Mutagenetix > Incidental Mutation

Incidental Mutation 'FR4737:Zfp462'

511614

Institutional Source

Beutler Lab

Gene Symbol

Zfp462

Ensembl Gene

ENSMUSG00000060206

Gene Name

zinc finger protein 462

Synonyms

Zfpip, 9430078C22Rik, Gt4-2

Accession Numbers

Essential gene?

Probably essential (E-score: 0.831) question?

Stock #

FR4737 ()

Quality Score

218.257

Status

Not validated

Chromosome

Chromosomal Location

54945048-55083563 bp(+) (GRCm38)

Type of Mutation

unclassified

DNA Base Change (assembly)

CCACC to CCACCTCAGCCACAGTCACC at 55009758 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000122775 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000030131] [ENSMUST00000079605] [ENSMUST00000098070] [ENSMUST00000133895]

AlphaFold

B1AWL2

Predicted Effect

probably benign
Transcript: ENSMUST00000030131

SMART Domains

Protein: ENSMUSP00000030131
Gene: ENSMUSG00000060206

Domain	Start	End	E-Value	Type
ZnF_C2H2	35	58	4.81e0	SMART
ZnF_C2H2	106	129	6.67e-2	SMART
ZnF_C2H2	153	176	3.47e0	SMART
ZnF_C2H2	210	233	7.29e0	SMART
ZnF_C2H2	311	334	2.17e-1	SMART
ZnF_C2H2	356	379	6.57e0	SMART
ZnF_C2H2	418	441	5.34e-1	SMART
low complexity region	450	463	N/A	INTRINSIC
ZnF_C2H2	501	524	8.22e-2	SMART
ZnF_C2H2	538	561	5.34e0	SMART
ZnF_C2H2	608	631	6.4e0	SMART
low complexity region	655	676	N/A	INTRINSIC
ZnF_C2H2	687	711	3.05e1	SMART
ZnF_C2H2	733	755	1.08e-1	SMART
low complexity region	757	771	N/A	INTRINSIC
ZnF_C2H2	809	831	1.51e0	SMART
ZnF_C2H2	892	914	3.11e-2	SMART
ZnF_C2H2	926	948	4.11e-2	SMART
ZnF_C2H2	955	978	4.98e-1	SMART
ZnF_C2H2	984	1007	5.5e-3	SMART
ZnF_C2H2	1092	1115	7.05e-1	SMART
ZnF_C2H2	1121	1144	5.48e0	SMART
ZnF_C2H2	1155	1177	6.13e-1	SMART
ZnF_C2H2	1201	1223	1.26e-2	SMART
ZnF_C2H2	1229	1252	2.02e-1	SMART
low complexity region	1273	1296	N/A	INTRINSIC
ZnF_C2H2	1315	1337	2.2e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000079605

SMART Domains

Protein: ENSMUSP00000078555
Gene: ENSMUSG00000060206

Domain	Start	End	E-Value	Type
ZnF_C2H2	35	58	4.81e0	SMART
ZnF_C2H2	106	129	6.67e-2	SMART
ZnF_C2H2	153	176	3.47e0	SMART
ZnF_C2H2	210	233	7.29e0	SMART
ZnF_C2H2	311	334	2.17e-1	SMART
ZnF_C2H2	356	379	6.57e0	SMART
ZnF_C2H2	418	441	5.34e-1	SMART
low complexity region	450	463	N/A	INTRINSIC
ZnF_C2H2	501	524	8.22e-2	SMART
ZnF_C2H2	538	561	5.34e0	SMART
ZnF_C2H2	608	631	6.4e0	SMART
low complexity region	655	676	N/A	INTRINSIC
ZnF_C2H2	687	711	3.05e1	SMART
ZnF_C2H2	733	755	1.08e-1	SMART
low complexity region	757	771	N/A	INTRINSIC
ZnF_C2H2	809	831	1.51e0	SMART
ZnF_C2H2	893	915	3.11e-2	SMART
ZnF_C2H2	927	949	4.11e-2	SMART
ZnF_C2H2	956	979	4.98e-1	SMART
ZnF_C2H2	985	1008	5.5e-3	SMART
ZnF_C2H2	1093	1116	7.05e-1	SMART
ZnF_C2H2	1122	1145	5.48e0	SMART
ZnF_C2H2	1156	1178	6.13e-1	SMART
ZnF_C2H2	1202	1224	1.26e-2	SMART
ZnF_C2H2	1230	1253	2.02e-1	SMART
low complexity region	1274	1297	N/A	INTRINSIC
ZnF_C2H2	1316	1338	2.2e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000098070

