Mutagenetix > Incidental Mutation

Incidental Mutation 'R6329:Mycbp2'

509427

Institutional Source

Beutler Lab

Gene Symbol

Mycbp2

Ensembl Gene

ENSMUSG00000033004

Gene Name

MYC binding protein 2, E3 ubiquitin protein ligase

Synonyms

Phr1, Pam, C130061D10Rik

MMRRC Submission

044483-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R6329 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

103350847-103584250 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 103393288 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Valine at position 3091 (A3091V)

Ref Sequence

ENSEMBL: ENSMUSP00000124710 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000159855] [ENSMUST00000160758]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000159855
AA Change: A3091V

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

SMART Domains

Protein: ENSMUSP00000124710
Gene: ENSMUSG00000033004
AA Change: A3091V

Domain	Start	End	E-Value	Type
low complexity region	5	27	N/A	INTRINSIC
low complexity region	47	55	N/A	INTRINSIC
low complexity region	100	127	N/A	INTRINSIC
low complexity region	178	191	N/A	INTRINSIC
Pfam:RCC1_2	683	712	1.4e-10	PFAM
low complexity region	737	750	N/A	INTRINSIC
low complexity region	793	815	N/A	INTRINSIC
Pfam:RCC1_2	942	971	5.5e-10	PFAM
Pfam:RCC1	958	1006	4.8e-15	PFAM
Pfam:PHR	1235	1385	8.2e-44	PFAM
Pfam:PHR	1723	1880	1.4e-43	PFAM
low complexity region	1935	1948	N/A	INTRINSIC
low complexity region	2182	2195	N/A	INTRINSIC
Pfam:Filamin	2261	2431	7.5e-9	PFAM
Pfam:SH3_3	2472	2539	4.1e-9	PFAM
internal_repeat_3	2612	2679	1.69e-7	PROSPERO
low complexity region	2701	2710	N/A	INTRINSIC
low complexity region	2884	2917	N/A	INTRINSIC
low complexity region	2970	2984	N/A	INTRINSIC
coiled coil region	3263	3290	N/A	INTRINSIC
low complexity region	3352	3365	N/A	INTRINSIC
low complexity region	3418	3433	N/A	INTRINSIC
low complexity region	3678	3695	N/A	INTRINSIC
APC10	3810	3968	1.11e-18	SMART
low complexity region	4103	4115	N/A	INTRINSIC
low complexity region	4190	4212	N/A	INTRINSIC
Blast:BBOX	4327	4370	7e-7	BLAST
RING	4496	4546	5.35e-5	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000160758
AA Change: A2981V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000124601
Gene: ENSMUSG00000033004
AA Change: A2981V

Domain	Start	End	E-Value	Type
low complexity region	14	22	N/A	INTRINSIC
low complexity region	67	94	N/A	INTRINSIC
low complexity region	145	158	N/A	INTRINSIC
Pfam:RCC1_2	650	679	1e-10	PFAM
low complexity region	704	717	N/A	INTRINSIC
low complexity region	760	782	N/A	INTRINSIC
Pfam:RCC1_2	909	938	1.5e-9	PFAM
Pfam:RCC1	925	973	1.3e-15	PFAM
Pfam:PHR	1202	1353	1.6e-50	PFAM
Pfam:PHR	1690	1848	3.1e-58	PFAM
low complexity region	1902	1915	N/A	INTRINSIC
low complexity region	2149	2162	N/A	INTRINSIC
Pfam:Filamin	2228	2398	7.6e-9	PFAM
Pfam:SH3_3	2439	2507	2.3e-10	PFAM
internal_repeat_3	2554	2621	2e-7	PROSPERO
low complexity region	2643	2652	N/A	INTRINSIC
low complexity region	2774	2807	N/A	INTRINSIC
low complexity region	2860	2874	N/A	INTRINSIC
coiled coil region	3153	3180	N/A	INTRINSIC
low complexity region	3242	3255	N/A	INTRINSIC
low complexity region	3308	3323	N/A	INTRINSIC
low complexity region	3568	3585	N/A	INTRINSIC
APC10	3700	3858	1.11e-18	SMART
low complexity region	3993	4005	N/A	INTRINSIC
low complexity region	4080	4102	N/A	INTRINSIC
Blast:BBOX	4217	4260	7e-7	BLAST
RING	4386	4436	5.35e-5	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000161008

SMART Domains

Protein: ENSMUSP00000124443
Gene: ENSMUSG00000033004

Domain	Start	End	E-Value	Type
low complexity region	66	79	N/A	INTRINSIC
low complexity region	132	147	N/A	INTRINSIC
low complexity region	392	409	N/A	INTRINSIC
APC10	524	682	1.11e-18	SMART
low complexity region	820	832	N/A	INTRINSIC
low complexity region	907	929	N/A	INTRINSIC
Blast:BBOX	1042	1085	2e-6	BLAST
RING	1213	1263	5.35e-5	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000161278
AA Change: A691V

SMART Domains

Protein: ENSMUSP00000125189
Gene: ENSMUSG00000033004
AA Change: A691V

Domain	Start	End	E-Value	Type
Blast:IG_FLMN	2	66	1e-37	BLAST
SCOP:d1qfha1	14	64	2e-7	SMART
Pfam:SH3_3	98	165	5.8e-10	PFAM
internal_repeat_1	213	280	8.77e-8	PROSPERO
low complexity region	302	311	N/A	INTRINSIC
low complexity region	485	518	N/A	INTRINSIC
low complexity region	571	585	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000162762

