Incidental Mutation 'R6334:2810021J22Rik'
ID 510715
Institutional Source Beutler Lab
Gene Symbol 2810021J22Rik
Ensembl Gene ENSMUSG00000020491
Gene Name RIKEN cDNA 2810021J22 gene
Synonyms
MMRRC Submission 044488-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R6334 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 58758042-58774114 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 58770940 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 141 (S141T)
Ref Sequence ENSEMBL: ENSMUSP00000073579 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073924] [ENSMUST00000132570]
AlphaFold Q8BIB6
Predicted Effect probably benign
Transcript: ENSMUST00000073924
AA Change: S141T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000073579
Gene: ENSMUSG00000020491
AA Change: S141T

DomainStartEndE-ValueType
KRAB 8 68 2.38e-30 SMART
ZnF_C2H2 242 264 1.68e1 SMART
ZnF_C2H2 370 392 1.56e-2 SMART
ZnF_C2H2 398 420 1.03e-2 SMART
ZnF_C2H2 426 448 1.38e-3 SMART
ZnF_C2H2 454 476 3.16e-3 SMART
ZnF_C2H2 482 504 1.6e-4 SMART
ZnF_C2H2 510 532 7.78e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000132570
SMART Domains Protein: ENSMUSP00000120692
Gene: ENSMUSG00000020491

