	possibly damaging	Het
Cts8	T	A	13: 61,397,037 (GRCm39)	K294N	possibly damaging	Het
Dcakd	T	G	11: 102,890,618 (GRCm39)	E56D	possibly damaging	Het
Dnah17	T	C	11: 117,998,987 (GRCm39)	I929V	probably benign	Het
Dock9	T	C	14: 121,872,006 (GRCm39)	D536G	probably damaging	Het
Drc3	A	G	11: 60,284,596 (GRCm39)	N467S	possibly damaging	Het
Dysf	A	G	6: 84,084,118 (GRCm39)		probably null	Het
Ecpas	T	G	4: 58,877,157 (GRCm39)	T93P	probably damaging	Het
Evpl	A	T	11: 116,121,748 (GRCm39)	L378Q	probably damaging	Het
Fer1l4	A	T	2: 155,866,660 (GRCm39)	H1520Q	probably damaging	Het
Fhod1	A	T	8: 106,063,780 (GRCm39)		probably benign	Het
Gabra1	T	A	11: 42,073,205 (GRCm39)		probably benign	Het
Gm10549	C	A	18: 33,597,358 (GRCm39)		probably benign	Het
Gm14137	A	G	2: 119,005,572 (GRCm39)	T44A	possibly damaging	Het
H2bl1	T	A	13: 99,120,974 (GRCm39)	R17S	probably benign	Het
Herc2	T	C	7: 55,841,013 (GRCm39)	M3444T	probably benign	Het
Igsf5	T	C	16: 96,197,648 (GRCm39)	S208P	possibly damaging	Het
Ino80b	A	G	6: 83,102,066 (GRCm39)	L12P	possibly damaging	Het
Insrr	A	G	3: 87,720,272 (GRCm39)	D970G	probably damaging	Het
Iqcf4	G	A	9: 106,445,874 (GRCm39)	A91V	probably benign	Het
Itga10	A	G	3: 96,564,078 (GRCm39)	T911A	probably benign	Het
Katnip	T	C	7: 125,469,869 (GRCm39)	V1446A	probably benign	Het
Klhl30	A	T	1: 91,285,086 (GRCm39)	D314V	probably benign	Het
Lpcat1	T	C	13: 73,659,074 (GRCm39)	V330A	possibly damaging	Het
Myef2l	T	C	3: 10,154,239 (GRCm39)	I336T	probably damaging	Het
Nhlrc3	A	T	3: 53,359,944 (GRCm39)	D306E	possibly damaging	Het
Notum	T	A	11: 120,548,766 (GRCm39)	I187F	probably damaging	Het
Nphp3	T	C	9: 103,892,640 (GRCm39)	L288P	probably damaging	Het
Ntrk2	G	T	13: 59,019,570 (GRCm39)	E394*	probably null	Het
Or6k2	T	A	1: 173,979,748 (GRCm39)	V222D	probably benign	Het
Pbld2	A	G	10: 62,874,931 (GRCm39)	K63E	probably benign	Het
Phc2	T	C	4: 128,641,982 (GRCm39)	M768T	possibly damaging	Het
Pik3c2g	G	A	6: 139,603,561 (GRCm39)	C249Y	probably damaging	Het
Plod1	G	A	4: 148,000,772 (GRCm39)		probably benign	Het
Plscr2	A	T	9: 92,172,772 (GRCm39)	T9S	probably benign	Het
Pnrc1	T	A	4: 33,246,315 (GRCm39)	M215L	probably benign	Het
Prcp	G	T	7: 92,577,841 (GRCm39)	C370F	probably damaging	Het
Pter	A	G	2: 12,983,205 (GRCm39)	N70S	probably damaging	Het
Ptprt	G	T	2: 161,395,779 (GRCm39)	H1131Q	probably damaging	Het
Rasal2	T	C	1: 157,239,432 (GRCm39)	D8G	possibly damaging	Het
Rcn2	A	C	9: 55,960,209 (GRCm39)	K159Q	probably benign	Het
Rex2	T	A	4: 147,141,972 (GRCm39)	C153*	probably null	Het
Rps6ka2	T	C	17: 7,437,766 (GRCm39)	F8S	possibly damaging	Het
Samd9l	A	G	6: 3,375,383 (GRCm39)	L626S	probably damaging	Het
Sptb	A	G	12: 76,667,428 (GRCm39)		probably null	Het
Srgap3	A	T	6: 112,793,571 (GRCm39)	V135D	probably damaging	Het
Srsf7	T	C	17: 80,514,682 (GRCm39)		probably benign	Het
Tacc2	A	G	7: 130,228,255 (GRCm39)	T1647A	probably benign	Het
Thap12	G	T	7: 98,352,612 (GRCm39)	A6S	probably damaging	Het