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.3%
20x: 97.6%

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a targeted allele exhibit neonatal lethality, defective diaphragm innervation, abnormal brain morphology and defective axonal guidance. [provided by MGI curators]

Allele List at MGI

All alleles(10) : Targeted, knock-out(1) Targeted, other(1) Gene trapped(5) Chemically induced(3)

Other mutations in this stock

Total: 77 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930579F01Rik	T	C	3: 137,879,457 (GRCm39)	H72R	probably damaging	Het
Abca13	A	T	11: 9,227,937 (GRCm39)	N660I	probably damaging	Het
Actr8	C	T	14: 29,715,041 (GRCm39)	R619*	probably null	Het
Adam18	C	A	8: 25,104,843 (GRCm39)	G657V	probably damaging	Het
Adcyap1	A	G	17: 93,510,227 (GRCm39)	E85G	probably benign	Het
Akr1c14	A	G	13: 4,137,302 (GRCm39)	Y305C	probably damaging	Het
Ankdd1b	T	A	13: 96,591,388 (GRCm39)	H37L	possibly damaging	Het
Ap4e1	T	C	2: 126,903,636 (GRCm39)	L846P	probably benign	Het
Aqp9	A	T	9: 71,039,966 (GRCm39)	Y105*	probably null	Het
Arid1b	C	T	17: 5,387,538 (GRCm39)	Q1664*	probably null	Het
Aup1	A	G	6: 83,031,588 (GRCm39)		probably benign	Het
Bnip1	C	A	17: 27,005,684 (GRCm39)	S64*	probably null	Het
Calcr	T	A	6: 3,687,621 (GRCm39)	Q422L	probably damaging	Het
Ccdc162	T	A	10: 41,539,147 (GRCm39)	D407V	possibly damaging	Het
Ccdc66	G	T	14: 27,208,441 (GRCm39)	S760R	probably benign	Het
Cd22	T	A	7: 30,577,193 (GRCm39)	E38V	probably damaging	Het
Cggbp1	T	C	16: 64,676,383 (GRCm39)	Y150H	probably damaging	Het
Chd3	T	C	11: 69,252,510 (GRCm39)	K263R	possibly damaging	Het
Col4a2	T	A	8: 11,496,238 (GRCm39)	F1620I	probably damaging	Het
Col6a2	T	C	10: 76,435,662 (GRCm39)	T858A	probably benign	Het
Dnah7a	T	A	1: 53,580,273 (GRCm39)	D1554V	probably damaging	Het
Dnajc25	A	T	4: 59,013,678 (GRCm39)	Q132L	probably benign	Het
Dnase1l1	C	T	X: 73,320,644 (GRCm39)		probably null	Homo
Ehbp1l1	A	C	19: 5,768,795 (GRCm39)	I836S	possibly damaging	Het
Elf1	A	G	14: 79,810,779 (GRCm39)	Q288R	possibly damaging	Het
Fbn1	C	A	2: 125,150,393 (GRCm39)	V2608L	possibly damaging	Het
Frmpd1	T	C	4: 45,268,551 (GRCm39)	I232T	possibly damaging	Het
Fuca1	T	A	4: 135,662,137 (GRCm39)	I355N	probably damaging	Het
Gcnt4	A	G	13: 97,083,781 (GRCm39)	D359G	probably damaging	Het
Gm5134	T	C	10: 75,790,494 (GRCm39)	M30T	possibly damaging	Het
Grk1	T	G	8: 13,455,704 (GRCm39)	L196R	probably damaging	Het
Igkv14-126	A	C	6: 67,873,548 (GRCm39)	D92A	probably damaging	Het
Kmt2c	A	G	5: 25,520,600 (GRCm39)	S1837P	probably benign	Het
Lhx4	T	A	1: 155,578,300 (GRCm39)	T281S	probably benign	Het
Lrrc55	G	T	2: 85,026,653 (GRCm39)	H124N	probably benign	Het
Marchf8	T	A	6: 116,383,277 (GRCm39)	I566N	possibly damaging	Het
Nlrp4b	A	G	7: 10,458,847 (GRCm39)	N355S	probably benign	Het
Nmur2	A	G	11: 55,920,411 (GRCm39)	V278A	probably benign	Het
Nod1	T	C	6: 54,921,689 (GRCm39)	M210V	probably benign	Het
Nt5c1b	T	A	12: 10,422,138 (GRCm39)	C63*	probably null	Het
Or1e1f	A	G	11: 73,855,568 (GRCm39)	I45V	possibly damaging	Het
Or1j17	A	T	2: 36,578,694 (GRCm39)	K227*	probably null	Het
Or4g7	C	T	2: 111,309,573 (GRCm39)	A148V	possibly damaging	Het
Or5d37	G	A	2: 87,924,008 (GRCm39)	P91S	probably damaging	Het
Or7g21	A	C	9: 19,032,253 (GRCm39)	M1L	probably benign	Het
Or8b37	T	C	9: 37,959,121 (GRCm39)	V201A	probably benign	Het
Or8g24	C	T	9: 38,989,199 (GRCm39)	V281I	probably benign	Het
Osbp2	T	A	11: 3,665,153 (GRCm39)	S517C	probably damaging	Het
Pcdha1	C	T	18: 37,065,301 (GRCm39)	P655L	probably damaging	Het
Pdcd6	A	G	13: 74,452,098 (GRCm39)	Y181H	probably damaging	Het
Perp	G	A	10: 18,731,502 (GRCm39)	G154S	probably damaging	Het
Perp	G	T	10: 18,731,503 (GRCm39)	G154V	probably damaging	Het
Pira13	T	C	7: 3,825,850 (GRCm39)	T340A	probably damaging	Het
Prokr1	T	G	6: 87,558,774 (GRCm39)	T204P	possibly damaging	Het
Prpf3	A	T	3: 95,739,890 (GRCm39)	C630S	probably damaging	Het
Pter	C	A	2: 12,985,359 (GRCm39)	H230N	probably damaging	Het
Ptprs	A	T	17: 56,724,427 (GRCm39)	Y1167*	probably null	Het
Rad54l2	T	C	9: 106,595,121 (GRCm39)	I279V	possibly damaging	Het
Rora	T	A	9: 69,280,468 (GRCm39)	L347Q	probably damaging	Het
Runx1t1	T	G	4: 13,785,136 (GRCm39)	M1R	probably null	Het
Sdcbp	A	G	4: 6,381,064 (GRCm39)	S70G	probably benign	Het
Serpinb12	A	G	1: 106,881,493 (GRCm39)	Y210C	probably damaging	Het
Sipa1	T	C	19: 5,701,517 (GRCm39)	E1015G	probably damaging	Het
Slc15a2	A	C	16: 36,572,144 (GRCm39)	L740R	possibly damaging	Het
Specc1	A	G	11: 62,047,379 (GRCm39)	E916G	probably damaging	Het
Spta1	T	C	1: 174,041,743 (GRCm39)	I1371T	possibly damaging	Het
Tagln3	T	C	16: 45,533,365 (GRCm39)	M130V	probably benign	Het
Tchh	A	T	3: 93,353,752 (GRCm39)	E1064V	unknown	Het
Tdp1	A	T	12: 99,880,330 (GRCm39)	S464C	probably damaging	Het
Tdp1	G	C	12: 99,880,331 (GRCm39)	S464T	probably benign	Het
Tenm3	T	C	8: 48,729,884 (GRCm39)	Y1374C	probably damaging	Het
Tmprss3	A	T	17: 31,402,833 (GRCm39)	Y455*	probably null	Het
Ttc5	A	G	14: 51,003,385 (GRCm39)	V433A	possibly damaging	Het
Wnt5a	A	T	14: 28,240,449 (GRCm39)	R180*	probably null	Het
Zfp53	A	G	17: 21,728,372 (GRCm39)	D135G	probably benign	Het
Zfp619	T	A	7: 39,186,969 (GRCm39)	C1000S	probably damaging	Het
Zfp647	G	A	15: 76,796,285 (GRCm39)	P125L	probably damaging	Het

