Mutagenetix > Incidental Mutation

Incidental Mutation 'R6329:Tenm3'

509397

Institutional Source

Beutler Lab

Gene Symbol

Tenm3

Ensembl Gene

ENSMUSG00000031561

Gene Name

teneurin transmembrane protein 3

Synonyms

Ten-m3, Odz3, 2610100B16Rik

MMRRC Submission

044483-MU

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.598) question?

Stock #

R6329 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

48227682-48843951 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 48276849 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 1374 (Y1374C)

Ref Sequence

ENSEMBL: ENSMUSP00000033965 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000033965] [ENSMUST00000190840]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000033965
AA Change: Y1374C

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000033965
Gene: ENSMUSG00000031561
AA Change: Y1374C

Domain	Start	End	E-Value	Type
Pfam:Ten_N	11	177	6.9e-91	PFAM
Pfam:Ten_N	171	308	1e-72	PFAM
transmembrane domain	309	331	N/A	INTRINSIC
EGF	517	545	2.32e-1	SMART
EGF_like	548	576	4.11e1	SMART
EGF	581	610	1.69e1	SMART
EGF	613	642	1.35e-2	SMART
EGF	647	677	6.11e-1	SMART
EGF	680	708	7.95e0	SMART
EGF	711	739	1.28e1	SMART
EGF	751	783	1.64e-1	SMART
PDB:1RWL\|A	1276	1511	9e-6	PDB
low complexity region	2593	2602	N/A	INTRINSIC
Pfam:Tox-GHH	2631	2708	1.5e-34	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000145344

Predicted Effect

probably damaging
Transcript: ENSMUST00000190840
AA Change: Y1358C

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000140141
Gene: ENSMUSG00000031561
AA Change: Y1358C

