Incidental Mutation 'R6298:Vmn2r116'
ID 508938
Institutional Source Beutler Lab
Gene Symbol Vmn2r116
Ensembl Gene ENSMUSG00000090966
Gene Name vomeronasal 2, receptor 116
Synonyms V2Rp5, EG619697
MMRRC Submission 044408-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R6298 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 23603777-23620838 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 23605736 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 216 (D216G)
Ref Sequence ENSEMBL: ENSMUSP00000128106 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164856]
AlphaFold E9Q6I0
Predicted Effect probably damaging
Transcript: ENSMUST00000164856
AA Change: D216G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000128106
Gene: ENSMUSG00000090966
AA Change: D216G

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 73 469 4.4e-30 PFAM
Pfam:NCD3G 511 564 1.2e-22 PFAM
low complexity region 589 594 N/A INTRINSIC
Pfam:7tm_3 595 832 8.7e-57 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.5%
Validation Efficiency 98% (79/81)
MGI Phenotype PHENOTYPE: Female mice homozygous for a knock-out allele stimulated with male pheromone (Gm6084) fail to exhibit an increase in lordosis behavior and successful intromission. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 81 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abtb2 A T 2: 103,539,833 (GRCm39) M733L probably benign Het
Acss3 G A 10: 106,920,717 (GRCm39) P131L probably damaging Het
Adgrv1 T A 13: 81,539,886 (GRCm39) I5678F probably benign Het
Aff1 C T 5: 103,902,586 (GRCm39) L6F possibly damaging Het
Ank3 G T 10: 69,686,006 (GRCm39) R273L probably damaging Het
Anks1b G A 10: 90,516,699 (GRCm39) G898D probably damaging Het
Anxa11 C T 14: 25,873,158 (GRCm39) P131S unknown Het
Ap4e1 T A 2: 126,889,035 (GRCm39) M500K probably benign Het
Bag3 T C 7: 128,141,922 (GRCm39) S138P probably damaging Het
Capn9 T C 8: 125,344,193 (GRCm39) V670A probably benign Het
Ccne2 T A 4: 11,199,306 (GRCm39) W236R probably damaging Het
Cdh23 A T 10: 60,262,451 (GRCm39) Y702* probably null Het
Chd1l G A 3: 97,494,483 (GRCm39) A399V probably damaging Het
Cit A T 5: 116,086,124 (GRCm39) E896V probably damaging Het
Cntln T A 4: 85,014,998 (GRCm39) N1096K probably damaging Het
Cntnap5c T C 17: 58,411,747 (GRCm39) C544R probably damaging Het
Csf1 A T 3: 107,655,675 (GRCm39) L452Q possibly damaging Het
Cts8 T A 13: 61,397,037 (GRCm39) K294N possibly damaging Het
Dcakd T G 11: 102,890,618 (GRCm39) E56D possibly damaging Het
Dnah17 T C 11: 117,998,987 (GRCm39) I929V probably benign Het
Dnah2 G T 11: 69,382,467 (GRCm39) H1214Q probably benign Het
Dock9 T C 14: 121,872,006 (GRCm39) D536G probably damaging Het
Drc3 A G 11: 60,284,596 (GRCm39) N467S possibly damaging Het
Dysf A G 6: 84,084,118 (GRCm39) probably null Het
Ecpas T G 4: 58,877,157 (GRCm39) T93P probably damaging Het
Evpl A T 11: 116,121,748 (GRCm39) L378Q probably damaging Het
