Mutagenetix > Incidental Mutation

Incidental Mutation 'FR4304:Dnah12'

511042

Institutional Source

Beutler Lab

Gene Symbol

Dnah12

Ensembl Gene

ENSMUSG00000021879

Gene Name

dynein, axonemal, heavy chain 12

Synonyms

HL19, DHC3, Dnahc7l, 4921531P07Rik, HL-19, LOC380889, Hdhc3, Dnahc12, DLP12

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.196) question?

Stock #

FR4304 ()

Quality Score

221.999

Status

Not validated

Chromosome

Chromosomal Location

26414429-26613660 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 26571342 bp (GRCm39)

Zygosity

Homozygous

Amino Acid Change

Glycine to Valine at position 2817 (G2817V)

Ref Sequence

ENSEMBL: ENSMUSP00000022433 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000022433]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000022433
AA Change: G2817V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000022433
Gene: ENSMUSG00000021879
AA Change: G2817V

Domain	Start	End	E-Value	Type
low complexity region	127	140	N/A	INTRINSIC
coiled coil region	588	666	N/A	INTRINSIC
Pfam:DHC_N2	676	1113	1.1e-147	PFAM
AAA	1268	1407	1.15e0	SMART
Pfam:AAA_5	1552	1695	1.5e-7	PFAM
Blast:AAA	1709	1827	2e-24	BLAST
Blast:AAA	1848	1898	1e-16	BLAST
AAA	1903	2051	5.42e-4	SMART
Pfam:AAA_8	2238	2316	2e-18	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000165269
AA Change: G197V

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000130609
Gene: ENSMUSG00000021879
AA Change: G197V

Domain	Start	End	E-Value	Type
Pfam:MT	1	248	5.7e-40	PFAM
Pfam:AAA_9	270	495	3.8e-96	PFAM
low complexity region	593	606	N/A	INTRINSIC
Pfam:Dynein_heavy	631	1336	2e-287	PFAM