SMART Domains

Protein: ENSMUSP00000095677
Gene: ENSMUSG00000060206

Domain	Start	End	E-Value	Type
ZnF_C2H2	4	27	5.81e-2	SMART
low complexity region	81	94	N/A	INTRINSIC
ZnF_C2H2	108	131	1.79e-2	SMART
ZnF_C2H2	162	185	4.65e-1	SMART
low complexity region	194	215	N/A	INTRINSIC
ZnF_C2H2	243	266	4.98e-1	SMART
low complexity region	332	343	N/A	INTRINSIC
ZnF_C2H2	440	463	1.01e-1	SMART
ZnF_C2H2	471	493	2.86e-1	SMART
low complexity region	503	515	N/A	INTRINSIC
low complexity region	536	592	N/A	INTRINSIC
ZnF_C2H2	593	616	2.53e-2	SMART
low complexity region	707	736	N/A	INTRINSIC
ZnF_C2H2	835	858	5.62e0	SMART
ZnF_C2H2	878	900	2.14e0	SMART
ZnF_C2H2	917	940	6.67e-2	SMART
ZnF_C2H2	1023	1046	5.72e-1	SMART
low complexity region	1092	1100	N/A	INTRINSIC
ZnF_C2H2	1107	1130	4.23e0	SMART
ZnF_C2H2	1183	1206	4.81e0	SMART
ZnF_C2H2	1254	1277	6.67e-2	SMART
ZnF_C2H2	1301	1324	3.47e0	SMART
ZnF_C2H2	1358	1381	7.29e0	SMART
ZnF_C2H2	1459	1482	2.17e-1	SMART
ZnF_C2H2	1504	1527	6.57e0	SMART
ZnF_C2H2	1566	1589	5.34e-1	SMART
low complexity region	1598	1611	N/A	INTRINSIC
ZnF_C2H2	1649	1672	8.22e-2	SMART
ZnF_C2H2	1686	1709	5.34e0	SMART
ZnF_C2H2	1756	1779	6.4e0	SMART
low complexity region	1803	1824	N/A	INTRINSIC
ZnF_C2H2	1835	1859	3.05e1	SMART
ZnF_C2H2	1881	1903	1.08e-1	SMART
low complexity region	1905	1919	N/A	INTRINSIC
ZnF_C2H2	1957	1979	1.51e0	SMART
ZnF_C2H2	2014	2036	4.11e-2	SMART
ZnF_C2H2	2043	2066	4.98e-1	SMART
ZnF_C2H2	2072	2095	5.5e-3	SMART
ZnF_C2H2	2180	2203	7.05e-1	SMART
ZnF_C2H2	2209	2232	5.48e0	SMART
ZnF_C2H2	2243	2265	6.13e-1	SMART
ZnF_C2H2	2289	2311	1.26e-2	SMART
ZnF_C2H2	2317	2340	2.02e-1	SMART
low complexity region	2361	2384	N/A	INTRINSIC
ZnF_C2H2	2403	2425	2.2e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000133895

SMART Domains

Protein: ENSMUSP00000122775
Gene: ENSMUSG00000060206

Domain	Start	End	E-Value	Type
ZnF_C2H2	4	27	5.81e-2	SMART
low complexity region	81	93	N/A	INTRINSIC

Coding Region Coverage

1x: 99.8%
3x: 99.6%
10x: 98.8%
20x: 97.0%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to C2H2-type zinc finger family of proteins. It contains multiple C2H2-type zinc fingers and may be involved in transcriptional regulation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