Fer1l4 A T 2: 155,866,660 (GRCm39) H1520Q probably damaging Het
Fhod1 A T 8: 106,063,780 (GRCm39) probably benign Het
Gabra1 T A 11: 42,073,205 (GRCm39) probably benign Het
Gm10549 C A 18: 33,597,358 (GRCm39) probably benign Het
Gm14137 A G 2: 119,005,572 (GRCm39) T44A possibly damaging Het
H2bl1 T A 13: 99,120,974 (GRCm39) R17S probably benign Het
Herc2 T C 7: 55,841,013 (GRCm39) M3444T probably benign Het
Igsf5 T C 16: 96,197,648 (GRCm39) S208P possibly damaging Het
Ino80b A G 6: 83,102,066 (GRCm39) L12P possibly damaging Het
Insrr A G 3: 87,720,272 (GRCm39) D970G probably damaging Het
Iqcf4 G A 9: 106,445,874 (GRCm39) A91V probably benign Het
Itga10 A G 3: 96,564,078 (GRCm39) T911A probably benign Het
Katnip T C 7: 125,469,869 (GRCm39) V1446A probably benign Het
Klhl30 A T 1: 91,285,086 (GRCm39) D314V probably benign Het
Lpcat1 T C 13: 73,659,074 (GRCm39) V330A possibly damaging Het
Myef2l T C 3: 10,154,239 (GRCm39) I336T probably damaging Het
Nhlrc3 A T 3: 53,359,944 (GRCm39) D306E possibly damaging Het
Notum T A 11: 120,548,766 (GRCm39) I187F probably damaging Het
Nphp3 T C 9: 103,892,640 (GRCm39) L288P probably damaging Het
Ntrk2 G T 13: 59,019,570 (GRCm39) E394* probably null Het
Or6k2 T A 1: 173,979,748 (GRCm39) V222D probably benign Het
Pbld2 A G 10: 62,874,931 (GRCm39) K63E probably benign Het
Phc2 T C 4: 128,641,982 (GRCm39) M768T possibly damaging Het
Pik3c2g G A 6: 139,603,561 (GRCm39) C249Y probably damaging Het
Plod1 G A 4: 148,000,772 (GRCm39) probably benign Het
Plscr2 A T 9: 92,172,772 (GRCm39) T9S probably benign Het
Pnrc1 T A 4: 33,246,315 (GRCm39) M215L probably benign Het
Prcp G T 7: 92,577,841 (GRCm39) C370F probably damaging Het
Pter A G 2: 12,983,205 (GRCm39) N70S probably damaging Het
Ptprt G T 2: 161,395,779 (GRCm39) H1131Q probably damaging Het
Rasal2 T C 1: 157,239,432 (GRCm39) D8G possibly damaging Het
Rcn2 A C 9: 55,960,209 (GRCm39) K159Q probably benign Het
Rex2 T A 4: 147,141,972 (GRCm39) C153* probably null Het
Rps6ka2 T C 17: 7,437,766 (GRCm39) F8S possibly damaging Het
Samd9l A G 6: 3,375,383 (GRCm39) L626S probably damaging Het
Sptb A G 12: 76,667,428 (GRCm39) probably null Het
Srgap3 A T 6: 112,793,571 (GRCm39) V135D probably damaging Het
Srsf7 T C 17: 80,514,682 (GRCm39) probably benign Het
Tacc2 A G 7: 130,228,255 (GRCm39) T1647A probably benign Het
Thap12 G T 7: 98,352,612 (GRCm39) A6S probably damaging Het
Tmem33 T A 5: 67,425,894 (GRCm39) L146* probably null Het
Trip13 C A 13: 74,084,378 (GRCm39) E36* probably null Het
Vkorc1l1 T A 5: 129,971,079 (GRCm39) C23S probably damaging Het
Vmn1r20 G A 6: 57,409,112 (GRCm39) R146H probably benign Het
Vmn1r222 T A 13: 23,416,965 (GRCm39) I83F probably benign Het
Vmn2r107 A T 17: 20,576,044 (GRCm39) I125F probably benign Het
Vwa3a C T 7: 120,394,874 (GRCm39) T898I probably benign Het
Wdfy3 T C 5: 102,116,812 (GRCm39) D76G probably damaging Het
Wdhd1 T C 14: 47,510,579 (GRCm39) D148G possibly damaging Het
