Incidental Mutation 'U24488:Mical3'
ID 509866
Institutional Source Beutler Lab
Gene Symbol Mical3
Ensembl Gene ENSMUSG00000051586
Gene Name microtubule associated monooxygenase, calponin and LIM domain containing 3
Synonyms C130040D16Rik, MICAL-3
Accession Numbers
Essential gene? Probably non essential (E-score: 0.163) question?
Stock # U24488 (G0')
Quality Score 111.008
Status Not validated
Chromosome 6
Chromosomal Location 120908668-121107959 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 120978457 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Proline at position 225 (Q225P)
Ref Sequence ENSEMBL: ENSMUSP00000144972 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000204302] [ENSMUST00000207889]
AlphaFold Q8CJ19
Predicted Effect noncoding transcript
Transcript: ENSMUST00000098457
SMART Domains Protein: ENSMUSP00000096056
Gene: ENSMUSG00000051586

DomainStartEndE-ValueType
low complexity region 33 45 N/A INTRINSIC
low complexity region 57 80 N/A INTRINSIC
coiled coil region 114 148 N/A INTRINSIC
low complexity region 191 225 N/A INTRINSIC
coiled coil region 238 265 N/A INTRINSIC
low complexity region 317 330 N/A INTRINSIC
low complexity region 374 383 N/A INTRINSIC
low complexity region 548 562 N/A INTRINSIC
low complexity region 582 592 N/A INTRINSIC
low complexity region 625 637 N/A INTRINSIC
low complexity region 794 824 N/A INTRINSIC
low complexity region 861 882 N/A INTRINSIC
low complexity region 911 929 N/A INTRINSIC
low complexity region 950 962 N/A INTRINSIC
DUF3585 968 1110 1.39e-65 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150503
SMART Domains Protein: ENSMUSP00000115131
Gene: ENSMUSG00000051586

DomainStartEndE-ValueType
SCOP:d1bjt__ 41 141 8e-3 SMART
coiled coil region 192 219 N/A INTRINSIC
low complexity region 271 284 N/A INTRINSIC
low complexity region 328 337 N/A INTRINSIC
low complexity region 502 516 N/A INTRINSIC
low complexity region 536 546 N/A INTRINSIC
low complexity region 579 591 N/A INTRINSIC
low complexity region 748 778 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203013
Predicted Effect possibly damaging
Transcript: ENSMUST00000204302
AA Change: Q225P

PolyPhen 2 Score 0.900 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000144972
Gene: ENSMUSG00000051586
AA Change: Q225P

DomainStartEndE-ValueType
LIM 82 136 5.39e-11 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000207889
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.3%
  • 20x: 98.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd36 A G 11: 5,580,772 (GRCm39) Y922C probably damaging Het
Arhgef40 A G 14: 52,235,673 (GRCm39) T1185A probably benign Het
Atf7ip2 A G 16: 10,022,537 (GRCm39) N72S probably damaging Het
Carmil3 A G 14: 55,734,636 (GRCm39) D455G probably benign Het
Ccdc171 A T 4: 83,579,954 (GRCm39) E567V probably damaging Het
Chmp1b T A 18: 67,338,945 (GRCm39) L125Q probably damaging Het
Cnr1 T A 4: 33,944,927 (GRCm39) N438K probably benign Het
Cplane1 G T 15: 8,211,694 (GRCm39) G345C probably damaging Het
Csmd3 G A 15: 47,573,795 (GRCm39) T2091M probably damaging Het
Cyp4a29 A T 4: 115,108,204 (GRCm39) H342L possibly damaging Het
Dnah10 G A 5: 124,891,044 (GRCm39) D3212N probably damaging Het
Dnah2 G A 11: 69,374,648 (GRCm39) T1447I probably damaging Het
