Incidental Mutation 'R6312:Trim14'
ID 509803
Institutional Source Beutler Lab
Gene Symbol Trim14
Ensembl Gene ENSMUSG00000039853
Gene Name tripartite motif-containing 14
Synonyms 5830400N10Rik
MMRRC Submission 044415-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6312 (G1)
Quality Score 153.008
Status Not validated
Chromosome 4
Chromosomal Location 46505072-46536148 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 46507257 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Asparagine at position 320 (H320N)
Ref Sequence ENSEMBL: ENSMUSP00000038719 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030018] [ENSMUST00000046897] [ENSMUST00000102924] [ENSMUST00000184112]
AlphaFold Q8BVW3
Predicted Effect probably benign
Transcript: ENSMUST00000030018
SMART Domains Protein: ENSMUSP00000030018
Gene: ENSMUSG00000028334

DomainStartEndE-ValueType
Pfam:NeuB 39 278 4.7e-81 PFAM
SAF 292 351 2.38e-3 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000046897
AA Change: H320N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000038719
Gene: ENSMUSG00000039853
AA Change: H320N

DomainStartEndE-ValueType
BBOX 17 59 1.84e-8 SMART
low complexity region 115 126 N/A INTRINSIC
PRY 264 316 2.63e-13 SMART
SPRY 317 440 2.48e-24 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000102924
SMART Domains Protein: ENSMUSP00000099988
Gene: ENSMUSG00000039853

DomainStartEndE-ValueType
BBOX 17 59 1.84e-8 SMART
low complexity region 115 126 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136978
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142502
Predicted Effect probably benign
Transcript: ENSMUST00000184112
SMART Domains Protein: ENSMUSP00000138876
Gene: ENSMUSG00000039853