Meta Mutation Damage Score

0.2993

Coding Region Coverage

1x: 99.8%
3x: 99.6%
10x: 98.6%
20x: 96.4%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 137 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700001K19Rik	CTT	CTTTTT	12: 110,634,883 (GRCm39)		probably benign	Homo
1700001K19Rik	TTC	TTCGTC	12: 110,634,884 (GRCm39)		probably benign	Homo
4930433I11Rik	ACCTC	AC	7: 40,642,480 (GRCm39)		probably benign	Het
4930447C04Rik	AAGT	A	12: 72,928,061 (GRCm39)		probably benign	Homo
Acbd4	CAG	CAGACTAG	11: 102,994,931 (GRCm39)		probably null	Homo
Ahdc1	CT	CTCTT	4: 132,790,070 (GRCm39)		probably benign	Homo
Alpk3	TCT	TCTGCT	7: 80,727,510 (GRCm39)		probably benign	Het
Anapc4	C	T	5: 53,021,868 (GRCm39)	T650M	probably damaging	Homo
Ankhd1	GGCGGC	GGCGGCTGCGGC	18: 36,693,977 (GRCm39)		probably benign	Het
Ankrd35	TAGC	TAGCAGC	3: 96,591,163 (GRCm39)		probably benign	Homo
Apc	GCCAATAAA	GCCAATAAAACCAATAAA	18: 34,415,050 (GRCm39)		probably benign	Het
Apol6	TTGT	TTGTCTGT	15: 76,935,636 (GRCm39)		probably null	Het
Arhgap30	TGGCCC	TGGCCCTGGCCCAGGCCTTGGCCCCGGCCC	1: 171,232,736 (GRCm39)		probably benign	Het
Arpc1b	GCC	GCCTGTCC	5: 145,063,601 (GRCm39)		probably null	Het
Blm	CT	CTACGT	7: 80,113,521 (GRCm39)		probably null	Homo
Blm	TCCTCCTCCTCC	TCCTCCTCCTCCACCTCCTCCTCC	7: 80,162,667 (GRCm39)		probably benign	Het
Btnl10	GA	GAATA	11: 58,814,756 (GRCm39)		probably benign	Homo
Cacna1f	AGG	AGGCGG	X: 7,486,300 (GRCm39)		probably benign	Het
Calhm3	CG	CGG	19: 47,140,335 (GRCm39)		probably null	Homo
Catsper2	C	CTTTTACTTTTTA	2: 121,228,023 (GRCm39)		probably null	Homo
Catsper2	CAT	CATTAT	2: 121,228,263 (GRCm39)		probably benign	Het
Ccdc121	GAGAAG	GAG	5: 31,644,717 (GRCm39)		probably benign	Homo
Ccdc15	AC	ACTTTCC	9: 37,226,453 (GRCm39)		probably null	Het
Ccdc162	T	C	10: 41,432,117 (GRCm39)	D1792G	possibly damaging	Het
Ccdc170	CCA	CCATCA	10: 4,511,021 (GRCm39)		probably benign	Het
Ccdc73	TAAG	T	2: 104,822,185 (GRCm39)		probably benign	Homo
Ccdc85c	GCC	GCCCCC	12: 108,240,871 (GRCm39)		probably benign	Het
Cd22	C	T	7: 30,577,507 (GRCm39)	R2H	possibly damaging	Het
Cd80	AGA	AGAGGA	16: 38,306,677 (GRCm39)		probably benign	Homo
Cep89	GACT	G	7: 35,109,066 (GRCm39)		probably benign	Het
Cfap74	A	G	4: 155,500,217 (GRCm39)	D21G	possibly damaging	Homo
Cgref1	T	TCTA	5: 31,091,124 (GRCm39)		probably benign	Homo
Chd4	GCC	GCCACTCCC	6: 125,099,107 (GRCm39)		probably benign	Het
Cnpy3	TCC	TCCCCC	17: 47,047,669 (GRCm39)		probably benign	Het
Cnpy3	TCC	TCCACC	17: 47,047,672 (GRCm39)		probably benign	Het
Cntnap1	AGCCCC	AGCCCCCGCCCC	11: 101,080,407 (GRCm39)		probably benign	Het
Cntnap1	CCCCAG	CCCCAGACCCAG	11: 101,080,415 (GRCm39)		probably benign	Het
Col2a1	C	A	15: 97,886,862 (GRCm39)		probably null	Homo
Cpeb4	T	TGA	11: 31,877,638 (GRCm39)		probably benign	Homo
Cpne1	AGA	AGAGAGA	2: 155,913,945 (GRCm39)		probably null	Homo
Cttnbp2	ATTGCTG	ATTGCTGTTGCTG	6: 18,367,457 (GRCm39)		probably benign	Het
Dhx37	CTGG	C	5: 125,504,594 (GRCm39)		probably benign	Het
Dhx8	CGAGAC	CGAGACGGAGAC	11: 101,629,014 (GRCm39)		probably benign	Homo
Dnaaf9	TCC	TCCCCC	2: 130,612,668 (GRCm39)		probably benign	Het