F11 A G 8: 45,695,349 (GRCm39) S540P probably benign Het
Fcrl6 T A 1: 172,426,437 (GRCm39) H120L probably damaging Het
Frmd6 T C 12: 70,940,653 (GRCm39) S433P probably damaging Het
Fundc1 G T X: 17,434,342 (GRCm39) A64E probably damaging Het
Garin2 A T 12: 78,761,811 (GRCm39) K158N probably damaging Het
Grid1 A G 14: 35,302,534 (GRCm39) E933G probably benign Het
Haus5 C T 7: 30,358,401 (GRCm39) W298* probably null Het
Hoxb3 C A 11: 96,235,456 (GRCm39) Q128K probably benign Het
Il6st C T 13: 112,631,168 (GRCm39) T369M possibly damaging Het
Itk A C 11: 46,228,971 (GRCm39) M403R probably damaging Het
Katnip A T 7: 125,369,853 (GRCm39) D147V probably damaging Het
Kif2c T C 4: 117,039,639 (GRCm39) Q17R probably benign Het
Kifap3 T C 1: 163,610,604 (GRCm39) I28T possibly damaging Het
Kit A T 5: 75,783,674 (GRCm39) R384* probably null Het
Ksr1 T A 11: 78,938,267 (GRCm39) I42F probably damaging Het
Lhcgr T A 17: 89,079,513 (GRCm39) probably null Het
Lrrc36 C T 8: 106,176,384 (GRCm39) H253Y probably benign Het
Mad1l1 T A 5: 140,300,840 (GRCm39) N19Y probably damaging Het
Marf1 A T 16: 13,950,230 (GRCm39) L1022* probably null Het
Minar1 C A 9: 89,485,100 (GRCm39) G99V probably damaging Het
Myt1l T A 12: 29,876,895 (GRCm39) M182K unknown Het
Nepro A G 16: 44,554,949 (GRCm39) T342A probably benign Het
Nlrp5 A T 7: 23,117,653 (GRCm39) D459V possibly damaging Het
Nrcam C T 12: 44,584,042 (GRCm39) P39S probably damaging Het
Or2ag1b A T 7: 106,288,296 (GRCm39) I214N probably damaging Het
Ostm1 A G 10: 42,555,227 (GRCm39) D83G possibly damaging Het
Otoa A T 7: 120,717,763 (GRCm39) probably null Het
Pi4ka A G 16: 17,143,040 (GRCm39) I824T probably damaging Het
Plec C T 15: 76,061,930 (GRCm39) R2534H probably benign Het
Plin2 A G 4: 86,580,314 (GRCm39) V60A probably damaging Het
Rps6ka4 A G 19: 6,809,724 (GRCm39) L367P probably damaging Het
Senp7 A G 16: 56,005,182 (GRCm39) N912D probably damaging Het
Slc25a21 G T 12: 56,785,282 (GRCm39) N198K possibly damaging Het
Slc4a10 A G 2: 61,877,002 (GRCm39) D5G probably benign Het
Tex16 T C X: 111,028,815 (GRCm39) V438A probably benign Het
Tmem37 T C 1: 119,995,684 (GRCm39) Y131C probably benign Het
Top2a A C 11: 98,913,252 (GRCm39) M60R probably damaging Het
Ush2a C T 1: 188,162,963 (GRCm39) T1015I probably damaging Het
Vmn1r172 A T 7: 23,359,171 (GRCm39) I19F probably benign Het
Vmn1r230 A C 17: 21,067,014 (GRCm39) I68L probably benign Het
Vmn2r45 A C 7: 8,475,361 (GRCm39) C556G probably damaging Het
Vmn2r54 A G 7: 12,349,356 (GRCm39) I742T possibly damaging Het
Vps13c A G 9: 67,813,198 (GRCm39) K960E probably benign Het
Wdcp T A 12: 4,900,405 (GRCm39) V87E probably damaging Het
Wiz C T 17: 32,606,649 (GRCm39) E29K probably damaging Het
Wnk3 C T X: 149,992,456 (GRCm39) T298I probably damaging Het
Yif1b A C 7: 28,943,594 (GRCm39) Q56P probably benign Het
Zbtb25 A G 12: 76,396,014 (GRCm39) W403R probably benign Het
Zcrb1 A T 15: 93,285,515 (GRCm39) S155R probably damaging Het
Zmym4 A T 4: 126,819,453 (GRCm39) I150K possibly damaging Het
Other mutations in Mical3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00569:Mical3 APN 6 120,938,585 (GRCm39) missense possibly damaging 0.73
IGL00718:Mical3 APN 6 121,017,410 (GRCm39) missense probably damaging 0.98