Xylt1 T C 7: 117,255,960 (GRCm39) I844T probably damaging Het
Zfp106 A T 2: 120,353,185 (GRCm39) V1535D probably damaging Het
Zfp385b A T 2: 77,244,323 (GRCm39) L315Q possibly damaging Het
Zfp458 T A 13: 67,404,870 (GRCm39) H523L probably damaging Het
Zfp712 T C 13: 67,189,393 (GRCm39) H378R probably damaging Het
Zic1 T C 9: 91,246,556 (GRCm39) Y172C probably damaging Het
Other mutations in Vmn2r116
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00898:Vmn2r116 APN 17 23,604,969 (GRCm39) missense possibly damaging 0.94
IGL00985:Vmn2r116 APN 17 23,620,489 (GRCm39) missense probably damaging 1.00
IGL00990:Vmn2r116 APN 17 23,606,210 (GRCm39) missense probably benign 0.12
IGL00990:Vmn2r116 APN 17 23,616,701 (GRCm39) missense probably damaging 1.00
IGL01383:Vmn2r116 APN 17 23,620,575 (GRCm39) missense probably damaging 1.00
IGL01459:Vmn2r116 APN 17 23,603,903 (GRCm39) missense probably damaging 1.00
IGL01725:Vmn2r116 APN 17 23,605,619 (GRCm39) missense probably damaging 1.00
IGL02125:Vmn2r116 APN 17 23,616,601 (GRCm39) splice site probably benign
IGL02170:Vmn2r116 APN 17 23,603,907 (GRCm39) missense probably benign
IGL02209:Vmn2r116 APN 17 23,607,761 (GRCm39) missense probably damaging 1.00
IGL02226:Vmn2r116 APN 17 23,603,808 (GRCm39) missense probably null
IGL02272:Vmn2r116 APN 17 23,604,978 (GRCm39) missense probably damaging 1.00
IGL02272:Vmn2r116 APN 17 23,604,973 (GRCm39) missense probably benign 0.06
IGL02403:Vmn2r116 APN 17 23,606,338 (GRCm39) missense probably damaging 1.00
IGL02686:Vmn2r116 APN 17 23,607,767 (GRCm39) missense probably damaging 0.99
IGL02750:Vmn2r116 APN 17 23,616,608 (GRCm39) splice site probably benign
IGL02977:Vmn2r116 APN 17 23,607,748 (GRCm39) missense possibly damaging 0.90
PIT4449001:Vmn2r116 UTSW 17 23,607,921 (GRCm39) missense probably benign 0.41
R0015:Vmn2r116 UTSW 17 23,620,823 (GRCm39) missense probably benign 0.03
R0219:Vmn2r116 UTSW 17 23,605,072 (GRCm39) nonsense probably null
R0281:Vmn2r116 UTSW 17 23,620,387 (GRCm39) missense possibly damaging 0.90
R0415:Vmn2r116 UTSW 17 23,606,253 (GRCm39) missense possibly damaging 0.55
R0592:Vmn2r116 UTSW 17 23,605,889 (GRCm39) missense probably damaging 0.99
R0610:Vmn2r116 UTSW 17 23,606,286 (GRCm39) missense probably damaging 1.00
R0635:Vmn2r116 UTSW 17 23,605,861 (GRCm39) missense possibly damaging 0.95
R0843:Vmn2r116 UTSW 17 23,619,934 (GRCm39) missense probably benign 0.01
R1329:Vmn2r116 UTSW 17 23,606,162 (GRCm39) missense possibly damaging 0.89
R1396:Vmn2r116 UTSW 17 23,605,115 (GRCm39) missense probably benign
R1401:Vmn2r116 UTSW 17 23,605,570 (GRCm39) splice site probably benign
R1574:Vmn2r116 UTSW 17 23,606,063 (GRCm39) missense probably damaging 0.99
R1574:Vmn2r116 UTSW 17 23,606,063 (GRCm39) missense probably damaging 0.99
R1766:Vmn2r116 UTSW 17 23,620,740 (GRCm39) missense probably damaging 0.98
R2157:Vmn2r116 UTSW 17 23,620,443 (GRCm39) missense probably damaging 1.00