Dst	C	A	1: 34,240,045 (GRCm39)	S1798Y	probably damaging	Het
Eif3a	TA	TATTTCA	19: 60,763,728 (GRCm39)		probably benign	Homo
Ermn	TTC	TTCCTC	2: 57,938,090 (GRCm39)		probably benign	Het
Ermn	CTT	CTTGTT	2: 57,938,098 (GRCm39)		probably benign	Het
Fbxo43	TGTGCC	TGTGCCAGTGCC	15: 36,152,243 (GRCm39)		probably benign	Het
Fbxo43	GCCTGT	GCCTGTCCCTGT	15: 36,152,246 (GRCm39)		probably benign	Het
Fbxo43	GCCTGT	GCCTGTTCCTGT	15: 36,152,240 (GRCm39)		probably benign	Het
Fmn1	TCC	TCCTCCACC	2: 113,356,128 (GRCm39)		probably benign	Homo
Fmn1	TCCTCC	TCCTCCCCCTCC	2: 113,356,119 (GRCm39)		probably benign	Het
Foxd3	GGACCCTACGGCCG	GG	4: 99,545,633 (GRCm39)		probably benign	Homo
Frmpd2	G	T	14: 33,232,978 (GRCm39)	L399F	probably damaging	Homo
Gabre	ACTCCGGCTCCGGCTCAGGCTCAGGCTCCGGCTCAGGCTCCGGCTCCGGCTCCGGCTC	ACTCCGGCTCCGGCTCCGGCTCAGGCTCAGGCTCCGGCTCAGGCTCCGGCTCCGGCTCCGGCTC	X: 71,313,648 (GRCm39)		probably benign	Homo
Gbp2b	A	G	3: 142,309,413 (GRCm39)	I175V	probably benign	Het
Gm4340	CAG	CAGAAG	10: 104,031,933 (GRCm39)		probably benign	Het
Gm4340	AGC	AGCGGC	10: 104,031,943 (GRCm39)		probably benign	Het
Gm5114	T	C	7: 39,060,529 (GRCm39)	R107G	probably benign	Het
Gm5114	A	C	7: 39,060,530 (GRCm39)	H106Q	probably benign	Het
H1f6	GAGAA	GA	13: 23,879,903 (GRCm39)		probably benign	Homo
H2-Q4	G	A	17: 35,599,381 (GRCm39)	D155N	probably damaging	Het
H2-T10	TGTTTCCCACTG	T	17: 36,431,173 (GRCm39)		probably null	Het
Ifi203	C	T	1: 173,755,894 (GRCm39)		probably benign	Het
Ifi208	ATGGTG	ATG	1: 173,505,264 (GRCm39)		probably benign	Homo
Ighv5-9	C	T	12: 113,625,497 (GRCm39)	S82N	probably benign	Homo
Il17rd	CGG	CGGTGG	14: 26,804,637 (GRCm39)		probably benign	Het
Il2	AGTGG	AGTGGGGCTTGAGGTGG	3: 37,179,975 (GRCm39)		probably benign	Het
Ipo9	TCC	TCCGCC	1: 135,314,013 (GRCm39)		probably benign	Het
Ipo9	CCT	CCTACT	1: 135,314,017 (GRCm39)		probably null	Het
Isg20l2	AAG	AAGCAG	3: 87,839,019 (GRCm39)		probably benign	Homo
Kmt2b	TCCTCC	TCCTCCCCCTCC	7: 30,285,788 (GRCm39)		probably benign	Het
Kmt2c	TGCTGCTG	TGCTGCTGCTGCTG	5: 25,520,764 (GRCm39)		probably benign	Homo
Krt10	CGCC	CGCCGCC	11: 99,277,025 (GRCm39)		probably benign	Het
Krt10	CCTCCT	CCTCCTACTCCT	11: 99,280,100 (GRCm39)		probably benign	Het
Las1l	GAG	GAGCAG	X: 94,984,426 (GRCm39)		probably benign	Het
Las1l	AGG	AGGCGG	X: 94,984,427 (GRCm39)		probably benign	Het
Lkaaear1	GCTCCAGCTCCAGCTCCAGCTCCA	GCTCCAGCTCCATCTCCAGCTCCAGCTCCAGCTCCA	2: 181,339,372 (GRCm39)		probably benign	Het
Lrch1	A	T	14: 75,057,005 (GRCm39)	C241S	possibly damaging	Het
Lrit3	G	GCTT	3: 129,582,468 (GRCm39)		probably benign	Het
Maml2	GCAGCAGCAACAGCAGCA	GCAGCAGCA	9: 13,532,755 (GRCm39)		probably benign	Homo
Mast4	T	TTTC	13: 102,871,370 (GRCm39)		probably benign	Het
Med12l	AGC	AGCGGC	3: 59,183,403 (GRCm39)		probably benign	Het
Muc21	T	G	17: 35,933,013 (GRCm39)		probably benign	Homo
Noc2l	TGC	TGCAGC	4: 156,324,553 (GRCm39)		probably benign	Het
Nrg3	G	GACATTT	14: 38,119,230 (GRCm39)		probably benign	Homo
Or51q1	TCC	TCCC	7: 103,629,110 (GRCm39)		probably null	Het
Padi3	TCTCAC	TC	4: 140,520,283 (GRCm39)		probably benign	Homo
Patl2	GCT	GCTTCT	2: 121,956,616 (GRCm39)		probably benign	Het