Allele List at MGI

Other mutations in this stock

Total: 210 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700001K19Rik	TCT	TCTCCT	12: 110,668,448 (GRCm38)		probably benign	Het
2010300C02Rik	T	A	1: 37,625,035 (GRCm38)	E594V	probably benign	Homo
2010300C02Rik	C	A	1: 37,625,036 (GRCm38)	E594*	probably null	Homo
4930402H24Rik	CC	CCTGC	2: 130,770,752 (GRCm38)		probably benign	Het
4932415D10Rik	TTCA	T	10: 82,285,469 (GRCm38)		probably benign	Homo
4932438A13Rik	TTATTAT	TTATTATTATTATTACTATTAT	3: 37,050,754 (GRCm38)		probably benign	Het
A630001G21Rik	CTGTT	CT	1: 85,723,135 (GRCm38)		probably benign	Homo
Abcb11	C	A	2: 69,243,518 (GRCm38)	R1221L	probably damaging	Homo
Abcb4	GAAA	G	5: 8,896,597 (GRCm38)		probably benign	Homo
Ahdc1	CT	CTCGT	4: 133,062,759 (GRCm38)		probably benign	Homo
Alpk3	TCT	TCTACT	7: 81,077,762 (GRCm38)		probably benign	Het
Amfr	C	G	8: 94,005,159 (GRCm38)	G30R	probably damaging	Homo
Ankrd35	GC	GCTAC	3: 96,683,849 (GRCm38)		probably benign	Homo
Anxa7	C	T	14: 20,469,411 (GRCm38)	G113E	probably damaging	Homo
Apc	CAATAAAGC	CAATAAAGCTAATAAAGC	18: 34,281,999 (GRCm38)		probably benign	Homo
Apol6	GTTT	GTTTCTTT	15: 77,051,442 (GRCm38)		probably null	Homo
Arpc1b	GGTGGC	GGTGGCGTGGC	5: 145,126,787 (GRCm38)		probably null	Het
AY358078	C	T	14: 51,805,698 (GRCm38)	S281L	unknown	Homo
BC051142	GCA	GCATCA	17: 34,460,068 (GRCm38)		probably benign	Het
BC051142	CAG	CAGAAG	17: 34,460,051 (GRCm38)		probably benign	Het
Blm	ACCTGC	ACCTGCCTGC	7: 80,463,771 (GRCm38)		probably null	Het
Blm	T	TACCA	7: 80,463,774 (GRCm38)		probably null	Het
Blzf1	TTGT	TT	1: 164,303,917 (GRCm38)		probably null	Homo
Btnl10	A	AAGG	11: 58,923,931 (GRCm38)		probably benign	Homo
Cacna1a	ACC	ACCCCC	8: 84,638,726 (GRCm38)		probably benign	Homo
Cacna1a	ACC	ACCGCC	8: 84,638,720 (GRCm38)		probably benign	Het
Catsper2	TTC	TTCTTTTACTTTGTC	2: 121,397,540 (GRCm38)		probably benign	Homo
Ccdc170	ACC	ACCTCC	10: 4,561,023 (GRCm38)		probably benign	Het
Ccdc170	AC	ACCCC	10: 4,561,029 (GRCm38)		probably benign	Het
Ccdc73	TAAG	T	2: 104,991,840 (GRCm38)		probably benign	Homo
Ccnk	TTCCCAC	T	12: 108,202,507 (GRCm38)		probably benign	Het
Cdan1	A	C	2: 120,724,971 (GRCm38)	V763G	probably damaging	Het
Cdk6	A	G	5: 3,344,211 (GRCm38)		probably benign	Het
Cdx1	TGCTGC	TGCTGCCGCTGC	18: 61,019,874 (GRCm38)		probably benign	Het
Cdx1	GCTGCT	GCTGCTTCTGCT	18: 61,019,878 (GRCm38)		probably benign	Het
Cfap46	CCTTCT	CCTTCTTCT	7: 139,638,930 (GRCm38)		probably benign	Homo
Chd4	GC	GCTCCCCC	6: 125,122,131 (GRCm38)		probably benign	Homo
Cluh	CCCCGAGCC	CCCCGAGCCCGAGCC	11: 74,669,514 (GRCm38)		probably benign	Het
Cluh	AGCCTG	AGCCTGCGCCTG	11: 74,669,519 (GRCm38)		probably benign	Het
Cluh	GAGCCT	GAGCCTAAGCCT	11: 74,669,524 (GRCm38)		probably benign	Het
Cluh	CC	CCTGAGGC	11: 74,669,533 (GRCm38)		probably benign	Het
Cntnap1	AGCCCC	AGCCCCCGCCCC	11: 101,189,569 (GRCm38)		probably benign	Het
Cntnap1	GCCCCA	GCCCCAACCCCA	11: 101,189,576 (GRCm38)		probably benign	Het
Cntnap1	GCCCCA	GCCCCACCCCCA	11: 101,189,582 (GRCm38)		probably benign	Het
Cntnap1	CCCAGC	CCCAGCGCCAGC	11: 101,189,590 (GRCm38)		probably benign	Het
Cul9	CTC	CTCTTC	17: 46,500,858 (GRCm38)		probably benign	Het
Cul9	CTCTTC	CTCTTCTTC	17: 46,500,846 (GRCm38)		probably benign	Het
Cyth2	C	A	7: 45,813,042 (GRCm38)	S102I	possibly damaging	Het
Dbr1	GGAGG	GGAGGACGAGG	9: 99,583,699 (GRCm38)		probably benign	Het
Dbr1	AGGAGG	AGGAGGCGGAGG	9: 99,583,686 (GRCm38)		probably benign	Het
Dhx8	GACCGA	GACCGATACCGA	11: 101,738,179 (GRCm38)		probably benign	Homo
