Incidental Mutation 'IGL01143:Morn1'
ID50977
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Morn1
Ensembl Gene ENSMUSG00000029049
Gene NameMORN repeat containing 1
Synonyms2900057D20Rik, 4930417P05Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01143
Quality Score
Status
Chromosome4
Chromosomal Location155086577-155145505 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 155092304 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Histidine at position 132 (Y132H)
Ref Sequence ENSEMBL: ENSMUSP00000116794 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030915] [ENSMUST00000127457] [ENSMUST00000132367] [ENSMUST00000155775]
Predicted Effect probably damaging
Transcript: ENSMUST00000030915
AA Change: Y132H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000030915
Gene: ENSMUSG00000029049
AA Change: Y132H

DomainStartEndE-ValueType
Pfam:MORN 23 35 1.4e-3 PFAM
MORN 37 58 4.11e-6 SMART
MORN 60 81 2.41e-1 SMART
MORN 84 105 1.43e-1 SMART
MORN 107 128 8.05e0 SMART
MORN 130 151 2.06e-6 SMART
MORN 153 174 7.56e-5 SMART
MORN 176 197 1.2e0 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000127457
AA Change: Y132H

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000116690
Gene: ENSMUSG00000029049
AA Change: Y132H

DomainStartEndE-ValueType
Pfam:MORN 23 35 5.5e-4 PFAM
MORN 37 58 4.11e-6 SMART
MORN 60 81 2.41e-1 SMART
MORN 84 105 1.43e-1 SMART
MORN 107 128 8.05e0 SMART
MORN 130 151 2.06e-6 SMART
MORN 153 174 7.56e-5 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129180
Predicted Effect probably damaging
Transcript: ENSMUST00000132367
AA Change: Y132H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000116794
Gene: ENSMUSG00000029049
AA Change: Y132H

DomainStartEndE-ValueType
Pfam:MORN 23 35 6.8e-4 PFAM
MORN 37 58 4.11e-6 SMART
MORN 60 81 2.41e-1 SMART
MORN 84 105 1.43e-1 SMART
MORN 107 128 8.05e0 SMART
MORN 130 151 2.06e-6 SMART
MORN 153 174 7.56e-5 SMART
MORN 176 197 1.2e0 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155375
Predicted Effect probably damaging
Transcript: ENSMUST00000155775
AA Change: Y95H

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000123207
Gene: ENSMUSG00000029049
AA Change: Y95H

DomainStartEndE-ValueType
Pfam:MORN 23 35 2.7e-4 PFAM
MORN 37 58 4.11e-6 SMART
MORN 60 81 2.41e-1 SMART
MORN 93 114 2.06e-6 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrl4 A G 3: 151,500,229 probably null Het
Adgrv1 A C 13: 81,419,351 D5234E probably benign Het
Bmp7 G T 2: 172,879,482 H267N probably benign Het
Btbd11 A T 10: 85,654,471 probably benign Het
Ccdc113 T C 8: 95,534,260 V30A probably damaging Het
Ccdc185 A T 1: 182,747,852 L424Q probably damaging Het
Cep192 T A 18: 67,804,375 D58E probably damaging Het
Ces1f C T 8: 93,271,830 probably null Het
Chaf1a T A 17: 56,063,336 D600E possibly damaging Het
Cndp2 A G 18: 84,677,317 probably null Het
Dnah11 T A 12: 118,012,740 D2727V probably damaging Het
Dync1li2 T C 8: 104,429,453 D252G probably damaging Het
Ephx2 C T 14: 66,089,522 R408Q probably damaging Het
Fat1 C A 8: 45,035,532 T3427K possibly damaging Het
Gal3st4 A G 5: 138,271,402 M1T probably null Het
Gm5828 T C 1: 16,769,948 noncoding transcript Het
Gm7694 C T 1: 170,302,825 M1I probably null Het
Gpatch1 A G 7: 35,301,572 probably benign Het
Grik1 G T 16: 87,957,600 probably null Het
Gtf2ird2 A G 5: 134,196,553 T161A possibly damaging Het
Hk2 T C 6: 82,729,552 I790V possibly damaging Het
Ints9 G A 14: 65,037,421 V609I probably benign Het
Kcnq4 T G 4: 120,698,623 D585A probably damaging Het
Large2 T C 2: 92,366,339 Y464C probably damaging Het
Lpar6 G A 14: 73,238,637 D13N probably damaging Het
Nphp1 C T 2: 127,780,136 V24I probably benign Het
Olfr1141 T C 2: 87,753,934 N20D probably benign Het
Olfr1457 A T 19: 13,095,112 F179I probably damaging Het
Olfr905 G T 9: 38,473,042 M98I possibly damaging Het
Pcdhb13 T C 18: 37,442,637 W23R probably benign Het
Plekhg3 T C 12: 76,564,982 probably null Het
Slx4 T C 16: 3,990,888 K396R probably benign Het
Snx13 A G 12: 35,132,160 D736G probably damaging Het
Spag17 A G 3: 99,939,298 D46G probably benign Het
Spata31 T G 13: 64,920,816 Y259* probably null Het
Synj1 T C 16: 90,951,976 E1064G probably damaging Het
Tom1 A G 8: 75,058,457 T81A probably benign Het
Ttc23l A G 15: 10,530,689 I279T probably damaging Het
Ttc39a T C 4: 109,442,813 probably null Het
Vmn2r108 C A 17: 20,462,465 A826S possibly damaging Het
Zyg11b A T 4: 108,244,994 V510E possibly damaging Het
Other mutations in Morn1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00471:Morn1 APN 4 155092328 missense possibly damaging 0.81
IGL02214:Morn1 APN 4 155092319 missense probably damaging 1.00
IGL03112:Morn1 APN 4 155093144 missense probably damaging 1.00
R0091:Morn1 UTSW 4 155145172 missense probably damaging 1.00
R0573:Morn1 UTSW 4 155111016 missense possibly damaging 0.87
R0639:Morn1 UTSW 4 155089503 missense possibly damaging 0.92
R0918:Morn1 UTSW 4 155087471 missense probably damaging 1.00
R2041:Morn1 UTSW 4 155090942 missense probably damaging 1.00
R2360:Morn1 UTSW 4 155092313 missense probably damaging 0.98
R5831:Morn1 UTSW 4 155101276 missense probably benign 0.02
R6897:Morn1 UTSW 4 155086655 missense probably benign 0.06
R8178:Morn1 UTSW 4 155128703 missense probably benign 0.00
R8505:Morn1 UTSW 4 155093335 missense unknown
Posted On2013-06-21