Domain	Start	End	E-Value	Type
Pfam:Ten_N	10	182	7.6e-77	PFAM
Pfam:Ten_N	168	308	6.6e-50	PFAM
transmembrane domain	309	331	N/A	INTRINSIC
EGF	517	545	2.32e-1	SMART
EGF_like	548	576	4.11e1	SMART
EGF	581	610	1.69e1	SMART
EGF	613	642	1.35e-2	SMART
EGF	647	677	6.11e-1	SMART
EGF	680	708	7.95e0	SMART
EGF	711	739	1.28e1	SMART
EGF	751	783	1.64e-1	SMART
PDB:1RWL\|A	1276	1511	9e-6	PDB
low complexity region	2593	2602	N/A	INTRINSIC
Pfam:Tox-GHH	2630	2708	3.2e-35	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.3%
20x: 97.6%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a large transmembrane protein that may be involved in the regulation of neuronal development. Mutation in this gene causes microphthalmia. [provided by RefSeq, Aug 2015]
PHENOTYPE: Mice homozygous for a null mutation display abnormal ipsilateral retinal ganglion cell projections and impaired performance in visually mediated behavioral tasks. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 77 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930579F01Rik	T	C	3: 138,173,696 (GRCm38)	H72R	probably damaging	Het
Abca13	A	T	11: 9,277,937 (GRCm38)	N660I	probably damaging	Het
Actr8	C	T	14: 29,993,084 (GRCm38)	R619*	probably null	Het
Adam18	C	A	8: 24,614,827 (GRCm38)	G657V	probably damaging	Het
Adcyap1	A	G	17: 93,202,799 (GRCm38)	E85G	probably benign	Het
Akr1c14	A	G	13: 4,087,302 (GRCm38)	Y305C	probably damaging	Het
Ankdd1b	T	A	13: 96,454,880 (GRCm38)	H37L	possibly damaging	Het
Ap4e1	T	C	2: 127,061,716 (GRCm38)	L846P	probably benign	Het
Aqp9	A	T	9: 71,132,684 (GRCm38)	Y105*	probably null	Het
Arid1b	C	T	17: 5,337,263 (GRCm38)	Q1664*	probably null	Het
Aup1	A	G	6: 83,054,607 (GRCm38)		probably benign	Het
Bnip1	C	A	17: 26,786,710 (GRCm38)	S64*	probably null	Het
Calcr	T	A	6: 3,687,621 (GRCm38)	Q422L	probably damaging	Het
Ccdc162	T	A	10: 41,663,151 (GRCm38)	D407V	possibly damaging	Het
Ccdc66	G	T	14: 27,486,484 (GRCm38)	S760R	probably benign	Het
Cd22	T	A	7: 30,877,768 (GRCm38)	E38V	probably damaging	Het
Cggbp1	T	C	16: 64,856,020 (GRCm38)	Y150H	probably damaging	Het
Chd3	T	C	11: 69,361,684 (GRCm38)	K263R	possibly damaging	Het
Col4a2	T	A	8: 11,446,238 (GRCm38)	F1620I	probably damaging	Het
Col6a2	T	C	10: 76,599,828 (GRCm38)	T858A	probably benign	Het
Dnah7a	T	A	1: 53,541,114 (GRCm38)	D1554V	probably damaging	Het
Dnajc25	A	T	4: 59,013,678 (GRCm38)	Q132L	probably benign	Het
Dnase1l1	C	T	X: 74,277,038 (GRCm38)		probably null	Homo
Ehbp1l1	A	C	19: 5,718,767 (GRCm38)	I836S	possibly damaging	Het
Elf1	A	G	14: 79,573,339 (GRCm38)	Q288R	possibly damaging	Het
Fbn1	C	A	2: 125,308,473 (GRCm38)	V2608L	possibly damaging	Het
Frmpd1	T	C	4: 45,268,551 (GRCm38)	I232T	possibly damaging	Het
Fuca1	T	A	4: 135,934,826 (GRCm38)	I355N	probably damaging	Het
Gcnt4	A	G	13: 96,947,273 (GRCm38)	D359G	probably damaging	Het
Gm15448	T	C	7: 3,822,851 (GRCm38)	T340A	probably damaging	Het
