Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01062:Oas1d'

51010

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Oas1d

Ensembl Gene

ENSMUSG00000032623

Gene Name

2'-5' oligoadenylate synthetase 1D

Synonyms

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01062

Quality Score

Status

Chromosome

Chromosomal Location

121052881-121059711 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to A at 121057127 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 244 (Y244*)

Ref Sequence

ENSEMBL: ENSMUSP00000048054 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000044224]

AlphaFold

Q8VI95

Predicted Effect

probably null
Transcript: ENSMUST00000044224
AA Change: Y244*

SMART Domains

Protein: ENSMUSP00000048054
Gene: ENSMUSG00000032623
AA Change: Y244*

Domain	Start	End	E-Value	Type
low complexity region	107	119	N/A	INTRINSIC
Pfam:OAS1_C	168	353	9.4e-76	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous null females exhibit reduced fertility due to defects in ovarian follicle development and decreased efficiency of ovulation. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aen	G	A	7: 78,557,050 (GRCm39)	M299I	probably damaging	Het
Amer3	A	G	1: 34,625,820 (GRCm39)	K20E	probably damaging	Het
Arhgap31	A	G	16: 38,421,818 (GRCm39)	L1416P	probably damaging	Het
Avpr1a	G	A	10: 122,285,434 (GRCm39)	C242Y	probably damaging	Het
Bclaf3	T	C	X: 158,336,415 (GRCm39)	Y281H	probably benign	Het
Cdc14a	T	A	3: 116,068,361 (GRCm39)		probably benign	Het
Cfap206	C	T	4: 34,721,562 (GRCm39)	S162N	probably damaging	Het
Cntn4	T	C	6: 106,595,239 (GRCm39)		probably benign	Het
Cyp3a44	T	A	5: 145,731,149 (GRCm39)	D217V	possibly damaging	Het
Eprs1	A	G	1: 185,111,812 (GRCm39)	E274G	probably benign	Het
Ercc6l2	G	T	13: 63,995,268 (GRCm39)	Q354H	probably null	Het
Glb1l	A	T	1: 75,177,882 (GRCm39)	I392N	probably damaging	Het
Gm3173	T	C	14: 15,728,472 (GRCm39)		probably null	Het
Hadh	C	T	3: 131,034,640 (GRCm39)	V219M	probably damaging	Het
Hspb9	A	G	11: 100,604,761 (GRCm39)	H29R	possibly damaging	Het
Iqgap3	G	T	3: 88,017,429 (GRCm39)	V240L	probably benign	Het
Jmjd1c	T	C	10: 67,062,494 (GRCm39)	S1616P	probably damaging	Het
Knl1	A	G	2: 118,907,461 (GRCm39)	I1662V	probably benign	Het
Maco1	A	T	4: 134,560,608 (GRCm39)	V125E	probably damaging	Het
Mapre3	A	G	5: 31,022,240 (GRCm39)	I236V	probably benign	Het
Med17	T	C	9: 15,190,917 (GRCm39)	E58G	probably benign	Het
Myh6	T	C	14: 55,189,749 (GRCm39)	E1099G	probably damaging	Het
Myt1	T	A	2: 181,439,522 (GRCm39)	V348D	probably damaging	Het
Nat10	A	T	2: 103,573,393 (GRCm39)	I368N	probably damaging	Het
Nol6	T	C	4: 41,118,205 (GRCm39)	I811V	probably benign	Het
Or6e1	A	T	14: 54,520,181 (GRCm39)	M57K	probably damaging	Het
Osbpl1a	A	G	18: 13,038,132 (GRCm39)	V273A	probably benign	Het
Pigw	T	C	11: 84,768,769 (GRCm39)	R187G	probably benign	Het
Plekhg5	G	A	4: 152,192,953 (GRCm39)	D603N	probably damaging	Het
Ptprk	T	C	10: 28,456,414 (GRCm39)	V1058A	probably damaging	Het
Robo4	G	A	9: 37,317,296 (GRCm39)	S537N	probably benign	Het
Rptn	T	A	3: 93,304,489 (GRCm39)	F607L	probably benign	Het
Sall1	A	G	8: 89,759,972 (GRCm39)	V44A	probably damaging	Het
Sh3bp4	C	A	1: 89,071,682 (GRCm39)	Q177K	probably benign	Het
Skic3	T	A	13: 76,303,581 (GRCm39)	L1225*	probably null	Het
Spmip6	T	A	4: 41,511,433 (GRCm39)	E93D	probably damaging	Het
Srrt	C	A	5: 137,294,569 (GRCm39)	G779V	probably damaging	Het
Tamalin	A	G	15: 101,126,777 (GRCm39)		probably benign	Het
Tex21	T	C	12: 76,245,718 (GRCm39)	D526G	probably benign	Het
Vmn1r10	A	G	6: 57,090,821 (GRCm39)	S138G	possibly damaging	Het
Yars2	C	T	16: 16,124,406 (GRCm39)	R338*	probably null	Het
Zfp454	T	C	11: 50,765,033 (GRCm39)	E22G	probably benign	Het
Zzef1	T	A	11: 72,765,795 (GRCm39)	C1441S	probably benign	Het