Tmem33	T	A	5: 67,425,894 (GRCm39)	L146*	probably null	Het
Trip13	C	A	13: 74,084,378 (GRCm39)	E36*	probably null	Het
Vkorc1l1	T	A	5: 129,971,079 (GRCm39)	C23S	probably damaging	Het
Vmn1r20	G	A	6: 57,409,112 (GRCm39)	R146H	probably benign	Het
Vmn1r222	T	A	13: 23,416,965 (GRCm39)	I83F	probably benign	Het
Vmn2r107	A	T	17: 20,576,044 (GRCm39)	I125F	probably benign	Het
Vmn2r116	A	G	17: 23,605,736 (GRCm39)	D216G	probably damaging	Het
Vwa3a	C	T	7: 120,394,874 (GRCm39)	T898I	probably benign	Het
Wdfy3	T	C	5: 102,116,812 (GRCm39)	D76G	probably damaging	Het
Wdhd1	T	C	14: 47,510,579 (GRCm39)	D148G	possibly damaging	Het
Xylt1	T	C	7: 117,255,960 (GRCm39)	I844T	probably damaging	Het
Zfp106	A	T	2: 120,353,185 (GRCm39)	V1535D	probably damaging	Het
Zfp385b	A	T	2: 77,244,323 (GRCm39)	L315Q	possibly damaging	Het
Zfp458	T	A	13: 67,404,870 (GRCm39)	H523L	probably damaging	Het
Zfp712	T	C	13: 67,189,393 (GRCm39)	H378R	probably damaging	Het
Zic1	T	C	9: 91,246,556 (GRCm39)	Y172C	probably damaging	Het

Other mutations in Dnah2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00087:Dnah2	APN	11	69,383,498 (GRCm39)	missense	possibly damaging	0.93
IGL00418:Dnah2	APN	11	69,385,892 (GRCm39)	splice site	probably benign
IGL00772:Dnah2	APN	11	69,342,083 (GRCm39)	missense	probably damaging	0.97
IGL00819:Dnah2	APN	11	69,364,176 (GRCm39)	critical splice donor site	probably null
IGL00827:Dnah2	APN	11	69,339,283 (GRCm39)	missense	probably damaging	1.00
IGL01060:Dnah2	APN	11	69,368,918 (GRCm39)	missense	possibly damaging	0.86
IGL01340:Dnah2	APN	11	69,384,010 (GRCm39)	missense	probably damaging	0.99
IGL01349:Dnah2	APN	11	69,366,432 (GRCm39)	missense	probably damaging	0.99
IGL01413:Dnah2	APN	11	69,323,790 (GRCm39)	missense	probably damaging	0.99
IGL01451:Dnah2	APN	11	69,365,017 (GRCm39)	splice site	probably benign
IGL01480:Dnah2	APN	11	69,349,197 (GRCm39)	missense	possibly damaging	0.91
IGL01537:Dnah2	APN	11	69,406,906 (GRCm39)	missense	probably benign	0.17
IGL01592:Dnah2	APN	11	69,321,913 (GRCm39)	missense	probably benign	0.14
IGL01612:Dnah2	APN	11	69,355,889 (GRCm39)	splice site	probably benign
IGL01667:Dnah2	APN	11	69,435,221 (GRCm39)	missense	probably benign
IGL01667:Dnah2	APN	11	69,411,767 (GRCm39)	missense	probably damaging	0.98
IGL01691:Dnah2	APN	11	69,430,269 (GRCm39)	missense	probably benign
IGL02019:Dnah2	APN	11	69,365,111 (GRCm39)	missense	probably damaging	1.00
IGL02039:Dnah2	APN	11	69,390,038 (GRCm39)	missense	probably damaging	1.00
IGL02076:Dnah2	APN	11	69,313,385 (GRCm39)	missense	probably damaging	0.99
IGL02085:Dnah2	APN	11	69,349,011 (GRCm39)	missense	probably benign	0.07
IGL02158:Dnah2	APN	11	69,348,949 (GRCm39)	missense	probably benign
IGL02381:Dnah2	APN	11	69,337,118 (GRCm39)	missense	probably benign	0.25
IGL02681:Dnah2	APN	11	69,343,759 (GRCm39)	missense	probably benign	0.40
IGL02957:Dnah2	APN	11	69,339,333 (GRCm39)	missense	possibly damaging	0.96