Gm5134	T	C	10: 75,954,660 (GRCm38)	M30T	possibly damaging	Het
Grk1	T	G	8: 13,405,704 (GRCm38)	L196R	probably damaging	Het
Igkv14-126	A	C	6: 67,896,564 (GRCm38)	D92A	probably damaging	Het
Kmt2c	A	G	5: 25,315,602 (GRCm38)	S1837P	probably benign	Het
Lhx4	T	A	1: 155,702,554 (GRCm38)	T281S	probably benign	Het
Lrrc55	G	T	2: 85,196,309 (GRCm38)	H124N	probably benign	Het
March8	T	A	6: 116,406,316 (GRCm38)	I566N	possibly damaging	Het
Mycbp2	G	A	14: 103,155,852 (GRCm38)	A3091V	probably benign	Het
Nlrp4b	A	G	7: 10,724,920 (GRCm38)	N355S	probably benign	Het
Nmur2	A	G	11: 56,029,585 (GRCm38)	V278A	probably benign	Het
Nod1	T	C	6: 54,944,704 (GRCm38)	M210V	probably benign	Het
Nt5c1b	T	A	12: 10,372,138 (GRCm38)	C63*	probably null	Het
Olfr1164	G	A	2: 88,093,664 (GRCm38)	P91S	probably damaging	Het
Olfr1288	C	T	2: 111,479,228 (GRCm38)	A148V	possibly damaging	Het
Olfr346	A	T	2: 36,688,682 (GRCm38)	K227*	probably null	Het
Olfr397	A	G	11: 73,964,742 (GRCm38)	I45V	possibly damaging	Het
Olfr836	A	C	9: 19,120,957 (GRCm38)	M1L	probably benign	Het
Olfr884	T	C	9: 38,047,825 (GRCm38)	V201A	probably benign	Het
Olfr938	C	T	9: 39,077,903 (GRCm38)	V281I	probably benign	Het
Osbp2	T	A	11: 3,715,153 (GRCm38)	S517C	probably damaging	Het
Pcdha1	C	T	18: 36,932,248 (GRCm38)	P655L	probably damaging	Het
Pdcd6	A	G	13: 74,303,979 (GRCm38)	Y181H	probably damaging	Het
Perp	G	A	10: 18,855,754 (GRCm38)	G154S	probably damaging	Het
Perp	G	T	10: 18,855,755 (GRCm38)	G154V	probably damaging	Het
Prokr1	T	G	6: 87,581,792 (GRCm38)	T204P	possibly damaging	Het
Prpf3	A	T	3: 95,832,578 (GRCm38)	C630S	probably damaging	Het
Pter	C	A	2: 12,980,548 (GRCm38)	H230N	probably damaging	Het
Ptprs	A	T	17: 56,417,427 (GRCm38)	Y1167*	probably null	Het
Rad54l2	T	C	9: 106,717,922 (GRCm38)	I279V	possibly damaging	Het
Rora	T	A	9: 69,373,186 (GRCm38)	L347Q	probably damaging	Het
Runx1t1	T	G	4: 13,785,136 (GRCm38)	M1R	probably null	Het
Sdcbp	A	G	4: 6,381,064 (GRCm38)	S70G	probably benign	Het
Serpinb12	A	G	1: 106,953,763 (GRCm38)	Y210C	probably damaging	Het
Sipa1	T	C	19: 5,651,489 (GRCm38)	E1015G	probably damaging	Het
Slc15a2	A	C	16: 36,751,782 (GRCm38)	L740R	possibly damaging	Het
Specc1	A	G	11: 62,156,553 (GRCm38)	E916G	probably damaging	Het
Spta1	T	C	1: 174,214,177 (GRCm38)	I1371T	possibly damaging	Het
Tagln3	T	C	16: 45,713,002 (GRCm38)	M130V	probably benign	Het
Tchh	A	T	3: 93,446,445 (GRCm38)	E1064V	unknown	Het
Tdp1	G	C	12: 99,914,072 (GRCm38)	S464T	probably benign	Het
Tdp1	A	T	12: 99,914,071 (GRCm38)	S464C	probably damaging	Het
Tmprss3	A	T	17: 31,183,859 (GRCm38)	Y455*	probably null	Het
Ttc5	A	G	14: 50,765,928 (GRCm38)	V433A	possibly damaging	Het
Wnt5a	A	T	14: 28,518,492 (GRCm38)	R180*	probably null	Het
Zfp53	A	G	17: 21,508,110 (GRCm38)	D135G	probably benign	Het
Zfp619	T	A	7: 39,537,545 (GRCm38)	C1000S	probably damaging	Het
Zfp647	G	A	15: 76,912,085 (GRCm38)	P125L	probably damaging	Het

