Incidental Mutation 'R6334:Vmn2r101'
ID 510728
Institutional Source Beutler Lab
Gene Symbol Vmn2r101
Ensembl Gene ENSMUSG00000094892
Gene Name vomeronasal 2, receptor 101
Synonyms EG627576
MMRRC Submission 044488-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.124) question?
Stock # R6334 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 19797493-19832579 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 19810112 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 299 (M299I)
Ref Sequence ENSEMBL: ENSMUSP00000131583 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171914]
AlphaFold E9PZS9
Predicted Effect possibly damaging
Transcript: ENSMUST00000171914
AA Change: M299I

PolyPhen 2 Score 0.830 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000131583
Gene: ENSMUSG00000094892
AA Change: M299I

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:ANF_receptor 82 466 1.6e-36 PFAM
Pfam:NCD3G 509 562 6.4e-22 PFAM
Pfam:7tm_3 595 830 1.4e-51 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.5%
Validation Efficiency 100% (64/64)
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810021J22Rik T A 11: 58,770,940 (GRCm39) S141T probably benign Het
Afap1l2 A G 19: 56,906,408 (GRCm39) probably null Het
Aox1 C T 1: 58,346,566 (GRCm39) Q567* probably null Het
Aqp4 T A 18: 15,526,648 (GRCm39) M278L probably benign Het
Atp23 A C 10: 126,723,538 (GRCm39) L188R probably benign Het
Catsperg1 C T 7: 28,905,782 (GRCm39) G215D probably benign Het
Cavin4 T C 4: 48,663,824 (GRCm39) V68A possibly damaging Het
Ccl4 T C 11: 83,553,504 (GRCm39) S6P unknown Het
Cfap46 T C 7: 139,260,747 (GRCm39) E117G probably damaging Het
Cfhr4 A G 1: 139,701,662 (GRCm39) probably null Het
Chek1 A G 9: 36,625,788 (GRCm39) S286P possibly damaging Het
Cntn4 G A 6: 106,321,747 (GRCm39) V35I probably benign Het
Cntn4 C A 6: 106,483,153 (GRCm39) P236Q probably benign Het
Cyp2d40 C A 15: 82,645,753 (GRCm39) G84V probably benign Het
Dnah12 A T 14: 26,427,989 (GRCm39) H205L possibly damaging Het
Dock1 G A 7: 134,453,305 (GRCm39) V845I probably benign Het
Drg1 T C 11: 3,216,292 (GRCm39) K7E possibly damaging Het
Eloa G A 4: 135,737,133 (GRCm39) P488S probably damaging Het
Evi5 G A 5: 107,968,387 (GRCm39) R187* probably null Het
Fam53a T A 5: 33,758,219 (GRCm39) L301F probably damaging Het
Fmnl3 T C 15: 99,235,534 (GRCm39) K63E probably damaging Het
Gast C A 11: 100,227,438 (GRCm39) Q44K probably benign Het
Gng10 T A 4: 59,035,257 (GRCm39) V7E probably benign Het
Gtf3c5 G A 2: 28,460,474 (GRCm39) T375I probably benign Het
Haus5 C T 7: 30,358,401 (GRCm39) W298* probably null Het
Hspa14 A T 2: 3,490,109 (GRCm39) probably null Het
Kcna3 T C 3: 106,943,740 (GRCm39) M1T probably null Het
Kcnj15 T G 16: 95,097,095 (GRCm39) L239R probably damaging Het
Klhl2 G T 8: 65,212,842 (GRCm39) D232E probably benign Het
Lamb3 A T 1: 193,017,782 (GRCm39) I888F probably damaging Het
Lars1 C A 18: 42,350,551 (GRCm39) M919I probably benign Het
Lfng T C 5: 140,598,522 (GRCm39) V247A possibly damaging Het
Lrp1b C T 2: 41,679,045 (GRCm39) A16T probably benign Het
Mamdc2 A T 19: 23,341,270 (GRCm39) I235N probably damaging Het
Map9 T A 3: 82,290,612 (GRCm39) L492Q probably damaging Het
Mcpt8 A G 14: 56,322,604 (GRCm39) V14A possibly damaging Het
Myo1b T C 1: 51,807,810 (GRCm39) K823R probably null Het
Nbea G T 3: 55,944,570 (GRCm39) T598K probably damaging Het
Nrcam C A 12: 44,619,083 (GRCm39) H877N probably benign Het
