Mutagenetix > Incidental Mutation

Incidental Mutation 'R6304:Vmn2r51'

509199

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r51

Ensembl Gene

ENSMUSG00000058685

Gene Name

vomeronasal 2, receptor 51

Synonyms

MMRRC Submission

044380-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

R6304 (G1)

Quality Score

169.009

Status

Not validated

Chromosome

Chromosomal Location

10087198-10105659 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 10098237 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Arginine at position 474 (Q474R)

Ref Sequence

ENSEMBL: ENSMUSP00000092459 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094863]

AlphaFold

L7N215

Predicted Effect

probably benign
Transcript: ENSMUST00000094863
AA Change: Q474R

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000092459
Gene: ENSMUSG00000058685
AA Change: Q474R

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	469	2.4e-31	PFAM
Pfam:NCD3G	512	565	8.1e-21	PFAM
Pfam:7tm_3	598	833	2.7e-54	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.5%
20x: 98.4%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932415D10Rik	T	A	10: 82,290,368	K2269N	possibly damaging	Het
5330417C22Rik	A	C	3: 108,461,256	C806W	probably damaging	Het
Apol9b	T	A	15: 77,735,304	V100E	probably damaging	Het
Bin3	A	G	14: 70,137,176	D218G	possibly damaging	Het
Cbll1	A	G	12: 31,494,589		probably null	Het
Cped1	A	T	6: 22,016,923	R90S	probably benign	Het
Csmd1	A	T	8: 16,058,674	L1905Q	probably damaging	Het
Etaa1	A	C	11: 17,947,505	M204R	probably damaging	Het
G6pc	A	G	11: 101,367,909	D38G	probably damaging	Het
Gramd4	A	G	15: 86,134,919	E596G	possibly damaging	Het
Ifna5	T	C	4: 88,835,910	V129A	probably benign	Het
Igsf9b	C	T	9: 27,342,575	R1354W	probably benign	Het
Kcnh3	T	C	15: 99,227,038	V123A	probably benign	Het
Kcnh7	A	T	2: 62,764,616	Y703*	probably null	Het
Kdm2b	A	G	5: 122,881,744	S260P	probably benign	Het
Kdm6b	G	T	11: 69,404,258	T1061K	unknown	Het
Lingo4	G	A	3: 94,403,206	G484R	probably damaging	Het
Lpar1	T	C	4: 58,487,013	Y86C	probably damaging	Het
Lrrc10b	T	C	19: 10,456,978	Q113R	probably benign	Het
Lrrc8c	A	T	5: 105,608,609	N750I	probably benign	Het
Miip	T	C	4: 147,863,083	M207V	probably benign	Het
Mup4	T	C	4: 59,960,084	H60R	possibly damaging	Het
Naip5	C	T	13: 100,223,166	A521T	possibly damaging	Het
Nrp2	T	C	1: 62,745,406	L238P	probably damaging	Het
Nup155	T	C	15: 8,118,042	S262P	probably damaging	Het
Olfr639	G	A	7: 104,012,031	L224F	probably damaging	Het
Osbpl3	A	G	6: 50,312,674	S604P	probably damaging	Het
Pcdhb6	C	T	18: 37,335,921	R632*	probably null	Het
Pcdhb9	T	A	18: 37,401,367	V138E	probably damaging	Het
Pclo	A	T	5: 14,677,893		probably benign	Het
Phyhipl	A	G	10: 70,559,557		probably null	Het
Plcg1	A	G	2: 160,761,463	T1185A	possibly damaging	Het
Pomt1	T	A	2: 32,250,790	L478Q	probably damaging	Het
Robo2	T	A	16: 73,958,308	Y779F	probably damaging	Het
Sesn3	A	T	9: 14,322,561		probably null	Het
Sh3gl1	A	T	17: 56,036,431	F10Y	probably benign	Het
Soga1	T	C	2: 157,040,764	N456S	possibly damaging	Het
Spsb1	C	T	4: 149,906,731	V127I	probably benign	Het
Taf4b	T	C	18: 14,807,355	I297T	probably damaging	Het
Trim14	C	A	4: 46,522,118	M186I	probably benign	Het
Ttn	A	T	2: 76,891,099		probably benign	Het
Ttn	G	T	2: 76,915,735		probably benign	Het
Usp54	T	C	14: 20,560,968	D1260G	possibly damaging	Het
Vmn1r3	T	A	4: 3,184,975	T111S	probably damaging	Het
Wdr78	T	C	4: 103,087,356	E266G	probably benign	Het