Other mutations in Tenm3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00272:Tenm3	APN	8	48,417,060 (GRCm38)	missense	probably damaging	1.00
IGL00538:Tenm3	APN	8	48,236,025 (GRCm38)	missense	probably damaging	1.00
IGL00719:Tenm3	APN	8	48,279,042 (GRCm38)	missense	probably benign	0.39
IGL00720:Tenm3	APN	8	48,276,421 (GRCm38)	missense	probably damaging	0.98
IGL00870:Tenm3	APN	8	48,417,132 (GRCm38)	missense	probably benign	0.00
IGL00976:Tenm3	APN	8	48,256,841 (GRCm38)	missense	probably benign	0.14
IGL01469:Tenm3	APN	8	48,236,423 (GRCm38)	missense	probably damaging	1.00
IGL01508:Tenm3	APN	8	48,276,645 (GRCm38)	missense	probably benign	0.09
IGL01590:Tenm3	APN	8	48,228,802 (GRCm38)	missense	probably damaging	1.00
IGL01610:Tenm3	APN	8	48,254,477 (GRCm38)	missense	probably damaging	1.00
IGL01874:Tenm3	APN	8	48,236,758 (GRCm38)	nonsense	probably null
IGL01892:Tenm3	APN	8	48,276,396 (GRCm38)	missense	probably benign	0.09
IGL02098:Tenm3	APN	8	48,276,576 (GRCm38)	missense	possibly damaging	0.94
IGL02382:Tenm3	APN	8	48,235,476 (GRCm38)	missense	probably damaging	1.00
IGL02397:Tenm3	APN	8	48,236,694 (GRCm38)	missense	possibly damaging	0.94
IGL02475:Tenm3	APN	8	48,279,198 (GRCm38)	splice site	probably benign
IGL02502:Tenm3	APN	8	48,288,016 (GRCm38)	missense	probably damaging	1.00
IGL02508:Tenm3	APN	8	48,299,639 (GRCm38)	missense	probably benign	0.30
IGL02543:Tenm3	APN	8	48,298,956 (GRCm38)	missense	probably damaging	1.00
IGL02723:Tenm3	APN	8	48,276,903 (GRCm38)	missense	probably benign	0.02
IGL03037:Tenm3	APN	8	48,298,878 (GRCm38)	missense	possibly damaging	0.90
IGL03160:Tenm3	APN	8	48,646,418 (GRCm38)	missense	probably benign	0.05
IGL03268:Tenm3	APN	8	48,235,523 (GRCm38)	missense	probably damaging	1.00
IGL02988:Tenm3	UTSW	8	48,235,346 (GRCm38)	missense	probably damaging	0.99
PIT4431001:Tenm3	UTSW	8	48,235,607 (GRCm38)	missense	probably damaging	1.00
PIT4504001:Tenm3	UTSW	8	48,293,657 (GRCm38)	missense	probably damaging	1.00
R0079:Tenm3	UTSW	8	48,343,345 (GRCm38)	missense	possibly damaging	0.90
R0121:Tenm3	UTSW	8	48,342,659 (GRCm38)	missense	probably damaging	0.99
R0123:Tenm3	UTSW	8	48,674,472 (GRCm38)	missense	probably damaging	1.00
R0134:Tenm3	UTSW	8	48,674,472 (GRCm38)	missense	probably damaging	1.00
R0147:Tenm3	UTSW	8	48,236,720 (GRCm38)	missense	probably damaging	1.00
R0148:Tenm3	UTSW	8	48,236,720 (GRCm38)	missense	probably damaging	1.00
R0309:Tenm3	UTSW	8	48,341,034 (GRCm38)	missense	probably damaging	1.00
R0322:Tenm3	UTSW	8	48,236,912 (GRCm38)	splice site	probably benign
R0335:Tenm3	UTSW	8	48,232,105 (GRCm38)	missense	probably damaging	1.00
R0355:Tenm3	UTSW	8	48,228,975 (GRCm38)	missense	probably damaging	1.00
R0411:Tenm3	UTSW	8	48,287,791 (GRCm38)	missense	possibly damaging	0.61