IGL02961:Dnah2	APN	11	69,409,240 (GRCm39)	missense	probably damaging	1.00
IGL02969:Dnah2	APN	11	69,412,013 (GRCm39)	missense	possibly damaging	0.80
IGL03117:Dnah2	APN	11	69,327,117 (GRCm39)	splice site	probably benign
IGL03120:Dnah2	APN	11	69,312,674 (GRCm39)	missense	probably damaging	1.00
IGL03183:Dnah2	APN	11	69,349,314 (GRCm39)	missense	possibly damaging	0.94
IGL03197:Dnah2	APN	11	69,350,089 (GRCm39)	missense	probably damaging	1.00
IGL03263:Dnah2	APN	11	69,420,207 (GRCm39)	critical splice donor site	probably null
IGL03333:Dnah2	APN	11	69,385,949 (GRCm39)	missense	probably damaging	1.00
IGL03338:Dnah2	APN	11	69,387,403 (GRCm39)	missense	probably benign	0.13
argyrios	UTSW	11	69,407,416 (GRCm39)	missense	possibly damaging	0.47
Aureus	UTSW	11	69,320,174 (GRCm39)	missense	probably damaging	1.00
platinum	UTSW	11	69,348,868 (GRCm39)	missense	probably damaging	0.96
R0334_dnah2_144	UTSW	11	69,327,662 (GRCm39)	missense	probably damaging	1.00
R2150_dnah2_212	UTSW	11	69,406,587 (GRCm39)	missense	probably benign	0.14
BB005:Dnah2	UTSW	11	69,321,661 (GRCm39)	missense	probably damaging	0.98
BB015:Dnah2	UTSW	11	69,321,661 (GRCm39)	missense	probably damaging	0.98
E0370:Dnah2	UTSW	11	69,406,441 (GRCm39)	splice site	probably null
P0026:Dnah2	UTSW	11	69,355,773 (GRCm39)	missense	probably damaging	1.00
R0133:Dnah2	UTSW	11	69,311,835 (GRCm39)	missense	probably damaging	1.00
R0190:Dnah2	UTSW	11	69,326,075 (GRCm39)	missense	probably damaging	1.00
R0334:Dnah2	UTSW	11	69,327,662 (GRCm39)	missense	probably damaging	1.00
R0359:Dnah2	UTSW	11	69,420,357 (GRCm39)	missense	probably benign	0.00
R0386:Dnah2	UTSW	11	69,338,687 (GRCm39)	missense	probably damaging	1.00
R0414:Dnah2	UTSW	11	69,390,064 (GRCm39)	missense	probably benign	0.26
R0427:Dnah2	UTSW	11	69,343,705 (GRCm39)	missense	probably damaging	0.99
R0433:Dnah2	UTSW	11	69,350,114 (GRCm39)	missense	probably damaging	1.00
R0442:Dnah2	UTSW	11	69,339,368 (GRCm39)	missense	probably damaging	1.00
R0462:Dnah2	UTSW	11	69,350,027 (GRCm39)	missense	probably damaging	1.00
R0463:Dnah2	UTSW	11	69,313,952 (GRCm39)	missense	probably damaging	1.00
R0611:Dnah2	UTSW	11	69,390,020 (GRCm39)	missense	probably damaging	1.00
R0626:Dnah2	UTSW	11	69,368,509 (GRCm39)	missense	probably benign	0.07
R0924:Dnah2	UTSW	11	69,312,134 (GRCm39)	missense	probably damaging	1.00
R0968:Dnah2	UTSW	11	69,339,345 (GRCm39)	missense	possibly damaging	0.67
R1066:Dnah2	UTSW	11	69,338,645 (GRCm39)	missense	probably damaging	1.00
R1183:Dnah2	UTSW	11	69,337,474 (GRCm39)	missense	possibly damaging	0.95
R1184:Dnah2	UTSW	11	69,390,016 (GRCm39)	missense	probably damaging	1.00
R1186:Dnah2	UTSW	11	69,406,526 (GRCm39)	missense	probably damaging	0.99
R1453:Dnah2	UTSW	11	69,341,876 (GRCm39)	missense	probably damaging	0.99
R1498:Dnah2	UTSW	11	69,411,493 (GRCm39)	splice site	probably null
R1538:Dnah2	UTSW	11	69,368,028 (GRCm39)	missense	probably benign	0.17
