Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01140:Zmym1'

50973

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zmym1

Ensembl Gene

ENSMUSG00000043872

Gene Name

zinc finger, MYM domain containing 1

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.206) question?

Stock #

IGL01140

Quality Score

Status

Chromosome

Chromosomal Location

127047094-127061152 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 127049642 bp

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 318 (F318L)

Ref Sequence

ENSEMBL: ENSMUSP00000101708 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055013] [ENSMUST00000106099] [ENSMUST00000106102] [ENSMUST00000136186]

Predicted Effect

probably damaging
Transcript: ENSMUST00000055013
AA Change: F318L

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000050669
Gene: ENSMUSG00000043872
AA Change: F318L

Domain	Start	End	E-Value	Type
Pfam:zf-FCS	6	46	2.4e-8	PFAM
Pfam:zf-FCS	53	96	1.6e-10	PFAM
low complexity region	155	168	N/A	INTRINSIC
low complexity region	229	243	N/A	INTRINSIC
Pfam:DUF4371	335	569	4.9e-55	PFAM
Pfam:Dimer_Tnp_hAT	870	959	5.1e-18	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000106099

SMART Domains

Protein: ENSMUSP00000101705
Gene: ENSMUSG00000043872

Domain	Start	End	E-Value	Type
Pfam:zf-FCS	6	46	3.3e-9	PFAM
Pfam:zf-FCS	53	96	4.6e-10	PFAM
low complexity region	155	168	N/A	INTRINSIC
Pfam:DUF4371	237	471	2.8e-52	PFAM
Pfam:Dimer_Tnp_hAT	772	861	5.3e-18	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000106102
AA Change: F318L

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000101708
Gene: ENSMUSG00000043872
AA Change: F318L

Domain	Start	End	E-Value	Type
Pfam:zf-FCS	6	46	7.8e-9	PFAM
Pfam:zf-FCS	53	96	1.1e-9	PFAM
low complexity region	155	168	N/A	INTRINSIC
low complexity region	229	243	N/A	INTRINSIC
Pfam:DUF4371	335	569	7.4e-52	PFAM
Pfam:Dimer_Tnp_hAT	870	959	1.7e-17	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000117934

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000124429

Predicted Effect

probably benign
Transcript: ENSMUST00000136186

SMART Domains

Protein: ENSMUSP00000120772
Gene: ENSMUSG00000043872

Domain	Start	End	E-Value	Type
Pfam:zf-FCS	6	46	1.5e-10	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000137236

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000140605

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000152607

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Afm	A	G	5: 90,524,867	E187G	probably damaging	Het
Asap2	T	C	12: 21,206,316	V205A	probably damaging	Het
Atg16l1	A	G	1: 87,774,853	I279V	probably benign	Het
Atp2b2	C	T	6: 113,789,971	V436I	possibly damaging	Het
Cald1	T	A	6: 34,762,261	S640T	possibly damaging	Het
Cdc23	A	G	18: 34,636,332	Y460H	probably benign	Het
Cenpk	T	A	13: 104,236,234		probably benign	Het
Ctss	A	G	3: 95,538,725	E52G	probably damaging	Het
Cuzd1	A	T	7: 131,311,794	C365S	probably damaging	Het
Cyp2c55	T	C	19: 39,018,649	L163P	probably benign	Het
Cyp4f37	T	C	17: 32,629,053	S182P	probably benign	Het
Flt4	G	T	11: 49,634,943	E740*	probably null	Het
Galntl6	T	A	8: 57,958,322	R291S	probably damaging	Het
Hydin	G	A	8: 110,398,062	V568I	probably benign	Het
Kcnab3	A	G	11: 69,329,879	K145R	probably benign	Het
Lama1	T	C	17: 67,802,933	V2183A	probably benign	Het
Lrmda	C	T	14: 22,596,517	A75V	possibly damaging	Het
Mbtd1	A	G	11: 93,924,432	E282G	probably damaging	Het
Muc19	A	T	15: 91,899,399		noncoding transcript	Het
Mug1	A	G	6: 121,882,734	T1231A	probably benign	Het
Nkpd1	A	G	7: 19,523,462	T389A	possibly damaging	Het
Nudt19	A	G	7: 35,547,911	*358Q	probably null	Het
Nup160	G	T	2: 90,700,565	M522I	possibly damaging	Het
Obsl1	T	A	1: 75,489,756		probably benign	Het
Olfr1475	G	A	19: 13,479,787	T137I	possibly damaging	Het
Olfr734	T	A	14: 50,320,275	I187F	probably damaging	Het
Olfr994	T	C	2: 85,430,140	T230A	probably benign	Het
Osbpl10	C	T	9: 115,176,002	P341S	probably benign	Het
Papola	C	A	12: 105,809,597	C7*	probably null	Het
Pld1	C	A	3: 28,078,237	L525I	probably benign	Het
Prom2	T	C	2: 127,531,205		probably benign	Het
Psmb5	G	A	14: 54,617,807	T62I	possibly damaging	Het
Sag	A	G	1: 87,823,364	E184G	probably benign	Het
Slc16a10	T	C	10: 40,076,925	Y191C	probably damaging	Het
Slc22a22	T	C	15: 57,263,338	T93A	probably damaging	Het
Ssx2ip	A	G	3: 146,427,843	Y231C	probably benign	Het
Trib1	A	G	15: 59,651,627	Y170C	probably damaging	Het
Trmt10a	G	A	3: 138,156,698		probably benign	Het
Troap	G	T	15: 99,082,146	Q402H	probably damaging	Het
Ttc30a1	A	G	2: 75,979,915	V608A	probably benign	Het
Vmn2r70	G	A	7: 85,565,171	Q258*	probably null	Het
Zfp128	A	G	7: 12,891,022	Y439C	probably benign	Het
Zswim2	A	G	2: 83,915,328	S589P	probably benign	Het