Pdik1l	TTTT	TTTTGTTTTTGGTTT	4: 134,006,685 (GRCm39)		probably null	Homo
Pik3c2g	AG	AGAGGG	6: 139,612,654 (GRCm39)		probably null	Homo
Plekhs1	T	TTCAGACCTCCCC	19: 56,468,290 (GRCm39)		probably benign	Het
Prkd3	G	T	17: 79,283,249 (GRCm39)		probably null	Homo
Prkn	G	A	17: 12,073,650 (GRCm39)	V323M	probably damaging	Het
Prr13	TCC	TCCCCC	15: 102,370,612 (GRCm39)		probably benign	Homo
Prrc2b	G	A	2: 32,111,179 (GRCm39)	A1852T	probably damaging	Homo
Ptms	CTT	CTTTTT	6: 124,891,421 (GRCm39)		probably benign	Homo
Rtl1	TTCCTCTTCCTCCTC	TTCCTC	12: 109,557,632 (GRCm39)		probably benign	Homo
Scaf4	TGCGGC	TGC	16: 90,026,742 (GRCm39)		probably benign	Homo
Serac1	T	A	17: 6,121,083 (GRCm39)	K70N	probably damaging	Homo
Six3	CGG	CGGTGG	17: 85,928,796 (GRCm39)		probably benign	Het
Sry	GTG	GTGCTG	Y: 2,662,837 (GRCm39)		probably benign	Homo
Stard8	GGAAGA	GGAAGAAGA	X: 98,110,111 (GRCm39)		probably benign	Het
Supt20	TTCAGCA	TTCAGCATCAGCA	3: 54,635,068 (GRCm39)		probably benign	Het
Supt20	CAGCAG	CAGCAGTAGCAG	3: 54,635,085 (GRCm39)		probably null	Het
Supt20	AGCAGC	AGCAGCGGCAGC	3: 54,635,083 (GRCm39)		probably benign	Het
Sytl1	CTCT	C	4: 132,984,304 (GRCm39)		probably benign	Homo
Tcof1	AGC	AGCGGC	18: 60,968,814 (GRCm39)		probably benign	Het
Tdpoz2	T	TCA	3: 93,558,922 (GRCm39)		probably null	Homo
Tert	GCC	GCCAAGGGTTCC	13: 73,796,421 (GRCm39)		probably benign	Homo
Tfeb	GCA	GCAACA	17: 48,097,019 (GRCm39)		probably benign	Het
Ticrr	ATT	ATTTTT	7: 79,344,059 (GRCm39)		probably benign	Homo
Tnfaip8	ACACACACTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC	AC	18: 50,179,906 (GRCm39)		probably null	Homo
Tnfrsf9	T	TGCC	4: 151,018,852 (GRCm39)		probably benign	Homo
Tob1	GCA	GCAACA	11: 94,105,290 (GRCm39)		probably benign	Het
Tob1	CA	CAGTA	11: 94,105,303 (GRCm39)		probably null	Het
Trav15-2-dv6-2	GGGAG	GGGAGGAG	14: 53,887,207 (GRCm39)		probably benign	Homo
Triobp	TCGTCG	TCGTCGTCG	15: 78,877,587 (GRCm39)		probably benign	Homo
Tsbp1	A	AGCC	17: 34,679,029 (GRCm39)		probably benign	Het
Tsbp1	GC	GCATC	17: 34,679,051 (GRCm39)		probably benign	Het
Tsen2	AGG	AGGGGG	6: 115,537,030 (GRCm39)		probably benign	Het
Ubtf	TCC	TCCGCC	11: 102,197,782 (GRCm39)		probably benign	Het
Ubtf	CTCGTCGTC	CTCGTCGTCGTC	11: 102,197,784 (GRCm39)		probably benign	Het
Vars1	TGG	TGGAGTCCTGGGCGG	17: 35,234,965 (GRCm39)		probably benign	Homo
Vmn1r171	C	T	7: 23,332,105 (GRCm39)	A110V	probably benign	Het
Vmn2r31	G	T	7: 7,387,607 (GRCm39)	Q655K	probably damaging	Het
Vmn2r87	C	T	10: 130,314,583 (GRCm39)	M334I	probably benign	Homo
Zc3h13	CG	CGAGATGTGTG	14: 75,561,050 (GRCm39)		probably benign	Het
Zc3h13	AGATGTGCG	AGATGTGCGGGATGTGCG	14: 75,561,043 (GRCm39)		probably benign	Het
Zfp282	GGC	GGCCGC	6: 47,881,731 (GRCm39)		probably benign	Het
Zfp384	AGGC	AGGCCCAGGCCCCGGC	6: 125,013,456 (GRCm39)		probably benign	Het
Zfp459	TGA	TGAGCGA	13: 67,556,393 (GRCm39)		probably null	Homo
Zfp462	GCCACC	GCCACCTCAGCCACAACCACC	4: 55,009,757 (GRCm39)		probably benign	Het
Zfp462	CCACC	CCACCTCAGCCACAGTCACC	4: 55,009,758 (GRCm39)		probably benign	Het
Zfp598	CACCAC	CACCACAACCAC	17: 24,899,749 (GRCm39)		probably benign	Het
Zfp831	CCT	CCTGCT	2: 174,487,274 (GRCm39)		probably benign	Het