R1574:Dnah2	UTSW	11	69,405,514 (GRCm39)	missense	probably benign	0.26
R1574:Dnah2	UTSW	11	69,405,514 (GRCm39)	missense	probably benign	0.26
R1590:Dnah2	UTSW	11	69,412,024 (GRCm39)	missense	probably benign	0.00
R1590:Dnah2	UTSW	11	69,313,580 (GRCm39)	critical splice donor site	probably null
R1655:Dnah2	UTSW	11	69,364,680 (GRCm39)	missense	probably damaging	1.00
R1695:Dnah2	UTSW	11	69,405,517 (GRCm39)	missense	possibly damaging	0.74
R1726:Dnah2	UTSW	11	69,388,715 (GRCm39)	missense	probably damaging	1.00
R1764:Dnah2	UTSW	11	69,314,369 (GRCm39)	missense	probably damaging	1.00
R1815:Dnah2	UTSW	11	69,366,400 (GRCm39)	missense	probably damaging	1.00
R1822:Dnah2	UTSW	11	69,405,630 (GRCm39)	missense	probably damaging	1.00
R1859:Dnah2	UTSW	11	69,328,712 (GRCm39)	missense	probably damaging	0.99
R1911:Dnah2	UTSW	11	69,406,578 (GRCm39)	missense	possibly damaging	0.64
R1913:Dnah2	UTSW	11	69,355,756 (GRCm39)	missense	probably damaging	1.00
R1981:Dnah2	UTSW	11	69,365,151 (GRCm39)	missense	probably damaging	1.00
R2010:Dnah2	UTSW	11	69,349,184 (GRCm39)	critical splice donor site	probably null
R2016:Dnah2	UTSW	11	69,327,896 (GRCm39)	missense	probably damaging	0.97
R2017:Dnah2	UTSW	11	69,327,896 (GRCm39)	missense	probably damaging	0.97
R2044:Dnah2	UTSW	11	69,415,066 (GRCm39)	missense	probably benign	0.14
R2077:Dnah2	UTSW	11	69,387,432 (GRCm39)	missense	possibly damaging	0.73
R2096:Dnah2	UTSW	11	69,346,742 (GRCm39)	missense	probably damaging	0.98
R2099:Dnah2	UTSW	11	69,384,063 (GRCm39)	missense	probably damaging	1.00
R2127:Dnah2	UTSW	11	69,349,011 (GRCm39)	missense	probably benign	0.02
R2128:Dnah2	UTSW	11	69,349,011 (GRCm39)	missense	probably benign	0.02
R2146:Dnah2	UTSW	11	69,406,587 (GRCm39)	missense	probably benign	0.14
R2147:Dnah2	UTSW	11	69,406,587 (GRCm39)	missense	probably benign	0.14
R2150:Dnah2	UTSW	11	69,406,587 (GRCm39)	missense	probably benign	0.14
R2404:Dnah2	UTSW	11	69,328,047 (GRCm39)	missense	probably damaging	0.99
R2510:Dnah2	UTSW	11	69,415,032 (GRCm39)	nonsense	probably null
R2517:Dnah2	UTSW	11	69,407,470 (GRCm39)	missense	probably damaging	1.00
R3014:Dnah2	UTSW	11	69,321,304 (GRCm39)	missense	probably benign
R3741:Dnah2	UTSW	11	69,339,295 (GRCm39)	missense	probably damaging	1.00
R3814:Dnah2	UTSW	11	69,383,476 (GRCm39)	splice site	probably null
R3872:Dnah2	UTSW	11	69,320,174 (GRCm39)	missense	probably damaging	1.00
R3873:Dnah2	UTSW	11	69,320,174 (GRCm39)	missense	probably damaging	1.00
R3874:Dnah2	UTSW	11	69,320,174 (GRCm39)	missense	probably damaging	1.00
R3875:Dnah2	UTSW	11	69,320,174 (GRCm39)	missense	probably damaging	1.00
R3881:Dnah2	UTSW	11	69,342,173 (GRCm39)	missense	possibly damaging	0.94
R3953:Dnah2	UTSW	11	69,344,929 (GRCm39)	missense	probably damaging	1.00
R3956:Dnah2	UTSW	11	69,374,847 (GRCm39)	missense	probably benign	0.00
R4501:Dnah2	UTSW	11	69,368,485 (GRCm39)	missense	probably benign
R4515:Dnah2	UTSW	11	69,356,457 (GRCm39)	missense	possibly damaging	0.61
