Incidental Mutation 'IGL00264:Or13a25'
ID 5100
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or13a25
Ensembl Gene ENSMUSG00000059136
Gene Name olfactory receptor family 13 subfamily A member 25
Synonyms GA_x6K02T2PBJ9-42813436-42814368, Olfr539, MOR253-4
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # IGL00264
Quality Score
Status
Chromosome 7
Chromosomal Location 140247202-140248161 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 140247854 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 211 (I211N)
Ref Sequence ENSEMBL: ENSMUSP00000151522 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078967] [ENSMUST00000210973] [ENSMUST00000218865]
AlphaFold Q8VGL9
Predicted Effect probably benign
Transcript: ENSMUST00000078967
AA Change: I218N

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000077990
Gene: ENSMUSG00000059136
AA Change: I218N

DomainStartEndE-ValueType
Pfam:7tm_4 40 316 6.5e-50 PFAM
Pfam:7tm_1 50 299 4.9e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210499
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210973
AA Change: I211N
Predicted Effect probably benign
Transcript: ENSMUST00000218865
AA Change: I211N

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219579
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219853
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr3 T G 1: 125,324,966 (GRCm39) I319L probably benign Het
Akap7 C T 10: 25,047,138 (GRCm39) D20N probably benign Het
Ambra1 T A 2: 91,741,934 (GRCm39) S1070T probably benign Het
Arhgef9 T C X: 94,125,237 (GRCm39) probably null Het
Ascc3 T G 10: 50,590,531 (GRCm39) V1083G probably damaging Het
Asns T A 6: 7,680,179 (GRCm39) E312D probably damaging Het
Bpifc A C 10: 85,796,392 (GRCm39) V472G possibly damaging Het
Ccdc71 T A 9: 108,340,237 (GRCm39) S17T probably damaging Het
Cebpzos T C 17: 79,225,777 (GRCm39) probably benign Het
Cfi T C 3: 129,666,744 (GRCm39) I489T probably damaging Het
Chrm2 T A 6: 36,500,326 (GRCm39) F61Y probably damaging Het
Cpxm1 T C 2: 130,237,863 (GRCm39) Y149C probably damaging Het
Dnah6 A G 6: 73,172,720 (GRCm39) I246T probably benign Het
Ereg C A 5: 91,222,638 (GRCm39) S7Y probably benign Het
Ghsr T A 3: 27,429,022 (GRCm39) L349Q possibly damaging Het
Gm10754 A G 10: 97,518,274 (GRCm39) probably benign Het
Gm8237 A T 14: 5,864,475 (GRCm38) L29H probably benign Het
Hexim2 A G 11: 103,029,281 (GRCm39) E111G probably damaging Het
Itga1 A T 13: 115,128,899 (GRCm39) N586K possibly damaging Het
Kat6b A G 14: 21,718,627 (GRCm39) D1102G probably benign Het
Kif27 A T 13: 58,485,418 (GRCm39) M514K probably benign Het
Matn2 T C 15: 34,428,616 (GRCm39) I660T probably damaging Het
Mki67 C A 7: 135,309,549 (GRCm39) G301* probably null Het
Or1l4b T C 2: 37,037,079 (GRCm39) F285S probably damaging Het
Or5b121 A C 19: 13,507,214 (GRCm39) Y103S probably damaging Het
Or5b99 A G 19: 12,976,683 (GRCm39) Y111C probably damaging Het
Pcdhb8 A T 18: 37,488,526 (GRCm39) H68L probably benign Het
Pkhd1l1 T C 15: 44,354,425 (GRCm39) V272A possibly damaging Het
Pstpip2 T C 18: 77,959,259 (GRCm39) probably benign Het
Rdh14 G T 12: 10,441,134 (GRCm39) G99W probably damaging Het
Rmc1 T C 18: 12,312,276 (GRCm39) V172A probably benign Het
Sra1 A T 18: 36,801,792 (GRCm39) S99R probably benign Het
Tbrg1 G T 9: 37,562,337 (GRCm39) N280K probably benign Het
Ugt8a A G 3: 125,708,285 (GRCm39) probably null Het
Usp40 A T 1: 87,931,960 (GRCm39) probably benign Het
Vmn1r45 T A 6: 89,910,646 (GRCm39) Y108F probably damaging Het
Zfp521 A G 18: 13,979,559 (GRCm39) Y285H probably benign Het
Other mutations in Or13a25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01610:Or13a25 APN 7 140,247,584 (GRCm39) missense probably damaging 1.00
IGL02959:Or13a25 APN 7 140,247,463 (GRCm39) missense probably damaging 1.00
IGL03406:Or13a25 APN 7 140,247,424 (GRCm39) missense probably damaging 1.00
R0671:Or13a25 UTSW 7 140,247,590 (GRCm39) missense probably damaging 1.00
R1771:Or13a25 UTSW 7 140,248,048 (GRCm39) missense probably benign
R1934:Or13a25 UTSW 7 140,247,951 (GRCm39) nonsense probably null
R1985:Or13a25 UTSW 7 140,247,734 (GRCm39) missense probably damaging 1.00
R2962:Or13a25 UTSW 7 140,247,862 (GRCm39) missense probably benign
R4239:Or13a25 UTSW 7 140,247,496 (GRCm39) missense probably benign 0.07
R4240:Or13a25 UTSW 7 140,247,496 (GRCm39) missense probably benign 0.07
R4360:Or13a25 UTSW 7 140,247,730 (GRCm39) missense probably damaging 0.98
R4841:Or13a25 UTSW 7 140,247,502 (GRCm39) missense probably damaging 1.00
R4842:Or13a25 UTSW 7 140,247,502 (GRCm39) missense probably damaging 1.00
R4851:Or13a25 UTSW 7 140,247,226 (GRCm39) missense probably benign
R5325:Or13a25 UTSW 7 140,247,705 (GRCm39) missense probably benign 0.33
R5766:Or13a25 UTSW 7 140,247,266 (GRCm39) missense probably benign 0.02
R6363:Or13a25 UTSW 7 140,247,995 (GRCm39) missense possibly damaging 0.93
R6836:Or13a25 UTSW 7 140,248,093 (GRCm39) missense possibly damaging 0.86
R7777:Or13a25 UTSW 7 140,247,854 (GRCm39) missense probably benign 0.01
R7920:Or13a25 UTSW 7 140,247,814 (GRCm39) missense possibly damaging 0.92
R8134:Or13a25 UTSW 7 140,247,680 (GRCm39) missense possibly damaging 0.90
R8712:Or13a25 UTSW 7 140,248,052 (GRCm39) missense possibly damaging 0.89
R9095:Or13a25 UTSW 7 140,247,813 (GRCm39) missense probably damaging 1.00
R9158:Or13a25 UTSW 7 140,247,547 (GRCm39) missense possibly damaging 0.76
R9603:Or13a25 UTSW 7 140,247,794 (GRCm39) missense probably damaging 1.00
Posted On 2012-04-20