Other mutations in Dnah12

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01412:Dnah12	APN	14	26,492,962 (GRCm39)	missense	probably damaging	1.00
IGL01602:Dnah12	APN	14	26,431,430 (GRCm39)	splice site	probably benign
IGL01681:Dnah12	APN	14	26,443,315 (GRCm39)	missense	probably benign
IGL02082:Dnah12	APN	14	26,428,317 (GRCm39)	missense	possibly damaging	0.79
IGL02140:Dnah12	APN	14	26,437,732 (GRCm39)	missense	probably benign	0.20
IGL02170:Dnah12	APN	14	26,495,069 (GRCm39)	missense	probably damaging	0.99
IGL02174:Dnah12	APN	14	26,428,072 (GRCm39)	missense	probably benign	0.00
IGL02367:Dnah12	APN	14	26,430,316 (GRCm39)	missense	probably benign	0.30
IGL02418:Dnah12	APN	14	26,495,679 (GRCm39)	missense	probably damaging	1.00
IGL03039:Dnah12	APN	14	26,445,667 (GRCm39)	missense	probably benign	0.02
IGL03066:Dnah12	APN	14	26,418,553 (GRCm39)	missense	probably benign	0.06
drippings	UTSW	14	26,576,761 (GRCm39)	missense	probably damaging	1.00
grueben	UTSW	14	26,600,036 (GRCm39)	missense	probably damaging	1.00
BB010:Dnah12	UTSW	14	26,488,072 (GRCm39)	missense	probably benign	0.00
BB020:Dnah12	UTSW	14	26,488,072 (GRCm39)	missense	probably benign	0.00
F5770:Dnah12	UTSW	14	26,495,050 (GRCm39)	missense	possibly damaging	0.95
FR4340:Dnah12	UTSW	14	26,571,342 (GRCm39)	missense	probably damaging	1.00
FR4342:Dnah12	UTSW	14	26,571,342 (GRCm39)	missense	probably damaging	1.00
FR4589:Dnah12	UTSW	14	26,571,342 (GRCm39)	missense	probably damaging	1.00
IGL03055:Dnah12	UTSW	14	26,594,697 (GRCm39)	missense	probably damaging	1.00
LCD18:Dnah12	UTSW	14	26,571,342 (GRCm39)	missense	probably damaging	1.00
R0003:Dnah12	UTSW	14	26,494,601 (GRCm39)	missense	probably damaging	1.00
R0110:Dnah12	UTSW	14	26,520,856 (GRCm39)	missense	probably damaging	1.00
R0302:Dnah12	UTSW	14	26,521,956 (GRCm39)	missense	probably damaging	1.00
R0355:Dnah12	UTSW	14	26,427,272 (GRCm39)	splice site	probably null
R0364:Dnah12	UTSW	14	26,445,628 (GRCm39)	missense	probably benign	0.10
R0469:Dnah12	UTSW	14	26,520,856 (GRCm39)	missense	probably damaging	1.00
R0558:Dnah12	UTSW	14	26,430,465 (GRCm39)	missense	probably benign	0.00
R0709:Dnah12	UTSW	14	26,606,222 (GRCm39)	splice site	probably benign
R0734:Dnah12	UTSW	14	26,521,970 (GRCm39)	missense	probably benign	0.00
R1273:Dnah12	UTSW	14	26,460,375 (GRCm39)	nonsense	probably null
R1496:Dnah12	UTSW	14	26,431,403 (GRCm39)	missense	probably benign
R1503:Dnah12	UTSW	14	26,495,649 (GRCm39)	missense	probably damaging	1.00
R1535:Dnah12	UTSW	14	26,538,279 (GRCm39)	missense	possibly damaging	0.91
R1608:Dnah12	UTSW	14	26,488,147 (GRCm39)	missense	probably damaging	1.00
R1682:Dnah12	UTSW	14	26,500,840 (GRCm39)	missense	possibly damaging	0.71
R1758:Dnah12	UTSW	14	26,488,071 (GRCm39)	missense	probably benign	0.02
R1826:Dnah12	UTSW	14	26,432,174 (GRCm39)	missense	probably benign	0.01
R1829:Dnah12	UTSW	14	26,522,032 (GRCm39)	missense	probably damaging	1.00
R1829:Dnah12	UTSW	14	26,494,980 (GRCm39)	missense	probably damaging	1.00
R1862:Dnah12	UTSW	14	26,430,412 (GRCm39)	missense	probably benign	0.30
R1862:Dnah12	UTSW	14	26,418,553 (GRCm39)	missense	probably benign	0.06
R1913:Dnah12	UTSW	14	26,514,221 (GRCm39)	splice site	probably null
R1933:Dnah12	UTSW	14	26,455,650 (GRCm39)	missense	probably damaging	0.98
R2006:Dnah12	UTSW	14	26,536,416 (GRCm39)	missense	possibly damaging	0.95
R2045:Dnah12	UTSW	14	26,503,485 (GRCm39)	missense	probably null	1.00
R2113:Dnah12	UTSW	14	26,488,098 (GRCm39)	missense	probably damaging	1.00
R2125:Dnah12	UTSW	14	26,445,613 (GRCm39)	nonsense	probably null
R2126:Dnah12	UTSW	14	26,445,613 (GRCm39)	nonsense	probably null
R2207:Dnah12	UTSW	14	26,503,744 (GRCm39)	missense	probably damaging	0.99
R2213:Dnah12	UTSW	14	26,460,485 (GRCm39)	missense	probably benign	0.06
R2511:Dnah12	UTSW	14	26,491,907 (GRCm39)	missense	possibly damaging	0.65