Other mutations in Mycbp2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00094:Mycbp2	APN	14	103,460,486 (GRCm39)	missense	probably damaging	1.00
IGL00518:Mycbp2	APN	14	103,393,244 (GRCm39)	missense	probably damaging	1.00
IGL00650:Mycbp2	APN	14	103,380,664 (GRCm39)	missense	probably damaging	0.97
IGL00653:Mycbp2	APN	14	103,380,664 (GRCm39)	missense	probably damaging	0.97
IGL00742:Mycbp2	APN	14	103,438,788 (GRCm39)	missense	probably damaging	1.00
IGL00755:Mycbp2	APN	14	103,432,057 (GRCm39)	missense	possibly damaging	0.72
IGL00793:Mycbp2	APN	14	103,364,189 (GRCm39)	missense	possibly damaging	0.77
IGL00916:Mycbp2	APN	14	103,528,719 (GRCm39)	splice site	probably benign
IGL00960:Mycbp2	APN	14	103,466,820 (GRCm39)	missense	possibly damaging	0.95
IGL00977:Mycbp2	APN	14	103,410,078 (GRCm39)	missense	probably damaging	0.98
IGL01349:Mycbp2	APN	14	103,359,983 (GRCm39)	missense	probably damaging	0.98
IGL01369:Mycbp2	APN	14	103,392,946 (GRCm39)	missense	possibly damaging	0.61
IGL01410:Mycbp2	APN	14	103,466,928 (GRCm39)	splice site	probably null
IGL01586:Mycbp2	APN	14	103,378,305 (GRCm39)	critical splice donor site	probably null
IGL01593:Mycbp2	APN	14	103,528,723 (GRCm39)	critical splice donor site	probably null
IGL01693:Mycbp2	APN	14	103,365,415 (GRCm39)	missense	probably damaging	0.99
IGL01730:Mycbp2	APN	14	103,372,640 (GRCm39)	nonsense	probably null
IGL01820:Mycbp2	APN	14	103,425,937 (GRCm39)	missense	probably damaging	1.00
IGL01974:Mycbp2	APN	14	103,380,647 (GRCm39)	missense	possibly damaging	0.88
IGL02071:Mycbp2	APN	14	103,392,343 (GRCm39)	nonsense	probably null
IGL02178:Mycbp2	APN	14	103,461,802 (GRCm39)	missense	probably benign	0.01
IGL02324:Mycbp2	APN	14	103,479,643 (GRCm39)	missense	probably damaging	1.00
IGL02442:Mycbp2	APN	14	103,551,811 (GRCm39)	missense	probably benign
IGL02607:Mycbp2	APN	14	103,522,709 (GRCm39)	missense	probably damaging	1.00
IGL02679:Mycbp2	APN	14	103,442,621 (GRCm39)	missense	probably benign
IGL02702:Mycbp2	APN	14	103,457,560 (GRCm39)	missense	probably benign	0.01
IGL02709:Mycbp2	APN	14	103,392,697 (GRCm39)	missense	probably damaging	0.97
IGL02736:Mycbp2	APN	14	103,351,678 (GRCm39)	splice site	probably benign
IGL02866:Mycbp2	APN	14	103,367,428 (GRCm39)	missense	probably damaging	0.98
IGL02939:Mycbp2	APN	14	103,414,715 (GRCm39)	missense	probably benign
IGL03082:Mycbp2	APN	14	103,441,805 (GRCm39)	missense	probably benign	0.23
IGL03142:Mycbp2	APN	14	103,536,212 (GRCm39)	missense	probably damaging	0.99
IGL03155:Mycbp2	APN	14	103,392,889 (GRCm39)	missense	probably benign	0.06
IGL03236:Mycbp2	APN	14	103,536,134 (GRCm39)	missense	probably damaging	0.99
IGL03256:Mycbp2	APN	14	103,426,025 (GRCm39)	missense	possibly damaging	0.92
IGL03303:Mycbp2	APN	14	103,485,194 (GRCm39)	missense	probably damaging	1.00
compost	UTSW	14	103,393,889 (GRCm39)	missense	probably damaging	1.00
decompose	UTSW	14	103,457,415 (GRCm39)	missense	probably benign	0.12
moulder	UTSW	14	103,426,028 (GRCm39)	missense	probably damaging	1.00
N/A - 293:Mycbp2	UTSW	14	103,461,898 (GRCm39)	splice site	probably benign
R0040:Mycbp2	UTSW	14	103,461,708 (GRCm39)	missense	probably benign	0.11
R0040:Mycbp2	UTSW	14	103,461,708 (GRCm39)	missense	probably benign	0.11
R0057:Mycbp2	UTSW	14	103,389,578 (GRCm39)	missense	probably damaging	0.97
R0063:Mycbp2	UTSW	14	103,394,070 (GRCm39)	unclassified	probably benign