Dhx8	CGAGAC	CGAGACGGAGAC	11: 101,738,182 (GRCm38)		probably benign	Homo
Dhx8	GAGACC	GAGACCCAGACC	11: 101,738,189 (GRCm38)		probably benign	Homo
Dnah8	CCTCCCG	C	17: 30,635,477 (GRCm38)		probably benign	Homo
Dnah8	ACTGCCCCT	ACT	17: 30,635,465 (GRCm38)		probably benign	Het
Dnajb5	AGGTG	A	4: 42,957,126 (GRCm38)		probably null	Het
Dusp10	G	T	1: 184,037,056 (GRCm38)	C73F	probably damaging	Homo
E4f1	CCG	CCGACG	17: 24,455,192 (GRCm38)		probably benign	Homo
Eif3a	TTA	TTATTATA	19: 60,775,289 (GRCm38)		probably benign	Het
Fam81b	TTC	TTCGTC	13: 76,271,319 (GRCm38)		probably benign	Het
Fbxo22	G	A	9: 55,209,382 (GRCm38)	R56H	probably damaging	Het
Fcgr1	T	C	3: 96,287,094 (GRCm38)	D159G	probably benign	Homo
Fcgr1	CTTCT	C	3: 96,284,504 (GRCm38)		probably null	Het
Fmn1	CCTCCT	CCTCCTACTCCT	2: 113,525,778 (GRCm38)		probably benign	Het
Fmn1	CC	CCCCCTGC	2: 113,525,781 (GRCm38)		probably benign	Het
Fmn1	CC	CCTCCTTC	2: 113,525,784 (GRCm38)		probably benign	Het
G530012D18Rik	GA	GACAGAGATA	1: 85,577,178 (GRCm38)		probably null	Het
Gli3	G	A	13: 15,644,357 (GRCm38)	R248H	probably damaging	Het
Gm16503	G	A	4: 147,541,253 (GRCm38)	G68E	unknown	Het
Gm19345	GGATGGCAGGTG	GG	7: 19,857,602 (GRCm38)		probably null	Het
Gm4340	GCA	GCAACA	10: 104,196,077 (GRCm38)		probably benign	Het
Gm4340	AGC	AGCTGC	10: 104,196,097 (GRCm38)		probably benign	Het
Gm4340	AG	AGCGG	10: 104,196,100 (GRCm38)		probably benign	Het
Gm6309	C	T	5: 146,168,183 (GRCm38)	V307I	probably benign	Het
Gpatch11	AAGAGG	AAGAGGCAGAGG	17: 78,842,171 (GRCm38)		probably benign	Het
Gpatch11	AGGAA	AGGAAGCGGAA	17: 78,842,180 (GRCm38)		probably benign	Het
Hoxa10	T	A	6: 52,234,186 (GRCm38)	Q250L	possibly damaging	Homo
Hrh1	T	C	6: 114,481,123 (GRCm38)	I455T	possibly damaging	Het
Hspa1b	GCGCC	GC	17: 34,957,129 (GRCm38)		probably benign	Homo
Iba57	GAAA	GAAAAA	11: 59,161,505 (GRCm38)		probably null	Homo
Igf1r	TGGAGC	TGGAGCTGGAGAGGGAGC	7: 68,226,181 (GRCm38)		probably benign	Het
Il17rd	CGG	CGGAGG	14: 27,082,680 (GRCm38)		probably benign	Het
Il2	AGGTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTG	AGCTGCTGCTGCTGCTGCTGCTGCTG	3: 37,125,764 (GRCm38)		probably benign	Het
Il2	TGG	TGGGGCTTGAAGCGG	3: 37,125,828 (GRCm38)		probably benign	Het
Kcng4	G	T	8: 119,633,519 (GRCm38)	Y39*	probably null	Homo
Klra2	G	GAAATCCACAT	6: 131,221,852 (GRCm38)		probably null	Het
Kmt2b	TCCTCC	TCCTCCCCCTCC	7: 30,586,378 (GRCm38)		probably benign	Het
Kmt2b	CCTCCT	CCTCCTGCTCCT	7: 30,586,370 (GRCm38)		probably benign	Het
Kmt2b	CCTCCT	CCTCCTTCTCCT	7: 30,586,367 (GRCm38)		probably benign	Het
Kmt2b	TCCTCC	TCCTCCCCCTCC	7: 30,586,366 (GRCm38)		probably benign	Het
Krt10	TCCGCC	TCCGCCGCC	11: 99,386,197 (GRCm38)		probably benign	Homo
Krt10	TCCTCC	TCCTCCGCCTCC	11: 99,389,273 (GRCm38)		probably benign	Het
Krt10	TCC	TCCTCCACC	11: 99,389,279 (GRCm38)		probably benign	Homo
Krtap28-10	TCCCACA	TCCCACACCCACA	1: 83,042,123 (GRCm38)		probably benign	Homo
Krtap4-2	A	ACAC	11: 99,635,013 (GRCm38)		probably benign	Het
Krtap9-3	AC	ACAGGTGTCGC	11: 99,598,004 (GRCm38)		probably benign	Het
Las1l	AGG	AGGGGG	X: 95,940,821 (GRCm38)		probably benign	Het
Las1l	AGG	AGGCGG	X: 95,940,827 (GRCm38)		probably benign	Het
Las1l	GAG	GAGCAG	X: 95,940,829 (GRCm38)		probably benign	Het
Lrit3	AC	ACATTC	3: 129,803,913 (GRCm38)		probably null	Homo
Lrit3	GCT	GCTTCT	3: 129,788,810 (GRCm38)		probably benign	Het
Lrit3	TGC	TGCAGC	3: 129,788,806 (GRCm38)		probably benign	Het
Luzp1	A	AGGTGGCCTCTTCAGT	4: 136,543,196 (GRCm38)		probably benign	Het
Mamld1	GCA	GCAACA	X: 71,118,839 (GRCm38)		probably benign	Het