Other mutations in Oas1d

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00656:Oas1d	APN	5	121,057,270 (GRCm39)	missense	possibly damaging	0.90
IGL01114:Oas1d	APN	5	121,054,907 (GRCm39)	missense	probably benign	0.08
IGL02336:Oas1d	APN	5	121,057,111 (GRCm39)	missense	probably damaging	1.00
IGL02444:Oas1d	APN	5	121,058,071 (GRCm39)	missense	probably benign	0.25
R0080:Oas1d	UTSW	5	121,054,955 (GRCm39)	missense	possibly damaging	0.61
R0388:Oas1d	UTSW	5	121,055,091 (GRCm39)	missense	probably damaging	1.00
R0674:Oas1d	UTSW	5	121,058,049 (GRCm39)	missense	probably benign
R1344:Oas1d	UTSW	5	121,052,959 (GRCm39)	missense	probably damaging	1.00
R1719:Oas1d	UTSW	5	121,058,025 (GRCm39)	missense	possibly damaging	0.79
R1771:Oas1d	UTSW	5	121,053,900 (GRCm39)	missense	probably damaging	0.98
R3810:Oas1d	UTSW	5	121,053,049 (GRCm39)	missense	probably damaging	1.00
R4516:Oas1d	UTSW	5	121,057,233 (GRCm39)	missense	probably damaging	1.00
R4559:Oas1d	UTSW	5	121,054,958 (GRCm39)	missense	probably benign	0.00
R4819:Oas1d	UTSW	5	121,053,780 (GRCm39)	missense	probably damaging	1.00
R4926:Oas1d	UTSW	5	121,053,831 (GRCm39)	missense	probably benign
R5199:Oas1d	UTSW	5	121,057,208 (GRCm39)	missense	probably benign	0.03
R5392:Oas1d	UTSW	5	121,055,003 (GRCm39)	missense	possibly damaging	0.95
R5695:Oas1d	UTSW	5	121,053,074 (GRCm39)	missense	probably benign
R5769:Oas1d	UTSW	5	121,054,917 (GRCm39)	missense	probably benign	0.00
R6259:Oas1d	UTSW	5	121,057,244 (GRCm39)	nonsense	probably null
R7276:Oas1d	UTSW	5	121,054,944 (GRCm39)	missense	possibly damaging	0.48
R7446:Oas1d	UTSW	5	121,058,054 (GRCm39)	missense	probably benign
R7808:Oas1d	UTSW	5	121,053,034 (GRCm39)	nonsense	probably null
R7976:Oas1d	UTSW	5	121,057,210 (GRCm39)	missense	probably damaging	1.00
R8284:Oas1d	UTSW	5	121,057,221 (GRCm39)	nonsense	probably null
R9446:Oas1d	UTSW	5	121,054,947 (GRCm39)	missense	probably benign	0.00
Z1176:Oas1d	UTSW	5	121,052,977 (GRCm39)	missense	probably benign	0.00

Posted On

2013-06-21