R0097:Mycbp2	UTSW	14	103,393,198 (GRCm39)	missense	probably damaging	1.00
R0097:Mycbp2	UTSW	14	103,393,198 (GRCm39)	missense	probably damaging	1.00
R0268:Mycbp2	UTSW	14	103,551,761 (GRCm39)	nonsense	probably null
R0388:Mycbp2	UTSW	14	103,394,103 (GRCm39)	missense	probably benign	0.01
R0410:Mycbp2	UTSW	14	103,372,569 (GRCm39)	missense	probably damaging	1.00
R0530:Mycbp2	UTSW	14	103,419,895 (GRCm39)	missense	probably damaging	1.00
R0591:Mycbp2	UTSW	14	103,433,827 (GRCm39)	unclassified	probably benign
R0671:Mycbp2	UTSW	14	103,432,024 (GRCm39)	missense	possibly damaging	0.95
R0755:Mycbp2	UTSW	14	103,412,230 (GRCm39)	missense	probably damaging	1.00
R0817:Mycbp2	UTSW	14	103,466,854 (GRCm39)	missense	probably damaging	0.99
R0818:Mycbp2	UTSW	14	103,466,854 (GRCm39)	missense	probably damaging	0.99
R0819:Mycbp2	UTSW	14	103,466,854 (GRCm39)	missense	probably damaging	0.99
R0881:Mycbp2	UTSW	14	103,457,449 (GRCm39)	missense	probably benign
R0903:Mycbp2	UTSW	14	103,513,293 (GRCm39)	missense	probably damaging	0.99
R0940:Mycbp2	UTSW	14	103,500,129 (GRCm39)	unclassified	probably benign
R0961:Mycbp2	UTSW	14	103,422,271 (GRCm39)	missense	probably damaging	1.00
R1004:Mycbp2	UTSW	14	103,378,353 (GRCm39)	missense	probably benign	0.00
R1138:Mycbp2	UTSW	14	103,412,262 (GRCm39)	missense	possibly damaging	0.84
R1170:Mycbp2	UTSW	14	103,437,588 (GRCm39)	nonsense	probably null
R1211:Mycbp2	UTSW	14	103,357,999 (GRCm39)	missense	probably benign	0.31
R1268:Mycbp2	UTSW	14	103,446,218 (GRCm39)	missense	probably damaging	1.00
R1298:Mycbp2	UTSW	14	103,393,334 (GRCm39)	missense	probably damaging	1.00
R1341:Mycbp2	UTSW	14	103,536,303 (GRCm39)	splice site	probably benign
R1469:Mycbp2	UTSW	14	103,425,956 (GRCm39)	missense	probably damaging	0.99
R1469:Mycbp2	UTSW	14	103,425,956 (GRCm39)	missense	probably damaging	0.99
R1513:Mycbp2	UTSW	14	103,441,825 (GRCm39)	missense	probably damaging	1.00
R1528:Mycbp2	UTSW	14	103,470,033 (GRCm39)	missense	possibly damaging	0.91
R1564:Mycbp2	UTSW	14	103,407,287 (GRCm39)	splice site	probably null
R1565:Mycbp2	UTSW	14	103,489,945 (GRCm39)	missense	possibly damaging	0.82
R1656:Mycbp2	UTSW	14	103,485,194 (GRCm39)	missense	probably damaging	1.00
R1694:Mycbp2	UTSW	14	103,464,947 (GRCm39)	missense	probably damaging	1.00
R1709:Mycbp2	UTSW	14	103,461,852 (GRCm39)	missense	probably damaging	1.00
R1728:Mycbp2	UTSW	14	103,392,614 (GRCm39)	missense	probably damaging	0.98
R1751:Mycbp2	UTSW	14	103,485,841 (GRCm39)	missense	probably damaging	0.98
R1767:Mycbp2	UTSW	14	103,485,841 (GRCm39)	missense	probably damaging	0.98
R1772:Mycbp2	UTSW	14	103,419,855 (GRCm39)	missense	probably damaging	1.00
R1784:Mycbp2	UTSW	14	103,392,614 (GRCm39)	missense	probably damaging	0.98
R1823:Mycbp2	UTSW	14	103,489,945 (GRCm39)	missense	possibly damaging	0.82
R1824:Mycbp2	UTSW	14	103,489,945 (GRCm39)	missense	possibly damaging	0.82
R1844:Mycbp2	UTSW	14	103,393,150 (GRCm39)	missense	possibly damaging	0.94
R1916:Mycbp2	UTSW	14	103,422,319 (GRCm39)	missense	probably damaging	1.00
R1944:Mycbp2	UTSW	14	103,466,840 (GRCm39)	missense	probably damaging	1.00
R1983:Mycbp2	UTSW	14	103,383,407 (GRCm39)	missense	probably damaging	0.97
R2002:Mycbp2	UTSW	14	103,485,839 (GRCm39)	missense	probably damaging	0.98
R2031:Mycbp2	UTSW	14	103,426,028 (GRCm39)	missense	probably damaging	1.00
R2035:Mycbp2	UTSW	14	103,497,675 (GRCm39)	missense	probably damaging	1.00