Mamld1	AGC	AGCCGC	X: 71,118,835 (GRCm38)		probably benign	Het
Mapk8ip3	G	A	17: 24,902,119 (GRCm38)		probably null	Homo
Mbd1	TGTCTGCATCTGCGTCTTCGTCTGCATCTGCATCTGCGTCTTCGTCTGCATCTGCATCTGC	TATCTGCATCTGCGTCTTCGTCTGCATCTGCATCTGC	18: 74,273,573 (GRCm38)		probably benign	Het
Nat8f2	T	A	6: 85,867,686 (GRCm38)	L231F	possibly damaging	Homo
Nfxl1	CC	CCGGGGAC	5: 72,559,121 (GRCm38)		probably benign	Het
Noc2l	GGTAG	GG	4: 156,241,501 (GRCm38)		probably benign	Homo
Noc2l	CTG	CTGTTG	4: 156,240,095 (GRCm38)		probably benign	Het
Noc2l	GCT	GCTTCT	4: 156,240,094 (GRCm38)		probably benign	Het
Nxpe5	C	T	5: 138,229,934 (GRCm38)		probably benign	Het
Olfr1038-ps	CAG	CAGAG	2: 86,122,760 (GRCm38)		probably null	Homo
Olfr418	GGGCTGCTTGTGGCAAT	G	1: 173,270,630 (GRCm38)		probably null	Het
Olfr568	CT	CTAATTGCCTT	7: 102,877,233 (GRCm38)		probably benign	Homo
Olfr644	G	C	7: 104,071,292 (GRCm38)		probably benign	Homo
Olfr890	A	G	9: 38,143,188 (GRCm38)	I13V	probably benign	Homo
Osmr	C	CTCA	15: 6,837,706 (GRCm38)		probably null	Homo
Patl2	C	CTGA	2: 122,126,145 (GRCm38)		probably benign	Het
Patl2	GC	GCTAC	2: 122,126,144 (GRCm38)		probably null	Het
Patl2	CTG	CTGTTG	2: 122,126,136 (GRCm38)		probably benign	Het
Pdik1l	ACCACC	ACCACCCCCACC	4: 134,279,506 (GRCm38)		probably benign	Het
Pdik1l	GTTTTTGTTTT	GTTTTTGTTTTTTTTTTGTTTT	4: 134,279,367 (GRCm38)		probably null	Homo
Phc1	GCTG	GCTGCTTCTG	6: 122,323,598 (GRCm38)		probably benign	Het
Piezo1	G	A	8: 122,495,569 (GRCm38)	R503W	probably damaging	Homo
Pitrm1	TTTTA	T	13: 6,560,596 (GRCm38)		probably benign	Homo
Pkdrej	TG	TGGGAGCG	15: 85,819,680 (GRCm38)		probably benign	Homo
Pla2g4e	AGGG	A	2: 120,244,724 (GRCm38)		probably benign	Homo
Plekhs1	AC	ACCTCCCCCGAGCC	19: 56,479,863 (GRCm38)		probably benign	Het
Pnmal1	CCTCATGATGCACCTGCTTCAACATC	CCTCATGATGCACCTGCTTCAACATCTCATGATGCACCTGCTTCAACATC	7: 16,961,425 (GRCm38)		probably benign	Homo
Pnmal2	TGGA	T	7: 16,946,006 (GRCm38)		probably benign	Het
Ppp1r3f	C	A	X: 7,560,336 (GRCm38)	G562V	probably damaging	Homo
Prr13	CTC	CTCATC	15: 102,462,173 (GRCm38)		probably benign	Het
Prss41	CACA	C	17: 23,844,097 (GRCm38)		probably benign	Het
Prtg	GTAAC	G	9: 72,857,081 (GRCm38)		probably benign	Het
Ptk2b	C	T	14: 66,173,849 (GRCm38)	R411Q	possibly damaging	Homo
Ptms	TCT	TCTGCT	6: 124,914,457 (GRCm38)		probably benign	Homo
Ptms	TTC	TTCGTC	6: 124,914,459 (GRCm38)		probably benign	Homo
Ptms	C	CTTG	6: 124,914,461 (GRCm38)		probably benign	Homo
Ptpn23	G	T	9: 110,387,633 (GRCm38)	P1052T	probably benign	Homo
Rab3il1	C	A	19: 10,033,751 (GRCm38)	A264E	probably damaging	Homo
Rbm6	GCTGT	G	9: 107,782,755 (GRCm38)		probably null	Homo
Rtbdn	GGC	GGCAGCTGC	8: 84,956,177 (GRCm38)		probably benign	Het
Rtbdn	CGGC	CGGCAGGGGC	8: 84,956,176 (GRCm38)		probably benign	Het
Rtbdn	AGCG	AGCGTCCGCG	8: 84,956,168 (GRCm38)		probably benign	Het
Rtbdn	TAG	TAGGGGCAG	8: 84,956,161 (GRCm38)		probably benign	Het
Sbp	G	GCTGACAACAAAGATC	17: 23,945,389 (GRCm38)		probably benign	Het
Sbp	CAAAG	CAAAGCTGCTGACAAAAAAG	17: 23,945,382 (GRCm38)		probably benign	Het
Setd1a	GTGGTAGTG	GTGGTAGTGTTGGTAGTG	7: 127,785,312 (GRCm38)		probably benign	Het
Sfswap	GCCCACTC	GCCCACTCATCCCACTC	5: 129,569,756 (GRCm38)		probably benign	Het
Six3	CGG	CGGGGG	17: 85,621,368 (GRCm38)		probably benign	Het
Six3	CGG	CGGGGG	17: 85,621,365 (GRCm38)		probably benign	Het
Six3	GGC	GGCAGC	17: 85,621,363 (GRCm38)		probably benign	Het
Six3	CGG	CGGGGG	17: 85,621,362 (GRCm38)		probably benign	Het
Six3	GGC	GGCAGC	17: 85,621,357 (GRCm38)		probably benign	Het
Six3	GCG	GCGCCG	17: 85,621,358 (GRCm38)		probably benign	Het