IGL00940:Mical3 APN 6 120,999,371 (GRCm39) missense possibly damaging 0.55
IGL00973:Mical3 APN 6 120,911,885 (GRCm39) splice site probably benign
IGL01503:Mical3 APN 6 120,935,537 (GRCm39) missense probably benign 0.09
IGL01991:Mical3 APN 6 120,912,172 (GRCm39) missense probably damaging 0.98
IGL02794:Mical3 APN 6 120,984,270 (GRCm39) missense probably damaging 0.99
IGL02996:Mical3 APN 6 120,935,519 (GRCm39) missense probably damaging 1.00
IGL03105:Mical3 APN 6 121,019,199 (GRCm39) missense probably benign 0.01
IGL03109:Mical3 APN 6 120,986,085 (GRCm39) missense probably damaging 1.00
IGL03236:Mical3 APN 6 120,946,345 (GRCm39) missense probably benign 0.00
P0028:Mical3 UTSW 6 121,001,650 (GRCm39) missense probably benign 0.33
R0244:Mical3 UTSW 6 120,934,683 (GRCm39) missense probably benign 0.00
R0494:Mical3 UTSW 6 120,936,162 (GRCm39) missense possibly damaging 0.94
R0586:Mical3 UTSW 6 121,006,602 (GRCm39) unclassified probably benign
R1029:Mical3 UTSW 6 120,911,639 (GRCm39) missense probably benign 0.02
R1263:Mical3 UTSW 6 120,929,430 (GRCm39) missense probably damaging 0.99
R1507:Mical3 UTSW 6 121,019,199 (GRCm39) missense probably benign 0.36
R1527:Mical3 UTSW 6 121,001,740 (GRCm39) missense probably damaging 0.99
R1623:Mical3 UTSW 6 121,001,768 (GRCm39) missense probably damaging 0.99
R1680:Mical3 UTSW 6 120,936,604 (GRCm39) missense probably benign 0.09
R1697:Mical3 UTSW 6 120,984,369 (GRCm39) missense possibly damaging 0.84
R1817:Mical3 UTSW 6 121,019,196 (GRCm39) missense probably benign 0.06
R1875:Mical3 UTSW 6 121,019,025 (GRCm39) missense probably damaging 1.00
R1961:Mical3 UTSW 6 120,959,568 (GRCm39) missense possibly damaging 0.94
R2004:Mical3 UTSW 6 120,928,283 (GRCm39) missense probably damaging 1.00
R2093:Mical3 UTSW 6 121,017,347 (GRCm39) missense probably damaging 1.00
R2141:Mical3 UTSW 6 121,008,095 (GRCm39) splice site probably null
R2142:Mical3 UTSW 6 121,008,095 (GRCm39) splice site probably null
R2257:Mical3 UTSW 6 121,010,696 (GRCm39) missense possibly damaging 0.94
R2404:Mical3 UTSW 6 120,936,789 (GRCm39) missense probably benign 0.01
R2419:Mical3 UTSW 6 120,936,884 (GRCm39) missense probably benign
R2509:Mical3 UTSW 6 121,011,118 (GRCm39) missense probably damaging 1.00
R3784:Mical3 UTSW 6 120,998,298 (GRCm39) missense probably benign 0.00
R4342:Mical3 UTSW 6 120,911,799 (GRCm39) nonsense probably null
R4343:Mical3 UTSW 6 120,911,799 (GRCm39) nonsense probably null
R4579:Mical3 UTSW 6 120,935,660 (GRCm39) missense probably benign
R4603:Mical3 UTSW 6 120,911,799 (GRCm39) nonsense probably null
R4605:Mical3 UTSW 6 121,011,041 (GRCm39) nonsense probably null
R4610:Mical3 UTSW 6 120,911,799 (GRCm39) nonsense probably null
R4611:Mical3 UTSW 6 120,911,799 (GRCm39) nonsense probably null
R4623:Mical3 UTSW 6 120,938,586 (GRCm39) nonsense probably null
R4669:Mical3 UTSW 6 120,934,664 (GRCm39) missense probably damaging 0.98
R4704:Mical3 UTSW 6 120,935,649 (GRCm39) missense probably benign 0.00
R4722:Mical3 UTSW 6 121,015,486 (GRCm39) missense probably benign 0.00
R4863:Mical3 UTSW 6 121,010,748 (GRCm39) missense probably damaging 0.99
R4878:Mical3 UTSW 6 120,946,348 (GRCm39) missense possibly damaging 0.51
R4885:Mical3 UTSW 6 120,912,214 (GRCm39) missense probably damaging 1.00
R4907:Mical3 UTSW 6 120,984,259 (GRCm39) missense probably benign 0.00
