Incidental Mutation 'R6316:Trgv2'
ID 509996
Institutional Source Beutler Lab
Gene Symbol Trgv2
Ensembl Gene ENSMUSG00000076754
Gene Name T cell receptor gamma variable 2
Synonyms Vgamma2, Tcrg-V2
MMRRC Submission 044416-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.049) question?
Stock # R6316 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 19520743-19521196 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 19520912 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Stop codon at position 61 (Q61*)
Ref Sequence ENSEMBL: ENSMUSP00000100341 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103563] [ENSMUST00000103564]
AlphaFold A2J008
Predicted Effect probably null
Transcript: ENSMUST00000103563
AA Change: Q61*
SMART Domains Protein: ENSMUSP00000100341
Gene: ENSMUSG00000076754
AA Change: Q61*

DomainStartEndE-ValueType
IGv 34 114 1.66e-9 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000103564
SMART Domains Protein: ENSMUSP00000100342
Gene: ENSMUSG00000076755

DomainStartEndE-ValueType
IGv 34 113 8.44e-11 SMART
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 98.0%
Validation Efficiency 97% (38/39)
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T C 1: 71,353,118 (GRCm39) T775A probably benign Het
Adam6a A T 12: 113,509,196 (GRCm39) N523I probably benign Het
Adgrv1 T C 13: 81,647,187 (GRCm39) T3118A possibly damaging Het
Arhgef4 G A 1: 34,762,558 (GRCm39) A605T unknown Het
Asxl3 A G 18: 22,655,839 (GRCm39) Y1283C probably damaging Het
Btbd2 T A 10: 80,480,612 (GRCm39) I319F probably damaging Het
Eno4 G A 19: 58,948,723 (GRCm39) probably null Het
Glis2 T A 16: 4,431,700 (GRCm39) probably benign Het
Grin2b A T 6: 135,757,277 (GRCm39) C395S probably benign Het
H1f8 T C 6: 115,925,876 (GRCm39) probably null Het
Kansl1l T A 1: 66,774,744 (GRCm39) Y694F probably benign Het
Kcnj1 A T 9: 32,308,632 (GRCm39) E332V probably damaging Het
Klhdc7a T C 4: 139,694,113 (GRCm39) E278G probably benign Het
Krt33a T C 11: 99,905,027 (GRCm39) N160D probably damaging Het
Ksr2 A G 5: 117,823,567 (GRCm39) N448S probably damaging Het
Lpar6 A G 14: 73,476,774 (GRCm39) Y245C probably damaging Het
Magel2 T C 7: 62,028,467 (GRCm39) I457T possibly damaging Het
Manf A G 9: 106,766,385 (GRCm39) L132P probably damaging Het
Moxd2 T C 6: 40,860,481 (GRCm39) D321G probably damaging Het
Mtmr12 T A 15: 12,236,199 (GRCm39) C153S probably null Het
Muc16 T C 9: 18,553,115 (GRCm39) T4393A probably benign Het
Notch3 T C 17: 32,356,787 (GRCm39) probably null Het
Or9e1 A G 11: 58,732,768 (GRCm39) Y276C probably damaging Het
Pirb T A 7: 3,720,822 (GRCm39) K225N probably damaging Het
Plch1 C T 3: 63,688,811 (GRCm39) W131* probably null Het
Rilpl2 A G 5: 124,615,943 (GRCm39) V69A probably damaging Het
Smdt1 T C 15: 82,232,210 (GRCm39) V99A probably damaging Het
Smpd1 T C 7: 105,204,709 (GRCm39) V196A probably benign Het
Supt20 TCAGCAGCAGCAGCAGCAGCAGCA TCAGCAGCAGCAGCAGCAGCAGCAGCA 3: 54,635,069 (GRCm39) probably benign Het
Tcte1 A G 17: 45,845,786 (GRCm39) H130R probably benign Het
Tead1 C A 7: 112,491,046 (GRCm39) Q296K probably damaging Het
Thoc2l G C 5: 104,667,595 (GRCm39) G706R probably damaging Het
Tmem163 C T 1: 127,479,102 (GRCm39) S139N probably benign Het
Tor1aip2 G T 1: 155,937,840 (GRCm39) D192Y probably damaging Het
Trib1 T C 15: 59,521,264 (GRCm39) S85P probably benign Het
Trrap T A 5: 144,750,336 (GRCm39) N1581K probably benign Het
Vmn1r181 G A 7: 23,684,183 (GRCm39) R216Q probably benign Het
Xrn2 A G 2: 146,883,930 (GRCm39) Y563C probably damaging Het
Other mutations in Trgv2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R3810:Trgv2 UTSW 13 19,521,011 (GRCm39) missense possibly damaging 0.95
R6268:Trgv2 UTSW 13 19,521,001 (GRCm39) missense probably benign 0.30
R6968:Trgv2 UTSW 13 19,520,896 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATGTTGTGCTCATCCAGACTGC -3'
(R):5'- TGCAGGAGACAGTGAACTCATC -3'

Sequencing Primer
(F):5'- TCATCCAGACTGCACAGTAGTAGG -3'
(R):5'- GGAGACAGTGAACTCATCCTCATTTC -3'
Posted On 2018-04-02