R4612:Dnah2	UTSW	11	69,374,193 (GRCm39)	missense	possibly damaging	0.93
R4625:Dnah2	UTSW	11	69,354,487 (GRCm39)	missense	probably damaging	1.00
R4627:Dnah2	UTSW	11	69,356,202 (GRCm39)	missense	probably damaging	1.00
R4642:Dnah2	UTSW	11	69,387,385 (GRCm39)	missense	probably benign	0.00
R4683:Dnah2	UTSW	11	69,349,768 (GRCm39)	missense	probably damaging	1.00
R4698:Dnah2	UTSW	11	69,389,358 (GRCm39)	missense	probably damaging	1.00
R4710:Dnah2	UTSW	11	69,368,903 (GRCm39)	missense	probably damaging	1.00
R4712:Dnah2	UTSW	11	69,407,416 (GRCm39)	missense	possibly damaging	0.47
R4713:Dnah2	UTSW	11	69,367,514 (GRCm39)	missense	probably damaging	1.00
R4717:Dnah2	UTSW	11	69,320,183 (GRCm39)	missense	probably benign	0.00
R4740:Dnah2	UTSW	11	69,348,868 (GRCm39)	missense	probably damaging	0.96
R4780:Dnah2	UTSW	11	69,364,697 (GRCm39)	missense	probably damaging	0.97
R4825:Dnah2	UTSW	11	69,314,031 (GRCm39)	missense	probably damaging	1.00
R4864:Dnah2	UTSW	11	69,313,416 (GRCm39)	missense	probably damaging	0.98
R4868:Dnah2	UTSW	11	69,354,474 (GRCm39)	missense	probably damaging	1.00
R4879:Dnah2	UTSW	11	69,367,517 (GRCm39)	missense	probably damaging	1.00
R4908:Dnah2	UTSW	11	69,411,973 (GRCm39)	missense	probably benign	0.00
R4911:Dnah2	UTSW	11	69,389,930 (GRCm39)	critical splice donor site	probably null
R4954:Dnah2	UTSW	11	69,430,322 (GRCm39)	missense	possibly damaging	0.61
R4962:Dnah2	UTSW	11	69,346,799 (GRCm39)	nonsense	probably null
R5015:Dnah2	UTSW	11	69,388,708 (GRCm39)	missense	possibly damaging	0.89
R5049:Dnah2	UTSW	11	69,338,992 (GRCm39)	missense	probably damaging	1.00
R5055:Dnah2	UTSW	11	69,411,599 (GRCm39)	missense	possibly damaging	0.67
R5153:Dnah2	UTSW	11	69,411,759 (GRCm39)	missense	possibly damaging	0.84
R5155:Dnah2	UTSW	11	69,313,362 (GRCm39)	missense	probably damaging	1.00
R5186:Dnah2	UTSW	11	69,326,710 (GRCm39)	missense	probably damaging	1.00
R5187:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5208:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5252:Dnah2	UTSW	11	69,420,295 (GRCm39)	missense	probably damaging	0.98
R5296:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5298:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5299:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5301:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5324:Dnah2	UTSW	11	69,348,819 (GRCm39)	missense	probably benign	0.07
R5350:Dnah2	UTSW	11	69,406,862 (GRCm39)	missense	possibly damaging	0.48
R5377:Dnah2	UTSW	11	69,312,674 (GRCm39)	missense	probably damaging	1.00
R5393:Dnah2	UTSW	11	69,391,683 (GRCm39)	missense	probably benign
R5421:Dnah2	UTSW	11	69,326,462 (GRCm39)	missense	probably damaging	1.00
R5452:Dnah2	UTSW	11	69,415,209 (GRCm39)	missense	probably damaging	1.00
R5461:Dnah2	UTSW	11	69,364,177 (GRCm39)	critical splice donor site	probably null