Other mutations in Vmn2r51

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01398:Vmn2r51	APN	7	10102414	missense	probably benign
IGL01574:Vmn2r51	APN	7	10102454	missense	probably damaging	1.00
IGL01743:Vmn2r51	APN	7	10100227	missense	probably damaging	0.98
IGL01820:Vmn2r51	APN	7	10105482	missense	probably damaging	1.00
IGL02563:Vmn2r51	APN	7	10100316	missense	probably benign	0.00
IGL02825:Vmn2r51	APN	7	10098119	splice site	probably benign
IGL02834:Vmn2r51	APN	7	10098136	nonsense	probably null
R0617:Vmn2r51	UTSW	7	10100469	missense	possibly damaging	0.65
R0967:Vmn2r51	UTSW	7	10100085	missense	probably damaging	0.97
R1465:Vmn2r51	UTSW	7	10100322	missense	probably damaging	1.00
R1465:Vmn2r51	UTSW	7	10100322	missense	probably damaging	1.00
R1559:Vmn2r51	UTSW	7	10102445	missense	possibly damaging	0.58
R1559:Vmn2r51	UTSW	7	10102446	missense	possibly damaging	0.87
R1598:Vmn2r51	UTSW	7	10105505	missense	probably benign
R1754:Vmn2r51	UTSW	7	10099946	missense	probably benign	0.04
R1836:Vmn2r51	UTSW	7	10098163	nonsense	probably null
R1836:Vmn2r51	UTSW	7	10098164	nonsense	probably null
R3151:Vmn2r51	UTSW	7	10100041	missense	probably damaging	1.00
R4566:Vmn2r51	UTSW	7	10102414	missense	probably benign
R4933:Vmn2r51	UTSW	7	10098320	missense	probably damaging	1.00
R5004:Vmn2r51	UTSW	7	10088005	missense	probably benign
R5050:Vmn2r51	UTSW	7	10100422	missense	probably damaging	0.99
R5510:Vmn2r51	UTSW	7	10102618	missense	possibly damaging	0.95
R5559:Vmn2r51	UTSW	7	10092201	missense	probably damaging	1.00
R6127:Vmn2r51	UTSW	7	10105631	missense	probably damaging	1.00
R6154:Vmn2r51	UTSW	7	10087994	missense	possibly damaging	0.74
R6370:Vmn2r51	UTSW	7	10098216	missense	probably damaging	1.00
R6471:Vmn2r51	UTSW	7	10102583	missense	possibly damaging	0.48
R6800:Vmn2r51	UTSW	7	10098264	missense	probably damaging	0.99
R6883:Vmn2r51	UTSW	7	10100098	missense	possibly damaging	0.75
R7191:Vmn2r51	UTSW	7	10100553	missense	probably null	1.00
R7246:Vmn2r51	UTSW	7	10102501	missense	probably benign	0.00
R8939:Vmn2r51	UTSW	7	10100026	missense	possibly damaging	0.85
R9154:Vmn2r51	UTSW	7	10105553	missense	probably damaging	0.96
R9428:Vmn2r51	UTSW	7	10099785	critical splice donor site	probably benign
R9451:Vmn2r51	UTSW	7	10099889	missense	probably damaging	1.00
R9729:Vmn2r51	UTSW	7	10105552	missense	probably benign	0.00
R9767:Vmn2r51	UTSW	7	10105480	missense	probably benign	0.09
Z1176:Vmn2r51	UTSW	7	10088057	missense	possibly damaging	0.76
Z1176:Vmn2r51	UTSW	7	10099908	missense	probably benign	0.12

Predicted Primers

PCR Primer
(F):5'- GCCGTGTATTCATCTGACACTG -3'
(R):5'- GCAATTGCATTTGTTGTGATTCCTC -3'

Sequencing Primer
(F):5'- GTGTATTCATCTGACACTGTTTACTG -3'
(R):5'- TGCCTTTGCTATGAAATCAGAATG -3'

Posted On

2018-04-02