Slc12a1	ACC	ACCTTTGGCCACAACTCC	2: 125,154,214 (GRCm38)		probably benign	Homo
Smarca2	CAGCAGCAGCAGCAGCAGCA	CAGCAGCAGCAGCAGCAGCAGCAGCA	19: 26,630,999 (GRCm38)		probably benign	Homo
Spaca1	TCGCTC	TCGCTCGCGCTC	4: 34,049,836 (GRCm38)		probably benign	Het
Spag1	TTC	TTCGTC	15: 36,197,733 (GRCm38)		probably benign	Het
Spag17	AGG	AGGCGG	3: 100,056,257 (GRCm38)		probably benign	Het
Srebf2	G	T	15: 82,185,335 (GRCm38)	A693S	probably damaging	Homo
Srpk2	T	C	5: 23,545,196 (GRCm38)		probably null	Homo
Sry	GTG	GTGTTG	Y: 2,662,837 (GRCm38)		probably benign	Homo
Sry	TGG	TGGGGG	Y: 2,662,838 (GRCm38)		probably benign	Homo
Sry	AACTGCT	A	Y: 2,663,195 (GRCm38)		probably benign	Het
St5	CACCACACTGGGGCAGCCCACACTGGGGCAG	CCCCACACTGGGGCAG	7: 109,556,921 (GRCm38)		probably benign	Het
Stard9	C	CTAAGGGACTAGTAGG	2: 120,696,085 (GRCm38)		probably benign	Het
Supt20	GCAGCA	GCAGCAACAGCA	3: 54,727,657 (GRCm38)		probably benign	Het
Supt20	CAGCAG	CAGCAGGAGCAG	3: 54,727,658 (GRCm38)		probably benign	Het
Supt20	CAGCAG	CAGCAGAAGCAG	3: 54,727,661 (GRCm38)		probably benign	Het
Tcof1	GGGTA	G	18: 60,828,650 (GRCm38)		probably benign	Homo
Tdpoz3	A	C	3: 93,826,674 (GRCm38)	N219H	probably benign	Het
Tesk1	C	CCCCG	4: 43,447,004 (GRCm38)		probably null	Homo
Tob1	A	AGCC	11: 94,214,478 (GRCm38)		probably benign	Het
Tob1	GCA	GCAACA	11: 94,214,464 (GRCm38)		probably benign	Het
Tob1	CACA	CACAACA	11: 94,214,451 (GRCm38)		probably benign	Het
Trav15-2-dv6-2	G	GAAA	14: 53,649,757 (GRCm38)		probably benign	Homo
Trav15-2-dv6-2	AG	AGAGG	14: 53,649,756 (GRCm38)		probably benign	Homo
Trim63	GAGT	G	4: 134,327,725 (GRCm38)		probably benign	Het
Tsen2	G	GAGA	6: 115,560,077 (GRCm38)		probably benign	Het
Ttf2	TC	TCCCC	3: 100,963,160 (GRCm38)		probably benign	Homo
Tusc1	ACCGCC	ACCGCCCCCGCC	4: 93,335,313 (GRCm38)		probably benign	Homo
Ubqlnl	TGAG	T	7: 104,149,835 (GRCm38)		probably benign	Homo
Ubtf	CCT	CCTACT	11: 102,306,948 (GRCm38)		probably null	Het
Ubtf	TCC	TCCACC	11: 102,306,950 (GRCm38)		probably benign	Het
Vps13b	G	T	15: 35,846,957 (GRCm38)	A2629S	probably damaging	Homo
Wasf3	G	T	5: 146,470,250 (GRCm38)	R460L	probably damaging	Het
Zc3h13	ATGTGCGAG	ATGTGCGAGGTGTGCGAG	14: 75,323,596 (GRCm38)		probably benign	Homo
Zc3h13	TGCGAGATG	TGCGAGATGAGCGAGATG	14: 75,323,599 (GRCm38)		probably benign	Homo
Zfhx3	GCAACA	GCAACAACAACAACA	8: 108,956,088 (GRCm38)		probably benign	Het
Zfhx3	AGCA	AGCAACAGACGCA	8: 108,956,102 (GRCm38)		probably benign	Het
Zfhx3	GCA	GCAACAGCACCA	8: 108,956,103 (GRCm38)		probably benign	Het
Zfp111	TCA	TCAACA	7: 24,199,805 (GRCm38)		probably benign	Homo
Zfp112	CATGA	CATGATGA	7: 24,125,407 (GRCm38)		probably benign	Homo
Zfp26	C	A	9: 20,438,546 (GRCm38)	A241S	probably benign	Homo
Zfp282	CGG	CGGGGG	6: 47,904,799 (GRCm38)		probably benign	Het
Zfp282	CGG	CGGGGG	6: 47,904,790 (GRCm38)		probably benign	Het
Zfp335	TC	TCCCC	2: 164,907,484 (GRCm38)		probably benign	Het
Zfp335	TCC	TCCGCC	2: 164,907,475 (GRCm38)		probably benign	Het
Zfp335	CTC	CTCGTC	2: 164,907,474 (GRCm38)		probably benign	Het
Zfp598	AC	ACCACCGC	17: 24,680,791 (GRCm38)		probably benign	Het
Zfp598	ACCACC	ACCACCGCCACC	17: 24,680,782 (GRCm38)		probably benign	Het
Zfp598	ACCACC	ACCACCCCCACC	17: 24,680,776 (GRCm38)		probably benign	Het
Zfp831	CTC	CTCATC	2: 174,645,476 (GRCm38)		probably benign	Het
Zfp831	TC	TCCGC	2: 174,645,483 (GRCm38)		probably benign	Het
Zfp831	TCC	TCCCCC	2: 174,645,471 (GRCm38)		probably benign	Het
Zfp93	CAGGCATAG	CAG	7: 24,275,389 (GRCm38)		probably benign	Homo
Zscan10	TGACG	TG	17: 23,609,445 (GRCm38)		probably benign	Homo