Other mutations in Zmym1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02326:Zmym1	APN	4	127047760	missense	probably damaging	1.00
IGL02392:Zmym1	APN	4	127048463	missense	probably damaging	1.00
IGL02431:Zmym1	APN	4	127047764	nonsense	probably null
IGL02512:Zmym1	APN	4	127048672	missense	probably damaging	1.00
IGL03303:Zmym1	APN	4	127049134	missense	probably damaging	1.00
BB009:Zmym1	UTSW	4	127050785	missense	possibly damaging	0.77
BB019:Zmym1	UTSW	4	127050785	missense	possibly damaging	0.77
R0195:Zmym1	UTSW	4	127047911	missense	possibly damaging	0.85
R0266:Zmym1	UTSW	4	127048025	missense	possibly damaging	0.86
R0416:Zmym1	UTSW	4	127058820	missense	probably benign	0.00
R1374:Zmym1	UTSW	4	127049611	missense	probably damaging	1.00
R1480:Zmym1	UTSW	4	127048612	missense	probably damaging	0.99
R1704:Zmym1	UTSW	4	127048384	missense	probably damaging	1.00
R1806:Zmym1	UTSW	4	127048079	missense	probably damaging	1.00
R1815:Zmym1	UTSW	4	127049021	missense	possibly damaging	0.76
R2124:Zmym1	UTSW	4	127049570	missense	probably benign	0.05
R2169:Zmym1	UTSW	4	127054203	splice site	probably null
R4027:Zmym1	UTSW	4	127049879	missense	probably benign	0.08
R4410:Zmym1	UTSW	4	127048104	nonsense	probably null
R4572:Zmym1	UTSW	4	127050835	missense	probably benign	0.39
R4788:Zmym1	UTSW	4	127054297	missense	probably benign	0.10
R5120:Zmym1	UTSW	4	127051437	splice site	probably null
R5130:Zmym1	UTSW	4	127048658	missense	probably damaging	1.00
R5615:Zmym1	UTSW	4	127049398	missense	probably damaging	1.00
R6190:Zmym1	UTSW	4	127047884	missense	probably damaging	0.99
R7426:Zmym1	UTSW	4	127049398	missense	possibly damaging	0.81
R7464:Zmym1	UTSW	4	127058935	nonsense	probably null
R7540:Zmym1	UTSW	4	127048757	missense	probably benign
R7779:Zmym1	UTSW	4	127054245	missense	probably benign
R7807:Zmym1	UTSW	4	127047874	missense	probably damaging	1.00
R7876:Zmym1	UTSW	4	127047703	missense	probably damaging	0.98
R7932:Zmym1	UTSW	4	127050785	missense	possibly damaging	0.77
R8183:Zmym1	UTSW	4	127058856	missense	probably benign	0.07
R8276:Zmym1	UTSW	4	127054258	missense	probably damaging	0.99
T0722:Zmym1	UTSW	4	127047947	missense	probably benign	0.00
T0722:Zmym1	UTSW	4	127048250	missense	probably benign	0.01
T0722:Zmym1	UTSW	4	127049673	missense	probably benign	0.05
T0975:Zmym1	UTSW	4	127047947	missense	probably benign	0.00
T0975:Zmym1	UTSW	4	127048250	missense	probably benign	0.01
T0975:Zmym1	UTSW	4	127049673	missense	probably benign	0.05

Posted On

2013-06-21