R5007:Mical3 UTSW 6 121,015,030 (GRCm39) missense probably damaging 0.98
R5299:Mical3 UTSW 6 120,936,473 (GRCm39) missense possibly damaging 0.71
R5303:Mical3 UTSW 6 120,936,941 (GRCm39) missense probably benign
R5368:Mical3 UTSW 6 120,936,434 (GRCm39) missense probably damaging 1.00
R5955:Mical3 UTSW 6 121,010,711 (GRCm39) missense probably damaging 0.99
R5970:Mical3 UTSW 6 120,935,232 (GRCm39) nonsense probably null
R6000:Mical3 UTSW 6 120,998,281 (GRCm39) missense probably benign 0.06
R6101:Mical3 UTSW 6 121,010,671 (GRCm39) missense probably damaging 1.00
R6195:Mical3 UTSW 6 120,993,796 (GRCm39) intron probably benign
R6210:Mical3 UTSW 6 121,017,478 (GRCm39) splice site probably null
R6225:Mical3 UTSW 6 120,935,684 (GRCm39) missense probably damaging 0.98
R6258:Mical3 UTSW 6 120,985,991 (GRCm39) missense probably damaging 1.00
R6260:Mical3 UTSW 6 120,985,991 (GRCm39) missense probably damaging 1.00
R6349:Mical3 UTSW 6 120,936,486 (GRCm39) missense probably benign
R6352:Mical3 UTSW 6 120,929,434 (GRCm39) missense probably damaging 0.97
R6480:Mical3 UTSW 6 121,011,236 (GRCm39) missense possibly damaging 0.76
R6704:Mical3 UTSW 6 120,986,761 (GRCm39) intron probably benign
R6783:Mical3 UTSW 6 120,935,786 (GRCm39) missense possibly damaging 0.85
R6925:Mical3 UTSW 6 120,936,351 (GRCm39) missense probably benign 0.05
R6960:Mical3 UTSW 6 120,935,504 (GRCm39) missense probably damaging 1.00
R7170:Mical3 UTSW 6 120,950,694 (GRCm39) splice site probably null
R7344:Mical3 UTSW 6 121,013,505 (GRCm39) nonsense probably null
R7414:Mical3 UTSW 6 121,011,074 (GRCm39) missense probably damaging 1.00
R7455:Mical3 UTSW 6 120,935,705 (GRCm39) missense probably damaging 1.00
R7649:Mical3 UTSW 6 120,911,909 (GRCm39) missense probably damaging 1.00
R8236:Mical3 UTSW 6 120,989,504 (GRCm39) missense
R8286:Mical3 UTSW 6 120,998,149 (GRCm39) missense possibly damaging 0.68
R8316:Mical3 UTSW 6 120,911,944 (GRCm39) missense probably damaging 1.00
R8328:Mical3 UTSW 6 120,912,138 (GRCm39) missense probably damaging 0.98
R8354:Mical3 UTSW 6 120,950,381 (GRCm39) missense probably damaging 0.99
R8511:Mical3 UTSW 6 121,015,513 (GRCm39) missense possibly damaging 0.78
R8687:Mical3 UTSW 6 120,936,438 (GRCm39) missense probably benign 0.19
R8728:Mical3 UTSW 6 120,950,514 (GRCm39) missense probably damaging 0.99
R8925:Mical3 UTSW 6 120,984,325 (GRCm39) missense probably benign 0.00
R8927:Mical3 UTSW 6 120,984,325 (GRCm39) missense probably benign 0.00
R8986:Mical3 UTSW 6 120,991,822 (GRCm39) missense
R9026:Mical3 UTSW 6 120,986,848 (GRCm39) splice site probably benign
R9415:Mical3 UTSW 6 120,934,712 (GRCm39) missense probably damaging 1.00
R9515:Mical3 UTSW 6 121,001,758 (GRCm39) missense probably damaging 1.00
R9720:Mical3 UTSW 6 120,935,238 (GRCm39) missense probably damaging 0.99
R9777:Mical3 UTSW 6 120,959,529 (GRCm39) missense possibly damaging 0.91
Z1177:Mical3 UTSW 6 120,936,689 (GRCm39) missense possibly damaging 0.71
Z1190:Mical3 UTSW 6 120,998,319 (GRCm39) critical splice acceptor site probably null
Predicted Primers PCR Primer
(F):5'- AAGCACCTCGGTGTGTCTTG -3'
(R):5'- GACTCTTCTAGGAAGTCAAAGGAG -3'

Sequencing Primer
(F):5'- CTTGTGGGTTGTGGGGGTAAC -3'
(R):5'- CTTCTAGGAAGTCAAAGGAGCCCTG -3'
Posted On 2018-04-02