Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01122:Tmprss11b'

51148

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmprss11b

Ensembl Gene

ENSMUSG00000035861

Gene Name

transmembrane protease, serine 11B

Synonyms

Tmprss11bnl, 9930019B18Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01122

Quality Score

Status

Chromosome

Chromosomal Location

86806326-86824221 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 86811376 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Lysine at position 186 (T186K)

Ref Sequence

ENSEMBL: ENSMUSP00000042406 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000038448]

AlphaFold

Q14C59

Predicted Effect

probably benign
Transcript: ENSMUST00000038448
AA Change: T186K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000042406
Gene: ENSMUSG00000035861
AA Change: T186K

Domain	Start	End	E-Value	Type
transmembrane domain	12	34	N/A	INTRINSIC
Pfam:SEA	46	148	2.3e-26	PFAM
Tryp_SPc	184	410	6.19e-89	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arhgap6	A	T	X: 168,029,666 (GRCm39)	K142N	possibly damaging	Het
Atp13a1	T	A	8: 70,251,555 (GRCm39)	L540Q	probably damaging	Het
Cacna1a	T	C	8: 85,341,422 (GRCm39)		probably null	Het
Cops6	A	G	5: 138,160,635 (GRCm39)	K129E	probably benign	Het
Cracd	T	C	5: 77,018,522 (GRCm39)	*1289Q	probably null	Het
Cyp11a1	T	C	9: 57,923,589 (GRCm39)	I98T	probably damaging	Het
Cyp2c65	A	G	19: 39,060,621 (GRCm39)		probably null	Het
Dapl1	A	T	2: 59,324,839 (GRCm39)	K30I	probably damaging	Het
Dlg2	A	G	7: 92,091,816 (GRCm39)	M894V	possibly damaging	Het
Eme2	C	T	17: 25,112,320 (GRCm39)	A202T	possibly damaging	Het
Fbxw22	A	T	9: 109,215,739 (GRCm39)	S170T	probably damaging	Het
Havcr2	A	G	11: 46,347,254 (GRCm39)	Y77C	probably damaging	Het
Ivd	T	A	2: 118,707,361 (GRCm39)		probably benign	Het
Map3k9	T	C	12: 81,778,900 (GRCm39)	D471G	possibly damaging	Het
Med12	T	C	X: 100,325,149 (GRCm39)		probably benign	Het
Megf6	C	T	4: 154,338,264 (GRCm39)	R445W	probably damaging	Het
Mptx1	A	G	1: 174,159,964 (GRCm39)	Y90C	probably damaging	Het
Nek1	G	A	8: 61,574,000 (GRCm39)	V1083I	possibly damaging	Het
Nepn	T	A	10: 52,267,911 (GRCm39)	I59N	probably damaging	Het
Or4a72	A	G	2: 89,405,767 (GRCm39)	I101T	possibly damaging	Het
Pbdc1	T	C	X: 104,126,297 (GRCm39)		probably benign	Het
Phlpp1	G	T	1: 106,101,166 (GRCm39)	R478L	possibly damaging	Het
Ppp2r3c	C	T	12: 55,344,587 (GRCm39)	G127D	probably benign	Het
Ppp2r3d	A	G	9: 101,088,844 (GRCm39)	L493P	probably benign	Het
Pramel24	A	G	4: 143,454,971 (GRCm39)	D423G	probably benign	Het
Psap	T	C	10: 60,135,253 (GRCm39)	V303A	probably benign	Het
Rdh13	T	C	7: 4,445,694 (GRCm39)	K60R	probably benign	Het
Scaf4	A	G	16: 90,045,518 (GRCm39)	S528P	unknown	Het
Sfmbt1	A	G	14: 30,532,268 (GRCm39)	I543V	probably damaging	Het
Speg	T	C	1: 75,386,679 (GRCm39)	L1271P	probably damaging	Het
Stard9	C	A	2: 120,528,960 (GRCm39)	T1739K	possibly damaging	Het
Tas2r134	G	T	2: 51,517,671 (GRCm39)	C50F	probably damaging	Het
U2surp	G	T	9: 95,372,287 (GRCm39)	Q291K	probably benign	Het
Ulk4	A	G	9: 120,997,358 (GRCm39)	I738T	possibly damaging	Het
Urb1	A	T	16: 90,601,346 (GRCm39)	S142T	possibly damaging	Het
Vmn2r112	T	A	17: 22,821,988 (GRCm39)	I222N	probably benign	Het
Zmym4	T	C	4: 126,758,045 (GRCm39)	N1503S	probably damaging	Het

Other mutations in Tmprss11b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02340:Tmprss11b	APN	5	86,810,090 (GRCm39)	missense	probably benign
IGL02500:Tmprss11b	APN	5	86,815,182 (GRCm39)	critical splice donor site	probably null
demolished	UTSW	5	86,812,173 (GRCm39)	missense	probably damaging	1.00
R0356:Tmprss11b	UTSW	5	86,808,326 (GRCm39)	makesense	probably null
R0506:Tmprss11b	UTSW	5	86,809,499 (GRCm39)	missense	probably damaging	1.00
R0528:Tmprss11b	UTSW	5	86,819,753 (GRCm39)	missense	probably damaging	1.00
R1424:Tmprss11b	UTSW	5	86,812,832 (GRCm39)	missense	probably benign	0.09
R1471:Tmprss11b	UTSW	5	86,808,355 (GRCm39)	missense	possibly damaging	0.76
R1554:Tmprss11b	UTSW	5	86,809,490 (GRCm39)	missense	probably benign	0.01
R3436:Tmprss11b	UTSW	5	86,815,443 (GRCm39)	nonsense	probably null
R3829:Tmprss11b	UTSW	5	86,809,449 (GRCm39)	missense	probably damaging	0.98
R4409:Tmprss11b	UTSW	5	86,812,137 (GRCm39)	missense	probably benign	0.26
R4495:Tmprss11b	UTSW	5	86,812,922 (GRCm39)	nonsense	probably null
R4624:Tmprss11b	UTSW	5	86,812,895 (GRCm39)	missense	probably benign	0.04
R4834:Tmprss11b	UTSW	5	86,811,418 (GRCm39)	missense	probably damaging	1.00
R5436:Tmprss11b	UTSW	5	86,810,092 (GRCm39)	missense	probably benign	0.10
R5812:Tmprss11b	UTSW	5	86,812,957 (GRCm39)	missense	possibly damaging	0.67
R6262:Tmprss11b	UTSW	5	86,810,119 (GRCm39)	missense	probably benign	0.07
R6882:Tmprss11b	UTSW	5	86,819,530 (GRCm39)	splice site	probably null
R6893:Tmprss11b	UTSW	5	86,811,245 (GRCm39)	critical splice donor site	probably null
R7312:Tmprss11b	UTSW	5	86,812,173 (GRCm39)	missense	probably damaging	1.00
R7771:Tmprss11b	UTSW	5	86,809,554 (GRCm39)	splice site	probably null
R8101:Tmprss11b	UTSW	5	86,812,821 (GRCm39)	critical splice donor site	probably null
X0067:Tmprss11b	UTSW	5	86,810,059 (GRCm39)	missense	probably damaging	1.00
Z1177:Tmprss11b	UTSW	5	86,809,472 (GRCm39)	missense	probably benign	0.13
Z1177:Tmprss11b	UTSW	5	86,808,400 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-06-21