Nrxn2 T C 19: 6,581,322 (GRCm39) probably null Het
Nwd2 A T 5: 63,957,596 (GRCm39) I309F possibly damaging Het
Phyhd1 G A 2: 30,164,736 (GRCm39) probably null Het
Pkp2 C T 16: 16,043,933 (GRCm39) T229I probably damaging Het
Plagl2 G A 2: 153,074,611 (GRCm39) P97S probably benign Het
Plekhh2 C A 17: 84,874,294 (GRCm39) N526K probably benign Het
Plin4 A G 17: 56,410,261 (GRCm39) L1217P probably benign Het
Polr3e T C 7: 120,527,222 (GRCm39) S67P possibly damaging Het
Postn A G 3: 54,292,703 (GRCm39) K757E probably benign Het
Prpf39 T A 12: 65,089,587 (GRCm39) probably null Het
Ptprg C T 14: 12,166,832 (GRCm38) T745I probably damaging Het
Pxylp1 C G 9: 96,707,307 (GRCm39) A292P probably damaging Het
Rpl35 G T 2: 38,891,754 (GRCm39) D82E possibly damaging Het
Slc9a1 G A 4: 133,149,519 (GRCm39) V782I possibly damaging Het
Syn2 T A 6: 115,240,875 (GRCm39) M415K possibly damaging Het
Tmem117 A C 15: 94,909,324 (GRCm39) I246L probably benign Het
Tmem221 A T 8: 72,011,428 (GRCm39) V9E probably damaging Het
Trav13-5 A G 14: 54,033,399 (GRCm39) T103A probably damaging Het
Ubxn7 T A 16: 32,191,007 (GRCm39) probably null Het
Vmn2r103 T A 17: 20,014,344 (GRCm39) S379T probably damaging Het
Vmn2r109 T C 17: 20,761,440 (GRCm39) N639S probably benign Het
Wdr26 T C 1: 181,030,771 (GRCm39) Het
Zfp109 T A 7: 23,928,308 (GRCm39) Y367F probably damaging Het
Zfp143 G A 7: 109,685,338 (GRCm39) C389Y probably damaging Het
Zfp553 G T 7: 126,836,064 (GRCm39) probably null Het
Other mutations in Vmn2r101
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01121:Vmn2r101 APN 17 19,809,936 (GRCm39) missense probably damaging 0.99
IGL02125:Vmn2r101 APN 17 19,809,963 (GRCm39) missense possibly damaging 0.95
IGL02300:Vmn2r101 APN 17 19,832,199 (GRCm39) missense probably damaging 1.00
IGL02682:Vmn2r101 APN 17 19,832,507 (GRCm39) missense possibly damaging 0.82
IGL02825:Vmn2r101 APN 17 19,810,132 (GRCm39) missense probably benign 0.00
IGL02862:Vmn2r101 APN 17 19,831,867 (GRCm39) missense probably damaging 1.00
IGL02943:Vmn2r101 APN 17 19,831,666 (GRCm39) missense probably damaging 0.99
R0371:Vmn2r101 UTSW 17 19,810,394 (GRCm39) missense probably benign 0.07
R0462:Vmn2r101 UTSW 17 19,810,431 (GRCm39) missense probably benign 0.04
R0492:Vmn2r101 UTSW 17 19,809,245 (GRCm39) missense probably damaging 1.00
R0654:Vmn2r101 UTSW 17 19,810,373 (GRCm39) missense probably benign 0.01
R1120:Vmn2r101 UTSW 17 19,797,723 (GRCm39) splice site probably benign
R1323:Vmn2r101 UTSW 17 19,832,313 (GRCm39) missense probably damaging 1.00
R1323:Vmn2r101 UTSW 17 19,832,313 (GRCm39) missense probably damaging 1.00
R1676:Vmn2r101 UTSW 17 19,832,184 (GRCm39) missense probably benign 0.00
R2023:Vmn2r101 UTSW 17 19,810,368 (GRCm39) nonsense probably null
R2149:Vmn2r101 UTSW 17 19,809,225 (GRCm39) missense probably benign 0.00
R2350:Vmn2r101 UTSW 17 19,810,045 (GRCm39) missense probably benign 0.01
R2760:Vmn2r101 UTSW 17 19,809,901 (GRCm39) missense probably benign 0.14
R3085:Vmn2r101 UTSW 17 19,809,077 (GRCm39) splice site probably null
R3086:Vmn2r101 UTSW 17 19,809,077 (GRCm39) splice site probably null
R3719:Vmn2r101 UTSW 17 19,809,811 (GRCm39) missense possibly damaging 0.50
R3771:Vmn2r101 UTSW 17 19,809,919 (GRCm39) missense probably benign
R3773:Vmn2r101 UTSW 17 19,809,919 (GRCm39) missense probably benign
R4225:Vmn2r101 UTSW 17 19,831,951 (GRCm39) missense probably damaging 1.00