R5474:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5476:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5477:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5510:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5527:Dnah2	UTSW	11	69,328,014 (GRCm39)	nonsense	probably null
R5566:Dnah2	UTSW	11	69,407,395 (GRCm39)	nonsense	probably null
R5587:Dnah2	UTSW	11	69,328,068 (GRCm39)	missense	probably damaging	1.00
R5628:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5688:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5690:Dnah2	UTSW	11	69,382,370 (GRCm39)	missense	probably benign	0.15
R5711:Dnah2	UTSW	11	69,326,216 (GRCm39)	missense	probably damaging	1.00
R5735:Dnah2	UTSW	11	69,321,643 (GRCm39)	missense	possibly damaging	0.93
R5826:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5913:Dnah2	UTSW	11	69,339,256 (GRCm39)	missense	probably damaging	1.00
R5914:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5960:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5961:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5961:Dnah2	UTSW	11	69,321,974 (GRCm39)	missense	probably damaging	1.00
R5977:Dnah2	UTSW	11	69,411,707 (GRCm39)	missense	possibly damaging	0.79
R6020:Dnah2	UTSW	11	69,391,665 (GRCm39)	missense	probably benign
R6036:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R6036:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R6050:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R6086:Dnah2	UTSW	11	69,406,834 (GRCm39)	missense	probably benign	0.30
R6115:Dnah2	UTSW	11	69,337,475 (GRCm39)	missense	probably damaging	1.00
R6123:Dnah2	UTSW	11	69,409,185 (GRCm39)	missense	probably benign	0.29
R6159:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R6159:Dnah2	UTSW	11	69,349,368 (GRCm39)	missense	probably damaging	1.00
R6163:Dnah2	UTSW	11	69,411,729 (GRCm39)	nonsense	probably null
R6171:Dnah2	UTSW	11	69,313,868 (GRCm39)	missense	probably damaging	1.00
R6263:Dnah2	UTSW	11	69,348,238 (GRCm39)	missense	probably damaging	1.00
R6352:Dnah2	UTSW	11	69,339,053 (GRCm39)	missense	probably damaging	1.00
R6399:Dnah2	UTSW	11	69,349,344 (GRCm39)	missense	probably damaging	0.98
R6466:Dnah2	UTSW	11	69,430,241 (GRCm39)	missense	probably benign
R6478:Dnah2	UTSW	11	69,406,836 (GRCm39)	missense	probably benign	0.01
R6516:Dnah2	UTSW	11	69,356,212 (GRCm39)	missense	probably benign	0.34
R6538:Dnah2	UTSW	11	69,328,023 (GRCm39)	missense	possibly damaging	0.87
R6802:Dnah2	UTSW	11	69,314,516 (GRCm39)	missense	probably damaging	1.00
R6861:Dnah2	UTSW	11	69,346,789 (GRCm39)	missense	possibly damaging	0.64
R6869:Dnah2	UTSW	11	69,320,297 (GRCm39)	missense	probably damaging	1.00
R6894:Dnah2	UTSW	11	69,375,086 (GRCm39)	missense	probably benign	0.12
R6935:Dnah2	UTSW	11	69,312,567 (GRCm39)	missense	probably damaging	1.00
R7017:Dnah2	UTSW	11	69,382,373 (GRCm39)	nonsense	probably null
R7073:Dnah2	UTSW	11	69,321,318 (GRCm39)	nonsense	probably null
R7111:Dnah2	UTSW	11	69,337,579 (GRCm39)	splice site	probably null
