Mutagenetix > Incidental Mutations

Incidental Mutation 'R6324:Vmn2r108'

510671

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r108

Ensembl Gene

ENSMUSG00000091805

Gene Name

vomeronasal 2, receptor 108

Synonyms

EG627805

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.058) question?

Stock #

R6324 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

20462373-20481236 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 20471715 bp

Zygosity

Heterozygous

Amino Acid Change

Leucine to Stop codon at position 182 (L182*)

Ref Sequence

ENSEMBL: ENSMUSP00000130373 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167314]

Predicted Effect

probably null
Transcript: ENSMUST00000167314
AA Change: L182*

SMART Domains

Protein: ENSMUSP00000130373
Gene: ENSMUSG00000091805
AA Change: L182*

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	467	6e-33	PFAM
Pfam:NCD3G	510	563	9.2e-22	PFAM
Pfam:7tm_3	593	831	2.2e-51	PFAM

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.7%

Validation Efficiency

96% (47/49)

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700025F22Rik	T	A	19: 11,163,447	M3L	probably benign	Het
Arhgef4	G	A	1: 34,723,477	A605T	unknown	Het
Atp13a3	A	G	16: 30,332,285	V1069A	possibly damaging	Het
Atp1a2	C	G	1: 172,289,336	R238P	probably damaging	Het
Baz2b	A	G	2: 59,906,948	S1877P	probably damaging	Het
Ccdc114	A	G	7: 45,941,710	E203G	probably damaging	Het
Ccdc27	A	T	4: 154,036,191	S383T	probably benign	Het
Cr1l	A	G	1: 195,111,122	V377A	probably benign	Het
Dazap1	A	G	10: 80,277,660	E130G	probably benign	Het
Dchs1	G	T	7: 105,764,938	A890E	probably benign	Het
Dock10	G	A	1: 80,505,176	T2143I	probably benign	Het
Eif3j1	A	G	2: 122,041,178	D60G	probably benign	Het
Enah	A	G	1: 181,918,571	S382P	probably damaging	Het
Fam171b	A	T	2: 83,879,264	K427*	probably null	Het
Fmn2	A	T	1: 174,612,553	I1179L	possibly damaging	Het
Focad	C	T	4: 88,401,068	R1505*	probably null	Het
Frem1	T	C	4: 82,983,337	T985A	probably benign	Het
Gm3404	A	T	5: 146,528,107	Q219L	possibly damaging	Het
Gm5592	A	C	7: 41,286,535	S154R	probably damaging	Het
Gpn3	C	T	5: 122,372,575		probably benign	Het
Gpr158	A	G	2: 21,810,554	E586G	probably damaging	Het
Gstp2	A	T	19: 4,040,499	I162N	probably benign	Het
Lin7a	T	A	10: 107,380,215		probably null	Het
Loxl4	G	A	19: 42,595,378	L745F	probably benign	Het
Mybpc1	A	G	10: 88,568,619	I172T	possibly damaging	Het
Nalcn	A	G	14: 123,409,749	W571R	possibly damaging	Het
Nkx2-5	G	C	17: 26,841,121	P79A	probably benign	Het
Nufip2	A	G	11: 77,691,661	T134A	probably benign	Het
Olfr1042	C	T	2: 86,159,456	V305I	probably benign	Het
Olfr1342	G	A	4: 118,690,531		probably benign	Het
Olfr1463	A	G	19: 13,235,104	M285V	possibly damaging	Het
Phkb	A	G	8: 86,018,542	D616G	probably benign	Het
Plch1	C	T	3: 63,781,390	W131*	probably null	Het
Prl7b1	A	T	13: 27,602,895		probably null	Het
Prop1	G	A	11: 50,952,199	P54S	probably benign	Het
Ptcd3	C	T	6: 71,885,327	V509I	probably benign	Het
Ptprg	T	A	14: 12,226,314	D527E	probably damaging	Het
Rapgef2	C	T	3: 79,079,132	V1182I	probably benign	Het
Rfx7	C	A	9: 72,618,414	P962Q	probably damaging	Het
Rsf1	CG	CGACGGCGGTG	7: 97,579,908		probably benign	Homo
Slc38a9	A	G	13: 112,726,100	I444M	probably benign	Het
Sorbs1	T	C	19: 40,321,819	T492A	probably damaging	Het
Synj1	A	T	16: 90,938,630	S1478R	probably benign	Het
Tnn	T	A	1: 160,145,204	N276I	probably damaging	Het
Trbv19	G	A	6: 41,178,758	G21D	probably damaging	Het
Ube2o	A	T	11: 116,539,359	D1184E	probably benign	Het
Vmn1r181	G	A	7: 23,984,758	R216Q	probably benign	Het
Vmn2r15	A	G	5: 109,286,271	*856R	probably null	Het
Vmn2r70	G	A	7: 85,558,879	H797Y	probably benign	Het
Zfp11	C	T	5: 129,656,523	A625T	possibly damaging	Het