R0505:Tenm3	UTSW	8	48,341,160 (GRCm38)	splice site	probably benign
R0573:Tenm3	UTSW	8	48,674,399 (GRCm38)	splice site	probably benign
R0599:Tenm3	UTSW	8	48,277,710 (GRCm38)	missense	probably damaging	1.00
R0616:Tenm3	UTSW	8	48,276,156 (GRCm38)	missense	possibly damaging	0.76
R0637:Tenm3	UTSW	8	48,236,525 (GRCm38)	missense	probably damaging	1.00
R0726:Tenm3	UTSW	8	48,236,594 (GRCm38)	missense	probably damaging	1.00
R0840:Tenm3	UTSW	8	48,335,742 (GRCm38)	missense	probably damaging	0.99
R0981:Tenm3	UTSW	8	48,298,965 (GRCm38)	missense	probably damaging	1.00
R1006:Tenm3	UTSW	8	48,228,542 (GRCm38)	missense	probably damaging	1.00
R1199:Tenm3	UTSW	8	48,235,582 (GRCm38)	missense	probably damaging	0.99
R1223:Tenm3	UTSW	8	48,240,396 (GRCm38)	missense	possibly damaging	0.72
R1240:Tenm3	UTSW	8	48,287,893 (GRCm38)	missense	possibly damaging	0.74
R1394:Tenm3	UTSW	8	48,276,400 (GRCm38)	missense	probably benign
R1455:Tenm3	UTSW	8	48,279,048 (GRCm38)	missense	possibly damaging	0.87
R1459:Tenm3	UTSW	8	48,235,971 (GRCm38)	missense	probably damaging	1.00
R1473:Tenm3	UTSW	8	48,310,625 (GRCm38)	missense	probably damaging	1.00
R1501:Tenm3	UTSW	8	48,343,316 (GRCm38)	missense	probably damaging	0.99
R1507:Tenm3	UTSW	8	48,287,822 (GRCm38)	missense	probably benign	0.01
R1522:Tenm3	UTSW	8	48,395,576 (GRCm38)	missense	probably damaging	1.00
R1524:Tenm3	UTSW	8	48,228,981 (GRCm38)	missense	possibly damaging	0.92
R1553:Tenm3	UTSW	8	48,236,421 (GRCm38)	missense	probably damaging	1.00
R1572:Tenm3	UTSW	8	48,228,993 (GRCm38)	missense	possibly damaging	0.94
R1583:Tenm3	UTSW	8	48,279,074 (GRCm38)	missense	probably benign	0.09
R1676:Tenm3	UTSW	8	48,417,119 (GRCm38)	missense	possibly damaging	0.83
R1732:Tenm3	UTSW	8	48,310,634 (GRCm38)	missense	probably damaging	1.00
R1768:Tenm3	UTSW	8	48,232,104 (GRCm38)	missense	probably damaging	1.00
R1777:Tenm3	UTSW	8	48,417,179 (GRCm38)	missense	probably benign	0.05
R1793:Tenm3	UTSW	8	48,674,544 (GRCm38)	missense	probably damaging	0.98
R1801:Tenm3	UTSW	8	48,276,256 (GRCm38)	missense	probably benign	0.39
R1863:Tenm3	UTSW	8	48,276,346 (GRCm38)	missense	probably benign	0.20
R1898:Tenm3	UTSW	8	48,310,761 (GRCm38)	missense	probably damaging	1.00
R1971:Tenm3	UTSW	8	48,236,313 (GRCm38)	missense	probably damaging	1.00
R1972:Tenm3	UTSW	8	48,228,591 (GRCm38)	missense	probably damaging	1.00
R1996:Tenm3	UTSW	8	48,228,668 (GRCm38)	missense	probably damaging	1.00
R2061:Tenm3	UTSW	8	48,342,256 (GRCm38)	critical splice donor site	probably null
R2109:Tenm3	UTSW	8	48,343,349 (GRCm38)	missense	possibly damaging	0.94
R2124:Tenm3	UTSW	8	48,417,006 (GRCm38)	critical splice donor site	probably null
R2190:Tenm3	UTSW	8	48,395,544 (GRCm38)	missense	probably damaging	1.00