R2048:Mycbp2	UTSW	14	103,469,960 (GRCm39)	critical splice donor site	probably null
R2061:Mycbp2	UTSW	14	103,524,696 (GRCm39)	missense	probably damaging	0.99
R2113:Mycbp2	UTSW	14	103,457,512 (GRCm39)	missense	probably damaging	0.99
R2128:Mycbp2	UTSW	14	103,438,666 (GRCm39)	missense	probably benign	0.01
R2134:Mycbp2	UTSW	14	103,446,329 (GRCm39)	missense	probably damaging	1.00
R2135:Mycbp2	UTSW	14	103,446,329 (GRCm39)	missense	probably damaging	1.00
R2135:Mycbp2	UTSW	14	103,383,378 (GRCm39)	missense	probably benign
R2146:Mycbp2	UTSW	14	103,393,358 (GRCm39)	missense	probably damaging	0.97
R2147:Mycbp2	UTSW	14	103,393,358 (GRCm39)	missense	probably damaging	0.97
R2148:Mycbp2	UTSW	14	103,393,358 (GRCm39)	missense	probably damaging	0.97
R2150:Mycbp2	UTSW	14	103,393,358 (GRCm39)	missense	probably damaging	0.97
R2163:Mycbp2	UTSW	14	103,407,291 (GRCm39)	critical splice donor site	probably null
R2248:Mycbp2	UTSW	14	103,407,295 (GRCm39)	missense	possibly damaging	0.50
R2265:Mycbp2	UTSW	14	103,500,185 (GRCm39)	missense	probably benign	0.39
R2272:Mycbp2	UTSW	14	103,381,774 (GRCm39)	missense	probably null	0.66
R2379:Mycbp2	UTSW	14	103,412,386 (GRCm39)	missense	probably benign
R2495:Mycbp2	UTSW	14	103,437,554 (GRCm39)	missense	probably damaging	0.99
R2508:Mycbp2	UTSW	14	103,368,681 (GRCm39)	missense	probably damaging	0.99
R2510:Mycbp2	UTSW	14	103,392,691 (GRCm39)	missense	probably damaging	0.96
R2851:Mycbp2	UTSW	14	103,381,769 (GRCm39)	missense	probably damaging	0.99
R2852:Mycbp2	UTSW	14	103,381,769 (GRCm39)	missense	probably damaging	0.99
R2965:Mycbp2	UTSW	14	103,534,794 (GRCm39)	missense	probably benign	0.00
R3156:Mycbp2	UTSW	14	103,446,179 (GRCm39)	splice site	probably benign
R3404:Mycbp2	UTSW	14	103,437,550 (GRCm39)	missense	probably damaging	0.99
R3410:Mycbp2	UTSW	14	103,372,553 (GRCm39)	missense	probably damaging	1.00
R3429:Mycbp2	UTSW	14	103,466,866 (GRCm39)	missense	probably damaging	1.00
R3706:Mycbp2	UTSW	14	103,393,850 (GRCm39)	missense	probably benign	0.31
R3772:Mycbp2	UTSW	14	103,371,224 (GRCm39)	missense	possibly damaging	0.82
R3778:Mycbp2	UTSW	14	103,434,721 (GRCm39)	missense	probably damaging	0.99
R3883:Mycbp2	UTSW	14	103,532,686 (GRCm39)	missense	probably damaging	0.97
R3884:Mycbp2	UTSW	14	103,532,686 (GRCm39)	missense	probably damaging	0.97
R3887:Mycbp2	UTSW	14	103,412,233 (GRCm39)	missense	probably damaging	0.98
R3923:Mycbp2	UTSW	14	103,364,149 (GRCm39)	missense	probably damaging	1.00
R3926:Mycbp2	UTSW	14	103,441,936 (GRCm39)	missense	probably damaging	1.00
R3959:Mycbp2	UTSW	14	103,532,688 (GRCm39)	missense	probably benign	0.00
R3966:Mycbp2	UTSW	14	103,376,161 (GRCm39)	splice site	probably benign
R4021:Mycbp2	UTSW	14	103,389,593 (GRCm39)	missense	probably damaging	0.97
R4363:Mycbp2	UTSW	14	103,485,893 (GRCm39)	missense	probably damaging	1.00
R4405:Mycbp2	UTSW	14	103,360,881 (GRCm39)	missense	probably damaging	1.00
R4407:Mycbp2	UTSW	14	103,524,664 (GRCm39)	missense	probably damaging	1.00
R4410:Mycbp2	UTSW	14	103,372,702 (GRCm39)	missense	probably damaging	1.00
R4434:Mycbp2	UTSW	14	103,371,225 (GRCm39)	missense	probably damaging	0.99
R4448:Mycbp2	UTSW	14	103,425,938 (GRCm39)	missense	possibly damaging	0.89
R4452:Mycbp2	UTSW	14	103,393,094 (GRCm39)	missense	probably damaging	0.99
R4573:Mycbp2	UTSW	14	103,583,733 (GRCm39)	missense	probably benign	0.05