DomainStartEndE-ValueType
BBOX 17 59 1.84e-8 SMART
low complexity region 115 126 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and its function has not been determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930447C04Rik A G 12: 72,936,541 (GRCm39) S472P possibly damaging Het
Aadacl4fm1 A T 4: 144,255,072 (GRCm39) H164L probably benign Het
Abraxas2 G A 7: 132,476,694 (GRCm39) A145T probably damaging Het
AC153874.1 T A 10: 77,682,961 (GRCm39) probably benign Het
Acadvl T A 11: 69,902,593 (GRCm39) M375L probably damaging Het
Ankdd1a C T 9: 65,415,343 (GRCm39) A227T possibly damaging Het
Arl4d T C 11: 101,558,079 (GRCm39) *202R probably null Het
B3gat2 G T 1: 23,854,548 (GRCm39) E83* probably null Het
Bmper C A 9: 23,318,087 (GRCm39) Q569K possibly damaging Het
C2cd4d C A 3: 94,271,742 (GRCm39) P336H probably damaging Het
Cct2 A T 10: 116,891,960 (GRCm39) S363T probably benign Het
Cers5 A G 15: 99,644,996 (GRCm39) V119A probably benign Het
Cfhr2 C T 1: 139,758,817 (GRCm39) V78I possibly damaging Het
Crocc2 A T 1: 93,143,432 (GRCm39) K1345* probably null Het
Cyp4f39 T C 17: 32,702,268 (GRCm39) M255T probably benign Het
Dpp6 A T 5: 27,930,669 (GRCm39) I834F possibly damaging Het
Dpy19l4 T A 4: 11,289,671 (GRCm39) K205* probably null Het
Epg5 T A 18: 78,022,426 (GRCm39) D1056E possibly damaging Het
Fam20a A C 11: 109,565,456 (GRCm39) C452G probably damaging Het
Gnai2 A T 9: 107,512,316 (GRCm39) V34E probably damaging Het
Gng3 A G 19: 8,815,997 (GRCm39) V7A probably benign Het
Hdc A G 2: 126,449,326 (GRCm39) V77A possibly damaging Het
Hint1 G A 11: 54,760,816 (GRCm39) C85Y probably benign Het
Kif17 C T 4: 138,015,504 (GRCm39) S551L probably benign Het
Lgr5 A G 10: 115,288,829 (GRCm39) L581P probably damaging Het
Lig4 G T 8: 10,021,739 (GRCm39) N680K probably benign Het
Lipi T A 16: 75,370,803 (GRCm39) Y138F probably damaging Het
Lrp2 C T 2: 69,267,025 (GRCm39) G4294E probably damaging Het
Lrrc7 A G 3: 157,866,246 (GRCm39) M1165T probably benign Het
Mtpap T C 18: 4,396,175 (GRCm39) I489T possibly damaging Het
Nlrp1b T A 11: 71,119,223 (GRCm39) N24I probably benign Het
Nlrp4a A G 7: 26,148,821 (GRCm39) T143A probably benign Het
Nudt2 A G 4: 41,480,386 (GRCm39) T90A probably benign Het
Or1j20 A T 2: 36,760,477 (GRCm39) I300L probably benign Het
Or52n20 T A 7: 104,320,796 (GRCm39) Y296N probably damaging Het
Or8b36 GTTT GTTTGCTGTTTT 9: 37,937,842 (GRCm39) probably null Het
Or8b36 TTT TTTGCTGATT 9: 37,937,843 (GRCm39) probably null Het
Or8b36 T TGCTGTTC 9: 37,937,845 (GRCm39) probably null Het
Or8b36 ATTGCTGTTT ATTGCTGTTTGCTGTTT 9: 37,937,836 (GRCm39) probably null Het
Or8b36 TTGCTGT TTGCTGTCTGCTGT 9: 37,937,837 (GRCm39) probably null Het
Or8k53 A T 2: 86,177,925 (GRCm39) F62I probably damaging Het
Osmr A G 15: 6,853,119 (GRCm39) V592A probably damaging Het
Rbp2 G T 9: 98,372,700 (GRCm39) S13I probably benign Het
Rsf1 A AGGGCGACGG 7: 97,229,111 (GRCm39) probably null Het
Rusf1 T C 7: 127,872,715 (GRCm39) K411R probably benign Het
Slc6a7 A G 18: 61,135,457 (GRCm39) S381P probably benign Het
Slitrk6 A G 14: 110,987,679 (GRCm39) L676P probably benign Het
Sspo T C 6: 48,434,300 (GRCm39) probably null Het
Tectb CT C 19: 55,181,094 (GRCm39) probably null Homo
Tma16 T C 8: 66,934,118 (GRCm39) E79G probably damaging Het
Trim63 A G 4: 134,053,008 (GRCm39) D323G probably damaging Het
Vash2 C A 1: 190,690,880 (GRCm39) R309L probably benign Het
Vmn1r62 G A 7: 5,679,083 (GRCm39) V255M possibly damaging Het
Vmn2r53 T A 7: 12,332,566 (GRCm39) probably null Het
Zfp382 G A 7: 29,833,963 (GRCm39) R538H probably damaging Het
Zfp592 T A 7: 80,673,184 (GRCm39) D49E probably benign Het
Zfp60 T C 7: 27,448,201 (GRCm39) C290R probably damaging Het
Zfp69 G A 4: 120,806,714 (GRCm39) probably benign Het
Zfp790 G T 7: 29,527,647 (GRCm39) G111W probably damaging Het
Zfp948 T C 17: 21,807,429 (GRCm39) I207T possibly damaging Het
Other mutations in Trim14
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0034:Trim14 UTSW 4 46,523,627 (GRCm39) missense probably damaging 0.99
R0310:Trim14 UTSW 4 46,522,043 (GRCm39) missense probably damaging 0.99
R1766:Trim14 UTSW 4 46,522,039 (GRCm39) missense probably benign 0.00
R3436:Trim14 UTSW 4 46,523,739 (GRCm39) missense possibly damaging 0.63
R3437:Trim14 UTSW 4 46,523,739 (GRCm39) missense possibly damaging 0.63
R4085:Trim14 UTSW 4 46,523,709 (GRCm39) missense probably benign 0.03
R4086:Trim14 UTSW 4 46,523,709 (GRCm39) missense probably benign 0.03
R4087:Trim14 UTSW 4 46,523,709 (GRCm39) missense probably benign 0.03
R4088:Trim14 UTSW 4 46,523,709 (GRCm39) missense probably benign 0.03
R4992:Trim14 UTSW 4 46,507,110 (GRCm39) missense probably damaging 1.00
R5408:Trim14 UTSW 4 46,507,134 (GRCm39) missense possibly damaging 0.63
R5943:Trim14 UTSW 4 46,522,136 (GRCm39) missense probably benign 0.01
R5979:Trim14 UTSW 4 46,507,239 (GRCm39) missense probably damaging 0.97
R6029:Trim14 UTSW 4 46,506,998 (GRCm39) missense probably benign 0.33
R6303:Trim14 UTSW 4 46,522,118 (GRCm39) missense probably benign 0.00
R6304:Trim14 UTSW 4 46,522,118 (GRCm39) missense probably benign 0.00
R7671:Trim14 UTSW 4 46,507,238 (GRCm39) missense possibly damaging 0.89
R7996:Trim14 UTSW 4 46,533,086 (GRCm39) missense probably benign 0.04
R8370:Trim14 UTSW 4 46,523,711 (GRCm39) missense probably damaging 1.00
R9501:Trim14 UTSW 4 46,510,404 (GRCm39) missense unknown
Z1176:Trim14 UTSW 4 46,510,418 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AGGTGTGCAAGTGGCTCATG -3'
(R):5'- AGGCTTTCTGACAGCTGTC -3'

Sequencing Primer
(F):5'- TCGTAGTCCAGGAAGACGC -3'
(R):5'- TGACAGCTGTCCTCCCCG -3'
Posted On 2018-04-02