R2204:Tenm3	UTSW	8	48,674,550 (GRCm38)	missense	probably benign	0.17
R2233:Tenm3	UTSW	8	48,276,169 (GRCm38)	missense	probably benign	0.04
R2234:Tenm3	UTSW	8	48,276,169 (GRCm38)	missense	probably benign	0.04
R2235:Tenm3	UTSW	8	48,276,169 (GRCm38)	missense	probably benign	0.04
R2237:Tenm3	UTSW	8	48,342,337 (GRCm38)	missense	probably damaging	1.00
R2418:Tenm3	UTSW	8	48,276,658 (GRCm38)	missense	possibly damaging	0.87
R2419:Tenm3	UTSW	8	48,276,658 (GRCm38)	missense	possibly damaging	0.87
R2435:Tenm3	UTSW	8	48,287,953 (GRCm38)	missense	probably damaging	1.00
R2483:Tenm3	UTSW	8	48,240,270 (GRCm38)	missense	probably damaging	0.99
R3406:Tenm3	UTSW	8	48,228,555 (GRCm38)	missense	probably damaging	1.00
R3724:Tenm3	UTSW	8	48,277,746 (GRCm38)	missense	probably damaging	0.97
R4009:Tenm3	UTSW	8	48,349,223 (GRCm38)	missense	probably damaging	1.00
R4210:Tenm3	UTSW	8	48,349,404 (GRCm38)	missense	probably damaging	1.00
R4293:Tenm3	UTSW	8	48,395,658 (GRCm38)	missense	probably damaging	1.00
R4656:Tenm3	UTSW	8	48,293,726 (GRCm38)	missense	probably damaging	1.00
R4663:Tenm3	UTSW	8	48,235,970 (GRCm38)	missense	probably damaging	1.00
R4835:Tenm3	UTSW	8	48,313,236 (GRCm38)	critical splice donor site	probably null
R4851:Tenm3	UTSW	8	48,310,621 (GRCm38)	critical splice donor site	probably null
R4867:Tenm3	UTSW	8	48,235,821 (GRCm38)	missense	probably damaging	1.00
R4892:Tenm3	UTSW	8	48,276,861 (GRCm38)	missense	probably damaging	0.99
R4895:Tenm3	UTSW	8	48,300,971 (GRCm38)	missense	probably damaging	1.00
R4962:Tenm3	UTSW	8	48,278,961 (GRCm38)	nonsense	probably null
R4995:Tenm3	UTSW	8	48,229,137 (GRCm38)	missense	possibly damaging	0.87
R4996:Tenm3	UTSW	8	48,235,826 (GRCm38)	missense	probably damaging	0.97
R5091:Tenm3	UTSW	8	48,342,308 (GRCm38)	missense	probably benign	0.14
R5228:Tenm3	UTSW	8	48,236,355 (GRCm38)	missense	probably damaging	1.00
R5253:Tenm3	UTSW	8	48,229,198 (GRCm38)	missense	possibly damaging	0.92
R5260:Tenm3	UTSW	8	48,236,855 (GRCm38)	missense	probably damaging	1.00
R5363:Tenm3	UTSW	8	48,287,831 (GRCm38)	missense	possibly damaging	0.55
R5414:Tenm3	UTSW	8	48,236,355 (GRCm38)	missense	probably damaging	1.00
R5427:Tenm3	UTSW	8	48,236,564 (GRCm38)	missense	probably damaging	1.00
R5431:Tenm3	UTSW	8	48,367,377 (GRCm38)	nonsense	probably null
R5566:Tenm3	UTSW	8	48,279,006 (GRCm38)	missense	probably damaging	1.00
R5579:Tenm3	UTSW	8	48,236,764 (GRCm38)	missense	probably damaging	1.00
R5656:Tenm3	UTSW	8	48,228,762 (GRCm38)	missense	probably damaging	1.00
R5931:Tenm3	UTSW	8	48,646,498 (GRCm38)	missense	probably benign	0.00
R5959:Tenm3	UTSW	8	48,646,447 (GRCm38)	nonsense	probably null
R5965:Tenm3	UTSW	8	48,228,508 (GRCm38)	nonsense	probably null
R6062:Tenm3	UTSW	8	48,343,406 (GRCm38)	missense	possibly damaging	0.46