R4589:Mycbp2	UTSW	14	103,414,749 (GRCm39)	missense	probably benign	0.04
R4621:Mycbp2	UTSW	14	103,457,415 (GRCm39)	missense	probably benign	0.12
R4622:Mycbp2	UTSW	14	103,457,415 (GRCm39)	missense	probably benign	0.12
R4729:Mycbp2	UTSW	14	103,426,027 (GRCm39)	missense	probably damaging	1.00
R4770:Mycbp2	UTSW	14	103,457,380 (GRCm39)	missense	probably benign	0.41
R4790:Mycbp2	UTSW	14	103,466,873 (GRCm39)	missense	probably damaging	1.00
R4884:Mycbp2	UTSW	14	103,448,731 (GRCm39)	missense	probably damaging	1.00
R4885:Mycbp2	UTSW	14	103,383,382 (GRCm39)	missense	possibly damaging	0.86
R4956:Mycbp2	UTSW	14	103,524,675 (GRCm39)	missense	probably damaging	0.99
R4980:Mycbp2	UTSW	14	103,497,821 (GRCm39)	splice site	probably null
R4994:Mycbp2	UTSW	14	103,407,430 (GRCm39)	missense	probably benign
R5029:Mycbp2	UTSW	14	103,393,946 (GRCm39)	missense	probably benign	0.21
R5038:Mycbp2	UTSW	14	103,534,375 (GRCm39)	missense	probably damaging	1.00
R5044:Mycbp2	UTSW	14	103,376,671 (GRCm39)	critical splice donor site	probably null
R5231:Mycbp2	UTSW	14	103,583,650 (GRCm39)	critical splice donor site	probably null
R5305:Mycbp2	UTSW	14	103,583,757 (GRCm39)	missense	probably benign	0.00
R5322:Mycbp2	UTSW	14	103,423,119 (GRCm39)	critical splice acceptor site	probably null
R5376:Mycbp2	UTSW	14	103,479,868 (GRCm39)	nonsense	probably null
R5414:Mycbp2	UTSW	14	103,543,697 (GRCm39)	missense	probably damaging	1.00
R5453:Mycbp2	UTSW	14	103,438,837 (GRCm39)	missense	probably damaging	0.99
R5462:Mycbp2	UTSW	14	103,437,562 (GRCm39)	missense	probably damaging	1.00
R5499:Mycbp2	UTSW	14	103,479,615 (GRCm39)	missense	probably damaging	1.00
R5502:Mycbp2	UTSW	14	103,411,250 (GRCm39)	missense	probably damaging	1.00
R5524:Mycbp2	UTSW	14	103,532,673 (GRCm39)	missense	probably damaging	1.00
R5533:Mycbp2	UTSW	14	103,520,081 (GRCm39)	nonsense	probably null
R5569:Mycbp2	UTSW	14	103,372,679 (GRCm39)	missense	probably damaging	1.00
R5574:Mycbp2	UTSW	14	103,380,203 (GRCm39)	missense	possibly damaging	0.94
R5579:Mycbp2	UTSW	14	103,528,769 (GRCm39)	missense	probably damaging	0.98
R5590:Mycbp2	UTSW	14	103,360,791 (GRCm39)	missense	probably damaging	1.00
R5592:Mycbp2	UTSW	14	103,432,113 (GRCm39)	missense	probably benign	0.02
R5643:Mycbp2	UTSW	14	103,524,770 (GRCm39)	missense	probably damaging	1.00
R5644:Mycbp2	UTSW	14	103,524,770 (GRCm39)	missense	probably damaging	1.00
R5645:Mycbp2	UTSW	14	103,426,051 (GRCm39)	critical splice acceptor site	probably null
R5645:Mycbp2	UTSW	14	103,426,044 (GRCm39)	missense	probably damaging	1.00
R5646:Mycbp2	UTSW	14	103,407,346 (GRCm39)	missense	probably benign	0.09
R5648:Mycbp2	UTSW	14	103,528,778 (GRCm39)	missense	probably damaging	1.00
R5651:Mycbp2	UTSW	14	103,520,101 (GRCm39)	missense	probably null	0.99
R5668:Mycbp2	UTSW	14	103,357,955 (GRCm39)	missense	possibly damaging	0.62
R5745:Mycbp2	UTSW	14	103,393,889 (GRCm39)	missense	possibly damaging	0.94
R5751:Mycbp2	UTSW	14	103,385,986 (GRCm39)	missense	probably damaging	0.99
R5756:Mycbp2	UTSW	14	103,371,410 (GRCm39)	missense	probably damaging	0.99
R5837:Mycbp2	UTSW	14	103,361,839 (GRCm39)	missense	probably damaging	1.00
R5984:Mycbp2	UTSW	14	103,364,120 (GRCm39)	missense	probably damaging	0.98
R6005:Mycbp2	UTSW	14	103,394,159 (GRCm39)	missense	probably benign
R6063:Mycbp2	UTSW	14	103,372,582 (GRCm39)	missense	probably damaging	1.00
R6091:Mycbp2	UTSW	14	103,460,482 (GRCm39)	missense	probably damaging	1.00
