Incidental Mutation 'IGL01082:Vsig10'
ID 51059
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vsig10
Ensembl Gene ENSMUSG00000066894
Gene Name V-set and immunoglobulin domain containing 10
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # IGL01082
Quality Score
Status
Chromosome 5
Chromosomal Location 117457331-117493071 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 117472970 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 188 (I188V)
Ref Sequence ENSEMBL: ENSMUSP00000107598 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086464] [ENSMUST00000111967]
AlphaFold D3YX43
Predicted Effect probably benign
Transcript: ENSMUST00000086464
AA Change: I161V

PolyPhen 2 Score 0.145 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000083655
Gene: ENSMUSG00000066894
AA Change: I161V

DomainStartEndE-ValueType
low complexity region 2 16 N/A INTRINSIC
IG 23 114 4.03e-8 SMART
IG 132 214 9.49e-5 SMART
Pfam:Ig_2 215 300 2.6e-2 PFAM
Pfam:Ig_3 216 284 3.5e-4 PFAM
IGc2 313 384 1.12e-6 SMART
transmembrane domain 403 425 N/A INTRINSIC
coiled coil region 446 481 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000111967
AA Change: I188V

PolyPhen 2 Score 0.326 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000107598
Gene: ENSMUSG00000066894
AA Change: I188V

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
IG 50 141 4.03e-8 SMART
IG 159 241 9.49e-5 SMART
Blast:IG_like 248 327 2e-33 BLAST
IGc2 340 411 1.12e-6 SMART
transmembrane domain 430 452 N/A INTRINSIC
coiled coil region 473 508 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145052
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147182
SMART Domains Protein: ENSMUSP00000125808
Gene: ENSMUSG00000066894

DomainStartEndE-ValueType
Blast:IG_like 1 41 3e-14 BLAST
IGc2 54 125 1.12e-6 SMART
transmembrane domain 144 166 N/A INTRINSIC
coiled coil region 187 222 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(11) : Gene trapped(11)

Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 G A 1: 71,353,273 (GRCm39) S723F probably damaging Het
Cacng5 C T 11: 107,772,531 (GRCm39) V106I probably benign Het
Ccdc116 A G 16: 16,959,856 (GRCm39) S278P probably damaging Het
Cep152 A T 2: 125,411,465 (GRCm39) probably benign Het
Cftr T C 6: 18,226,102 (GRCm39) V350A probably damaging Het
Dsc2 A T 18: 20,176,849 (GRCm39) N399K probably damaging Het
Eif3d T C 15: 77,843,943 (GRCm39) T468A probably damaging Het
Fam110b C T 4: 5,799,461 (GRCm39) A293V possibly damaging Het
Flrt1 T C 19: 7,073,339 (GRCm39) T403A probably benign Het
H3c6 A G 13: 23,746,548 (GRCm39) probably benign Het
Ift140 T A 17: 25,267,429 (GRCm39) V609E possibly damaging Het
Klb G A 5: 65,533,283 (GRCm39) V531I possibly damaging Het
Krt73 T C 15: 101,707,372 (GRCm39) probably null Het
Mcm2 A G 6: 88,864,859 (GRCm39) V539A probably benign Het
Myb A G 10: 21,028,843 (GRCm39) V85A probably damaging Het
Ndufs1 T C 1: 63,203,976 (GRCm39) E102G probably damaging Het
Nr5a2 C A 1: 136,773,206 (GRCm39) A499S probably benign Het
Opa1 A T 16: 29,436,933 (GRCm39) probably benign Het
Or14j5 T A 17: 38,161,514 (GRCm39) S10R probably benign Het
Or4a47 A T 2: 89,674,407 (GRCm39) probably benign Het
Or4c11b T C 2: 88,625,637 (GRCm39) F304L probably benign Het
Pcnx1 G A 12: 82,037,372 (GRCm39) E1877K possibly damaging Het
Sel1l A G 12: 91,778,682 (GRCm39) V711A probably benign Het
Slc22a16 A G 10: 40,449,860 (GRCm39) T120A probably benign Het
Slc26a1 G T 5: 108,819,744 (GRCm39) T485N possibly damaging Het
Sp100 T C 1: 85,597,741 (GRCm39) V201A possibly damaging Het
Spz1 T G 13: 92,712,029 (GRCm39) K149T probably damaging Het
Stxbp5l A G 16: 37,024,940 (GRCm39) S553P possibly damaging Het
Szt2 A G 4: 118,254,821 (GRCm39) S290P probably damaging Het
Tbc1d10c A G 19: 4,239,026 (GRCm39) Y165H probably damaging Het
Tnxb C A 17: 34,933,584 (GRCm39) Q2335K probably damaging Het
Trim33 T C 3: 103,234,175 (GRCm39) I471T possibly damaging Het
Zfp109 A T 7: 23,933,784 (GRCm39) L45Q probably damaging Het
Other mutations in Vsig10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00163:Vsig10 APN 5 117,476,479 (GRCm39) missense probably benign 0.00
IGL00340:Vsig10 APN 5 117,489,652 (GRCm39) missense probably benign 0.03
IGL01285:Vsig10 APN 5 117,462,954 (GRCm39) missense probably benign 0.43
IGL01790:Vsig10 APN 5 117,476,379 (GRCm39) missense probably damaging 1.00
IGL03004:Vsig10 APN 5 117,463,140 (GRCm39) missense probably damaging 1.00
D3080:Vsig10 UTSW 5 117,481,884 (GRCm39) missense probably damaging 1.00
R0101:Vsig10 UTSW 5 117,473,134 (GRCm39) critical splice donor site probably null
R0403:Vsig10 UTSW 5 117,476,526 (GRCm39) missense probably benign 0.05
R0674:Vsig10 UTSW 5 117,481,911 (GRCm39) missense probably damaging 1.00
R1437:Vsig10 UTSW 5 117,489,635 (GRCm39) missense probably damaging 0.96
R1689:Vsig10 UTSW 5 117,490,825 (GRCm39) missense probably benign 0.00
R1710:Vsig10 UTSW 5 117,489,719 (GRCm39) missense probably benign
R1765:Vsig10 UTSW 5 117,456,880 (GRCm39) unclassified probably benign
R4422:Vsig10 UTSW 5 117,462,986 (GRCm39) missense probably benign 0.00
R4541:Vsig10 UTSW 5 117,490,881 (GRCm39) utr 3 prime probably benign
R4909:Vsig10 UTSW 5 117,476,308 (GRCm39) missense probably benign 0.31
R4999:Vsig10 UTSW 5 117,482,040 (GRCm39) missense probably damaging 1.00
R5855:Vsig10 UTSW 5 117,476,335 (GRCm39) missense probably damaging 1.00
R5866:Vsig10 UTSW 5 117,490,814 (GRCm39) critical splice acceptor site probably null
R6214:Vsig10 UTSW 5 117,481,989 (GRCm39) missense probably damaging 1.00
R6418:Vsig10 UTSW 5 117,486,361 (GRCm39) missense probably benign 0.03
R6505:Vsig10 UTSW 5 117,489,824 (GRCm39) missense possibly damaging 0.95
R6854:Vsig10 UTSW 5 117,476,472 (GRCm39) missense probably benign 0.36
R7121:Vsig10 UTSW 5 117,481,967 (GRCm39) missense probably damaging 1.00
R7596:Vsig10 UTSW 5 117,472,848 (GRCm39) missense possibly damaging 0.46
R8066:Vsig10 UTSW 5 117,489,849 (GRCm39) missense probably benign 0.00
R8335:Vsig10 UTSW 5 117,486,435 (GRCm39) missense probably damaging 1.00
R8787:Vsig10 UTSW 5 117,472,981 (GRCm39) missense probably benign 0.18
R9026:Vsig10 UTSW 5 117,476,323 (GRCm39) missense probably benign 0.00
R9257:Vsig10 UTSW 5 117,463,131 (GRCm39) missense probably benign 0.29
R9386:Vsig10 UTSW 5 117,463,140 (GRCm39) missense probably damaging 1.00
R9474:Vsig10 UTSW 5 117,463,104 (GRCm39) missense probably benign 0.00
Posted On 2013-06-21