R2875:Dnah12	UTSW	14	26,598,907 (GRCm39)	missense	probably benign	0.05
R2875:Dnah12	UTSW	14	26,414,625 (GRCm39)	missense	probably benign	0.04
R3551:Dnah12	UTSW	14	26,492,929 (GRCm39)	missense	probably benign	0.01
R3713:Dnah12	UTSW	14	26,534,747 (GRCm39)	missense	probably benign
R3729:Dnah12	UTSW	14	26,427,220 (GRCm39)	missense	probably benign	0.02
R3799:Dnah12	UTSW	14	26,492,880 (GRCm39)	missense	probably damaging	1.00
R3846:Dnah12	UTSW	14	26,431,366 (GRCm39)	missense	probably benign	0.00
R3892:Dnah12	UTSW	14	26,578,573 (GRCm39)	missense	probably benign	0.03
R3921:Dnah12	UTSW	14	26,493,008 (GRCm39)	missense	probably damaging	1.00
R3940:Dnah12	UTSW	14	26,444,754 (GRCm39)	missense	probably benign
R4065:Dnah12	UTSW	14	26,492,405 (GRCm39)	missense	probably benign	0.02
R4113:Dnah12	UTSW	14	26,414,722 (GRCm39)	missense	probably damaging	0.98
R4249:Dnah12	UTSW	14	26,430,341 (GRCm39)	missense	possibly damaging	0.70
R4259:Dnah12	UTSW	14	26,520,883 (GRCm39)	missense	probably benign	0.01
R4260:Dnah12	UTSW	14	26,520,883 (GRCm39)	missense	probably benign	0.01
R4348:Dnah12	UTSW	14	26,536,498 (GRCm39)	missense	possibly damaging	0.94
R4457:Dnah12	UTSW	14	26,537,464 (GRCm39)	missense	probably damaging	1.00
R4490:Dnah12	UTSW	14	26,455,758 (GRCm39)	missense	possibly damaging	0.67
R4491:Dnah12	UTSW	14	26,455,758 (GRCm39)	missense	possibly damaging	0.67
R4494:Dnah12	UTSW	14	26,593,812 (GRCm39)	missense	probably damaging	0.99
R4523:Dnah12	UTSW	14	26,598,915 (GRCm39)	missense	possibly damaging	0.83
R4523:Dnah12	UTSW	14	26,491,979 (GRCm39)	missense	probably damaging	0.97
R4546:Dnah12	UTSW	14	26,494,971 (GRCm39)	missense	probably damaging	1.00
R4584:Dnah12	UTSW	14	26,494,551 (GRCm39)	missense	probably damaging	1.00
R4624:Dnah12	UTSW	14	26,456,913 (GRCm39)	missense	possibly damaging	0.82
R4689:Dnah12	UTSW	14	26,427,994 (GRCm39)	missense	probably benign	0.00
R4727:Dnah12	UTSW	14	26,594,274 (GRCm39)	missense	probably damaging	1.00
R4732:Dnah12	UTSW	14	26,503,741 (GRCm39)	missense	probably damaging	1.00
R4733:Dnah12	UTSW	14	26,503,741 (GRCm39)	missense	probably damaging	1.00
R4851:Dnah12	UTSW	14	26,437,784 (GRCm39)	nonsense	probably null
R4879:Dnah12	UTSW	14	26,439,201 (GRCm39)	critical splice donor site	probably null
R4893:Dnah12	UTSW	14	26,431,325 (GRCm39)	missense	possibly damaging	0.66
R4915:Dnah12	UTSW	14	26,455,725 (GRCm39)	missense	probably damaging	1.00
R4927:Dnah12	UTSW	14	26,583,762 (GRCm39)	nonsense	probably null
R4939:Dnah12	UTSW	14	26,613,481 (GRCm39)	missense	probably damaging	1.00
R4962:Dnah12	UTSW	14	26,437,855 (GRCm39)	missense	probably benign	0.00
R5011:Dnah12	UTSW	14	26,431,326 (GRCm39)	missense	probably benign	0.03
R5013:Dnah12	UTSW	14	26,431,326 (GRCm39)	missense	probably benign	0.03
R5043:Dnah12	UTSW	14	26,606,147 (GRCm39)	missense	probably damaging	1.00
R5049:Dnah12	UTSW	14	26,456,852 (GRCm39)	missense	probably benign	0.09
R5122:Dnah12	UTSW	14	26,439,155 (GRCm39)	missense	probably benign	0.00
R5135:Dnah12	UTSW	14	26,492,434 (GRCm39)	missense	probably damaging	0.99
R5149:Dnah12	UTSW	14	26,572,883 (GRCm39)	nonsense	probably null
R5154:Dnah12	UTSW	14	26,571,320 (GRCm39)	missense	probably benign	0.12
R5206:Dnah12	UTSW	14	26,491,942 (GRCm39)	missense	probably damaging	1.00
R5307:Dnah12	UTSW	14	26,414,641 (GRCm39)	missense	possibly damaging	0.49
R5330:Dnah12	UTSW	14	26,495,787 (GRCm39)	missense	probably damaging	1.00
R5335:Dnah12	UTSW	14	26,601,695 (GRCm39)	missense	probably damaging	1.00
R5339:Dnah12	UTSW	14	26,536,494 (GRCm39)	missense	possibly damaging	0.83
R5354:Dnah12	UTSW	14	26,496,299 (GRCm39)	splice site	probably null
R5389:Dnah12	UTSW	14	26,456,904 (GRCm39)	missense	probably damaging	1.00
R5434:Dnah12	UTSW	14	26,581,256 (GRCm39)	missense	probably damaging	1.00
R5466:Dnah12	UTSW	14	26,493,007 (GRCm39)	missense	probably damaging	1.00
