|Institutional Source||Beutler Lab|
|Gene Name||fibronectin leucine rich transmembrane protein 1|
|Is this an essential gene?||Probably non essential (E-score: 0.232)|
|Stock #||R6326 (G1)|
|Chromosomal Location||7092014-7105729 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||C to T at 7096609 bp|
|Amino Acid Change||Serine to Asparagine at position 191 (S191N)|
|Ref Sequence||ENSEMBL: ENSMUSP00000109010 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000040261] [ENSMUST00000113383]|
|Predicted Effect||probably benign
|Predicted Effect||probably damaging
AA Change: S191N
PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
AA Change: S191N
|Meta Mutation Damage Score||0.3307|
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in kidney and brain. [provided by RefSeq, Jul 2008]
PHENOTYPE: No notable phenotype was detected in a high-throughput screen of homozygous mice. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Flrt1||
(F):5'- AGTTCCGTACTAGCGACAGC -3'
(R):5'- ATGACCTGGACGAGTTCCCTATC -3'
(F):5'- CGTGAGGTTCTGCAGCC -3'
(R):5'- TCCCTGAGAGAGCTGCATCTG -3'