R7125:Dnah2	UTSW	11	69,327,008 (GRCm39)	missense	probably damaging	0.99
R7137:Dnah2	UTSW	11	69,382,381 (GRCm39)	missense	probably damaging	1.00
R7190:Dnah2	UTSW	11	69,439,923 (GRCm39)	splice site	probably null
R7214:Dnah2	UTSW	11	69,321,935 (GRCm39)	missense	probably damaging	1.00
R7227:Dnah2	UTSW	11	69,312,222 (GRCm39)	missense	probably damaging	0.99
R7238:Dnah2	UTSW	11	69,349,972 (GRCm39)	critical splice donor site	probably null
R7256:Dnah2	UTSW	11	69,321,920 (GRCm39)	missense	probably damaging	1.00
R7267:Dnah2	UTSW	11	69,391,643 (GRCm39)	missense	probably damaging	1.00
R7420:Dnah2	UTSW	11	69,369,623 (GRCm39)	missense	possibly damaging	0.94
R7421:Dnah2	UTSW	11	69,383,631 (GRCm39)	missense	probably benign	0.25
R7437:Dnah2	UTSW	11	69,389,453 (GRCm39)	missense	probably damaging	1.00
R7461:Dnah2	UTSW	11	69,439,816 (GRCm39)	critical splice donor site	probably null
R7473:Dnah2	UTSW	11	69,382,484 (GRCm39)	missense	probably damaging	0.99
R7528:Dnah2	UTSW	11	69,391,622 (GRCm39)	missense	probably damaging	0.99
R7613:Dnah2	UTSW	11	69,439,816 (GRCm39)	critical splice donor site	probably null
R7615:Dnah2	UTSW	11	69,326,130 (GRCm39)	missense	probably damaging	0.99
R7626:Dnah2	UTSW	11	69,389,511 (GRCm39)	missense	probably damaging	0.99
R7745:Dnah2	UTSW	11	69,342,144 (GRCm39)	nonsense	probably null
R7764:Dnah2	UTSW	11	69,348,984 (GRCm39)	missense	probably benign	0.29
R7793:Dnah2	UTSW	11	69,386,040 (GRCm39)	missense	probably benign	0.00
R7819:Dnah2	UTSW	11	69,407,419 (GRCm39)	missense	probably benign	0.01
R7881:Dnah2	UTSW	11	69,322,064 (GRCm39)	missense	probably damaging	1.00
R7900:Dnah2	UTSW	11	69,409,254 (GRCm39)	missense	probably damaging	1.00
R7916:Dnah2	UTSW	11	69,311,974 (GRCm39)	critical splice acceptor site	probably null
R7921:Dnah2	UTSW	11	69,411,660 (GRCm39)	missense	probably benign
R7928:Dnah2	UTSW	11	69,321,661 (GRCm39)	missense	probably damaging	0.98
R7937:Dnah2	UTSW	11	69,408,511 (GRCm39)	nonsense	probably null
R7995:Dnah2	UTSW	11	69,411,563 (GRCm39)	missense	possibly damaging	0.77
R8202:Dnah2	UTSW	11	69,369,649 (GRCm39)	missense	probably benign	0.00
R8208:Dnah2	UTSW	11	69,411,678 (GRCm39)	missense	probably benign	0.05
R8215:Dnah2	UTSW	11	69,326,193 (GRCm39)	missense	probably damaging	1.00
R8279:Dnah2	UTSW	11	69,366,399 (GRCm39)	missense	probably damaging	1.00
R8338:Dnah2	UTSW	11	69,378,122 (GRCm39)	missense	probably damaging	1.00
R8348:Dnah2	UTSW	11	69,320,273 (GRCm39)	missense	possibly damaging	0.95
R8405:Dnah2	UTSW	11	69,349,289 (GRCm39)	missense	probably damaging	1.00
R8407:Dnah2	UTSW	11	69,350,104 (GRCm39)	missense	probably benign	0.00
R8493:Dnah2	UTSW	11	69,343,804 (GRCm39)	missense	probably damaging	1.00
R8673:Dnah2	UTSW	11	69,405,523 (GRCm39)	missense	probably benign	0.23
R8725:Dnah2	UTSW	11	69,415,005 (GRCm39)	missense	probably damaging	1.00
R8727:Dnah2	UTSW	11	69,415,005 (GRCm39)	missense	probably damaging	1.00
