Incidental Mutation 'U24488:Zmym4'
ID 509862
Institutional Source Beutler Lab
Gene Symbol Zmym4
Ensembl Gene ENSMUSG00000042446
Gene Name zinc finger, MYM-type 4
Synonyms Zfp262, 6330503C17Rik
Accession Numbers
Essential gene? Possibly essential (E-score: 0.586) question?
Stock # U24488 (G0')
Quality Score 225.009
Status Not validated
Chromosome 4
Chromosomal Location 126755732-126861928 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 126819453 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Lysine at position 150 (I150K)
Ref Sequence ENSEMBL: ENSMUSP00000101714 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106108]
AlphaFold A2A791
Predicted Effect possibly damaging
Transcript: ENSMUST00000106108
AA Change: I150K

PolyPhen 2 Score 0.691 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000101714
Gene: ENSMUSG00000042446
AA Change: I150K

DomainStartEndE-ValueType
TRASH 341 377 6.53e-4 SMART
TRASH 389 429 7.22e-6 SMART
TRASH 441 479 1.77e0 SMART
TRASH 486 525 4.95e-4 SMART
TRASH 531 569 1.05e-2 SMART
TRASH 579 615 2.82e1 SMART
low complexity region 640 649 N/A INTRINSIC
TRASH 687 723 8.49e-3 SMART
TRASH 729 764 1.14e-3 SMART
TRASH 772 810 4.48e-2 SMART
TRASH 816 851 2.06e-1 SMART
low complexity region 974 993 N/A INTRINSIC
low complexity region 1002 1021 N/A INTRINSIC
Pfam:DUF3504 1357 1527 1.7e-68 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123597
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129028
Predicted Effect probably benign
Transcript: ENSMUST00000135003
SMART Domains Protein: ENSMUSP00000120813
Gene: ENSMUSG00000042446

DomainStartEndE-ValueType
TRASH 90 126 6.53e-4 SMART
TRASH 138 178 7.22e-6 SMART
TRASH 190 228 1.77e0 SMART
TRASH 235 274 3.05e-4 SMART
low complexity region 300 309 N/A INTRINSIC
TRASH 347 383 8.49e-3 SMART
TRASH 389 424 1.14e-3 SMART
TRASH 432 470 4.48e-2 SMART
TRASH 476 511 2.06e-1 SMART
low complexity region 634 653 N/A INTRINSIC
low complexity region 662 681 N/A INTRINSIC
Pfam:DUF3504 1017 1187 1.5e-68 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151026
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154821
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.3%
  • 20x: 98.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd36 A G 11: 5,580,772 (GRCm39) Y922C probably damaging Het
Arhgef40 A G 14: 52,235,673 (GRCm39) T1185A probably benign Het
Atf7ip2 A G 16: 10,022,537 (GRCm39) N72S probably damaging Het
Carmil3 A G 14: 55,734,636 (GRCm39) D455G probably benign Het
Ccdc171 A T 4: 83,579,954 (GRCm39) E567V probably damaging Het
Chmp1b T A 18: 67,338,945 (GRCm39) L125Q probably damaging Het
Cnr1 T A 4: 33,944,927 (GRCm39) N438K probably benign Het
Cplane1 G T 15: 8,211,694 (GRCm39) G345C probably damaging Het
Csmd3 G A 15: 47,573,795 (GRCm39) T2091M probably damaging Het
Cyp4a29 A T 4: 115,108,204 (GRCm39) H342L possibly damaging Het
Dnah10 G A 5: 124,891,044 (GRCm39) D3212N probably damaging Het
Dnah2 G A 11: 69,374,648 (GRCm39) T1447I probably damaging Het
F11 A G 8: 45,695,349 (GRCm39) S540P probably benign Het
Fcrl6 T A 1: 172,426,437 (GRCm39) H120L probably damaging Het
Frmd6 T C 12: 70,940,653 (GRCm39) S433P probably damaging Het
Fundc1 G T X: 17,434,342 (GRCm39) A64E probably damaging Het
Garin2 A T 12: 78,761,811 (GRCm39) K158N probably damaging Het
Grid1 A G 14: 35,302,534 (GRCm39) E933G probably benign Het
Haus5 C T 7: 30,358,401 (GRCm39) W298* probably null Het
Hoxb3 C A 11: 96,235,456 (GRCm39) Q128K probably benign Het
Il6st C T 13: 112,631,168 (GRCm39) T369M possibly damaging Het
Itk A C 11: 46,228,971 (GRCm39) M403R probably damaging Het
Katnip A T 7: 125,369,853 (GRCm39) D147V probably damaging Het