DomainStartEndE-ValueType
KRAB 8 64 2.25e-17 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.5%
Validation Efficiency 100% (64/64)
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afap1l2 A G 19: 56,906,408 (GRCm39) probably null Het
Aox1 C T 1: 58,346,566 (GRCm39) Q567* probably null Het
Aqp4 T A 18: 15,526,648 (GRCm39) M278L probably benign Het
Atp23 A C 10: 126,723,538 (GRCm39) L188R probably benign Het
Catsperg1 C T 7: 28,905,782 (GRCm39) G215D probably benign Het
Cavin4 T C 4: 48,663,824 (GRCm39) V68A possibly damaging Het
Ccl4 T C 11: 83,553,504 (GRCm39) S6P unknown Het
Cfap46 T C 7: 139,260,747 (GRCm39) E117G probably damaging Het
Cfhr4 A G 1: 139,701,662 (GRCm39) probably null Het
Chek1 A G 9: 36,625,788 (GRCm39) S286P possibly damaging Het
Cntn4 G A 6: 106,321,747 (GRCm39) V35I probably benign Het
Cntn4 C A 6: 106,483,153 (GRCm39) P236Q probably benign Het
Cyp2d40 C A 15: 82,645,753 (GRCm39) G84V probably benign Het
Dnah12 A T 14: 26,427,989 (GRCm39) H205L possibly damaging Het
Dock1 G A 7: 134,453,305 (GRCm39) V845I probably benign Het
Drg1 T C 11: 3,216,292 (GRCm39) K7E possibly damaging Het
Eloa G A 4: 135,737,133 (GRCm39) P488S probably damaging Het
Evi5 G A 5: 107,968,387 (GRCm39) R187* probably null Het
Fam53a T A 5: 33,758,219 (GRCm39) L301F probably damaging Het
Fmnl3 T C 15: 99,235,534 (GRCm39) K63E probably damaging Het
Gast C A 11: 100,227,438 (GRCm39) Q44K probably benign Het
Gng10 T A 4: 59,035,257 (GRCm39) V7E probably benign Het
Gtf3c5 G A 2: 28,460,474 (GRCm39) T375I probably benign Het
Haus5 C T 7: 30,358,401 (GRCm39) W298* probably null Het
Hspa14 A T 2: 3,490,109 (GRCm39) probably null Het
Kcna3 T C 3: 106,943,740 (GRCm39) M1T probably null Het
Kcnj15 T G 16: 95,097,095 (GRCm39) L239R probably damaging Het
Klhl2 G T 8: 65,212,842 (GRCm39) D232E probably benign Het
Lamb3 A T 1: 193,017,782 (GRCm39) I888F probably damaging Het
Lars1 C A 18: 42,350,551 (GRCm39) M919I probably benign Het
Lfng T C 5: 140,598,522 (GRCm39) V247A possibly damaging Het
Lrp1b C T 2: 41,679,045 (GRCm39) A16T probably benign Het
Mamdc2 A T 19: 23,341,270 (GRCm39) I235N probably damaging Het
Map9 T A 3: 82,290,612 (GRCm39) L492Q probably damaging Het
Mcpt8 A G 14: 56,322,604 (GRCm39) V14A possibly damaging Het
Myo1b T C 1: 51,807,810 (GRCm39) K823R probably null Het
Nbea G T 3: 55,944,570 (GRCm39) T598K probably damaging Het
Nrcam C A 12: 44,619,083 (GRCm39) H877N probably benign Het
Nrxn2 T C 19: 6,581,322 (GRCm39) probably null Het
Nwd2 A T 5: 63,957,596 (GRCm39) I309F possibly damaging Het
Phyhd1 G A 2: 30,164,736 (GRCm39) probably null Het
Pkp2 C T 16: 16,043,933 (GRCm39) T229I probably damaging Het
Plagl2 G A 2: 153,074,611 (GRCm39) P97S probably benign Het
Plekhh2 C A 17: 84,874,294 (GRCm39) N526K probably benign Het
Plin4 A G 17: 56,410,261 (GRCm39) L1217P probably benign Het
Polr3e T C 7: 120,527,222 (GRCm39) S67P possibly damaging Het
Postn A G 3: 54,292,703 (GRCm39) K757E probably benign Het
Prpf39 T A 12: 65,089,587 (GRCm39) probably null Het
Ptprg C T 14: 12,166,832 (GRCm38) T745I probably damaging Het
Pxylp1 C G 9: 96,707,307 (GRCm39) A292P probably damaging Het
Rpl35 G T 2: 38,891,754 (GRCm39) D82E possibly damaging Het
Slc9a1 G A 4: 133,149,519 (GRCm39) V782I possibly damaging Het
Syn2 T A 6: 115,240,875 (GRCm39) M415K possibly damaging Het
Tmem117 A C 15: 94,909,324 (GRCm39) I246L probably benign Het
Tmem221 A T 8: 72,011,428 (GRCm39) V9E probably damaging Het
Trav13-5 A G 14: 54,033,399 (GRCm39) T103A probably damaging Het
Ubxn7 T A 16: 32,191,007 (GRCm39) probably null Het
Vmn2r101 G T 17: 19,810,112 (GRCm39) M299I possibly damaging Het
Vmn2r103 T A 17: 20,014,344 (GRCm39) S379T probably damaging Het
Vmn2r109 T C 17: 20,761,440 (GRCm39) N639S probably benign Het
Wdr26 T C 1: 181,030,771 (GRCm39) Het
Zfp109 T A 7: 23,928,308 (GRCm39) Y367F probably damaging Het
Zfp143 G A 7: 109,685,338 (GRCm39) C389Y probably damaging Het
Zfp553 G T 7: 126,836,064 (GRCm39) probably null Het
Other mutations in 2810021J22Rik
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00983:2810021J22Rik APN 11 58,771,438 (GRCm39) nonsense probably null
IGL01784:2810021J22Rik APN 11 58,771,445 (GRCm39) missense possibly damaging 0.89
IGL02287:2810021J22Rik APN 11 58,771,418 (GRCm39) missense probably benign 0.00
IGL03281:2810021J22Rik APN 11 58,771,601 (GRCm39) missense probably benign 0.01
H8562:2810021J22Rik UTSW 11 58,771,717 (GRCm39) missense probably damaging 1.00
R0480:2810021J22Rik UTSW 11 58,771,012 (GRCm39) missense probably damaging 0.99
R1148:2810021J22Rik UTSW 11 58,767,544 (GRCm39) missense probably damaging 0.97
R1148:2810021J22Rik UTSW 11 58,767,544 (GRCm39) missense probably damaging 0.97
R1493:2810021J22Rik UTSW 11 58,767,544 (GRCm39) missense probably damaging 0.97
R1565:2810021J22Rik UTSW 11 58,771,327 (GRCm39) missense probably benign 0.00
R1676:2810021J22Rik UTSW 11 58,771,819 (GRCm39) missense possibly damaging 0.70
R2070:2810021J22Rik UTSW 11 58,767,595 (GRCm39) missense probably damaging 0.98
R2071:2810021J22Rik UTSW 11 58,767,595 (GRCm39) missense probably damaging 0.98
R4402:2810021J22Rik UTSW 11 58,771,020 (GRCm39) missense probably benign 0.01
R4541:2810021J22Rik UTSW 11 58,769,676 (GRCm39) missense probably benign 0.16
R4685:2810021J22Rik UTSW 11 58,771,750 (GRCm39) missense probably damaging 0.97
R4765:2810021J22Rik UTSW 11 58,771,987 (GRCm39) missense probably benign 0.09
R4968:2810021J22Rik UTSW 11 58,769,616 (GRCm39) nonsense probably null
R5282:2810021J22Rik UTSW 11 58,771,166 (GRCm39) missense possibly damaging 0.84
R5519:2810021J22Rik UTSW 11 58,770,923 (GRCm39) missense probably benign
R6083:2810021J22Rik UTSW 11 58,769,677 (GRCm39) missense possibly damaging 0.73
R6134:2810021J22Rik UTSW 11 58,767,619 (GRCm39) missense probably damaging 1.00
R7108:2810021J22Rik UTSW 11 58,771,750 (GRCm39) missense probably damaging 0.97
R7288:2810021J22Rik UTSW 11 58,771,131 (GRCm39) missense probably benign 0.03
R7310:2810021J22Rik UTSW 11 58,771,094 (GRCm39) missense possibly damaging 0.89
R7422:2810021J22Rik UTSW 11 58,771,885 (GRCm39) missense probably damaging 1.00
R7829:2810021J22Rik UTSW 11 58,770,823 (GRCm39) missense not run
R8237:2810021J22Rik UTSW 11 58,771,373 (GRCm39) missense probably damaging 1.00
R8303:2810021J22Rik UTSW 11 58,770,966 (GRCm39) missense probably benign 0.00
R9453:2810021J22Rik UTSW 11 58,771,054 (GRCm39) missense probably benign 0.01
Z1177:2810021J22Rik UTSW 11 58,770,929 (GRCm39) missense probably damaging 0.99
Z1186:2810021J22Rik UTSW 11 58,771,361 (GRCm39) missense probably benign 0.00
Z1187:2810021J22Rik UTSW 11 58,771,361 (GRCm39) missense probably benign 0.00
Z1188:2810021J22Rik UTSW 11 58,771,361 (GRCm39) missense probably benign 0.00
Z1189:2810021J22Rik UTSW 11 58,771,361 (GRCm39) missense probably benign 0.00
Z1190:2810021J22Rik UTSW 11 58,771,361 (GRCm39) missense probably benign 0.00
Z1191:2810021J22Rik UTSW 11 58,771,361 (GRCm39) missense probably benign 0.00
Z1192:2810021J22Rik UTSW 11 58,771,361 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGCAGCCTATGAAGAGTCTG -3'
(R):5'- CACTGTACGCGTCCATACAG -3'

Sequencing Primer
(F):5'- CCTATGAAGAGTCTGAAGGAAGCC -3'
(R):5'- GTCCATACAGTGCGCACATCG -3'
Posted On 2018-04-02