R6151:Tenm3	UTSW	8	48,395,573 (GRCm38)	missense	probably damaging	1.00
R6157:Tenm3	UTSW	8	48,298,808 (GRCm38)	missense	probably damaging	0.96
R6167:Tenm3	UTSW	8	48,254,622 (GRCm38)	missense	possibly damaging	0.46
R6217:Tenm3	UTSW	8	48,293,665 (GRCm38)	missense	probably damaging	0.99
R6233:Tenm3	UTSW	8	48,417,059 (GRCm38)	missense	probably damaging	1.00
R6270:Tenm3	UTSW	8	48,367,394 (GRCm38)	missense	probably damaging	0.98
R6466:Tenm3	UTSW	8	48,236,063 (GRCm38)	missense	probably damaging	0.97
R6515:Tenm3	UTSW	8	48,417,222 (GRCm38)	missense	probably benign
R6516:Tenm3	UTSW	8	48,417,222 (GRCm38)	missense	probably benign
R6747:Tenm3	UTSW	8	48,343,243 (GRCm38)	missense	probably damaging	1.00
R6782:Tenm3	UTSW	8	48,646,256 (GRCm38)	critical splice donor site	probably null
R6788:Tenm3	UTSW	8	48,674,493 (GRCm38)	missense	probably damaging	1.00
R6823:Tenm3	UTSW	8	48,256,837 (GRCm38)	missense	probably damaging	0.99
R6846:Tenm3	UTSW	8	48,276,738 (GRCm38)	missense	probably benign	0.39
R6913:Tenm3	UTSW	8	48,298,937 (GRCm38)	missense	probably damaging	0.99
R6941:Tenm3	UTSW	8	48,674,416 (GRCm38)	missense	probably damaging	0.99
R6950:Tenm3	UTSW	8	48,240,479 (GRCm38)	nonsense	probably null
R6968:Tenm3	UTSW	8	48,236,439 (GRCm38)	missense	probably damaging	1.00
R6970:Tenm3	UTSW	8	48,236,439 (GRCm38)	missense	probably damaging	1.00
R6993:Tenm3	UTSW	8	48,236,439 (GRCm38)	missense	probably damaging	1.00
R7003:Tenm3	UTSW	8	48,240,444 (GRCm38)	missense	probably damaging	1.00
R7125:Tenm3	UTSW	8	48,674,553 (GRCm38)	missense	probably benign	0.00
R7140:Tenm3	UTSW	8	48,292,236 (GRCm38)	missense	probably damaging	1.00
R7222:Tenm3	UTSW	8	48,300,969 (GRCm38)	missense	probably damaging	1.00
R7232:Tenm3	UTSW	8	48,235,935 (GRCm38)	missense	probably damaging	1.00
R7336:Tenm3	UTSW	8	48,236,177 (GRCm38)	missense	possibly damaging	0.93
R7417:Tenm3	UTSW	8	48,236,183 (GRCm38)	missense	probably damaging	1.00
R7526:Tenm3	UTSW	8	48,287,812 (GRCm38)	missense	probably damaging	0.96
R7527:Tenm3	UTSW	8	48,276,600 (GRCm38)	missense	possibly damaging	0.60
R7616:Tenm3	UTSW	8	48,341,049 (GRCm38)	missense	possibly damaging	0.56
R7662:Tenm3	UTSW	8	48,335,727 (GRCm38)	missense	probably benign	0.27
R7734:Tenm3	UTSW	8	48,646,333 (GRCm38)	missense	probably damaging	1.00
R7802:Tenm3	UTSW	8	48,236,465 (GRCm38)	missense	probably damaging	1.00
R7812:Tenm3	UTSW	8	48,276,300 (GRCm38)	missense	probably benign	0.01
R7843:Tenm3	UTSW	8	48,229,111 (GRCm38)	nonsense	probably null
R7951:Tenm3	UTSW	8	48,310,703 (GRCm38)	missense	possibly damaging	0.86
R8293:Tenm3	UTSW	8	48,367,422 (GRCm38)	missense	possibly damaging	0.91
R8336:Tenm3	UTSW	8	48,293,773 (GRCm38)	missense	probably damaging	1.00