Kif2c T C 4: 117,039,639 (GRCm39) Q17R probably benign Het
Kifap3 T C 1: 163,610,604 (GRCm39) I28T possibly damaging Het
Kit A T 5: 75,783,674 (GRCm39) R384* probably null Het
Ksr1 T A 11: 78,938,267 (GRCm39) I42F probably damaging Het
Lhcgr T A 17: 89,079,513 (GRCm39) probably null Het
Lrrc36 C T 8: 106,176,384 (GRCm39) H253Y probably benign Het
Mad1l1 T A 5: 140,300,840 (GRCm39) N19Y probably damaging Het
Marf1 A T 16: 13,950,230 (GRCm39) L1022* probably null Het
Mical3 T G 6: 120,978,457 (GRCm39) Q225P possibly damaging Het
Minar1 C A 9: 89,485,100 (GRCm39) G99V probably damaging Het
Myt1l T A 12: 29,876,895 (GRCm39) M182K unknown Het
Nepro A G 16: 44,554,949 (GRCm39) T342A probably benign Het
Nlrp5 A T 7: 23,117,653 (GRCm39) D459V possibly damaging Het
Nrcam C T 12: 44,584,042 (GRCm39) P39S probably damaging Het
Or2ag1b A T 7: 106,288,296 (GRCm39) I214N probably damaging Het
Ostm1 A G 10: 42,555,227 (GRCm39) D83G possibly damaging Het
Otoa A T 7: 120,717,763 (GRCm39) probably null Het
Pi4ka A G 16: 17,143,040 (GRCm39) I824T probably damaging Het
Plec C T 15: 76,061,930 (GRCm39) R2534H probably benign Het
Plin2 A G 4: 86,580,314 (GRCm39) V60A probably damaging Het
Rps6ka4 A G 19: 6,809,724 (GRCm39) L367P probably damaging Het
Senp7 A G 16: 56,005,182 (GRCm39) N912D probably damaging Het
Slc25a21 G T 12: 56,785,282 (GRCm39) N198K possibly damaging Het
Slc4a10 A G 2: 61,877,002 (GRCm39) D5G probably benign Het
Tex16 T C X: 111,028,815 (GRCm39) V438A probably benign Het
Tmem37 T C 1: 119,995,684 (GRCm39) Y131C probably benign Het
Top2a A C 11: 98,913,252 (GRCm39) M60R probably damaging Het
Ush2a C T 1: 188,162,963 (GRCm39) T1015I probably damaging Het
Vmn1r172 A T 7: 23,359,171 (GRCm39) I19F probably benign Het
Vmn1r230 A C 17: 21,067,014 (GRCm39) I68L probably benign Het
Vmn2r45 A C 7: 8,475,361 (GRCm39) C556G probably damaging Het
Vmn2r54 A G 7: 12,349,356 (GRCm39) I742T possibly damaging Het
Vps13c A G 9: 67,813,198 (GRCm39) K960E probably benign Het
Wdcp T A 12: 4,900,405 (GRCm39) V87E probably damaging Het
Wiz C T 17: 32,606,649 (GRCm39) E29K probably damaging Het
Wnk3 C T X: 149,992,456 (GRCm39) T298I probably damaging Het
Yif1b A C 7: 28,943,594 (GRCm39) Q56P probably benign Het
Zbtb25 A G 12: 76,396,014 (GRCm39) W403R probably benign Het
Zcrb1 A T 15: 93,285,515 (GRCm39) S155R probably damaging Het
Other mutations in Zmym4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00537:Zmym4 APN 4 126,783,851 (GRCm39) missense probably benign
IGL00845:Zmym4 APN 4 126,794,406 (GRCm39) missense probably benign 0.28
IGL01122:Zmym4 APN 4 126,758,045 (GRCm39) missense probably damaging 1.00
IGL01374:Zmym4 APN 4 126,762,750 (GRCm39) missense probably damaging 1.00
IGL01564:Zmym4 APN 4 126,805,073 (GRCm39) missense possibly damaging 0.84
IGL02014:Zmym4 APN 4 126,794,462 (GRCm39) missense possibly damaging 0.67
IGL02187:Zmym4 APN 4 126,764,066 (GRCm39) missense probably damaging 0.97
IGL02887:Zmym4 APN 4 126,842,268 (GRCm39) missense probably damaging 0.96
IGL03371:Zmym4 APN 4 126,808,881 (GRCm39) missense possibly damaging 0.90
IGL03400:Zmym4 APN 4 126,816,920 (GRCm39) missense probably benign 0.12
arriba UTSW 4 126,809,415 (GRCm39) missense probably damaging 0.97
foreclosed UTSW 4 126,789,099 (GRCm39) missense probably damaging 1.00
Foreshortened UTSW 4 126,804,729 (GRCm39) missense possibly damaging 0.75
levantese UTSW 4 126,757,961 (GRCm39) missense probably damaging 0.99
terminated UTSW 4 126,819,588 (GRCm39) missense probably benign 0.02
BB004:Zmym4 UTSW 4 126,799,170 (GRCm39) missense probably benign 0.42
BB014:Zmym4 UTSW 4 126,799,170 (GRCm39) missense probably benign 0.42