R4248:Vmn2r101 UTSW 17 19,809,376 (GRCm39) missense probably damaging 1.00
R4290:Vmn2r101 UTSW 17 19,832,303 (GRCm39) missense probably damaging 1.00
R4291:Vmn2r101 UTSW 17 19,832,303 (GRCm39) missense probably damaging 1.00
R4293:Vmn2r101 UTSW 17 19,832,303 (GRCm39) missense probably damaging 1.00
R4307:Vmn2r101 UTSW 17 19,810,423 (GRCm39) missense probably damaging 1.00
R4721:Vmn2r101 UTSW 17 19,832,287 (GRCm39) missense probably damaging 0.99
R4829:Vmn2r101 UTSW 17 19,832,229 (GRCm39) missense probably benign 0.03
R5022:Vmn2r101 UTSW 17 19,831,649 (GRCm39) critical splice acceptor site probably null
R5110:Vmn2r101 UTSW 17 19,831,897 (GRCm39) missense possibly damaging 0.92
R5244:Vmn2r101 UTSW 17 19,831,788 (GRCm39) missense probably damaging 1.00
R5397:Vmn2r101 UTSW 17 19,809,104 (GRCm39) missense probably damaging 1.00
R5875:Vmn2r101 UTSW 17 19,809,092 (GRCm39) missense probably damaging 0.99
R5944:Vmn2r101 UTSW 17 19,809,769 (GRCm39) missense probably benign 0.00
R6216:Vmn2r101 UTSW 17 19,811,267 (GRCm39) missense probably benign 0.00
R6512:Vmn2r101 UTSW 17 19,809,146 (GRCm39) missense probably damaging 1.00
R6607:Vmn2r101 UTSW 17 19,832,296 (GRCm39) missense probably damaging 1.00
R6965:Vmn2r101 UTSW 17 19,811,284 (GRCm39) missense probably benign 0.00
R7101:Vmn2r101 UTSW 17 19,809,350 (GRCm39) missense probably null 0.14
R7183:Vmn2r101 UTSW 17 19,832,440 (GRCm39) missense probably damaging 1.00
R7344:Vmn2r101 UTSW 17 19,832,059 (GRCm39) missense probably benign 0.38
R7375:Vmn2r101 UTSW 17 19,831,652 (GRCm39) missense probably damaging 1.00
R7574:Vmn2r101 UTSW 17 19,831,899 (GRCm39) missense possibly damaging 0.91
R7575:Vmn2r101 UTSW 17 19,831,654 (GRCm39) missense probably benign 0.01
R7592:Vmn2r101 UTSW 17 19,811,443 (GRCm39) splice site probably null
R7626:Vmn2r101 UTSW 17 19,832,192 (GRCm39) nonsense probably null
R7715:Vmn2r101 UTSW 17 19,832,177 (GRCm39) missense probably damaging 1.00
R7730:Vmn2r101 UTSW 17 19,831,950 (GRCm39) missense possibly damaging 0.81
R8078:Vmn2r101 UTSW 17 19,810,507 (GRCm39) missense probably benign 0.07
R8228:Vmn2r101 UTSW 17 19,811,284 (GRCm39) missense probably benign 0.00
R8283:Vmn2r101 UTSW 17 19,832,253 (GRCm39) missense probably damaging 1.00
R8712:Vmn2r101 UTSW 17 19,811,397 (GRCm39) missense probably benign 0.24
R8765:Vmn2r101 UTSW 17 19,809,245 (GRCm39) missense probably damaging 1.00
R9091:Vmn2r101 UTSW 17 19,810,244 (GRCm39) missense probably benign
R9092:Vmn2r101 UTSW 17 19,809,807 (GRCm39) missense probably benign 0.07
R9113:Vmn2r101 UTSW 17 19,811,288 (GRCm39) missense possibly damaging 0.56
R9158:Vmn2r101 UTSW 17 19,809,161 (GRCm39) missense probably benign 0.00
R9168:Vmn2r101 UTSW 17 19,809,138 (GRCm39) missense probably damaging 1.00
R9235:Vmn2r101 UTSW 17 19,810,238 (GRCm39) missense probably damaging 0.99
R9270:Vmn2r101 UTSW 17 19,810,244 (GRCm39) missense probably benign
R9290:Vmn2r101 UTSW 17 19,811,395 (GRCm39) missense probably benign 0.05
R9296:Vmn2r101 UTSW 17 19,810,047 (GRCm39) missense probably damaging 0.98
R9602:Vmn2r101 UTSW 17 19,831,780 (GRCm39) nonsense probably null
R9706:Vmn2r101 UTSW 17 19,809,925 (GRCm39) missense probably damaging 1.00
Z1088:Vmn2r101 UTSW 17 19,809,237 (GRCm39) missense possibly damaging 0.78
Predicted Primers PCR Primer
(F):5'- TCAGATTTTAGGGACGAGATGG -3'
(R):5'- AATGTCAGCAAATGAGCACTTG -3'

Sequencing Primer
(F):5'- TGGAGAGAAAAGGCATCTGC -3'
(R):5'- GAGCACTTGAAAAATAAATACCACAG -3'
Posted On 2018-04-02