Other mutations in Zfp462

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00162:Zfp462	APN	4	55,011,483 (GRCm38)	splice site	probably null
IGL00421:Zfp462	APN	4	55,023,576 (GRCm38)	missense	probably benign	0.00
IGL00899:Zfp462	APN	4	55,007,732 (GRCm38)	missense	probably damaging	1.00
IGL01549:Zfp462	APN	4	55,013,181 (GRCm38)	missense	probably damaging	1.00
IGL01627:Zfp462	APN	4	55,008,912 (GRCm38)	missense	possibly damaging	0.93
IGL01715:Zfp462	APN	4	55,008,586 (GRCm38)	missense	probably benign	0.20
IGL01862:Zfp462	APN	4	55,023,441 (GRCm38)	missense	probably damaging	1.00
IGL01878:Zfp462	APN	4	55,010,613 (GRCm38)	missense	probably damaging	1.00
IGL01913:Zfp462	APN	4	55,012,138 (GRCm38)	missense	probably benign	0.04
IGL02029:Zfp462	APN	4	55,079,395 (GRCm38)	splice site	probably benign
IGL02338:Zfp462	APN	4	55,010,292 (GRCm38)	missense	possibly damaging	0.88
IGL02552:Zfp462	APN	4	55,010,613 (GRCm38)	missense	probably damaging	1.00
IGL02623:Zfp462	APN	4	55,012,986 (GRCm38)	missense	probably damaging	1.00
IGL02750:Zfp462	APN	4	55,060,236 (GRCm38)	missense	probably null	1.00
IGL02815:Zfp462	APN	4	55,051,303 (GRCm38)	missense	probably damaging	1.00
IGL03204:Zfp462	APN	4	55,080,785 (GRCm38)	missense	possibly damaging	0.80
FR4304:Zfp462	UTSW	4	55,009,758 (GRCm38)	unclassified	probably benign
FR4304:Zfp462	UTSW	4	55,009,757 (GRCm38)	unclassified	probably benign
FR4737:Zfp462	UTSW	4	55,009,760 (GRCm38)	unclassified	probably benign
FR4976:Zfp462	UTSW	4	55,009,761 (GRCm38)	unclassified	probably benign
FR4976:Zfp462	UTSW	4	55,009,760 (GRCm38)	unclassified	probably benign
P0035:Zfp462	UTSW	4	55,009,086 (GRCm38)	missense	probably benign
R0052:Zfp462	UTSW	4	55,011,762 (GRCm38)	missense	probably benign	0.03
R0143:Zfp462	UTSW	4	55,023,402 (GRCm38)	splice site	probably benign
R0145:Zfp462	UTSW	4	55,010,529 (GRCm38)	missense	probably damaging	1.00
R0315:Zfp462	UTSW	4	55,079,314 (GRCm38)	missense	probably damaging	0.99
R0349:Zfp462	UTSW	4	55,008,768 (GRCm38)	missense	probably benign
R0359:Zfp462	UTSW	4	55,013,689 (GRCm38)	missense	probably damaging	1.00
R0413:Zfp462	UTSW	4	55,010,534 (GRCm38)	missense	probably damaging	0.99
R0554:Zfp462	UTSW	4	55,013,689 (GRCm38)	missense	probably damaging	1.00
R0616:Zfp462	UTSW	4	55,011,951 (GRCm38)	missense	probably damaging	1.00
R0631:Zfp462	UTSW	4	55,007,563 (GRCm38)	start codon destroyed	possibly damaging	0.60
R1086:Zfp462	UTSW	4	55,013,000 (GRCm38)	missense	probably damaging	1.00
R1499:Zfp462	UTSW	4	55,060,046 (GRCm38)	missense	probably damaging	1.00
R1509:Zfp462	UTSW	4	55,007,667 (GRCm38)	missense	probably damaging	1.00
R1526:Zfp462	UTSW	4	55,009,002 (GRCm38)	missense	probably benign
R1541:Zfp462	UTSW	4	55,008,928 (GRCm38)	missense	possibly damaging	0.53
R1691:Zfp462	UTSW	4	55,013,489 (GRCm38)	missense	possibly damaging	0.70
R1843:Zfp462	UTSW	4	55,010,010 (GRCm38)	missense	possibly damaging	0.88
R2086:Zfp462	UTSW	4	55,010,830 (GRCm38)	missense	probably damaging	1.00
R2109:Zfp462	UTSW	4	55,008,496 (GRCm38)	missense	probably benign	0.00
R2148:Zfp462	UTSW	4	55,013,670 (GRCm38)	missense	probably benign	0.01
R2179:Zfp462	UTSW	4	55,009,524 (GRCm38)	missense	possibly damaging	0.73
R2325:Zfp462	UTSW	4	55,013,712 (GRCm38)	missense	probably benign
R2352:Zfp462	UTSW	4	55,008,313 (GRCm38)	missense	probably null
R2566:Zfp462	UTSW	4	55,008,522 (GRCm38)	missense	probably benign	0.00
R3879:Zfp462	UTSW	4	55,060,095 (GRCm38)	missense	probably damaging	1.00
R3969:Zfp462	UTSW	4	55,012,402 (GRCm38)	missense	probably damaging	1.00
R4273:Zfp462	UTSW	4	55,008,411 (GRCm38)	missense	probably benign	0.00
R4413:Zfp462	UTSW	4	55,012,672 (GRCm38)	missense	probably damaging	0.99
R4510:Zfp462	UTSW	4	55,008,934 (GRCm38)	missense	possibly damaging	0.86
R4511:Zfp462	UTSW	4	55,008,934 (GRCm38)	missense	possibly damaging	0.86
R4609:Zfp462	UTSW	4	55,011,889 (GRCm38)	missense	probably damaging	1.00
R4632:Zfp462	UTSW	4	55,012,981 (GRCm38)	missense	probably damaging	1.00
R4649:Zfp462	UTSW	4	55,009,349 (GRCm38)	missense	probably benign
R4682:Zfp462	UTSW	4	55,011,376 (GRCm38)	missense	probably damaging	1.00