R5655:Dnah12	UTSW	14	26,431,424 (GRCm39)	missense	probably benign	0.01
R5681:Dnah12	UTSW	14	26,537,452 (GRCm39)	missense	probably benign	0.32
R5824:Dnah12	UTSW	14	26,492,475 (GRCm39)	critical splice donor site	probably null
R5863:Dnah12	UTSW	14	26,576,878 (GRCm39)	missense	probably damaging	1.00
R5890:Dnah12	UTSW	14	26,428,039 (GRCm39)	missense	probably benign	0.09
R5912:Dnah12	UTSW	14	26,491,965 (GRCm39)	nonsense	probably null
R5916:Dnah12	UTSW	14	26,428,073 (GRCm39)	missense	possibly damaging	0.92
R5941:Dnah12	UTSW	14	26,428,022 (GRCm39)	missense	probably benign	0.00
R5987:Dnah12	UTSW	14	26,608,828 (GRCm39)	missense	possibly damaging	0.54
R5992:Dnah12	UTSW	14	26,418,496 (GRCm39)	missense	probably benign	0.04
R6132:Dnah12	UTSW	14	26,439,066 (GRCm39)	missense	probably damaging	1.00
R6136:Dnah12	UTSW	14	26,597,227 (GRCm39)	missense	probably damaging	0.99
R6158:Dnah12	UTSW	14	26,495,642 (GRCm39)	missense	possibly damaging	0.95
R6183:Dnah12	UTSW	14	26,583,726 (GRCm39)	missense	probably damaging	1.00
R6191:Dnah12	UTSW	14	26,431,412 (GRCm39)	missense	probably benign	0.03
R6235:Dnah12	UTSW	14	26,576,761 (GRCm39)	missense	probably damaging	1.00
R6277:Dnah12	UTSW	14	26,492,439 (GRCm39)	missense	probably damaging	1.00
R6332:Dnah12	UTSW	14	26,439,129 (GRCm39)	missense	probably damaging	0.99
R6334:Dnah12	UTSW	14	26,427,989 (GRCm39)	missense	possibly damaging	0.51
R6443:Dnah12	UTSW	14	26,600,008 (GRCm39)	missense	probably benign	0.06
R6480:Dnah12	UTSW	14	26,594,412 (GRCm39)	missense	probably damaging	1.00
R6530:Dnah12	UTSW	14	26,456,865 (GRCm39)	missense	probably damaging	1.00
R6678:Dnah12	UTSW	14	26,456,847 (GRCm39)	missense	probably damaging	1.00
R6709:Dnah12	UTSW	14	26,594,706 (GRCm39)	missense	probably damaging	1.00
R6724:Dnah12	UTSW	14	26,518,180 (GRCm39)	missense	probably benign	0.02
R6745:Dnah12	UTSW	14	26,428,383 (GRCm39)	missense	probably damaging	0.99
R6788:Dnah12	UTSW	14	26,523,470 (GRCm39)	missense	probably damaging	0.99
R6894:Dnah12	UTSW	14	26,456,904 (GRCm39)	missense	probably damaging	1.00
R6912:Dnah12	UTSW	14	26,600,036 (GRCm39)	missense	probably damaging	1.00
R6982:Dnah12	UTSW	14	26,521,033 (GRCm39)	splice site	probably null
R7001:Dnah12	UTSW	14	26,601,681 (GRCm39)	missense	probably damaging	0.99
R7002:Dnah12	UTSW	14	26,598,955 (GRCm39)	missense	probably damaging	1.00
R7017:Dnah12	UTSW	14	26,456,835 (GRCm39)	missense	probably benign
R7107:Dnah12	UTSW	14	26,500,869 (GRCm39)	critical splice donor site	probably null
R7108:Dnah12	UTSW	14	26,500,869 (GRCm39)	critical splice donor site	probably null
R7121:Dnah12	UTSW	14	26,500,869 (GRCm39)	critical splice donor site	probably null
R7122:Dnah12	UTSW	14	26,500,869 (GRCm39)	critical splice donor site	probably null
R7135:Dnah12	UTSW	14	26,500,869 (GRCm39)	critical splice donor site	probably null
R7135:Dnah12	UTSW	14	26,523,370 (GRCm39)	missense	probably damaging	0.99
R7150:Dnah12	UTSW	14	26,583,689 (GRCm39)	missense	probably damaging	0.99
R7188:Dnah12	UTSW	14	26,536,370 (GRCm39)	missense	probably benign	0.04
R7201:Dnah12	UTSW	14	26,536,579 (GRCm39)	missense	probably benign	0.08
R7202:Dnah12	UTSW	14	26,500,869 (GRCm39)	critical splice donor site	probably null
R7204:Dnah12	UTSW	14	26,503,442 (GRCm39)	missense	probably damaging	0.99
R7204:Dnah12	UTSW	14	26,500,869 (GRCm39)	critical splice donor site	probably null
R7205:Dnah12	UTSW	14	26,500,869 (GRCm39)	critical splice donor site	probably null
R7206:Dnah12	UTSW	14	26,500,869 (GRCm39)	critical splice donor site	probably null
R7219:Dnah12	UTSW	14	26,576,837 (GRCm39)	missense	probably damaging	0.99
R7337:Dnah12	UTSW	14	26,488,534 (GRCm39)	splice site	probably null
R7339:Dnah12	UTSW	14	26,594,277 (GRCm39)	missense	probably benign
R7363:Dnah12	UTSW	14	26,445,766 (GRCm39)	missense	probably benign
R7426:Dnah12	UTSW	14	26,445,781 (GRCm39)	missense	probably benign	0.01