R3622:Vmn2r116 UTSW 17 23,605,025 (GRCm39) missense probably benign 0.11
R3690:Vmn2r116 UTSW 17 23,603,798 (GRCm39) missense unknown
R4298:Vmn2r116 UTSW 17 23,620,801 (GRCm39) missense possibly damaging 0.69
R4373:Vmn2r116 UTSW 17 23,620,395 (GRCm39) missense probably benign 0.01
R4860:Vmn2r116 UTSW 17 23,620,777 (GRCm39) missense probably benign
R4941:Vmn2r116 UTSW 17 23,620,116 (GRCm39) missense probably damaging 1.00
R5119:Vmn2r116 UTSW 17 23,606,138 (GRCm39) missense probably benign 0.01
R5503:Vmn2r116 UTSW 17 23,605,778 (GRCm39) missense probably benign 0.07
R5510:Vmn2r116 UTSW 17 23,605,095 (GRCm39) missense probably damaging 1.00
R5538:Vmn2r116 UTSW 17 23,620,041 (GRCm39) missense probably benign 0.00
R5689:Vmn2r116 UTSW 17 23,616,693 (GRCm39) missense probably benign 0.30
R5765:Vmn2r116 UTSW 17 23,620,378 (GRCm39) missense probably damaging 0.99
R5794:Vmn2r116 UTSW 17 23,604,942 (GRCm39) missense probably damaging 0.99
R5807:Vmn2r116 UTSW 17 23,606,281 (GRCm39) missense probably damaging 1.00
R5837:Vmn2r116 UTSW 17 23,606,054 (GRCm39) missense probably damaging 1.00
R6262:Vmn2r116 UTSW 17 23,606,351 (GRCm39) missense probably benign 0.03
R6651:Vmn2r116 UTSW 17 23,607,805 (GRCm39) nonsense probably null
R6667:Vmn2r116 UTSW 17 23,620,066 (GRCm39) missense probably damaging 1.00
R7393:Vmn2r116 UTSW 17 23,605,099 (GRCm39) missense probably benign 0.14
R7571:Vmn2r116 UTSW 17 23,603,830 (GRCm39) splice site probably null
R7940:Vmn2r116 UTSW 17 23,605,946 (GRCm39) missense probably damaging 0.99
R8510:Vmn2r116 UTSW 17 23,604,905 (GRCm39) nonsense probably null
R8950:Vmn2r116 UTSW 17 23,620,467 (GRCm39) missense probably damaging 1.00
R8956:Vmn2r116 UTSW 17 23,605,736 (GRCm39) missense probably damaging 1.00
R8977:Vmn2r116 UTSW 17 23,605,916 (GRCm39) missense possibly damaging 0.56
R9030:Vmn2r116 UTSW 17 23,603,864 (GRCm39) missense possibly damaging 0.82
R9077:Vmn2r116 UTSW 17 23,604,956 (GRCm39) missense probably benign 0.14
R9223:Vmn2r116 UTSW 17 23,620,141 (GRCm39) missense probably damaging 1.00
R9401:Vmn2r116 UTSW 17 23,620,566 (GRCm39) missense probably damaging 1.00
R9449:Vmn2r116 UTSW 17 23,605,919 (GRCm39) missense probably benign 0.01
R9746:Vmn2r116 UTSW 17 23,620,797 (GRCm39) missense probably benign 0.08
R9755:Vmn2r116 UTSW 17 23,620,065 (GRCm39) missense probably damaging 1.00
R9759:Vmn2r116 UTSW 17 23,620,360 (GRCm39) missense possibly damaging 0.90
R9800:Vmn2r116 UTSW 17 23,620,399 (GRCm39) missense probably damaging 0.97
S24628:Vmn2r116 UTSW 17 23,606,253 (GRCm39) missense possibly damaging 0.55
Z1176:Vmn2r116 UTSW 17 23,620,402 (GRCm39) missense probably damaging 1.00
Z1177:Vmn2r116 UTSW 17 23,607,866 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- AGAATTCATTGTACCTCCTGCTGC -3'
(R):5'- GCTCACAGCTAAGGTACTGTC -3'

Sequencing Primer
(F):5'- ATTGTACCTCCTGCTGCTTCCTG -3'
(R):5'- CACAGCTAAGGTACTGTCTGTATCAC -3'
Posted On 2018-04-02