Incidental Mutation 'R6327:Vmn1r65'
ID 510468
Institutional Source Beutler Lab
Gene Symbol Vmn1r65
Ensembl Gene ENSMUSG00000066850
Gene Name vomeronasal 1 receptor 65
Synonyms V1rd6, V3R6
MMRRC Submission 044481-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R6327 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 6010749-6014009 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 6011651 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 194 (N194K)
Ref Sequence ENSEMBL: ENSMUSP00000083520 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086338]
AlphaFold Q9EPS7
Predicted Effect possibly damaging
Transcript: ENSMUST00000086338
AA Change: N194K

PolyPhen 2 Score 0.479 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000083520
Gene: ENSMUSG00000066850
AA Change: N194K

DomainStartEndE-ValueType
Pfam:TAS2R 20 308 7.3e-14 PFAM
Pfam:7tm_1 42 301 1.6e-6 PFAM
Pfam:V1R 53 308 5.6e-15 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227656
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.4%
Validation Efficiency 100% (43/43)
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 T C 6: 128,535,655 (GRCm39) probably null Het
Birc6 C A 17: 74,969,774 (GRCm39) H383Q probably damaging Het
C2 C A 17: 35,083,079 (GRCm39) A431S probably benign Het
C3ar1 C T 6: 122,827,105 (GRCm39) V371M probably damaging Het
Chd1l G A 3: 97,494,483 (GRCm39) A399V probably damaging Het
Ckap2l A G 2: 129,127,414 (GRCm39) S255P probably damaging Het
Clca3a1 T A 3: 144,436,558 (GRCm39) I842F probably benign Het
Cmc2 G T 8: 117,620,896 (GRCm39) H28Q probably damaging Het
Col11a2 C T 17: 34,262,291 (GRCm39) P176L probably benign Het
Csmd3 T C 15: 47,744,783 (GRCm39) D1404G probably damaging Het
Dld G A 12: 31,382,190 (GRCm39) P506S probably benign Het
Dsg3 T C 18: 20,672,927 (GRCm39) M866T probably benign Het
Ehd1 T C 19: 6,348,375 (GRCm39) I451T possibly damaging Het
Fosb T C 7: 19,041,152 (GRCm39) T114A probably benign Het
Foxd4 T A 19: 24,878,198 (GRCm39) M1L possibly damaging Het
Fstl5 T A 3: 76,615,108 (GRCm39) I723N probably benign Het
Gm10549 C A 18: 33,597,358 (GRCm39) probably benign Het
Gm11595 G A 11: 99,663,381 (GRCm39) R100C unknown Het
Hdlbp A G 1: 93,357,186 (GRCm39) S299P possibly damaging Het
Mast4 G A 13: 102,897,890 (GRCm39) R650C probably damaging Het
Micu3 A G 8: 40,819,238 (GRCm39) T306A probably benign Het
Mylk2 A G 2: 152,755,613 (GRCm39) Q259R possibly damaging Het
Nfkbiz T C 16: 55,642,325 (GRCm39) N31S probably damaging Het
Nisch A T 14: 30,893,444 (GRCm39) probably benign Het
Nudt17 T C 3: 96,615,080 (GRCm39) probably benign Het
Oprm1 A C 10: 6,780,063 (GRCm39) I242L probably damaging Het
Or13a26 T C 7: 140,284,616 (GRCm39) W151R probably damaging Het
Or14c39 T C 7: 86,343,760 (GRCm39) V32A probably benign Het
Or2y1d A C 11: 49,321,828 (GRCm39) H175P probably damaging Het
Otud6b A G 4: 14,826,496 (GRCm39) probably benign Het
Pamr1 A T 2: 102,472,519 (GRCm39) D606V probably damaging Het
Pcf11 T C 7: 92,308,817 (GRCm39) probably benign Het
Pom121l2 T C 13: 22,166,502 (GRCm39) S258P probably damaging Het
Rcsd1 T A 1: 165,483,403 (GRCm39) D196V possibly damaging Het
Sbf2 C T 7: 110,040,759 (GRCm39) R356Q probably damaging Het
Serpinf1 A G 11: 75,304,731 (GRCm39) probably null Het
Slc22a30 T G 19: 8,313,086 (GRCm39) probably benign Het
Strn4 G T 7: 16,550,384 (GRCm39) S36I probably benign Het
Taar6 A G 10: 23,861,177 (GRCm39) L123P probably damaging Het
Thbs1 G T 2: 117,943,137 (GRCm39) R5L unknown Het
Timp3 T C 10: 86,181,650 (GRCm39) Y174H probably benign Het
Trpm2 C T 10: 77,768,061 (GRCm39) V813M probably damaging Het
Uox C T 3: 146,330,332 (GRCm39) R163* probably null Het
Vcan A T 13: 89,852,951 (GRCm39) S670T probably damaging Het
Other mutations in Vmn1r65
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01636:Vmn1r65 APN 7 6,011,720 (GRCm39) missense probably benign 0.12
IGL02821:Vmn1r65 APN 7 6,011,893 (GRCm39) missense possibly damaging 0.62
R0991:Vmn1r65 UTSW 7 6,012,076 (GRCm39) missense probably damaging 0.99
R1457:Vmn1r65 UTSW 7 6,012,156 (GRCm39) missense probably benign 0.10
R1507:Vmn1r65 UTSW 7 6,012,108 (GRCm39) missense probably benign 0.13
R1856:Vmn1r65 UTSW 7 6,011,265 (GRCm39) missense possibly damaging 0.93
R2914:Vmn1r65 UTSW 7 6,012,040 (GRCm39) missense possibly damaging 0.69
R5147:Vmn1r65 UTSW 7 6,011,818 (GRCm39) missense probably benign 0.01
R5279:Vmn1r65 UTSW 7 6,011,754 (GRCm39) missense probably damaging 1.00
R5399:Vmn1r65 UTSW 7 6,011,809 (GRCm39) nonsense probably null
R5409:Vmn1r65 UTSW 7 6,012,012 (GRCm39) missense possibly damaging 0.77
R5646:Vmn1r65 UTSW 7 6,012,223 (GRCm39) missense probably benign 0.01
R5963:Vmn1r65 UTSW 7 6,011,608 (GRCm39) missense probably damaging 1.00
R6034:Vmn1r65 UTSW 7 6,011,868 (GRCm39) missense probably damaging 1.00
R6034:Vmn1r65 UTSW 7 6,011,868 (GRCm39) missense probably damaging 1.00
R7958:Vmn1r65 UTSW 7 6,011,254 (GRCm39) missense probably benign 0.01
R8121:Vmn1r65 UTSW 7 6,011,464 (GRCm39) missense possibly damaging 0.87
R8345:Vmn1r65 UTSW 7 6,011,256 (GRCm39) missense probably benign
R8725:Vmn1r65 UTSW 7 6,011,503 (GRCm39) missense probably damaging 1.00
R8727:Vmn1r65 UTSW 7 6,011,503 (GRCm39) missense probably damaging 1.00
R9246:Vmn1r65 UTSW 7 6,011,769 (GRCm39) missense possibly damaging 0.95
R9279:Vmn1r65 UTSW 7 6,011,988 (GRCm39) missense probably benign 0.06
R9778:Vmn1r65 UTSW 7 6,011,387 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CCAGCATCAGGACAGTATGG -3'
(R):5'- AGCACCTACCAGTTTGTCAC -3'

Sequencing Primer
(F):5'- ATCAGGACAGTATGGGCTGCTC -3'
(R):5'- CCTGGGCTAGGGTCATCTTCAG -3'
Posted On 2018-04-02