R0149:Zmym4 UTSW 4 126,804,938 (GRCm39) missense probably benign 0.00
R0361:Zmym4 UTSW 4 126,804,938 (GRCm39) missense probably benign 0.00
R0423:Zmym4 UTSW 4 126,776,112 (GRCm39) splice site probably benign
R0532:Zmym4 UTSW 4 126,792,194 (GRCm39) nonsense probably null
R0745:Zmym4 UTSW 4 126,796,496 (GRCm39) splice site probably benign
R1183:Zmym4 UTSW 4 126,819,632 (GRCm39) missense probably damaging 0.99
R1401:Zmym4 UTSW 4 126,804,962 (GRCm39) missense probably benign 0.00
R1446:Zmym4 UTSW 4 126,776,275 (GRCm39) missense probably damaging 1.00
R1491:Zmym4 UTSW 4 126,776,105 (GRCm39) critical splice acceptor site probably null
R1566:Zmym4 UTSW 4 126,804,940 (GRCm39) missense possibly damaging 0.94
R1962:Zmym4 UTSW 4 126,796,463 (GRCm39) missense possibly damaging 0.47
R2398:Zmym4 UTSW 4 126,816,929 (GRCm39) missense probably damaging 1.00
R2930:Zmym4 UTSW 4 126,819,316 (GRCm39) missense probably benign 0.00
R3891:Zmym4 UTSW 4 126,798,269 (GRCm39) missense probably benign 0.04
R3892:Zmym4 UTSW 4 126,798,269 (GRCm39) missense probably benign 0.04
R4659:Zmym4 UTSW 4 126,842,221 (GRCm39) splice site probably null
R4702:Zmym4 UTSW 4 126,816,958 (GRCm39) missense probably benign 0.01
R5160:Zmym4 UTSW 4 126,763,977 (GRCm39) missense probably damaging 0.97
R5614:Zmym4 UTSW 4 126,804,729 (GRCm39) missense possibly damaging 0.75
R5773:Zmym4 UTSW 4 126,799,163 (GRCm39) missense possibly damaging 0.52
R6450:Zmym4 UTSW 4 126,789,099 (GRCm39) missense probably damaging 1.00
R6741:Zmym4 UTSW 4 126,808,878 (GRCm39) missense possibly damaging 0.80
R7023:Zmym4 UTSW 4 126,762,593 (GRCm39) missense probably damaging 1.00
R7315:Zmym4 UTSW 4 126,776,385 (GRCm39) missense probably benign 0.09
R7468:Zmym4 UTSW 4 126,776,029 (GRCm39) missense probably benign 0.40
R7546:Zmym4 UTSW 4 126,757,961 (GRCm39) missense probably damaging 0.99
R7609:Zmym4 UTSW 4 126,819,588 (GRCm39) missense probably benign 0.02
R7764:Zmym4 UTSW 4 126,819,409 (GRCm39) missense probably benign 0.06
R7897:Zmym4 UTSW 4 126,783,332 (GRCm39) missense possibly damaging 0.76
R7918:Zmym4 UTSW 4 126,804,797 (GRCm39) critical splice acceptor site probably null
R7927:Zmym4 UTSW 4 126,799,170 (GRCm39) missense probably benign 0.42
R8129:Zmym4 UTSW 4 126,808,956 (GRCm39) missense possibly damaging 0.87
R8240:Zmym4 UTSW 4 126,798,188 (GRCm39) critical splice donor site probably null
R8248:Zmym4 UTSW 4 126,799,162 (GRCm39) missense possibly damaging 0.56
R8261:Zmym4 UTSW 4 126,798,360 (GRCm39) missense probably damaging 1.00
R8313:Zmym4 UTSW 4 126,804,762 (GRCm39) missense probably benign 0.19
R8353:Zmym4 UTSW 4 126,800,905 (GRCm39) missense possibly damaging 0.46
R8747:Zmym4 UTSW 4 126,787,198 (GRCm39) missense probably damaging 1.00
R8787:Zmym4 UTSW 4 126,816,953 (GRCm39) missense probably benign 0.41
R8795:Zmym4 UTSW 4 126,799,819 (GRCm39) missense probably benign 0.35
R8948:Zmym4 UTSW 4 126,758,060 (GRCm39) missense probably damaging 1.00
R9218:Zmym4 UTSW 4 126,809,415 (GRCm39) missense probably damaging 0.97
R9233:Zmym4 UTSW 4 126,776,310 (GRCm39) missense probably damaging 0.99
R9286:Zmym4 UTSW 4 126,783,812 (GRCm39) missense probably damaging 1.00
R9468:Zmym4 UTSW 4 126,800,993 (GRCm39) missense probably benign 0.01
R9542:Zmym4 UTSW 4 126,799,164 (GRCm39) missense probably benign 0.00
R9756:Zmym4 UTSW 4 126,771,502 (GRCm39) missense probably damaging 1.00
R9776:Zmym4 UTSW 4 126,804,942 (GRCm39) missense possibly damaging 0.51
Z1177:Zmym4 UTSW 4 126,801,005 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GCCTTCTCATCAAAATATTGCAAGC -3'
(R):5'- AACTCTGGGGATCTTGCAGG -3'

Sequencing Primer
(F):5'- AAAGCGCTATTACTGGTACTTTG -3'
(R):5'- ATCTTGCAGGAATTCCAGTCG -3'
Posted On 2018-04-02