R7472:Dnah12	UTSW	14	26,578,592 (GRCm39)	missense	probably benign	0.01
R7579:Dnah12	UTSW	14	26,492,460 (GRCm39)	missense	probably benign	0.05
R7655:Dnah12	UTSW	14	26,581,273 (GRCm39)	missense	probably benign	0.21
R7656:Dnah12	UTSW	14	26,581,273 (GRCm39)	missense	probably benign	0.21
R7694:Dnah12	UTSW	14	26,503,337 (GRCm39)	missense	probably damaging	1.00
R7730:Dnah12	UTSW	14	26,507,890 (GRCm39)	missense	probably damaging	1.00
R7837:Dnah12	UTSW	14	26,518,176 (GRCm39)	missense	probably benign	0.01
R7855:Dnah12	UTSW	14	26,551,286 (GRCm39)	missense	probably benign	0.14
R7870:Dnah12	UTSW	14	26,578,486 (GRCm39)	missense	probably benign	0.00
R7920:Dnah12	UTSW	14	26,578,499 (GRCm39)	missense	possibly damaging	0.58
R7933:Dnah12	UTSW	14	26,488,072 (GRCm39)	missense	probably benign	0.00
R7956:Dnah12	UTSW	14	26,430,427 (GRCm39)	missense	probably damaging	0.96
R8192:Dnah12	UTSW	14	26,428,036 (GRCm39)	missense	probably benign
R8263:Dnah12	UTSW	14	26,613,421 (GRCm39)	missense	noncoding transcript
R8287:Dnah12	UTSW	14	26,534,560 (GRCm39)	missense	probably benign
R8336:Dnah12	UTSW	14	26,432,220 (GRCm39)	missense	probably benign	0.01
R8362:Dnah12	UTSW	14	26,576,788 (GRCm39)	missense	probably damaging	1.00
R8392:Dnah12	UTSW	14	26,607,869 (GRCm39)	missense	probably benign
R8458:Dnah12	UTSW	14	26,548,849 (GRCm39)	critical splice acceptor site	probably null
R8481:Dnah12	UTSW	14	26,575,753 (GRCm39)	missense	probably benign	0.02
R8551:Dnah12	UTSW	14	26,496,227 (GRCm39)	missense	probably damaging	0.97
R8669:Dnah12	UTSW	14	26,552,582 (GRCm39)	splice site	probably benign
R8698:Dnah12	UTSW	14	26,428,418 (GRCm39)	missense	probably benign	0.02
R8709:Dnah12	UTSW	14	26,414,757 (GRCm39)	missense	probably benign	0.00
R8778:Dnah12	UTSW	14	26,455,718 (GRCm39)	missense	probably benign	0.29
R9049:Dnah12	UTSW	14	26,443,275 (GRCm39)	missense	probably benign	0.00
R9087:Dnah12	UTSW	14	26,546,503 (GRCm39)	missense	probably damaging	1.00
R9099:Dnah12	UTSW	14	26,492,325 (GRCm39)	missense	probably benign	0.31
R9153:Dnah12	UTSW	14	26,536,569 (GRCm39)	missense	probably damaging	1.00
R9177:Dnah12	UTSW	14	26,571,255 (GRCm39)	missense	possibly damaging	0.84
R9214:Dnah12	UTSW	14	26,445,060 (GRCm39)	missense	probably benign	0.02
R9268:Dnah12	UTSW	14	26,571,255 (GRCm39)	missense	possibly damaging	0.84
R9274:Dnah12	UTSW	14	26,537,374 (GRCm39)	missense	probably benign	0.00
R9293:Dnah12	UTSW	14	26,495,016 (GRCm39)	missense	probably benign
R9322:Dnah12	UTSW	14	26,492,934 (GRCm39)	missense	possibly damaging	0.75
R9353:Dnah12	UTSW	14	26,578,507 (GRCm39)	missense	probably damaging	1.00
R9506:Dnah12	UTSW	14	26,514,168 (GRCm39)	missense	probably benign	0.00
R9518:Dnah12	UTSW	14	26,495,713 (GRCm39)	missense	probably damaging	1.00
R9524:Dnah12	UTSW	14	26,572,494 (GRCm39)	missense	probably null	0.91
R9562:Dnah12	UTSW	14	26,597,281 (GRCm39)	missense	possibly damaging	0.58
R9565:Dnah12	UTSW	14	26,597,281 (GRCm39)	missense	possibly damaging	0.58
R9573:Dnah12	UTSW	14	26,414,619 (GRCm39)	missense	probably benign
R9581:Dnah12	UTSW	14	26,491,985 (GRCm39)	missense	probably damaging	1.00
R9689:Dnah12	UTSW	14	26,590,871 (GRCm39)	missense	probably null	1.00
R9727:Dnah12	UTSW	14	26,523,510 (GRCm39)	nonsense	probably null
V7580:Dnah12	UTSW	14	26,495,050 (GRCm39)	missense	possibly damaging	0.95
V7581:Dnah12	UTSW	14	26,495,050 (GRCm39)	missense	possibly damaging	0.95
X0018:Dnah12	UTSW	14	26,536,437 (GRCm39)	missense	probably damaging	1.00
X0027:Dnah12	UTSW	14	26,538,245 (GRCm39)	missense	probably damaging	1.00
X0065:Dnah12	UTSW	14	26,536,602 (GRCm39)	missense	possibly damaging	0.93
Z1177:Dnah12	UTSW	14	26,597,172 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AGGTTGTGGCTCCAAAGAAAGC -3'
(R):5'- ACACTGATCTTGCTCCCTTGAG -3'

Sequencing Primer
(F):5'- CCTTAGCAGAGACAATGGAGCTTTTG -3'
(R):5'- TCCCTTGAGAGTCCTAGCCAG -3'

Posted On

2018-04-05