R6120:Mycbp2	UTSW	14	103,513,323 (GRCm39)	missense	probably benign	0.01
R6129:Mycbp2	UTSW	14	103,522,836 (GRCm39)	missense	probably benign	0.21
R6147:Mycbp2	UTSW	14	103,392,945 (GRCm39)	nonsense	probably null
R6161:Mycbp2	UTSW	14	103,536,183 (GRCm39)	missense	probably damaging	1.00
R6187:Mycbp2	UTSW	14	103,384,453 (GRCm39)	missense	probably damaging	1.00
R6208:Mycbp2	UTSW	14	103,532,664 (GRCm39)	missense	probably benign	0.11
R6228:Mycbp2	UTSW	14	103,497,665 (GRCm39)	missense	probably benign	0.24
R6301:Mycbp2	UTSW	14	103,392,862 (GRCm39)	missense	probably damaging	1.00
R6311:Mycbp2	UTSW	14	103,500,176 (GRCm39)	missense	possibly damaging	0.93
R6439:Mycbp2	UTSW	14	103,392,911 (GRCm39)	missense	probably benign	0.00
R6462:Mycbp2	UTSW	14	103,373,993 (GRCm39)	critical splice donor site	probably null
R6528:Mycbp2	UTSW	14	103,380,317 (GRCm39)	missense	probably damaging	0.99
R6736:Mycbp2	UTSW	14	103,429,003 (GRCm39)	missense	probably null	1.00
R6821:Mycbp2	UTSW	14	103,376,845 (GRCm39)	missense	probably damaging	1.00
R6851:Mycbp2	UTSW	14	103,497,630 (GRCm39)	critical splice donor site	probably null
R6948:Mycbp2	UTSW	14	103,522,703 (GRCm39)	missense	possibly damaging	0.94
R6977:Mycbp2	UTSW	14	103,392,342 (GRCm39)	missense	probably damaging	0.99
R6985:Mycbp2	UTSW	14	103,444,117 (GRCm39)	missense	possibly damaging	0.79
R7035:Mycbp2	UTSW	14	103,412,417 (GRCm39)	missense	probably benign
R7054:Mycbp2	UTSW	14	103,393,534 (GRCm39)	missense	possibly damaging	0.90
R7108:Mycbp2	UTSW	14	103,360,039 (GRCm39)	missense	probably damaging	1.00
R7117:Mycbp2	UTSW	14	103,391,513 (GRCm39)	missense	probably benign	0.21
R7137:Mycbp2	UTSW	14	103,520,115 (GRCm39)	missense	possibly damaging	0.94
R7169:Mycbp2	UTSW	14	103,497,636 (GRCm39)	missense	possibly damaging	0.78
R7218:Mycbp2	UTSW	14	103,371,282 (GRCm39)	missense	probably benign
R7234:Mycbp2	UTSW	14	103,452,773 (GRCm39)	missense	probably damaging	0.98
R7238:Mycbp2	UTSW	14	103,393,733 (GRCm39)	missense	probably damaging	1.00
R7244:Mycbp2	UTSW	14	103,446,345 (GRCm39)	missense	probably damaging	0.98
R7265:Mycbp2	UTSW	14	103,434,679 (GRCm39)	critical splice donor site	probably null
R7286:Mycbp2	UTSW	14	103,358,027 (GRCm39)	missense	probably damaging	1.00
R7332:Mycbp2	UTSW	14	103,434,793 (GRCm39)	missense	probably damaging	0.97
R7332:Mycbp2	UTSW	14	103,393,889 (GRCm39)	missense	probably damaging	1.00
R7384:Mycbp2	UTSW	14	103,513,829 (GRCm39)	missense	probably damaging	0.99
R7392:Mycbp2	UTSW	14	103,480,564 (GRCm39)	missense	probably damaging	0.99
R7392:Mycbp2	UTSW	14	103,389,627 (GRCm39)	missense	probably damaging	1.00
R7409:Mycbp2	UTSW	14	103,526,180 (GRCm39)	missense	probably damaging	1.00
R7486:Mycbp2	UTSW	14	103,434,690 (GRCm39)	missense	probably damaging	0.97
R7643:Mycbp2	UTSW	14	103,583,701 (GRCm39)	missense	probably benign
R7661:Mycbp2	UTSW	14	103,450,059 (GRCm39)	missense	probably damaging	1.00
R7663:Mycbp2	UTSW	14	103,429,045 (GRCm39)	missense	probably damaging	0.99
R7730:Mycbp2	UTSW	14	103,360,791 (GRCm39)	missense	probably damaging	0.99
R7757:Mycbp2	UTSW	14	103,429,055 (GRCm39)	missense	probably damaging	1.00
R7773:Mycbp2	UTSW	14	103,485,840 (GRCm39)	missense	probably damaging	0.97
R7787:Mycbp2	UTSW	14	103,364,533 (GRCm39)	missense	probably damaging	1.00
R7822:Mycbp2	UTSW	14	103,376,851 (GRCm39)	missense	probably benign	0.00