R8351:Tenm3	UTSW	8	48,287,872 (GRCm38)	missense	probably damaging	0.96
R8387:Tenm3	UTSW	8	48,287,848 (GRCm38)	missense	probably damaging	0.98
R8414:Tenm3	UTSW	8	48,293,509 (GRCm38)	missense	probably damaging	1.00
R8451:Tenm3	UTSW	8	48,287,872 (GRCm38)	missense	probably damaging	0.96
R8465:Tenm3	UTSW	8	48,229,181 (GRCm38)	missense	probably damaging	1.00
R8528:Tenm3	UTSW	8	48,342,633 (GRCm38)	missense	probably damaging	1.00
R8717:Tenm3	UTSW	8	48,299,645 (GRCm38)	missense	possibly damaging	0.77
R8734:Tenm3	UTSW	8	48,349,356 (GRCm38)	missense	probably benign	0.16
R8781:Tenm3	UTSW	8	48,342,449 (GRCm38)	frame shift	probably null
R8820:Tenm3	UTSW	8	48,310,724 (GRCm38)	missense	probably damaging	0.96
R8821:Tenm3	UTSW	8	48,276,382 (GRCm38)	missense
R8831:Tenm3	UTSW	8	48,276,382 (GRCm38)	missense
R8853:Tenm3	UTSW	8	48,342,347 (GRCm38)	missense	probably damaging	1.00
R8900:Tenm3	UTSW	8	48,236,402 (GRCm38)	missense	probably damaging	1.00
R8931:Tenm3	UTSW	8	48,235,602 (GRCm38)	missense	probably damaging	1.00
R8933:Tenm3	UTSW	8	48,279,060 (GRCm38)	missense	possibly damaging	0.53
R8989:Tenm3	UTSW	8	48,235,348 (GRCm38)	nonsense	probably null
R8998:Tenm3	UTSW	8	48,276,687 (GRCm38)	missense	probably damaging	1.00
R9008:Tenm3	UTSW	8	48,342,653 (GRCm38)	missense	probably damaging	0.98
R9017:Tenm3	UTSW	8	48,254,633 (GRCm38)	missense	probably damaging	0.99
R9101:Tenm3	UTSW	8	48,292,151 (GRCm38)	missense	probably damaging	1.00
R9108:Tenm3	UTSW	8	48,313,236 (GRCm38)	critical splice donor site	probably null
R9142:Tenm3	UTSW	8	48,335,513 (GRCm38)	missense	unknown
R9231:Tenm3	UTSW	8	48,236,196 (GRCm38)	missense	probably damaging	1.00
R9309:Tenm3	UTSW	8	48,298,937 (GRCm38)	missense	probably damaging	0.99
R9310:Tenm3	UTSW	8	48,555,900 (GRCm38)	unclassified	probably benign
R9336:Tenm3	UTSW	8	48,417,080 (GRCm38)	missense	probably damaging	1.00
R9373:Tenm3	UTSW	8	48,299,655 (GRCm38)	missense	probably damaging	1.00
R9393:Tenm3	UTSW	8	48,674,524 (GRCm38)	missense	probably damaging	0.99
R9509:Tenm3	UTSW	8	48,313,257 (GRCm38)	nonsense	probably null
R9575:Tenm3	UTSW	8	48,235,761 (GRCm38)	missense	possibly damaging	0.94
R9698:Tenm3	UTSW	8	48,236,211 (GRCm38)	missense	probably damaging	1.00
R9722:Tenm3	UTSW	8	48,300,814 (GRCm38)	missense	probably benign	0.00
R9788:Tenm3	UTSW	8	48,335,561 (GRCm38)	missense	probably benign	0.02
X0010:Tenm3	UTSW	8	48,287,829 (GRCm38)	missense	probably damaging	0.98
X0025:Tenm3	UTSW	8	48,236,477 (GRCm38)	missense	probably damaging	1.00
Z1177:Tenm3	UTSW	8	48,276,780 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ATGTAAAGGACCCCGCTGTAGG -3'
(R):5'- GCAAATCTTTCCATGCACCG -3'

Sequencing Primer
(F):5'- TGTAGGACACAGCAATGGC -3'
(R):5'- GCACCGACTGCATCTTTAAATAAG -3'

Posted On

2018-04-02