Other mutations in Vmn2r108

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00903:Vmn2r108	APN	17	20462512	missense	probably damaging	0.98
IGL01143:Vmn2r108	APN	17	20462465	missense	possibly damaging	0.82
IGL01311:Vmn2r108	APN	17	20462677	nonsense	probably null
IGL01411:Vmn2r108	APN	17	20471020	missense	probably benign	0.01
IGL01414:Vmn2r108	APN	17	20471680	missense	probably benign	0.00
IGL01536:Vmn2r108	APN	17	20463281	missense	probably damaging	1.00
IGL01748:Vmn2r108	APN	17	20463214	missense	probably benign	0.03
IGL01769:Vmn2r108	APN	17	20471018	missense	probably benign	0.02
IGL02022:Vmn2r108	APN	17	20471725	missense	possibly damaging	0.77
IGL02041:Vmn2r108	APN	17	20463136	missense	probably damaging	1.00
IGL02049:Vmn2r108	APN	17	20471346	missense	probably benign	0.00
IGL02344:Vmn2r108	APN	17	20469143	missense	probably damaging	1.00
IGL02939:Vmn2r108	APN	17	20471283	missense	probably benign	0.05
IGL03202:Vmn2r108	APN	17	20471057	nonsense	probably null
PIT4498001:Vmn2r108	UTSW	17	20463017	missense	probably damaging	1.00
R0112:Vmn2r108	UTSW	17	20471635	missense	probably benign	0.07
R0505:Vmn2r108	UTSW	17	20462834	missense	possibly damaging	0.77
R0833:Vmn2r108	UTSW	17	20471459	missense	probably benign
R0836:Vmn2r108	UTSW	17	20471459	missense	probably benign
R0943:Vmn2r108	UTSW	17	20471135	nonsense	probably null
R1411:Vmn2r108	UTSW	17	20462845	missense	probably damaging	0.98
R1442:Vmn2r108	UTSW	17	20472361	nonsense	probably null
R1587:Vmn2r108	UTSW	17	20472121	missense	probably damaging	1.00
R1751:Vmn2r108	UTSW	17	20462524	missense	probably damaging	1.00
R1773:Vmn2r108	UTSW	17	20469073	missense	probably damaging	1.00
R2021:Vmn2r108	UTSW	17	20470990	missense	probably benign	0.00
R2159:Vmn2r108	UTSW	17	20469101	missense	probably benign	0.41
R2224:Vmn2r108	UTSW	17	20481033	nonsense	probably null
R2226:Vmn2r108	UTSW	17	20481033	nonsense	probably null
R2517:Vmn2r108	UTSW	17	20472315	missense	probably damaging	1.00
R3710:Vmn2r108	UTSW	17	20462670	missense	probably benign
R4470:Vmn2r108	UTSW	17	20462728	missense	probably damaging	1.00
R4686:Vmn2r108	UTSW	17	20471374	missense	probably damaging	0.99
R4729:Vmn2r108	UTSW	17	20472370	missense	probably damaging	0.99
R4799:Vmn2r108	UTSW	17	20462629	missense	probably damaging	1.00
R4993:Vmn2r108	UTSW	17	20481187	missense	probably benign	0.04
R5088:Vmn2r108	UTSW	17	20470192	missense	possibly damaging	0.46
R5213:Vmn2r108	UTSW	17	20471493	missense	probably benign	0.00
R5289:Vmn2r108	UTSW	17	20471604	missense	probably damaging	1.00
R5290:Vmn2r108	UTSW	17	20471403	missense	probably benign	0.00
R5713:Vmn2r108	UTSW	17	20471028	missense	probably damaging	1.00
R5753:Vmn2r108	UTSW	17	20462917	missense	probably damaging	0.99
R5792:Vmn2r108	UTSW	17	20463136	missense	probably damaging	0.99
R5798:Vmn2r108	UTSW	17	20472283	missense	probably benign	0.39
R5897:Vmn2r108	UTSW	17	20471318	missense	probably benign	0.01
R6018:Vmn2r108	UTSW	17	20463006	missense	possibly damaging	0.83
R6093:Vmn2r108	UTSW	17	20481140	missense	probably benign	0.00
R6156:Vmn2r108	UTSW	17	20472185	missense	probably benign	0.03
R6199:Vmn2r108	UTSW	17	20462382	missense	probably benign	0.01
R6259:Vmn2r108	UTSW	17	20463109	missense	possibly damaging	0.95
R6309:Vmn2r108	UTSW	17	20471398	missense	probably damaging	0.98
R6364:Vmn2r108	UTSW	17	20470998	missense	probably benign	0.00
R6446:Vmn2r108	UTSW	17	20472347	nonsense	probably null
R6541:Vmn2r108	UTSW	17	20481218	missense	probably benign	0.02
R7025:Vmn2r108	UTSW	17	20471083	missense	possibly damaging	0.67
R7063:Vmn2r108	UTSW	17	20481148	missense	probably damaging	1.00
R7092:Vmn2r108	UTSW	17	20481076	missense	probably benign	0.10
R7096:Vmn2r108	UTSW	17	20462500	missense	probably damaging	1.00
R7203:Vmn2r108	UTSW	17	20462776	missense	probably benign	0.12
R7458:Vmn2r108	UTSW	17	20472270	missense	probably benign	0.17
R7619:Vmn2r108	UTSW	17	20472195	missense	probably benign	0.02
R7841:Vmn2r108	UTSW	17	20470043	critical splice donor site	probably null
R7944:Vmn2r108	UTSW	17	20471628	missense	probably damaging	0.99
R8048:Vmn2r108	UTSW	17	20471500	missense	probably benign	0.29
R8213:Vmn2r108	UTSW	17	20470088	missense	probably benign	0.03
R8218:Vmn2r108	UTSW	17	20463203	missense	probably damaging	1.00
R8507:Vmn2r108	UTSW	17	20462933	nonsense	probably null
X0022:Vmn2r108	UTSW	17	20471109	missense	probably damaging	1.00
Z1088:Vmn2r108	UTSW	17	20471113	missense	probably benign	0.01
Z1177:Vmn2r108	UTSW	17	20470957	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- TCCATGTCATAGGGATCATTTTCAC -3'
(R):5'- CCTTGAAACAGACAGGCTTGG -3'

Sequencing Primer
(F):5'- CAAAAGCTATGCAGACTCCTTTTC -3'
(R):5'- AGACAGGCTTGGCACGAATTTTTG -3'

Posted On

2018-04-02