R4696:Zfp462	UTSW	4	55,008,612 (GRCm38)	missense	probably benign
R4744:Zfp462	UTSW	4	55,011,598 (GRCm38)	missense	probably damaging	1.00
R4747:Zfp462	UTSW	4	55,013,476 (GRCm38)	missense	probably benign	0.00
R4819:Zfp462	UTSW	4	55,060,044 (GRCm38)	missense	probably damaging	1.00
R4827:Zfp462	UTSW	4	55,012,213 (GRCm38)	missense	probably damaging	1.00
R4854:Zfp462	UTSW	4	55,010,668 (GRCm38)	missense	probably damaging	1.00
R4879:Zfp462	UTSW	4	55,009,444 (GRCm38)	missense	probably benign	0.02
R4891:Zfp462	UTSW	4	55,060,055 (GRCm38)	missense	probably damaging	1.00
R4993:Zfp462	UTSW	4	55,051,204 (GRCm38)	missense	possibly damaging	0.62
R5118:Zfp462	UTSW	4	55,010,667 (GRCm38)	missense	probably damaging	1.00
R5171:Zfp462	UTSW	4	55,016,986 (GRCm38)	splice site	probably null
R5173:Zfp462	UTSW	4	55,011,115 (GRCm38)	missense	probably damaging	0.99
R5221:Zfp462	UTSW	4	55,016,887 (GRCm38)	missense	possibly damaging	0.86
R5268:Zfp462	UTSW	4	55,012,299 (GRCm38)	missense	probably benign
R5314:Zfp462	UTSW	4	55,013,178 (GRCm38)	missense	probably damaging	1.00
R5429:Zfp462	UTSW	4	55,060,077 (GRCm38)	missense	probably damaging	1.00
R5518:Zfp462	UTSW	4	55,009,818 (GRCm38)	missense	probably damaging	0.99
R5525:Zfp462	UTSW	4	55,050,281 (GRCm38)	missense	possibly damaging	0.73
R5620:Zfp462	UTSW	4	55,013,464 (GRCm38)	missense	probably benign	0.01
R5775:Zfp462	UTSW	4	55,010,590 (GRCm38)	missense	probably damaging	0.99
R6126:Zfp462	UTSW	4	55,023,573 (GRCm38)	missense	probably benign	0.01
R6280:Zfp462	UTSW	4	55,010,253 (GRCm38)	missense	probably benign	0.00
R6325:Zfp462	UTSW	4	55,080,680 (GRCm38)	missense	probably benign	0.04
R6542:Zfp462	UTSW	4	55,023,433 (GRCm38)	missense	probably damaging	1.00
R6612:Zfp462	UTSW	4	55,012,324 (GRCm38)	splice site	probably null
R6663:Zfp462	UTSW	4	55,008,933 (GRCm38)	missense	possibly damaging	0.53
R6872:Zfp462	UTSW	4	55,012,326 (GRCm38)	missense	probably benign	0.01
R6889:Zfp462	UTSW	4	55,007,671 (GRCm38)	missense	probably damaging	1.00
R6896:Zfp462	UTSW	4	55,009,544 (GRCm38)	missense	possibly damaging	0.72
R6913:Zfp462	UTSW	4	55,007,775 (GRCm38)	missense	probably benign	0.25
R6988:Zfp462	UTSW	4	55,080,716 (GRCm38)	missense	probably benign	0.00
R7131:Zfp462	UTSW	4	55,009,380 (GRCm38)	missense	probably benign
R7151:Zfp462	UTSW	4	55,051,271 (GRCm38)	missense	probably damaging	0.99
R7684:Zfp462	UTSW	4	55,008,908 (GRCm38)	missense	probably benign
R7741:Zfp462	UTSW	4	55,008,637 (GRCm38)	missense	probably benign	0.00
R7750:Zfp462	UTSW	4	55,016,958 (GRCm38)	missense	probably benign	0.06
R7812:Zfp462	UTSW	4	55,008,509 (GRCm38)	missense	probably benign	0.00
R7863:Zfp462	UTSW	4	55,007,747 (GRCm38)	missense	probably benign
R7898:Zfp462	UTSW	4	55,012,995 (GRCm38)	missense	probably damaging	0.98
R7993:Zfp462	UTSW	4	55,011,907 (GRCm38)	missense	probably damaging	1.00
R7995:Zfp462	UTSW	4	55,011,907 (GRCm38)	missense	probably damaging	1.00
R8023:Zfp462	UTSW	4	55,073,106 (GRCm38)	critical splice donor site	probably null
R8394:Zfp462	UTSW	4	55,011,862 (GRCm38)	missense	probably damaging	1.00
R8669:Zfp462	UTSW	4	55,051,313 (GRCm38)	missense	probably damaging	0.99
R8877:Zfp462	UTSW	4	55,011,097 (GRCm38)	missense	probably damaging	0.98
R8980:Zfp462	UTSW	4	55,009,681 (GRCm38)	unclassified	probably benign
R9023:Zfp462	UTSW	4	55,007,563 (GRCm38)	start codon destroyed	probably null	0.00
R9243:Zfp462	UTSW	4	55,009,595 (GRCm38)	nonsense	probably null
R9378:Zfp462	UTSW	4	55,011,510 (GRCm38)	missense	probably benign	0.00
R9417:Zfp462	UTSW	4	55,016,988 (GRCm38)	missense	probably benign	0.26
R9476:Zfp462	UTSW	4	55,080,735 (GRCm38)	missense	probably benign
R9510:Zfp462	UTSW	4	55,080,735 (GRCm38)	missense	probably benign
R9610:Zfp462	UTSW	4	55,009,545 (GRCm38)	missense	possibly damaging	0.73
R9628:Zfp462	UTSW	4	55,009,423 (GRCm38)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- TGTGAATTCTCAAAGCGAAAGC -3'
(R):5'- TTTCCAGTGGTAGGCTCGAG -3'

Sequencing Primer
(F):5'- CCTCGTTGAATGAAGGAATGGTATC -3'
(R):5'- CCTTTCAGAGTCATGGTG -3'

Posted On

2018-04-05