R7838:Mycbp2	UTSW	14	103,414,729 (GRCm39)	missense	probably benign	0.10
R7841:Mycbp2	UTSW	14	103,384,267 (GRCm39)	critical splice donor site	probably null
R7858:Mycbp2	UTSW	14	103,393,741 (GRCm39)	missense	probably damaging	1.00
R7873:Mycbp2	UTSW	14	103,393,582 (GRCm39)	missense	probably damaging	1.00
R7911:Mycbp2	UTSW	14	103,437,621 (GRCm39)	missense	probably damaging	0.99
R7942:Mycbp2	UTSW	14	103,392,674 (GRCm39)	missense	probably damaging	0.99
R7951:Mycbp2	UTSW	14	103,452,898 (GRCm39)	missense	probably damaging	0.99
R7958:Mycbp2	UTSW	14	103,367,400 (GRCm39)	missense	probably benign	0.00
R8235:Mycbp2	UTSW	14	103,436,110 (GRCm39)	missense	probably damaging	0.99
R8246:Mycbp2	UTSW	14	103,392,640 (GRCm39)	missense	probably damaging	0.99
R8338:Mycbp2	UTSW	14	103,372,701 (GRCm39)	missense	probably damaging	1.00
R8343:Mycbp2	UTSW	14	103,398,111 (GRCm39)	splice site	probably null
R8361:Mycbp2	UTSW	14	103,376,250 (GRCm39)	missense	probably damaging	1.00
R8490:Mycbp2	UTSW	14	103,446,267 (GRCm39)	missense	probably benign	0.00
R8524:Mycbp2	UTSW	14	103,392,895 (GRCm39)	missense	probably benign	0.23
R8525:Mycbp2	UTSW	14	103,450,155 (GRCm39)	missense	probably damaging	1.00
R8711:Mycbp2	UTSW	14	103,407,430 (GRCm39)	missense	probably benign	0.08
R8735:Mycbp2	UTSW	14	103,460,586 (GRCm39)	missense	probably damaging	0.99
R8825:Mycbp2	UTSW	14	103,466,871 (GRCm39)	missense	probably damaging	1.00
R8928:Mycbp2	UTSW	14	103,393,781 (GRCm39)	missense	probably benign
R8974:Mycbp2	UTSW	14	103,361,857 (GRCm39)	missense	probably damaging	1.00
R8987:Mycbp2	UTSW	14	103,446,232 (GRCm39)	missense	probably damaging	1.00
R9021:Mycbp2	UTSW	14	103,551,752 (GRCm39)	missense	probably benign	0.08
R9062:Mycbp2	UTSW	14	103,479,796 (GRCm39)	missense	probably benign	0.00
R9077:Mycbp2	UTSW	14	103,469,974 (GRCm39)	missense	probably damaging	1.00
R9208:Mycbp2	UTSW	14	103,532,664 (GRCm39)	missense	probably benign	0.01
R9285:Mycbp2	UTSW	14	103,434,753 (GRCm39)	missense	probably damaging	0.97
R9290:Mycbp2	UTSW	14	103,425,960 (GRCm39)	missense	probably damaging	0.99
R9362:Mycbp2	UTSW	14	103,497,642 (GRCm39)	missense	probably damaging	0.97
R9520:Mycbp2	UTSW	14	103,497,705 (GRCm39)	missense	probably benign	0.02
R9557:Mycbp2	UTSW	14	103,372,697 (GRCm39)	missense	probably benign	0.03
R9639:Mycbp2	UTSW	14	103,433,817 (GRCm39)	missense	probably damaging	1.00
R9666:Mycbp2	UTSW	14	103,371,474 (GRCm39)	missense	probably damaging	0.98
R9732:Mycbp2	UTSW	14	103,448,749 (GRCm39)	missense	probably damaging	1.00
R9736:Mycbp2	UTSW	14	103,434,852 (GRCm39)	missense	probably damaging	0.96
R9739:Mycbp2	UTSW	14	103,520,229 (GRCm39)	missense	probably benign	0.11
R9755:Mycbp2	UTSW	14	103,551,806 (GRCm39)	missense	probably benign
X0024:Mycbp2	UTSW	14	103,384,378 (GRCm39)	missense	probably damaging	1.00
Z1176:Mycbp2	UTSW	14	103,583,685 (GRCm39)	missense	probably benign
Z1176:Mycbp2	UTSW	14	103,394,073 (GRCm39)	missense	probably benign	0.06
Z1177:Mycbp2	UTSW	14	103,407,309 (GRCm39)	missense	possibly damaging	0.83
Z1177:Mycbp2	UTSW	14	103,372,559 (GRCm39)	missense	probably damaging	1.00
Z1177:Mycbp2	UTSW	14	103,364,499 (GRCm39)	critical splice donor site	probably null

Predicted Primers

PCR Primer
(F):5'- GGGTGGTTGGCTATTCAAACTAC -3'
(R):5'- GGAAAACCTCCACAGTGAGG -3'

Sequencing Primer
(F):5'- ACTTCTTATAGGAGCATGTTCTTTG -3'
(R):5'- CCTCCACAGTGAGGTAGTTGAAGTC -3'

Posted On

2018-04-02