R8730:Dnah2	UTSW	11	69,384,087 (GRCm39)	missense	possibly damaging	0.73
R8804:Dnah2	UTSW	11	69,356,511 (GRCm39)	missense	probably benign	0.01
R8876:Dnah2	UTSW	11	69,382,348 (GRCm39)	missense	probably damaging	1.00
R8894:Dnah2	UTSW	11	69,383,048 (GRCm39)	missense	probably benign	0.01
R8938:Dnah2	UTSW	11	69,328,754 (GRCm39)	missense	probably damaging	0.99
R9044:Dnah2	UTSW	11	69,420,247 (GRCm39)	missense	probably benign
R9085:Dnah2	UTSW	11	69,320,224 (GRCm39)	missense	possibly damaging	0.69
R9110:Dnah2	UTSW	11	69,435,208 (GRCm39)	missense	probably benign
R9156:Dnah2	UTSW	11	69,313,687 (GRCm39)	missense
R9251:Dnah2	UTSW	11	69,406,619 (GRCm39)	missense	probably damaging	1.00
R9258:Dnah2	UTSW	11	69,368,079 (GRCm39)	missense	probably damaging	1.00
R9279:Dnah2	UTSW	11	69,409,104 (GRCm39)	missense	probably benign	0.01
R9318:Dnah2	UTSW	11	69,375,155 (GRCm39)	missense	probably benign	0.07
R9321:Dnah2	UTSW	11	69,338,939 (GRCm39)	critical splice donor site	probably null
R9350:Dnah2	UTSW	11	69,384,073 (GRCm39)	missense	probably benign	0.10
R9358:Dnah2	UTSW	11	69,406,592 (GRCm39)	missense	probably damaging	0.99
R9417:Dnah2	UTSW	11	69,326,990 (GRCm39)	missense	probably damaging	1.00
R9420:Dnah2	UTSW	11	69,368,942 (GRCm39)	missense	probably benign	0.09
R9438:Dnah2	UTSW	11	69,364,220 (GRCm39)	missense	probably damaging	1.00
R9469:Dnah2	UTSW	11	69,321,896 (GRCm39)	missense	probably damaging	1.00
R9487:Dnah2	UTSW	11	69,406,617 (GRCm39)	missense	possibly damaging	0.47
R9495:Dnah2	UTSW	11	69,345,208 (GRCm39)	missense	possibly damaging	0.89
R9579:Dnah2	UTSW	11	69,368,041 (GRCm39)	missense	probably damaging	1.00
R9608:Dnah2	UTSW	11	69,344,888 (GRCm39)	missense	probably null	1.00
R9651:Dnah2	UTSW	11	69,341,824 (GRCm39)	critical splice donor site	probably null
R9662:Dnah2	UTSW	11	69,343,763 (GRCm39)	missense	probably benign
RF004:Dnah2	UTSW	11	69,328,013 (GRCm39)	missense	probably benign	0.24
U24488:Dnah2	UTSW	11	69,374,648 (GRCm39)	missense	probably damaging	0.99
X0021:Dnah2	UTSW	11	69,339,388 (GRCm39)	missense	possibly damaging	0.81
Z1088:Dnah2	UTSW	11	69,321,619 (GRCm39)	missense	probably damaging	1.00
Z1176:Dnah2	UTSW	11	69,312,647 (GRCm39)	missense	possibly damaging	0.46
Z1176:Dnah2	UTSW	11	69,407,349 (GRCm39)	missense	probably damaging	1.00
Z1176:Dnah2	UTSW	11	69,407,307 (GRCm39)	missense	probably damaging	1.00
Z1176:Dnah2	UTSW	11	69,389,493 (GRCm39)	missense	probably benign	0.12
Z1176:Dnah2	UTSW	11	69,377,880 (GRCm39)	missense	possibly damaging	0.46
Z1176:Dnah2	UTSW	11	69,341,946 (GRCm39)	missense	probably benign
Z1177:Dnah2	UTSW	11	69,435,383 (GRCm39)	critical splice acceptor site	probably null
Z1177:Dnah2	UTSW	11	69,354,279 (GRCm39)	missense	possibly damaging	0.63

Predicted Primers

PCR Primer
(F):5'- TATCCCTGGTTTCTACGGGG -3'
(R):5'- GTCCAGATTTGGTGACCTTCC -3'

Sequencing Primer
(F):5'- TTTCTACGGGGCCCCAC -3'
(R):5'- TTTCAAGAGGCCGTGGA -3'

Posted On

2018-04-02